Pub Date : 2024-07-15DOI: 10.11648/j.ijgg.20241203.11
Babatunde Olowu, Ahmed Olaide, Oluwaloni Tinubu
Sickle cell anaemia is one of the haemoglobin abnormalities resulting from a genetic mutation— it is caused by inheriting two faulty genes that result in an abnormal substitution of glutamate for valine on the beta chain of haemoglobin, which causes haemoglobin molecules to stick together. According to a World Health Organization (WHO) report, 20 out of every 1,000 births suffer from sickle-cell anaemia, and 24% of Nigerians are carriers of this mutant gene. Scientists have suggested several solutions, including stem cell transplantation and gene therapies, but these have faced opposition due to ethical beliefs, high cost, and the ensuing immune issues. Research is now centered on advancing genome editing techniques for gene therapy. Ongoing studies have proven that genetic differences can be corrected methodically by modifying the genome at specific sites instead of introducing a new copy of the affected gene into the cells; due to the effectiveness of this method, scientists are testing its applications in manipulating genes in various systems. This review correlates a few studies that used the recently developed technique—CRISPR-Cas9—as a novel approach to gene therapy, dissecting the different clinical studies about sickle cell origin to point out many of its ethical and medical limitations, the consequences of these limitations, and the advancements this technology has made possible.
{"title":"CRISPR-Cas9 Gene Editing Therapy, a Curative Hope for Sickle Cell in Nigeria, West Africa","authors":"Babatunde Olowu, Ahmed Olaide, Oluwaloni Tinubu","doi":"10.11648/j.ijgg.20241203.11","DOIUrl":"https://doi.org/10.11648/j.ijgg.20241203.11","url":null,"abstract":"Sickle cell anaemia is one of the haemoglobin abnormalities resulting from a genetic mutation— it is caused by inheriting two faulty genes that result in an abnormal substitution of glutamate for valine on the beta chain of haemoglobin, which causes haemoglobin molecules to stick together. According to a World Health Organization (WHO) report, 20 out of every 1,000 births suffer from sickle-cell anaemia, and 24% of Nigerians are carriers of this mutant gene. Scientists have suggested several solutions, including stem cell transplantation and gene therapies, but these have faced opposition due to ethical beliefs, high cost, and the ensuing immune issues. Research is now centered on advancing genome editing techniques for gene therapy. Ongoing studies have proven that genetic differences can be corrected methodically by modifying the genome at specific sites instead of introducing a new copy of the affected gene into the cells; due to the effectiveness of this method, scientists are testing its applications in manipulating genes in various systems. This review correlates a few studies that used the recently developed technique—CRISPR-Cas9—as a novel approach to gene therapy, dissecting the different clinical studies about sickle cell origin to point out many of its ethical and medical limitations, the consequences of these limitations, and the advancements this technology has made possible.\u0000","PeriodicalId":508424,"journal":{"name":"International Journal of Genetics and Genomics","volume":" 65","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.11648/j.ijgg.20241201.13
Huluager Ayanaw, Zelalem Tamiru, Minida Tadese, A. Asefa
The growth and output of coffee are significantly hampered by drought. To lessen the effects of climate change on coffee production, it is crucial to choose genotypes of Arabica coffee that are resistant to drought. The goal of the study was to select genotypes of Wellega coffee that are drought-tolerant at the Haru Agricultural Research Sub-Center in the Oromia National Regional State, Western Ethiopia. The experiment was carried out in a controlled environment from 2017 to 2019 G. C., with three replications laid out in RCBD. For 28 days, two watering regimes—well-watered and water-stressed—were applied to fourteen genotypes of Wellega coffee. The mother trees of genotype were tested at field condition. The experiment's findings showed that the genotypes not differed significantly in terms of total dry matter, relative leaf water content, and leaf retention capacity as well as in terms of the degree of wilting and in all destructive parameters. So, to select the drought tolerance coffee genotypes the stress period should be minimized in to 15-21 days.
{"title":"Evaluation of Coffee Genotype for Drought Tolerance and Water Use Efficiency in Western Ethiopia at West Wollega","authors":"Huluager Ayanaw, Zelalem Tamiru, Minida Tadese, A. Asefa","doi":"10.11648/j.ijgg.20241201.13","DOIUrl":"https://doi.org/10.11648/j.ijgg.20241201.13","url":null,"abstract":"The growth and output of coffee are significantly hampered by drought. To lessen the effects of climate change on coffee production, it is crucial to choose genotypes of Arabica coffee that are resistant to drought. The goal of the study was to select genotypes of Wellega coffee that are drought-tolerant at the Haru Agricultural Research Sub-Center in the Oromia National Regional State, Western Ethiopia. The experiment was carried out in a controlled environment from 2017 to 2019 G. C., with three replications laid out in RCBD. For 28 days, two watering regimes—well-watered and water-stressed—were applied to fourteen genotypes of Wellega coffee. The mother trees of genotype were tested at field condition. The experiment's findings showed that the genotypes not differed significantly in terms of total dry matter, relative leaf water content, and leaf retention capacity as well as in terms of the degree of wilting and in all destructive parameters. So, to select the drought tolerance coffee genotypes the stress period should be minimized in to 15-21 days.","PeriodicalId":508424,"journal":{"name":"International Journal of Genetics and Genomics","volume":"25 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-11DOI: 10.11648/j.ijgg.20241201.11
Garome Shifaraw, S. Alamerew, Techale Birhan
{"title":"Morphological Variations in Bread Wheat (<i>Triticum aestivum</i> L.) Genotypes in Gechi District, South West Ethiopia","authors":"Garome Shifaraw, S. Alamerew, Techale Birhan","doi":"10.11648/j.ijgg.20241201.11","DOIUrl":"https://doi.org/10.11648/j.ijgg.20241201.11","url":null,"abstract":"","PeriodicalId":508424,"journal":{"name":"International Journal of Genetics and Genomics","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139625592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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