We have closely read the recent article titled “Evaluation of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia abyssinica in Mice” by Ayele et al. 1 Interestingly, according to our searches, there is limited research available on the Aqueous Leaf and Stem Extracts of Artemisia abyssinica (A. abyssinica) . Most previous studies have focused on the antibacterial and antioxidant effect of A. abyssinica using crude extracts and essential oils. Hence, this study is likely the first evaluation of the laxative effects of Aqueous Leaf and Stem Extracts of A. abyssinica . This study used a method to prepare aqueous leaves and stems of A. abyssinica extracts by heating a plant in 0.8L of distilled water in a 1:1 ratio. Sorita et al (2023) highlighted the benefits of using aqueous extracts, such as minimizing the reliance on organic solvents, reducing expenses, and lowering energy consumption. 2 Based on the results of this article, aqueous leaf and stem extracts of A. abyssinica have demonstrated laxative activity, specifically loperamide-induced constipation. The standard drugs (Castor oil) and bisacodyl used in this study also increased the wet fecal content and frequency of defecation. Ikarashi et al showed that the laxative effect of
{"title":"Evaluation of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia abyssinica in Mice [LETTER]","authors":"Siti Aliyah, Rizky Yulion, Santi Perawati","doi":"10.2147/JEP.S470683","DOIUrl":"https://doi.org/10.2147/JEP.S470683","url":null,"abstract":"We have closely read the recent article titled “Evaluation of the in vivo Laxative Effects of Aqueous Leaf and Stem Extracts of Artemisia abyssinica in Mice” by Ayele et al. 1 Interestingly, according to our searches, there is limited research available on the Aqueous Leaf and Stem Extracts of Artemisia abyssinica (A. abyssinica) . Most previous studies have focused on the antibacterial and antioxidant effect of A. abyssinica using crude extracts and essential oils. Hence, this study is likely the first evaluation of the laxative effects of Aqueous Leaf and Stem Extracts of A. abyssinica . This study used a method to prepare aqueous leaves and stems of A. abyssinica extracts by heating a plant in 0.8L of distilled water in a 1:1 ratio. Sorita et al (2023) highlighted the benefits of using aqueous extracts, such as minimizing the reliance on organic solvents, reducing expenses, and lowering energy consumption. 2 Based on the results of this article, aqueous leaf and stem extracts of A. abyssinica have demonstrated laxative activity, specifically loperamide-induced constipation. The standard drugs (Castor oil) and bisacodyl used in this study also increased the wet fecal content and frequency of defecation. Ikarashi et al showed that the laxative effect of","PeriodicalId":508701,"journal":{"name":"Journal of Experimental Pharmacology","volume":"347 ","pages":"173 - 174"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose To evaluate the diuretic effects of aqueous (AQ) and hydromethanolic crude extract (HM) the as well as the solvent fractions of the HM extract from Erica arborea flowers in mice. Methods Mice were administered AQ and HM crude extracts, along with solvent fractions of HM extracts of E. arborea flowers, including HXF (n-hexane fraction), EAF (ethyl acetate fraction), and AQF (aqueous fraction), at doses ranging from 100 to 400 mg/kg orally. The effects of these extracts and solvent fractions on urine and salt excretion over 5 hours were compared to the effects of the solvent used for reconstitution and a standard drug (furosemide 10 mg/kg), as well as to each other. Results The HM crude extract at a lower dose (100 mg/kg) significantly increased urine volume and salt excretion starting from the 3rd h compared to the AQ crude extract. Similar effects were observed for EAF. Notably, the HM extract and its EAF at 400 mg/kg showed comparable urine and salt excretion profiles to the standard drug. Conclusion This study demonstrated that HM extract and EAF promote better diuresis, likely due to their saluretic properties. Furthermore, it confirms the diuretic activity of Erica arborea flowers.
{"title":"Evaluation of Diuretic Activity of Aqueous and Hydro Methanolic Crude Extracts and Solvent Fraction of the Hydromethanolic Flower Extract of Erica Arborea L. (Ericaceae) in Swiss Albino Mice","authors":"Nardos Wondimu, Mestayet Mengistie, J. Yesuf","doi":"10.2147/JEP.S453578","DOIUrl":"https://doi.org/10.2147/JEP.S453578","url":null,"abstract":"Purpose To evaluate the diuretic effects of aqueous (AQ) and hydromethanolic crude extract (HM) the as well as the solvent fractions of the HM extract from Erica arborea flowers in mice. Methods Mice were administered AQ and HM crude extracts, along with solvent fractions of HM extracts of E. arborea flowers, including HXF (n-hexane fraction), EAF (ethyl acetate fraction), and AQF (aqueous fraction), at doses ranging from 100 to 400 mg/kg orally. The effects of these extracts and solvent fractions on urine and salt excretion over 5 hours were compared to the effects of the solvent used for reconstitution and a standard drug (furosemide 10 mg/kg), as well as to each other. Results The HM crude extract at a lower dose (100 mg/kg) significantly increased urine volume and salt excretion starting from the 3rd h compared to the AQ crude extract. Similar effects were observed for EAF. Notably, the HM extract and its EAF at 400 mg/kg showed comparable urine and salt excretion profiles to the standard drug. Conclusion This study demonstrated that HM extract and EAF promote better diuresis, likely due to their saluretic properties. Furthermore, it confirms the diuretic activity of Erica arborea flowers.","PeriodicalId":508701,"journal":{"name":"Journal of Experimental Pharmacology","volume":"1211 1","pages":"175 - 187"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teshome Gonfa, A. Temesgen, Tsegu Kiros, S. Muthusaravanan, Olyad Erba Urgessa, Tadele Teklu
{"title":"Phytochemical Investigation and in vitro Antimicrobial and Antioxidant Activities Evaluation of Erianthemum aethiopicum Wiens and Polhill","authors":"Teshome Gonfa, A. Temesgen, Tsegu Kiros, S. Muthusaravanan, Olyad Erba Urgessa, Tadele Teklu","doi":"10.2147/jep.s452098","DOIUrl":"https://doi.org/10.2147/jep.s452098","url":null,"abstract":"","PeriodicalId":508701,"journal":{"name":"Journal of Experimental Pharmacology","volume":"373 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teshome Gonfa, A. Temesgen, Tsegu Kiros, S. Muthusaravanan, Olyad Erba Urgessa, Tadele Teklu
{"title":"Phytochemical Investigation and in vitro Antimicrobial and Antioxidant Activities Evaluation of Erianthemum aethiopicum Wiens and Polhill","authors":"Teshome Gonfa, A. Temesgen, Tsegu Kiros, S. Muthusaravanan, Olyad Erba Urgessa, Tadele Teklu","doi":"10.2147/jep.s452098","DOIUrl":"https://doi.org/10.2147/jep.s452098","url":null,"abstract":"","PeriodicalId":508701,"journal":{"name":"Journal of Experimental Pharmacology","volume":"252 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faradila Tiarasanti, I. Sufiawati, Eri Amalia, Kartika Sari, Cucu Zubaedah, Veni Takarini
{"title":"The Effects of Potato (Solanum tuberosum L. vs. Granola; Solanaceae) Peel Extract Gel on Gingival Wound Healing in Wistar Rats","authors":"Faradila Tiarasanti, I. Sufiawati, Eri Amalia, Kartika Sari, Cucu Zubaedah, Veni Takarini","doi":"10.2147/jep.s443355","DOIUrl":"https://doi.org/10.2147/jep.s443355","url":null,"abstract":"","PeriodicalId":508701,"journal":{"name":"Journal of Experimental Pharmacology","volume":"248 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139636359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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