Background: Emergency cholecystectomy is the standard treatment for acute cholecystitis worldwide. However, in Ethiopia, it's only performed in a limited number of healthcare facilities, despite its recognition as the preferred treatment by many physicians. To date, there is no study examining the prevalence and outcomes of emergency cholecystectomy in Ethiopia. In our setting, this practice is relatively new, and its outcomes remain unstudied. Purpose: To assess the trends and outcome of emergency cholecystectomy at Yekatit 12 hospital medical college. Method: We employed a longitudinal study design, encompassing all patients who underwent emergency cholecystectomy throughout the study period. Data entry and analysis were conducted using SPSS statistical software version 25. Qualitative variables were depicted in frequencies and percentages, while continuous variables were summarized with mean and standard deviation (SD). Binary logistic regression was applied to evaluate the impact of independent variables on the outcome variable. A significance level of p < 0.05 was taken for statistical significance. Result: Between January 2022 and December 2023, 68 emergency cholecystectomies were performed. Females comprised 60.3% of the cases, with a mean age of 42.43 ± 14.03 years. Surgery for 44.1% of patients occurred between days 4 and 7 after symptom onset, while five patients underwent surgery after 10 days. The mean duration of surgery was 63.9 ± 17.14 minutes. Hospital stays ranged from 2 to 12 days, with a mean of 4.4 ± 2.47 days. Serum creatinine levels exceeding 1 mg/dl (p=0.004) were significantly linked to poor outcomes.
{"title":"Outcome of Emergency Cholecystectomy at Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia","authors":"Tolera Kebede, Getachew Desta, Alemu Kibret, Wondwossen Amtataw","doi":"10.11648/j.cmr.20241304.11","DOIUrl":"https://doi.org/10.11648/j.cmr.20241304.11","url":null,"abstract":"<i>Background</i>: Emergency cholecystectomy is the standard treatment for acute cholecystitis worldwide. However, in Ethiopia, it's only performed in a limited number of healthcare facilities, despite its recognition as the preferred treatment by many physicians. To date, there is no study examining the prevalence and outcomes of emergency cholecystectomy in Ethiopia. In our setting, this practice is relatively new, and its outcomes remain unstudied. <i>Purpose</i>: To assess the trends and outcome of emergency cholecystectomy at Yekatit 12 hospital medical college. <i>Method</i>: We employed a longitudinal study design, encompassing all patients who underwent emergency cholecystectomy throughout the study period. Data entry and analysis were conducted using SPSS statistical software version 25. Qualitative variables were depicted in frequencies and percentages, while continuous variables were summarized with mean and standard deviation (SD). Binary logistic regression was applied to evaluate the impact of independent variables on the outcome variable. A significance level of p < 0.05 was taken for statistical significance. <i>Result</i>: Between January 2022 and December 2023, 68 emergency cholecystectomies were performed. Females comprised 60.3% of the cases, with a mean age of 42.43 ± 14.03 years. Surgery for 44.1% of patients occurred between days 4 and 7 after symptom onset, while five patients underwent surgery after 10 days. The mean duration of surgery was 63.9 ± 17.14 minutes. Hospital stays ranged from 2 to 12 days, with a mean of 4.4 ± 2.47 days. Serum creatinine levels exceeding 1 mg/dl (p=0.004) were significantly linked to poor outcomes.","PeriodicalId":513252,"journal":{"name":"Clinical Medicine Research","volume":"139 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Crossed cerebellar diaschisis (CCD) often occurs after ischemic or hemorrhagic stroke that does great damage to the cortico-ponto-cerebellar pathway (CPCP). Nevertheless, as far as we know, CCD due to cerebral hyperperfusion syndrome (CHS) following carotid artery stenting (CAS) is rare. We report a case where CCD and new cerebral infarction after CHS following CAS was effectively treated by intravenous use of edaravone and mannitol. The patient was a 74-year-old female. She developed dizziness and vomiting accompanied with weakness of the right limb for 8 days and was admitted to our hospital. Computed tomography angiography scan revealed severe stenosis at the beginning of the left internal carotid artery. Further digital subtraction angiography (DSA) revealed severe stenosis at the beginning of the left internal carotid artery, with a stenosis rate of approximately 90%. Therefore, she underwent left CAS implantation. After the operation, the patient developed disturbance of consciousness and decreased muscle strength in the right limb. Intravenous infusion of edaravone and mannitol were then started. After 10 days of medical treatment, the condition of patient improved to mild hemiparesis. The findings in this present case strongly suggest that CHS after CAS for carotid artery stenosis may cause transient CCD.
交叉性小脑畸形（CCD）通常发生在对皮质-桥脑-小脑通路（CPCP）造成巨大损害的缺血性或出血性中风之后。然而，据我们所知，颈动脉支架置入术（CAS）后因脑高灌注综合征（CHS）引起的 CCD 并不多见。我们报告了一例通过静脉注射依达拉奉和甘露醇有效治疗 CAS 术后高灌注综合征导致的 CCD 和新发脑梗死的病例。患者是一名 74 岁的女性。她出现头晕、呕吐并伴有右侧肢体无力 8 天，被送入我院。计算机断层扫描血管造影显示左侧颈内动脉起始处严重狭窄。进一步的数字减影血管造影（DSA）显示，左侧颈内动脉起始处严重狭窄，狭窄率约为 90%。因此，她接受了左侧 CAS 植入术。术后，患者出现意识障碍和右侧肢体肌力下降。随后开始静脉输注依达拉奉和甘露醇。经过 10 天的药物治疗后，患者病情好转，恢复到轻度偏瘫。本病例的研究结果有力地表明，CAS 治疗颈动脉狭窄后的 CHS 可能会导致一过性 CCD。
{"title":"Crossed Cerebellar Diaschisis and Cerebral Infarction After Cerebral Hyperperfusion Syndrome Following Carotid Artery Stenting: A Case Report","authors":"Wei-Qin Ning, Si-Qi Chen, Sheng-Peng Diao, Shui-Sheng Zhong","doi":"10.11648/j.cmr.20241301.13","DOIUrl":"https://doi.org/10.11648/j.cmr.20241301.13","url":null,"abstract":"Crossed cerebellar diaschisis (CCD) often occurs after ischemic or hemorrhagic stroke that does great damage to the cortico-ponto-cerebellar pathway (CPCP). Nevertheless, as far as we know, CCD due to cerebral hyperperfusion syndrome (CHS) following carotid artery stenting (CAS) is rare. We report a case where CCD and new cerebral infarction after CHS following CAS was effectively treated by intravenous use of edaravone and mannitol. The patient was a 74-year-old female. She developed dizziness and vomiting accompanied with weakness of the right limb for 8 days and was admitted to our hospital. Computed tomography angiography scan revealed severe stenosis at the beginning of the left internal carotid artery. Further digital subtraction angiography (DSA) revealed severe stenosis at the beginning of the left internal carotid artery, with a stenosis rate of approximately 90%. Therefore, she underwent left CAS implantation. After the operation, the patient developed disturbance of consciousness and decreased muscle strength in the right limb. Intravenous infusion of edaravone and mannitol were then started. After 10 days of medical treatment, the condition of patient improved to mild hemiparesis. The findings in this present case strongly suggest that CHS after CAS for carotid artery stenosis may cause transient CCD.","PeriodicalId":513252,"journal":{"name":"Clinical Medicine Research","volume":"67 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.11648/j.cmr.20241301.12
Zebin Liu, Lipeng Lin, Guosheng Zhu, Liying Qiu
{"title":"Combining Multiple Tumor Markers to Construct a Clinical Prediction Model for Breast Cancer","authors":"Zebin Liu, Lipeng Lin, Guosheng Zhu, Liying Qiu","doi":"10.11648/j.cmr.20241301.12","DOIUrl":"https://doi.org/10.11648/j.cmr.20241301.12","url":null,"abstract":"","PeriodicalId":513252,"journal":{"name":"Clinical Medicine Research","volume":"168 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.11648/j.cmr.20241301.11
Rajesh Kumar Sharma, Priyanka Chandolia, Ravi Shankar Sundram, Kumari Isha, Sanjana Soni
{"title":"Therapeutic Effect of Hydroalcoholic Extract for Withania Coagulans for Diuretic Activity in Rodents","authors":"Rajesh Kumar Sharma, Priyanka Chandolia, Ravi Shankar Sundram, Kumari Isha, Sanjana Soni","doi":"10.11648/j.cmr.20241301.11","DOIUrl":"https://doi.org/10.11648/j.cmr.20241301.11","url":null,"abstract":"","PeriodicalId":513252,"journal":{"name":"Clinical Medicine Research","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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