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Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study 既往脑外伤是中重度脑外伤住院死亡率的风险因素:TRACK-TBI 队列研究
Pub Date : 2024-07-01 DOI: 10.1136/tsaco-2024-001501
J. Yue, Leila L. Etemad, Mahmoud M Elguindy, T. V. van Essen, Patrick J Belton, Lindsay D Nelson, M. McCrea, Rick J G Vreeburg, Christine J Gotthardt, Joye X Tracey, Bukre C Coskun, N. Krishnan, Cathra Halabi, Shawn R. Eagle, F. Korley, Claudia S Robertson, A. Duhaime, G. Satris, Phiroz E. Tarapore, Michael C. Huang, Debbie Y. Madhok, J. Giacino, Pratik Mukherjee, E. Yuh, A. Valadka, A. Puccio, David O. Okonkwo, Xiaoying Sun, S. Jain, G. Manley, A. DiGiorgio
An estimated 14–23% of patients with traumatic brain injury (TBI) incur multiple lifetime TBIs. The relationship between prior TBI and outcomes in patients with moderate to severe TBI (msTBI) is not well delineated. We examined the associations between prior TBI, in-hospital mortality, and outcomes up to 12 months after injury in a prospective US msTBI cohort.Data from hospitalized subjects with Glasgow Coma Scale score of 3–12 were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (enrollment period: 2014–2019). Prior TBI with amnesia or alteration of consciousness was assessed using the Ohio State University TBI Identification Method. Competing risk regressions adjusting for age, sex, psychiatric history, cranial injury and extracranial injury severity examined the associations between prior TBI and in-hospital mortality, with hospital discharged alive as the competing risk. Adjusted HRs (aHR (95% CI)) were reported. Multivariable logistic regressions assessed the associations between prior TBI, mortality, and unfavorable outcome (Glasgow Outcome Scale-Extended score 1–3 (vs. 4–8)) at 3, 6, and 12 months after injury.Of 405 acute msTBI subjects, 21.5% had prior TBI, which was associated with male sex (87.4% vs. 77.0%, p=0.037) and psychiatric history (34.5% vs. 20.7%, p=0.010). In-hospital mortality was 10.1% (prior TBI: 17.2%, no prior TBI: 8.2%, p=0.025). Competing risk regressions indicated that prior TBI was associated with likelihood of in-hospital mortality (aHR=2.06 (1.01–4.22)), but not with hospital discharged alive. Prior TBI was not associated with mortality or unfavorable outcomes at 3, 6, and 12 months.After acute msTBI, prior TBI history is independently associated with in-hospital mortality but not with mortality or unfavorable outcomes within 12 months after injury. This selective association underscores the importance of collecting standardized prior TBI history data early after acute hospitalization to inform risk stratification. Prospective validation studies are needed.IV.NCT02119182.
据估计,14%-23% 的创伤性脑损伤(TBI)患者一生中会遭受多次 TBI。中重度创伤性脑损伤(msTBI)患者既往创伤性脑损伤与预后之间的关系尚不明确。我们在一个前瞻性美国msTBI队列中研究了既往TBI、院内死亡率和伤后12个月内的预后之间的关系。格拉斯哥昏迷量表评分为3-12分的住院受试者的数据是从创伤性脑损伤研究和临床知识转化研究(注册期:2014-2019年)中提取的。使用俄亥俄州立大学创伤性脑损伤识别方法对之前发生过创伤性脑损伤并伴有失忆或意识改变的患者进行评估。调整年龄、性别、精神病史、颅脑损伤和颅外损伤严重程度的竞争风险回归检验了既往创伤性脑损伤与院内死亡率之间的关联,以出院时存活作为竞争风险。报告了调整后的 HRs(aHR (95% CI))。多变量逻辑回归评估了既往TBI、死亡率和伤后3个月、6个月和12个月的不利预后(格拉斯哥预后量表-扩展评分1-3分(对4-8分))之间的关联。在405名急性msTBI受试者中,21.5%的人有既往TBI,这与男性性别(87.4%对77.0%,p=0.037)和精神病史(34.5%对20.7%,p=0.010)有关。院内死亡率为10.1%(既往有创伤性脑损伤:17.2%,无创伤性脑损伤:8.2%,P=0.025)。竞争风险回归表明,既往的创伤性脑损伤与院内死亡率相关(aHR=2.06 (1.01-4.22)),但与出院后存活率无关。急性毫秒创伤性脑损伤后,既往的创伤性脑损伤病史与院内死亡率独立相关,但与伤后 12 个月内的死亡率或不良预后无关。这种选择性关联凸显了在急性住院后早期收集标准化既往 TBI 病史数据以进行风险分层的重要性。需要进行前瞻性验证研究。
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引用次数: 0
Changes in payer mix of new and established trauma centers: the new trauma center money grab? 新建和已建创伤中心支付方组合的变化:新的创伤中心抢钱行为?
Pub Date : 2024-07-01 DOI: 10.1136/tsaco-2024-001417
Diane N Haddad, J. Hatchimonji, Satvika Kumar, Jeremy W Cannon, Patrick M Reilly, Patrick Kim, Elinore Kaufman
Although timely access to trauma center (TC) care for injured patients is essential, the proliferation of new TCs does not always improve outcomes. Hospitals may seek TC accreditation for financial reasons, rather than to address community or geographic need. Introducing new TCs risks degrading case and payer mix at established TCs. We hypothesized that newly accredited TCs would see a disproportionate share of commercially insured patients.We collected data from all accredited adult TCs in Pennsylvania using the state trauma registry from 1999 to 2018. As state policy regarding supplemental reimbursement for underinsured patients changed in 2004, we compared patient characteristics and payer mix between TCs established before and after 2004. We used multivariable logistic regression to assess the relationship between payer and presentation to a new versus established TC in recent years.Over time, there was a 40% increase in the number of TCs from 23 to 38. Of 326 204 patients from 2010 to 2018, a total of 43 621 (13.4%) were treated at 15 new TCs. New TCs treated more blunt trauma and less severely injured patients (p<0.001). In multivariable analysis, patients presenting to new TCs were more likely to have Medicare (OR 2.0, 95% CI 1.9 to 2.1) and commercial insurance (OR 1.6, 95% CI 1.5 to 1.6) compared with Medicaid. Over time, fewer patients at established TCs and more patients at new TCs had private insurance.With the opening of new centers, payer mix changed unfavorably at established TCs. Trauma system development should consider community and regional needs, as well as impact on existing centers to ensure financial sustainability of TCs caring for vulnerable patients.Level III, prognostic/epidemiological.
尽管及时为受伤患者提供创伤中心 (TC) 医疗服务至关重要,但新创伤中心的增加并不总能改善治疗效果。医院寻求创伤中心认证可能是出于经济原因,而不是为了满足社区或地域需求。引入新的治疗中心可能会降低现有治疗中心的病例和付款人组合。我们假设,新通过鉴定的治疗中心将收治过多的商业保险患者。我们利用州创伤登记处收集了宾夕法尼亚州所有通过鉴定的成人治疗中心 1999 年至 2018 年的数据。由于州政府在 2004 年改变了对保险不足患者的补充报销政策,我们比较了 2004 年之前和之后成立的治疗中心的患者特征和付款人组合。我们使用多变量逻辑回归来评估付款人与患者就诊于近年来新成立的TC与已成立的TC之间的关系。随着时间的推移,TC的数量增加了40%,从23个增加到38个。在2010年至2018年的326 204名患者中,共有43 621人(13.4%)在15家新TC接受治疗。新TC治疗了更多的钝性创伤和伤势较轻的患者(P<0.001)。在多变量分析中,与医疗补助(Medicaid)相比,在新设医疗中心就诊的患者更有可能拥有医疗保险(OR 2.0,95% CI 1.9 至 2.1)和商业保险(OR 1.6,95% CI 1.5 至 1.6)。随着时间的推移,已有创伤中心的患者中拥有私人保险的人数减少,而新创伤中心的患者中拥有私人保险的人数增加。创伤系统的发展应考虑社区和地区的需求,以及对现有中心的影响,以确保为弱势患者提供治疗的创伤中心在财务上的可持续性。
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引用次数: 0
Do serial troponins predict the need for cardiac evaluation in trauma patients after ground-level fall? 连续肌钙蛋白能否预测地面坠落后的创伤患者是否需要进行心脏评估?
Pub Date : 2024-03-01 DOI: 10.1136/tsaco-2023-001328
Alyssa R Bellini, James T. Ross, Madelyn Larson, Skyler Pearson, Anamaria J. Robles, Rachael A. Callcut
Troponin T levels are routinely checked in trauma patients after experiencing a ground-level fall to identify potential cardiac causes of syncope. An elevated initial troponin prompts serial testing until the level peaks. However, the high sensitivity of the test may lead to repeat testing that is of little clinical value. Here, we examine the role of serial troponins in predicting the need for further cardiac workup in trauma patients after sustaining a fall.Retrospective review of all adult trauma activations for ground-level fall from January 1, 2021 to December 31, 2021 in patients who were hemodynamically and neurologically normal at presentation. Outcomes evaluated included need for cardiology consult, admission to cardiology service, outpatient cardiology follow-up, cardiology intervention and in-hospital mortality.There were 1555 trauma activations for ground-level fall in the study period. The cohort included 560 patients evaluated for a possible syncopal fall, hemodynamically stable, Glasgow Coma Scale score of 15, and with a troponin drawn at presentation. The initial median troponin was 20 ng/L (13–37). Second troponin values were drawn on 58% (median 33 ng/L (22–52)), with 42% of patients having an increase from first to second test. 29% of patients had a third troponin drawn (median 42 ng/L (26–67)). The initial troponin value was significantly associated with undergoing a subsequent echo (p=0.01), cardiology consult (p<0.01), admission for cardiac evaluation (p<0.01), cardiology follow-up (p<0.01), and in-hospital mortality (p=0.01); the initial troponin was not associated with cardiac intervention (p=0.91). An increase from the first to second troponin was not associated with any of outcomes of interest. Analysis was done with cut-off values of 30 ng/L, 50 ng/L, 70 ng/L, and 90 ng/L; a troponin T threshold of 19 ng/L was significant for cardiology consult (p=0.01) and cardiology follow-up (p=0.04). When the threshold was increased to 50 ng/L, it was also significant for admission for cardiac issue (p<0.01). When the threshold was increased to 90 ng/L, it was significant for the same three outcomes and in-hospital mortality (p=0.04).The initial serum troponin has clinical value in identifying underlying cardiac disease in patients who present after ground-level fall; however, that serial testing is likely of little value. Further, using a cut-off of >50 ng/L as a threshold for further clinical evaluation would improve the utility of the test and likely reduce unnecessary hospital stays and costs for otherwise healthy patients.Level III.
创伤患者在经历地面高空坠落后,需要常规检测肌钙蛋白 T 水平,以确定晕厥的潜在心脏原因。初始肌钙蛋白升高会导致连续检测,直到水平达到峰值。然而,该检测的高灵敏度可能会导致重复检测,而重复检测的临床价值不大。在此,我们研究了连续肌钙蛋白在预测创伤患者摔倒后是否需要进一步心脏检查中的作用。回顾性研究了 2021 年 1 月 1 日至 2021 年 12 月 31 日期间因地面摔倒而启动的所有成人创伤患者,这些患者在就诊时血液动力学和神经系统均正常。评估结果包括是否需要心脏科会诊、心脏科入院、心脏科门诊随访、心脏科干预和院内死亡率。在研究期间,共有 1555 例因地面摔倒而启动的创伤急救,其中包括 560 例因可能发生晕厥摔倒而接受评估的患者,这些患者血流动力学稳定,格拉斯哥昏迷量表评分为 15 分,并在就诊时抽取了肌钙蛋白。最初的肌钙蛋白中位数为 20 纳克/升(13-37)。58%的患者进行了第二次肌钙蛋白检测(中位数为 33 纳克/升(22-52)),其中 42% 的患者从第一次检测到第二次检测的结果均有所上升。29%的患者进行了第三次肌钙蛋白检测(中位数为 42 纳克/升(26-67))。最初的肌钙蛋白值与随后的回波检查(p=0.01)、心脏病咨询(p50 纳克/升作为进一步临床评估的阈值)显著相关,这将提高该检查的实用性,并可能减少原本健康的患者不必要的住院时间和费用。
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引用次数: 0
Treatment approach for coexisting chest wall fractures and unstable thoracolumbar spine fractures in polytrauma patients requiring prone spine surgery 需要俯卧位脊柱手术的多发性创伤患者胸壁骨折和不稳定胸腰椎骨折并存的治疗方法
Pub Date : 2024-03-01 DOI: 10.1136/tsaco-2023-001196
Aymen Alqazzaz, Zan Naseer, Carl A Beyer, Jeremy W Cannon, A. Khalsa
Concomitant chest wall fractures (sternal and/or rib fractures) with unstable thoracolumbar fractures that require surgical fixation are rare but highly morbid injuries that mandate a multidisciplinary approach to treatment. There is limited evidence in the literature regarding optimal timing and order of surgical fixation of these patients with multiple injuries. Here, we present our experience with two patients at a single institution that demonstrates the challenges that present with this patient population. We advocate for earlier fixation of the chest wall fractures in the appropriately indicated patients, prior to prone positioning for spinal fixation.
胸壁骨折(胸骨和/或肋骨骨折)与需要手术固定的不稳定胸腰椎骨折并发是一种罕见但高发病率的损伤,需要采用多学科方法进行治疗。关于这些多发伤患者手术固定的最佳时机和顺序,文献中证据有限。在此,我们介绍了我们在一家医疗机构对两名患者的治疗经验,以展示这类患者所面临的挑战。我们主张在俯卧位进行脊柱固定之前,对有适当指征的患者尽早进行胸壁骨折固定。
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引用次数: 0
Impact of COVID status and blood group on complications in patients in hemorrhagic shock COVID 状态和血型对失血性休克患者并发症的影响
Pub Date : 2024-03-01 DOI: 10.1136/tsaco-2023-001250
Jason B Brill, Krislynn M. Mueck, Madeline E. Cotton, Brian Tang, Mariela Sandoval, Lillian S Kao, Bryan A Cotton
Among critically injured patients of various blood groups, we sought to compare survival and complication rates between COVID-19-positive and COVID-19-negative cohorts.SARS-CoV-2 infections have been shown to cause endothelial injury and dysfunctional coagulation. We hypothesized that, among patients with trauma in hemorrhagic shock, COVID-19-positive status would be associated with increased mortality and inpatient complications. As a secondary hypothesis, we suspected group O patients with COVID-19 would experience fewer complications than non-group O patients with COVID-19.We evaluated all trauma patients admitted 4/2020–7/2020. Patients 16 years or older were included if they presented in hemorrhagic shock and received emergency release blood products. Patients were dichotomized by COVID-19 testing and then divided by blood groups.3281 patients with trauma were evaluated, and 417 met criteria for analysis. Seven percent (29) of patients were COVID-19 positive; 388 were COVID-19 negative. COVID-19-positive patients experienced higher complication rates than the COVID-19-negative cohort, including acute kidney injury, pneumonia, sepsis, venous thromboembolism, and systemic inflammatory response syndrome. Univariate analysis by blood groups demonstrated that survival for COVID-19-positive group O patients was similar to that of COVID-19-negative patients (79 vs 78%). However, COVID-19-positive non-group O patients had a significantly lower survival (38%). Controlling for age, sex and Injury Severity Score, COVID-19-positive patients had a greater than 70% decreased odds of survival (OR 0.28, 95% CI 0.09 to 0.81; p=0.019).COVID-19 status is associated with increased major complications and 70% decreased odds of survival in this group of patients with trauma. However, among patients with COVID-19, blood group O was associated with twofold increased survival over other blood groups. This survival rate was similar to that of patients without COVID-19.
在不同血型的重伤患者中,我们试图比较 COVID-19 阳性和 COVID-19 阴性人群的存活率和并发症发生率。我们假设,在失血性休克的外伤患者中,COVID-19 阳性与死亡率和住院并发症的增加有关。作为次要假设,我们怀疑O组COVID-19患者的并发症会少于非O组COVID-19患者。我们对 2020 年 4 月至 2020 年 7 月期间收治的所有外伤患者进行了评估。16 岁或以上的患者如果出现失血性休克并接受了紧急放血产品治疗,则被纳入评估范围。我们对 3281 名外伤患者进行了评估,其中 417 人符合分析标准。7%(29 人)的患者 COVID-19 阳性;388 人 COVID-19 阴性。COVID-19 阳性患者的并发症发生率高于 COVID-19 阴性患者,包括急性肾损伤、肺炎、败血症、静脉血栓栓塞和全身炎症反应综合征。按血型进行的单变量分析表明,COVID-19 阳性 O 组患者的存活率与 COVID-19 阴性患者相似(79% 对 78%)。然而,COVID-19 阳性的非 O 型血患者的存活率明显较低(38%)。在控制了年龄、性别和损伤严重程度评分后,COVID-19 阳性患者的存活率降低了 70% 以上(OR 0.28,95% CI 0.09 至 0.81;P=0.019)。然而,在 COVID-19 患者中,O 型血患者的存活率比其他血型患者高出两倍。这一存活率与无 COVID-19 血型的患者相似。
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引用次数: 0
Early control of non-compressible abdominal hemorrhage when resources are scarce: where do we stand and where should we go? 在资源匮乏的情况下及早控制非可压缩性腹腔出血:何去何从?
Pub Date : 2024-02-01 DOI: 10.1136/tsaco-2024-001393
Nikolay Bugaev, John J Como
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引用次数: 0
Early control of non-compressible abdominal hemorrhage when resources are scarce: where do we stand and where should we go? 在资源匮乏的情况下及早控制非可压缩性腹腔出血:何去何从?
Pub Date : 2024-02-01 DOI: 10.1136/tsaco-2024-001393
Nikolay Bugaev, John J Como
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引用次数: 0
期刊
Trauma Surgery &amp; Acute Care Open
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