Accumulated evidence highlights that exercise can modulate multiple cytokines, influencing transcriptional pathways, and reprogramming certain metabolic processes, ultimately promoting antitumor immunity and enhancing the efficacy of immune checkpoint inhibitors in cancer patients. Exploring the mechanisms behind this will, for one thing, help us uncover key factors and pathways in exercise-assisted cancer immunotherapy, offering more possibilities for future treatment methods. For another, it will support the development of more personalized and effective exercise prescriptions, thereby improving the prognosis of cancer patients.
{"title":"Crosstalk between Exercise and Immunotherapy: Current Understanding and Future Directions","authors":"Jiwei Liu, Weici Liu, Yuan Wan, Wenjun Mao","doi":"10.34133/research.0360","DOIUrl":"https://doi.org/10.34133/research.0360","url":null,"abstract":"Accumulated evidence highlights that exercise can modulate multiple cytokines, influencing transcriptional pathways, and reprogramming certain metabolic processes, ultimately promoting antitumor immunity and enhancing the efficacy of immune checkpoint inhibitors in cancer patients. Exploring the mechanisms behind this will, for one thing, help us uncover key factors and pathways in exercise-assisted cancer immunotherapy, offering more possibilities for future treatment methods. For another, it will support the development of more personalized and effective exercise prescriptions, thereby improving the prognosis of cancer patients.","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FM-FCN: a neural network with filtering modules for accurate vital signs extraction","authors":"Fangfang Zhu, Qichao Niu, Xiang Li, Qi Zhao, Honghong Su, Jianwei Shuai","doi":"10.34133/research.0361","DOIUrl":"https://doi.org/10.34133/research.0361","url":null,"abstract":"","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, J. Bae, I. Lee, Jae-Han Jeon, Chang-Won Hong
Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes. Here, we demonstrate that trained immunity mediates diabetes-induced NET priming in neutrophils. Under diabetic conditions, neutrophils exhibit robust metabolic reprogramming comprising enhanced glycolysis via the pentose phosphate pathway and fatty acid oxidation, which result in the accumulation of acetyl-coenzyme A. Adenosine 5′-triphosphate-citrate lyase-mediated accumulation of acetyl-coenzyme A and histone acetyltransferases further induce the acetylation of lysine residues on histone 3 (AcH3K9, AcH3K14, and AcH3K27) and histone 4 (AcH4K8). The pharmacological inhibition of adenosine 5′-triphosphate-citrate lyase and histone acetyltransferases completely inhibited high-glucose-induced NET priming. The trained immunity of neutrophils was further confirmed in neutrophils isolated from patients with diabetes. Our findings suggest that trained immunity mediates functional changes in neutrophils in diabetic environments, and targeting neutrophil-trained immunity may be a potential therapeutic target for controlling inflammatory complications of diabetes.
糖尿病期间，中性粒细胞会形成中性粒细胞胞外捕获物（NET），而中性粒细胞过度形成NET会损害糖尿病患者的伤口愈合。在这里，我们证明了训练有素的免疫介导了糖尿病诱导的中性粒细胞NET形成。在糖尿病条件下，中性粒细胞表现出强大的代谢重编程，包括通过磷酸戊糖途径增强糖酵解和脂肪酸氧化，从而导致乙酰辅酶 A 的积累。腺苷-5′-三磷酸柠檬酸裂解酶介导的乙酰辅酶 A 和组蛋白乙酰转移酶进一步诱导组蛋白 3（AcH3K9、AcH3K14 和 AcH3K27）和组蛋白 4（AcH4K8）上赖氨酸残基的乙酰化。药物抑制腺苷-5′-三磷酸柠檬酸酶和组蛋白乙酰转移酶可完全抑制高葡萄糖诱导的中性粒细胞免疫。从糖尿病患者体内分离出的中性粒细胞进一步证实了中性粒细胞训练有素的免疫力。我们的研究结果表明，训练有素的免疫介导了糖尿病环境中中性粒细胞的功能变化，针对中性粒细胞训练有素的免疫可能是控制糖尿病炎症并发症的潜在治疗靶点。
{"title":"Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity","authors":"Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, J. Bae, I. Lee, Jae-Han Jeon, Chang-Won Hong","doi":"10.34133/research.0365","DOIUrl":"https://doi.org/10.34133/research.0365","url":null,"abstract":"Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes. Here, we demonstrate that trained immunity mediates diabetes-induced NET priming in neutrophils. Under diabetic conditions, neutrophils exhibit robust metabolic reprogramming comprising enhanced glycolysis via the pentose phosphate pathway and fatty acid oxidation, which result in the accumulation of acetyl-coenzyme A. Adenosine 5′-triphosphate-citrate lyase-mediated accumulation of acetyl-coenzyme A and histone acetyltransferases further induce the acetylation of lysine residues on histone 3 (AcH3K9, AcH3K14, and AcH3K27) and histone 4 (AcH4K8). The pharmacological inhibition of adenosine 5′-triphosphate-citrate lyase and histone acetyltransferases completely inhibited high-glucose-induced NET priming. The trained immunity of neutrophils was further confirmed in neutrophils isolated from patients with diabetes. Our findings suggest that trained immunity mediates functional changes in neutrophils in diabetic environments, and targeting neutrophil-trained immunity may be a potential therapeutic target for controlling inflammatory complications of diabetes.","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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