Rakeshkumar Patel, B. Saha, Tripti Halder, Nitin Gupta
Besifloxacin hydrochloride (BSF) drug substance (DS), is effective against gram-positive and gram-negative microorganisms. BSF (liquid suspension form) is already available in two different market brands: Besivance and Besix. Both of these commercialized drug products (DP) have lower mucoadhesive characteristics, therefore they spend less time in contact with various ocular tissues (cornea and conjunctiva). This research work emphasized the design, development, and optimization of BSF-loaded solid-lipid nanoparticles (BSF@SLN) to increase antibacterial activity by enhancing drug absorption through passive diffusion techniques in the ocular organ compared to conventional dosage forms. The SLN was prepared through a very simple process hot homogenization process using glyceryl monostearate and polysorbate-80 along with poloxamer-188 and water for injection. Various characterization techniques like FTIR, DSC, and XRD were performed to check the compatibility between DS and excipients. The preliminary formulation of SLN was characterized through zeta potential, polydispersity index, and particle size techniques. The developed SLN was optimized following 32 factorial designs. Surface morphology and size of optimized BSF@SLN ophthalmic DP were confirmed by using advanced microscopic techniques such as SEM. In-vitro release of optimized BSF@SLN ophthalmic DP was performed by using two chambers of Franz diffusion cell. Stability studies of optimized BSF@SLN ophthalmic nanoformulations were tested for up to 6 months at 25°C ± 2°C/60% ± 5% RH. The antimicrobial activity of optimized ophthalmic nanoformulation was found 2.76 times more effective compared to the Besix eye drop. In-vivo study of BSF@SLN ophthalmic nanoformulations was carried out with an eye irritancy test and compared with marketed DP (Besix). and found significant pharmacological.
{"title":"An antibiotic efficacy comparative study between market-prescribed and solid-lipid fluoroquinolone ophthalmic nanoformulation against conjunctivitis","authors":"Rakeshkumar Patel, B. Saha, Tripti Halder, Nitin Gupta","doi":"10.37256/mp.3120244237","DOIUrl":"https://doi.org/10.37256/mp.3120244237","url":null,"abstract":"Besifloxacin hydrochloride (BSF) drug substance (DS), is effective against gram-positive and gram-negative microorganisms. BSF (liquid suspension form) is already available in two different market brands: Besivance and Besix. Both of these commercialized drug products (DP) have lower mucoadhesive characteristics, therefore they spend less time in contact with various ocular tissues (cornea and conjunctiva). This research work emphasized the design, development, and optimization of BSF-loaded solid-lipid nanoparticles (BSF@SLN) to increase antibacterial activity by enhancing drug absorption through passive diffusion techniques in the ocular organ compared to conventional dosage forms. The SLN was prepared through a very simple process hot homogenization process using glyceryl monostearate and polysorbate-80 along with poloxamer-188 and water for injection. Various characterization techniques like FTIR, DSC, and XRD were performed to check the compatibility between DS and excipients. The preliminary formulation of SLN was characterized through zeta potential, polydispersity index, and particle size techniques. The developed SLN was optimized following 32 factorial designs. Surface morphology and size of optimized BSF@SLN ophthalmic DP were confirmed by using advanced microscopic techniques such as SEM. In-vitro release of optimized BSF@SLN ophthalmic DP was performed by using two chambers of Franz diffusion cell. Stability studies of optimized BSF@SLN ophthalmic nanoformulations were tested for up to 6 months at 25°C ± 2°C/60% ± 5% RH. The antimicrobial activity of optimized ophthalmic nanoformulation was found 2.76 times more effective compared to the Besix eye drop. In-vivo study of BSF@SLN ophthalmic nanoformulations was carried out with an eye irritancy test and compared with marketed DP (Besix). and found significant pharmacological.","PeriodicalId":509068,"journal":{"name":"Materials Plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article demonstrates a statistical method to update the uncertainty in the flexural strength of silicon carbide, α-SiC. The previously reported uncertainty for the flexural strength of α-SiC was a constant ±15%. However, this uncertainty should be adjusted as more data becomes available. A Bayesian approach is proposed to rapidly and precisely update the uncertainty. To validate the method, five scenarios are demonstrated. The first scenario assumes the experimental data is distributed as the model predicts. The second and third scenarios have the model underestimating and overestimating flexural strength, respectively. The fourth and fifth scenarios use data from a thermo-mechanical fracture model. The thermo-mechanical fracture model introduces a change in the temperature transition of flexural strength. The uncertainty decreased from 15% to a range between 8.3% and 13.4%. Two parameters are inferred in the fourth scenario while five are inferred in the fifth scenario. Inferring five parameters leads to more consistent uncertainty across temperature.
{"title":"Bayesian Uncertainty Update to a Model of Flexural Strength of α-SiC","authors":"Eric A. Walker, Mengyuan Sun, James Chen","doi":"10.37256/mp.3120244395","DOIUrl":"https://doi.org/10.37256/mp.3120244395","url":null,"abstract":"This article demonstrates a statistical method to update the uncertainty in the flexural strength of silicon carbide, α-SiC. The previously reported uncertainty for the flexural strength of α-SiC was a constant ±15%. However, this uncertainty should be adjusted as more data becomes available. A Bayesian approach is proposed to rapidly and precisely update the uncertainty. To validate the method, five scenarios are demonstrated. The first scenario assumes the experimental data is distributed as the model predicts. The second and third scenarios have the model underestimating and overestimating flexural strength, respectively. The fourth and fifth scenarios use data from a thermo-mechanical fracture model. The thermo-mechanical fracture model introduces a change in the temperature transition of flexural strength. The uncertainty decreased from 15% to a range between 8.3% and 13.4%. Two parameters are inferred in the fourth scenario while five are inferred in the fifth scenario. Inferring five parameters leads to more consistent uncertainty across temperature.","PeriodicalId":509068,"journal":{"name":"Materials Plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140213272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard Turner, Callum Smith, Lily Zneimer, Louis Medlock, Albert Simms Ridgeway, Gokul Subramanian, Taahir Patel, Nils Warnken
Ti-6Al-4V warm forged fasteners are a critical part of the aerospace industry, as they are used in vast quantities for mechanical joining of components for the fuselage, wing-skin and aero-engine. These components are produced in vast quantities at rapid production rates through multi-blow axial forging However the rate that they are manufactured means that manufacturers rely upon periodic part conformance testing to understand if the part is within tolerance or if any undesirable manufacturing defects such as cracks or underfilling are present. Thus, a right-first-time manufacturing approach is essential to minimize non-conformant scrap. An analysis of the Ti-6Al-4V supplied raw material for axial forging, in a variety of different bar diameter sizes and from different industrial suppliers, was conducted. This was to attempt to understand whether material property variation or operator variation was the root cause for some material behaving differently during the manufacture route. Experimental testing was performed through microstructure characterization and mechanical testing methods. The volume fraction of the β-phase was noted to be marginally higher in material with good forgeability. The hardness of the inner core of the bar appears to be a critical material property for the Ti-6Al4V bar, with an overly hard bar-core hindering forgeability of the bar. This is believed to be due to the hotter central region malleability being key for forgeability. Micro-void porosity was also noted which could lead to stress concentration locations, or crack initiation, and as such is a deleterious property for forgeability. The experienced forgeability of the Ti-6Al-4V bars have been demonstrated to be sensitive to rather small variation in measured microstructure and mechanical property. It is believed that cumulative impacts of small differences, 1% variation in α-phase volume fraction, small variations in elongation to failure, 1% variation in elastic modulus and microhardness profile variation at the center of the bar of less than 10 HV0.3, can combine to significantly impact the forgeability of Ti-6Al-4V bar.
{"title":"Characterization of Ti-6Al-4V Bar for Aerospace Fastener Pin Axial Forging","authors":"Richard Turner, Callum Smith, Lily Zneimer, Louis Medlock, Albert Simms Ridgeway, Gokul Subramanian, Taahir Patel, Nils Warnken","doi":"10.37256/mp.3120244371","DOIUrl":"https://doi.org/10.37256/mp.3120244371","url":null,"abstract":"Ti-6Al-4V warm forged fasteners are a critical part of the aerospace industry, as they are used in vast quantities for mechanical joining of components for the fuselage, wing-skin and aero-engine. These components are produced in vast quantities at rapid production rates through multi-blow axial forging However the rate that they are manufactured means that manufacturers rely upon periodic part conformance testing to understand if the part is within tolerance or if any undesirable manufacturing defects such as cracks or underfilling are present. Thus, a right-first-time manufacturing approach is essential to minimize non-conformant scrap. An analysis of the Ti-6Al-4V supplied raw material for axial forging, in a variety of different bar diameter sizes and from different industrial suppliers, was conducted. This was to attempt to understand whether material property variation or operator variation was the root cause for some material behaving differently during the manufacture route. Experimental testing was performed through microstructure characterization and mechanical testing methods. The volume fraction of the β-phase was noted to be marginally higher in material with good forgeability. The hardness of the inner core of the bar appears to be a critical material property for the Ti-6Al4V bar, with an overly hard bar-core hindering forgeability of the bar. This is believed to be due to the hotter central region malleability being key for forgeability. Micro-void porosity was also noted which could lead to stress concentration locations, or crack initiation, and as such is a deleterious property for forgeability. The experienced forgeability of the Ti-6Al-4V bars have been demonstrated to be sensitive to rather small variation in measured microstructure and mechanical property. It is believed that cumulative impacts of small differences, 1% variation in α-phase volume fraction, small variations in elongation to failure, 1% variation in elastic modulus and microhardness profile variation at the center of the bar of less than 10 HV0.3, can combine to significantly impact the forgeability of Ti-6Al-4V bar.","PeriodicalId":509068,"journal":{"name":"Materials Plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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