Scripta medica最新文献

英文中文

CHRONOBIOLOGY OF HIGH BLOOD PRESSURE. 高血压的时间生物学。

Scripta medica

Pub Date : 2007-10-01

G Cornélissen, F Halberg, E E Bakken, Z Wang, R Tarquini, F Perfetto, G Laffi, C Maggioni, Y Kumagai, P Homolka, A Havelková, J Dušek, H Svačinová, J Siegelová, B Fišer

BIOCOS, the project aimed at studying BIOlogical systems in their COSmos, has obtained a great deal of expertise in the fields of blood pressure (BP) and heart rate (HR) monitoring and of marker rhythmometry for the purposes of screening, diagnosis, treatment, and prognosis. Prolonging the monitoring reduces the uncertainty in the estimation of circadian parameters; the current recommendation of BIOCOS requires monitoring for at least 7 days. The BIOCOS approach consists of a parametric and a non-parametric analysis of the data, in which the results from the individual subject are being compared with gender- and age-specified reference values in health.Chronobiological designs can offer important new information regarding the optimization of treatment by timing its administration as a function of circadian and other rhythms.New technological developments are needed to close the loop between the monitoring of blood pressure and the administration of antihypertensive drugs.

BIOCOS 项目旨在研究 COSmos 中的生物逻辑系统，该项目在血压（BP）和心率（HR）监测以及用于筛查、诊断、治疗和预后的标记节律测定方面获得了大量的专业知识。延长监测时间可减少昼夜节律参数估计的不确定性；目前的 BIOCOS 建议要求至少监测 7 天。BIOCOS 方法包括对数据进行参数分析和非参数分析，将受试者的结果与指定性别和年龄的健康参考值进行比较。时间生物学设计可提供有关优化治疗的重要新信息，根据昼夜节律和其他节律确定用药时间。

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FURTHER MAPPING OF THE NATALITY CHRONOME IN TODA CITY (JAPAN) MATERNITY HOSPITAL. 日本今天市妇产医院出生时程的进一步绘制。

Scripta medica

Pub Date : 2005-01-01

T Yamanaka, G Cornélissen, M Kazuma, N Kazuma, S Murakami, K Otsuka, J Siegelová, J Dušek, M Sosíková, F Halberg

In order to investigate any circannual and/or circaseptan variations in birth incidence and birth weight in Toda City (Japan), data on 4,411 consecutive births were obtained from the city's Maternity Hospital between 1 Jan 1999 and 31 Dec 2001. Data were analysed by cosinor separately for babies with birth weights in given ranges, and separately for boys and girls born at different gestational ages. A circannual rhythm was detected with statistical significance (P=0.047) for birth incidence of all vaginal deliveries, with an acrophase in the fall. A similar result for caesarean sections was of borderline statistical significance. A circaseptan component with a relatively consistent acrophase around midweek was of borderline statistical significance for birth incidence in some of the groups investigated. About-yearly and about-weekly variations were also found to characterize birth weight in some of the groups investigated.

为了调查户田市（日本）出生发生率和出生体重的任何年度和/或周期变化，从该市妇产医院获得了1999年1月1日至2001年12月31日期间连续4,411例分娩的数据。数据由cosinor分别对出生体重在给定范围内的婴儿和不同胎龄出生的男孩和女孩进行分析。所有阴道分娩的出生发生率均存在周期节律，且有统计学意义（P=0.047），并在秋季出现高峰期。剖宫产的类似结果具有临界统计学意义。在一些被调查的组中，在周中前后出现相对一致的顶相的circaseptan成分对出生发生率具有临界统计学意义。在一些被调查的群体中，大约每年和每周的变化也被发现是出生体重的特征。

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MAPPING OF CIRCASEPTAN AND CIRCADIAN CHANGES IN MOOD. circaseptan与情绪昼夜变化的映射。

Scripta medica

Pub Date : 2005-01-01

G Cornélissen, D Watson, G Mitsutake, B Fišer, J Siegelová, J Dušek, Vohlídalová, H Svaèinová, F Halberg

Circadian changes in mood have been described earlier. A positive affect (PA) has been separated from a negative affect (NA), as independent components in opposite admittedly subjective directions, a circadian rhythm characterizing both aspects. Herein, the time structure (chronome) of human mood is re-examined and extended from the circadian to the circaseptan domain by a meta-analysis of data on 196 clinically healthy students who filled out the positive (PA) and negative (NA) affective scale (PANAS), consisting each of 10-item mood scales. Both PA and NA are found by cosinor to be characterized by a circaseptan, circasemiseptan, and circadian variation. The circaseptan and circasemiseptan amplitudes are found to be larger than the circadian amplitude for NA, whereas the circadian amplitude is largest for PA. Complementing differences in relative circaseptan-to-circadian prominence between PA and NA are differences in the timing of the circadian, circasemiseptan, and circaseptan components of PA and NA. An even broader spectrum of rhythms may include a circadecadal modulation. With this qualification, the information on the time structure of mood provides endpoints to be considered in any attempt to optimize psychological well-being by making sleeping, dietary, and/or other lifestyle adjustments.

情绪的昼夜变化已经在前面描述过了。积极情感（PA）已经从消极情感（NA）中分离出来，作为对立的、公认的主观方向上的独立组成部分，具有两个方面的昼夜节律特征。本文通过对196名临床健康学生的数据进行meta分析，重新审视了人类情绪的时间结构（chronome），并将其从昼夜节律域扩展到circaseptan域。这些学生分别填写了由10项情绪量表组成的积极（PA）和消极（NA）情感量表（PANAS）。cosinor发现PA和NA都具有circaseptan， circasemiseptan和昼夜节律变化的特征。发现NA的circaseptan和circasemiseptan振幅大于昼夜节律振幅，而PA的昼夜节律振幅最大。PA和NA之间circaseptan- circadian的相对显著性差异的补充是PA和NA的昼夜节律、circaseptan和circaseptan成分的时间差异。更广泛的节奏范围可能包括昼夜节律调制。有了这个条件，关于情绪时间结构的信息为任何通过调整睡眠、饮食和/或其他生活方式来优化心理健康的尝试提供了考虑的终点。

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