Ageing & Longevity最新文献

{"title":"Development of hypoglycemia in patients with COVID-19: coincidence or the result of treatment?","authors":"O. Halushko, Yanina A. Saienko, Boris Mankovsky","doi":"10.47855/jal9020-2024-5-4","DOIUrl":"https://doi.org/10.47855/jal9020-2024-5-4","url":null,"abstract":"Hypoglycemia is a common complication of diabetes mellitus (DM), which also complicates the course of COVID-19.\u0000The aim: The purpose of this work is to analyze the available scientific information on the causes and risk factors of hypoglycemia during the treatment of patients with COVID-19.\u0000Materials and methods. Full-text articles were searched and analysed in the PubMed, Web of Science, Google Scholar, and Scopus databases. The search was conducted using the keywords: \"hypoglycemia in COVID-19 patients\", \"treatment of COVID-19 and hypoglycemia\" and \"COVID-19 vaccination and hypoglycemia\" from the beginning of the pandemic in December 2019 to February 1, 2024.\u0000Results. The analysis of literary sources showed that hypoglycemia can occur when using drugs from many pharmacotherapeutic groups for the treatment and vaccination of patients with COVID-19. In addition, patients with DM often have chronic complications that contribute to hypoglycemia occurrence in the case of COVID-19. The lockdown during the COVID-19 pandemic has further complicated the problem of hypoglycemia by restricting access to food, clinics, health services, and medicines.\u0000Conclusions: Hypoglycemia can be an incidental clinical finding. But it can also be a natural consequence of treatment if it is carried out without taking into account the possible hypoglycemic effects of drugs and without careful monitoring of the patient's condition. In the case of determining the program of treatment and vaccination against COVID-19 in patients with DM, the known and possible hypoglycemic effects of drugs and vaccines should be taken into account, the level of glycemia should be carefully controlled, and sudden changes in the type and dose of drugs, polypharmacy and the use of dangerous combinations of drugs should be avoided.\u0000_________________________________________________________________________________________\u0000Keywords: COVID-19, hypoglycemia, treatment, vaccination","PeriodicalId":516909,"journal":{"name":"Ageing & Longevity","volume":"208 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140437895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of war-related stress on the cardiovascular system, metabolism and the rate of ageing in women","authors":"A. Pisaruk, Ervin Asanov, S. Naskalova, I. Antoniuk-Shcheglova, Olena Bondarenko, I. Dyba, L. Mekhova, Ludmila Pisaruk, V. Shatilo","doi":"10.47855/jal9020-2024-5-3","DOIUrl":"https://doi.org/10.47855/jal9020-2024-5-3","url":null,"abstract":"Chronic war-related stress (WRS) due to disruption of adaptation mechanisms can affect physiological processes in the body, in particular, metabolism, neuroendocrine regulation, and the state of the cardiovascular and respiratory systems. WRS can also cause changes in the body's rate of ageing. Purpose of the Study: To investigate the effects of WRS on the cardiovascular system, metabolism and the rate of ageing in women.\u0000The study included 91 women aged from 30 to 74 years who experienced chronic WRS and 79 women examined before the Russian-Ukrainian war (control group). The biological age (BA) was determined according to the indicators of hemodynamics, heart rate variability and metabolism (cardiometabolic age) using a formula that was obtained by multiple stepwise regression. The indicators were selected, which correlate as much as possible with age and little among themselves.\u0000During the war, no statistically significant changes in heart rate, or systolic and diastolic blood pressure were observed, but a significant reduction in overall HRV in the supine position was obtained. Additionally, indices of parasympathetic nervous system activity are significantly lower during the war. In women, examined during the war, there is a statistically significant higher concentration of blood plasma glucose at fasting and 2-hour post-standard oral glucose tolerance test, they also exhibit higher plasma insulin concentration and a higher HOMA-IR index. An increased frequency of prediabetic disorders was observed. So, in the group of women examined before the war, an elevated fasting blood plasma glucose level was found in 6 %, while during the war it was observed in 19 %. Impaired glucose tolerance before the war was present in 10 % of women, and during the war, it increased to 25 %. \u0000To assess the effect of WRS on the rate of ageing, the BA of women before and during war was calculated. The formula for calculating BA was obtained on a group of healthy women before the war, and the ageing rate was calculated as the difference between BA and chronological age (CA). The average BA in the group of women before the war was 56.5±1.4 years, and in the group during the war – 64.7 ± 1.1 years. The difference between BA and CA is (0.02 ± 0.79) years in the women before the war and (10.8 ± 1.36) years during the war (p < 0.05). \u0000Chronic WRS leads to the disruption of the cardiovascular system's functioning and simultaneously triggers an imbalance in the autonomic nervous control in women. These changes indicate a state of heightened stress. Women exposed to chronic WRS experience unfavourable alterations in carbohydrate and lipid metabolism, increasing the risk of diabetes mellitus development. Chronic WRS accelerates the rate of cardiometabolic ageing in women.\u0000_________________________________________________________________________________________\u0000Keywords: cardiovascular system; metabolism; biological age; war-related stress; woman","PeriodicalId":516909,"journal":{"name":"Ageing &amp; Longevity","volume":"321 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139895048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns, plasma and hair trace element in Ukrainian cohort of adults during COVID-19 pandemic: a cross-sectional study","authors":"L. Piven, Mariana Romanenko, Svitlana Fus, Evgen Kyrylenko, Tetiana Papurina, L. Synieok","doi":"10.47855/jal9020-2024-5-2","DOIUrl":"https://doi.org/10.47855/jal9020-2024-5-2","url":null,"abstract":"Adequate mineral intake is important for optimal immune protection against viral infections. However, there is insufficient data on the mineral status of the Ukrainian adult population during the COVID-19 pandemic. The study included people aged 35-80 years with a history of COVID-19 (study group, n=35) and those without (control group, n=26). Dietary intake was assessed using 7-day weighted food records. Trace element analysis of plasma and hair was performed by X-ray fluorescence spectrometry (Elvatech, Ukraine). Low levels of zinc, copper, and, to a lesser extent, iron and selenium were found in the participants' plasma and hair samples. Low hair zinc levels were found in 75.8 % of participants in the study group and 95.8% in the control group (p=0.065). Hair zinc was positively associated with plasma levels (β 0.09, CI 0.03 to 0.15, p=0.007). Participants with a COVID-19 history had higher hair zinc levels than the control group, but still below normal. The difference between groups may be explained by the higher proportion of zinc supplementation (62.9% vs 16.0%, p=0.0005). The low supply of trace elements was independent of estimated dietary intake and history of COVID-19. With increasing age of the participants, the selenium content in their hair decreased (β -0.02, CI -0.03 to -0.01, p=0.001). Current findings show the need to improve the nutrition of Ukrainians, as well as to monitor the supply of minerals for the development of optimal nutritional interventions.\u0000_________________________________________________________________________________________\u0000Keywords: trace elements; zinc; selenium; dietary intake; age; COVID-19","PeriodicalId":516909,"journal":{"name":"Ageing &amp; Longevity","volume":"13 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of sarcopenia in subjects with osteoporosis and osteoarthritis","authors":"N. Zaverukha, N. Grygorieva, А.S. Musiіenko, M. Bystrytska","doi":"10.47855/jal19020-2024-5-1","DOIUrl":"https://doi.org/10.47855/jal19020-2024-5-1","url":null,"abstract":"The study aimed to determine the relationship between the risk of sarcopenia (SP) and common age-related diseases of the musculoskeletal system, such as osteoporosis (OP) and osteoarthritis (OA). There were examined 460 women aged 50-85 years (mean age 66.4 ± 8.8 years) and they were divided into 4 groups. Group I included 176 women without bone and joint diseases (BJD); Group II included 137 persons with a diagnosis of systemic OP; Group III included 95 subjects with knee and/or hip OA (2nd-3rd degree of Kellgren-Lawrence grades); IV group included 52 females with OP and large joints OA (2nd-3rd degree of Kellgren-Lawrence grades). Bone mineral density (BMD) and trabecular bone score (TBS) were determined in all patients using dual-energy X-ray absorptiometry (DXA), which was subsequently taken into account in the calculation of the 10-year probability of the major osteoporotic fractures according to the Ukrainian version of FRAX®. The following questionnaires were used: SARC-F, IADL, Desmond Fall Risk Questionnaire, and KOOS-12. Also, we used the chair stand test (5 times sit-to-stand) and hand grip dynamometer test. The frequency of persons with risk of SP in Group I was 20.3 %, and it was significantly higher in women with OP (33.5 %, χ2= 6.9 [3.4 – 23.0], p < 0.05), subjects with OA (34.7 %, χ2= 6.7 [3.4 – 25.7], p < 0.05), and women with combined pathology (44.2 %, χ2= 12.1 [9.8 – 38.2], p < 0.05). In patients with OA and risk of SP, pain intensity was significantly higher (43.7 [31.3 – 62.5] points compared to patients with OA without risk of SP - 68.8 [50.0 – 93.8] points, Z = 3.6, p < 0.05), as well as function, and daily living (43.8 [31.3 – 68.8] and 75.0 [56.3 – 100.0] points, respectively, Z = 4.1, p < 0.05 and quality of life 43.8 [37.5 – 62.8] and 75.0 [43.8 – 87.5] points, respectively (Z = 3.0, p < 0.05) according to the KOOS-12. The probability of the major OP fracture was significantly higher in the group of OP and risk of SP (11.0 [8.5 – 12.0] % compared to patients with OP without risk of SP - 8.1 [5.4 – 10.0] %, Z = - 3.8, p < 0.05). The same differences were found for the 10-year probability of hip fracture (5.0 [2.8 – 7.3] and 2.1 [1.5 – 3.5] %, respectively, Z = - 4.9, p < 0.05). High Risk of SP, falls and the need for external assistance were recorded significantly more often in women with OP pathology, and their skeletal muscle strength was significantly lower. Women with a high risk of SP had significantly lower skeletal muscle strength (according to hand grip dynamometry), a higher risk of falls and fractures, and a greater need for assistance. The combination of a risk of SP and OA was associated with more severe joint pain intensity, lower function, and quality of life, and the risk of SP and OP combination was associated with a higher risk of OP fracture.\u0000_________________________________________________________________________________________\u0000Keywords: sarcopenia; osteoporosis; osteoarthritis; FRAX; fracture; fall","PeriodicalId":516909,"journal":{"name":"Ageing &amp; Longevity","volume":"69 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140493891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}