Dr. Baskar Rajamanickam, Dr. Bharathkumar Govindaraju, Dr. Selvapriya Sikkal Selvaraaju, Dr. Hemadevi Thangarasu, Dr. Shameem Fathima Abdul kareem
Background: From ancient times Siddha medicines have been proven to treat a wide range of communicable and noncommunicable diseases. In India, the number of people affected with diabetes is increasing drastically and it is considered as an epidemic. Purpose: To assess the anti-diabetic activity of the active compounds of the polyherbal formulation – Madhu Mukthi Kudineer Chooranum (MKC) by docking against potent enzymes involved in diabetes mellitus by in silico method. Methods: The major target enzymes Dipeptidyl peptidase, Glycogen synthase kinase - 3β, Alpha-glucosidase and Alpha-amylase were docked against the 10 active compounds present in the MKC using Auto Dock tools. Conclusion: The strong interactions between the target enzymes and the active compounds proved the anti-diabetic efficacy of the MKC formulation. Thus, the intake of MKC has potential benefits in the treatment of Type II Diabetes Mellitus.
背景：自古以来，释迦医药就被证明可以治疗多种传染性和非传染性疾病。在印度，糖尿病患者人数急剧增加，被视为一种流行病。目的：通过与涉及糖尿病的强效酶对接，评估多草药配方 Madhu Mukthi Kudineer Chooranum（MKC）活性化合物的抗糖尿病活性。方法：使用 Auto Dock 工具将二肽基肽酶、糖原合酶激酶-3β、α-葡萄糖苷酶和α-淀粉酶等主要靶酶与 MKC 中的 10 种活性化合物进行对接。得出结论：目标酶和活性化合物之间的强烈相互作用证明了 MKC 配方的抗糖尿病功效。因此，摄入 MKC 有助于治疗 II 型糖尿病。
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