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The Lancet Regional Health - Western Pacific最新文献

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Use of the Chinese version of the MATRICS Consensus Cognitive Battery to assess cognitive functioning in individuals with high risk for psychosis, first-episode schizophrenia and chronic schizophrenia: a systematic review and meta-analysis 使用 MATRICS 共识认知测验中文版评估精神病高危人群、首发精神分裂症患者和慢性精神分裂症患者的认知功能:系统综述和荟萃分析
Pub Date : 2024-02-01 DOI: 10.1016/j.lanwpc.2024.101016
Bing Cai, Yikang Zhu, Dongyang Liu, Yaxi Li, Marlys Bueber, Xuezhi Yang, Guoshuai Luo, Ying Su, Margaux M. Grivel, Lawrence H. Yang, Min Qian, William S. Stone, Michael R. Phillips
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引用次数: 0
Protective effect of previous infection and vaccination against reinfection with BA.5 Omicron subvariant: a nationwide population-based study in Japan 既往感染和接种疫苗对再次感染 BA.5 Omicron 亚变异体的保护作用:日本全国人口研究
Pub Date : 2023-09-01 DOI: 10.2139/ssrn.4463500
Noriko Kitamura, Kanako Otani, Ryo Kinoshita, Fangyu Yan, Yu Takizawa, Kohei Fukushima, Daisuke Yoneoka, Motoi Suzuki, T. Kamigaki
Background: The Omicron variant of SARS-CoV-2 was reported to evade immunity derived from vaccination and previous infection. A better understanding of hybrid immunity informs effective infection control strategies. Since the reinfection risk was not well-assessed in East Asia, this study aims to evaluate the risk of infection with Omicron subvariant BA.5 among previously infected individuals in Japan.Methods: All notified cases were extracted from the Japanese national COVID-19 surveillance database including 20,297,335 records up to 25 September 2022. Reinfection with BA.5 was defined as the second infection notified during the BA.5 dominated period. The protective effect of prior infections against reinfections with BA.5 was estimated by applying a case-population design and the protective effect of vaccination was estimated by a multivariable Cox regression adjusting for age, sex, variants of prior infection, and the time since the last vaccination.Findings: Among 19,830,548 SARS-CoV-2 infections, 233,424 (1·2%) were reinfected with BA.5. The protective effect of prior infection with Wuhan, Alpha, Delta, and BA.1/BA.2 against BA.5 reinfection was 46·2% (45·5–47·0), 35·2% (34·2–36·2), 40·6% (39·9–41·2), and 73·9% (73·4–74·4), respectively. The risk of BA.5 reinfection was reduced by 14%, 41%, and 71% by two, three and four doses of vaccination, respectively, compared with one-dose vaccination.Interpretation: The prior infections with Omicron subvariant BA.1/BA.2 protected BA.5 reinfection more than pre-Omicron variants. Increased frequency of vaccination led to more protection from reinfection with BA.5. Up-to-date vaccination may be encouraged to prevent future reinfection among the previously infected population.Funding: RK received funding from the Japan Society for the Promotion of Science (JSPS) KAKENHI (21K17307). MS and TK received the Ministry of Health Labour and Welfare Science Research Grant (23HA2005).Declaration of Interest: The authors declare that they have no conflict of interest.Ethical Approval: No ethical approval was required because this study was conducted for public health purposes using national surveillance data.
背景:据报道,SARS-CoV-2 的 Omicron 变体可逃避疫苗接种和既往感染产生的免疫力。更好地了解混合免疫有助于制定有效的感染控制策略。由于东亚地区的再感染风险尚未得到充分评估,本研究旨在评估日本既往感染者感染 Omicron 亚变异体 BA.5 的风险:截至 2022 年 9 月 25 日,所有通报病例均来自日本国家 COVID-19 监测数据库,其中包括 20,297,335 条记录。BA.5的再感染定义为在BA.5主导期间通报的第二次感染。采用病例-人群设计估算了先前感染对再次感染 BA.5 的保护作用,并通过多变量 Cox 回归估算了接种疫苗的保护作用,该回归调整了年龄、性别、先前感染的变异性以及距上次接种疫苗的时间:在 19 830 548 例 SARS-CoV-2 感染者中,233 424 例(1-2%)再次感染了 BA.5。之前感染武汉、阿尔法、德尔塔和 BA.1/BA.2 对 BA.5 再感染的保护效果分别为 46-2%(45-5-47-0)、35-2%(34-2-36-2)、40-6%(39-9-41-2)和 73-9%(73-4-74-4)。与接种一剂疫苗相比,接种两剂、三剂和四剂疫苗的 BA.5 再感染风险分别降低了 14%、41% 和 71%:解释:之前感染过奥米克龙亚变体 BA.1/BA.2 对 BA.5 再感染的保护作用大于奥米克龙之前的变体。增加疫苗接种频率可更有效地防止再次感染 BA.5。可鼓励进行最新疫苗接种,以防止先前感染人群再次感染:RK获得了日本学术振兴会(JSPS)KAKENHI(21K17307)的资助。MS和TK获得了厚生劳动省科学研究补助金(23HA2005):作者声明他们没有利益冲突:本研究出于公共卫生目的,使用了国家监测数据,因此无需伦理批准。
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The Lancet Regional Health - Western Pacific
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