Infertility in females is a devastating problem whose solution has posed a lot of challenges due to the difficulty and complexity of identifying the exact cause and etiology among different individuals. This study evaluated copper/zinc ratio, total protein, albumin and reproductive hormones in infertile females in Port Harcourt. This was a case-control study, carried out among residents of Port Harcourt. A total of 130 female subjects within the age of 18 and 49 years were recruited for the study; 65 infertile subjects and 65 apparently healthy fertile control subjects. Approximately 10 mL of blood was collected using standard venipuncture technique from each subject on day 3 and 21 of the menstrual cycle. Samples for copper, zinc, total protein and albumin were analyzed using colorimetric methods, while the reproductive hormones were analyzed using Enzyme-Linked Immunosorbent Assay. Data generated were analyzed using Graph-Pad Prism version 8.0.2 and P≤0.05 was considered statistically significant. This study revealed a significant increase on day 3 and 21 in mean copper 27.68±10.78 and 20.29 ± 16.41 (P<0.001 and P=0.043) levels in infertile women when compared to the mean copper 16.82±4.52 and 15.20 ±5.29 of control group respectively. Copper/zinc ratio was also increased in the infertile group with mean levels of 11.40±1.82 and 3.27 ±0.59 on days 3 and 21 compared to the control group with mean levels of 4.53±0.76 and 1.46 ±0.12 (P=0.010 and P=0.004) respectively. There was significant decrease on day 3 of Menstrual cycle in Mean ± SD levels of Total Protein 72.62 ±7.84 in infertile group and 77.23 ±4.71 in control group (P< 0.001), and albumin 40.54 ±4.79 in infertile group and 44.82 ±3.64 in control group (P=< 0.001) respectively. There was no significant difference in mean zinc level (P=0.402) on day 3, but mean zinc level 10.74 ±4.58 was significantly decreased on day 21 in infertile females compared to the control 12.91 ±4.73 group (P=0.009). There was also significant increase in mean levels of Luteinizing hormone 8.64 ±4.32 infertile and 7.16 ±2.21 control (P=0.016), prolactin 27.02 ±18.55 infertile and 12.28 ±6.44 control (p<0.001), and testosterone 0.74 ±0.25 infertile and 0.38 ±0.18 control (P<0.001) respectively. There was a significant decrease in mean levels of estrogen 28.66 ±10.34 infertile and 41.79 ±4.55 control (P<0.001), and progesterone 7.71 ±6.38 infertile and 15.63 ±6.57 control (P<0.001) respectively. However, there was no significant difference in mean levels of follicle stimulating hormone (P=0.519). The findings in this study indicate that a high copper/zinc ratio is associated with alterations in levels of reproductive hormones. Hence, micronutrient supplementation to maintain optimum levels will be beneficial for infertile females.
{"title":"Evaluation of Copper /Zinc Ratio, Total Protein, Albumin and Reproductive Hormones among Infertile Women in Port Harcourt, Nigeria","authors":"Anyalebechi Eberechukwu Okwuchi, Onwuli, Donatus Onukwufor, Elechi-Amadi Kemzi Nosike","doi":"10.56557/jomahr/2024/v9i18645","DOIUrl":"https://doi.org/10.56557/jomahr/2024/v9i18645","url":null,"abstract":"Infertility in females is a devastating problem whose solution has posed a lot of challenges due to the difficulty and complexity of identifying the exact cause and etiology among different individuals. This study evaluated copper/zinc ratio, total protein, albumin and reproductive hormones in infertile females in Port Harcourt. This was a case-control study, carried out among residents of Port Harcourt. A total of 130 female subjects within the age of 18 and 49 years were recruited for the study; 65 infertile subjects and 65 apparently healthy fertile control subjects. Approximately 10 mL of blood was collected using standard venipuncture technique from each subject on day 3 and 21 of the menstrual cycle. Samples for copper, zinc, total protein and albumin were analyzed using colorimetric methods, while the reproductive hormones were analyzed using Enzyme-Linked Immunosorbent Assay. Data generated were analyzed using Graph-Pad Prism version 8.0.2 and P≤0.05 was considered statistically significant. This study revealed a significant increase on day 3 and 21 in mean copper 27.68±10.78 and 20.29 ± 16.41 (P<0.001 and P=0.043) levels in infertile women when compared to the mean copper 16.82±4.52 and 15.20 ±5.29 of control group respectively. Copper/zinc ratio was also increased in the infertile group with mean levels of 11.40±1.82 and 3.27 ±0.59 on days 3 and 21 compared to the control group with mean levels of 4.53±0.76 and 1.46 ±0.12 (P=0.010 and P=0.004) respectively. There was significant decrease on day 3 of Menstrual cycle in Mean ± SD levels of Total Protein 72.62 ±7.84 in infertile group and 77.23 ±4.71 in control group (P< 0.001), and albumin 40.54 ±4.79 in infertile group and 44.82 ±3.64 in control group (P=< 0.001) respectively. There was no significant difference in mean zinc level (P=0.402) on day 3, but mean zinc level 10.74 ±4.58 was significantly decreased on day 21 in infertile females compared to the control 12.91 ±4.73 group (P=0.009). There was also significant increase in mean levels of Luteinizing hormone 8.64 ±4.32 infertile and 7.16 ±2.21 control (P=0.016), prolactin 27.02 ±18.55 infertile and 12.28 ±6.44 control (p<0.001), and testosterone 0.74 ±0.25 infertile and 0.38 ±0.18 control (P<0.001) respectively. There was a significant decrease in mean levels of estrogen 28.66 ±10.34 infertile and 41.79 ±4.55 control (P<0.001), and progesterone 7.71 ±6.38 infertile and 15.63 ±6.57 control (P<0.001) respectively. However, there was no significant difference in mean levels of follicle stimulating hormone (P=0.519). The findings in this study indicate that a high copper/zinc ratio is associated with alterations in levels of reproductive hormones. Hence, micronutrient supplementation to maintain optimum levels will be beneficial for infertile females.","PeriodicalId":517865,"journal":{"name":"Journal of Medicine and Health Research","volume":"23 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-02DOI: 10.56557/jomahr/2024/v9i18567
Sathiyaseelan A., Arthi C, Prabavathy S.
Introduction: India has a total geographical area of 328.73 million hectares, with 306.04 million hectares reported for land usage. According to the Registrar General of India, the overall number of agricultural workers has increased from 234.1 million. Most agricultural workers have been linked to poor mental health outcomes in adult farmers and ranchers. Stress, anxiety, and insomnia are the most commonly reported mental health issues, affecting 55% of farmers. Somatic issues are the second most prevalent type of symptom. So, the planned instruction approach will assist farm workers in reducing and managing stress levels. Aim: To evaluate the effectiveness of structured teaching programme on reduction of level of stress among agricultural workers in selected area at Puducherry. Materials and Methods: A Quantitative research approach, pre-experimental (one group Pre-test and Post-test) was adopted in the study. Totally 40 Agricultural workers were selected by Convenient sampling technique at Senthanatham, Puducherry. Pre-test and post-test were done by the Cohen Perceived Stress Scale. A Structured teaching programme was given to the agricultural workers in reduction of level of stress. Results: The study result shows that the pretest and posttest mean values of stress was 6.6 and 17.9 respectively and the standard deviation value were 3.02 and 0.96 respectively. The obtained p-value of stress is highly statistically significant with a value of p<0.0001. So, this study concluded that structured teaching programme was most effective in reducing the level of stress among the agricultural workers.
{"title":"Effect of Structured Teaching Programme on Reduction of Level of Stress among Agricultural Workers in Selected Area at Puducherry","authors":"Sathiyaseelan A., Arthi C, Prabavathy S.","doi":"10.56557/jomahr/2024/v9i18567","DOIUrl":"https://doi.org/10.56557/jomahr/2024/v9i18567","url":null,"abstract":"Introduction: India has a total geographical area of 328.73 million hectares, with 306.04 million hectares reported for land usage. According to the Registrar General of India, the overall number of agricultural workers has increased from 234.1 million. Most agricultural workers have been linked to poor mental health outcomes in adult farmers and ranchers. Stress, anxiety, and insomnia are the most commonly reported mental health issues, affecting 55% of farmers. Somatic issues are the second most prevalent type of symptom. So, the planned instruction approach will assist farm workers in reducing and managing stress levels. \u0000Aim: To evaluate the effectiveness of structured teaching programme on reduction of level of stress among agricultural workers in selected area at Puducherry. \u0000Materials and Methods: A Quantitative research approach, pre-experimental (one group Pre-test and Post-test) was adopted in the study. Totally 40 Agricultural workers were selected by Convenient sampling technique at Senthanatham, Puducherry. Pre-test and post-test were done by the Cohen Perceived Stress Scale. A Structured teaching programme was given to the agricultural workers in reduction of level of stress. \u0000Results: The study result shows that the pretest and posttest mean values of stress was 6.6 and 17.9 respectively and the standard deviation value were 3.02 and 0.96 respectively. The obtained p-value of stress is highly statistically significant with a value of p<0.0001. So, this study concluded that structured teaching programme was most effective in reducing the level of stress among the agricultural workers.","PeriodicalId":517865,"journal":{"name":"Journal of Medicine and Health Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140285860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.56557/jomahr/2024/v9i18554
Tejaswi Chillara, A. Anitha, Y. Mounika, A. Divya, Gunisetti Tejaswini, Mattewada Himabindhu
Back Ground: It is a prospective observational study that included unexplained infertility cycles with COS –IUI protocols. Thin endometrium of less than 7mm has a negative effect on pregnancy rate. Endometrial function and receptivity factors are important in the success of implantation. Aim: To monitor the effects of G-CSF on thin endometrium in improving endometrium thickness and pregnancy rates in G-CSF administered COS-IUI cycles. Methods: This study was conducted in the Laxmi Narasimha hospital IVF center under the guidence Dr. Adaboina Anitha,Hanamkonda, warangal. Thin endometrium was defined less than 7mm on Trans vaginal ultrasound. Letrozole 5mg (2.5mg, BD) is used for ovulation induction on day 2 or day 3 of their cycle, G CSF 300units was added with significantly improved pregnancy rates in ART cycles. Trigger used was injection 10,000IU urinary hCG & 300 units G-CSF was instilled into the uterus. After 48hours ET was measured & IUI was performed under aseptic precautions. After 16 days β -hCG levels were monitored to determine whether there is a pregnancy. Results: In present study, we concluded that, 250 COS-IUI cycles were analysed and 50 cycles showed a thin endometrium and in them G-CSF was used. The pregnancy rate (28%) was evaluated, 14 members are positive for pregnancy. Conclusion: In our study we concluded that G-CSF and letrozole will improve increases endometrium thickness and conceiving rates in COS-IUI cycles.
{"title":"Role of Granulocyte Colony Stimulating Factor Effects on Unresponsive Thin Endometrium in Women Undergoing Controlled Ovarian Stimulated Intrauterine Insemination Cycles","authors":"Tejaswi Chillara, A. Anitha, Y. Mounika, A. Divya, Gunisetti Tejaswini, Mattewada Himabindhu","doi":"10.56557/jomahr/2024/v9i18554","DOIUrl":"https://doi.org/10.56557/jomahr/2024/v9i18554","url":null,"abstract":"Back Ground: It is a prospective observational study that included unexplained infertility cycles with COS –IUI protocols. Thin endometrium of less than 7mm has a negative effect on pregnancy rate. Endometrial function and receptivity factors are important in the success of implantation. \u0000Aim: To monitor the effects of G-CSF on thin endometrium in improving endometrium thickness and pregnancy rates in G-CSF administered COS-IUI cycles. \u0000Methods: This study was conducted in the Laxmi Narasimha hospital IVF center under the guidence Dr. Adaboina Anitha,Hanamkonda, warangal. Thin endometrium was defined less than 7mm on Trans vaginal ultrasound. Letrozole 5mg (2.5mg, BD) is used for ovulation induction on day 2 or day 3 of their cycle, G CSF 300units was added with significantly improved pregnancy rates in ART cycles. Trigger used was injection 10,000IU urinary hCG & 300 units G-CSF was instilled into the uterus. After 48hours ET was measured & IUI was performed under aseptic precautions. After 16 days β -hCG levels were monitored to determine whether there is a pregnancy. \u0000Results: In present study, we concluded that, 250 COS-IUI cycles were analysed and 50 cycles showed a thin endometrium and in them G-CSF was used. The pregnancy rate (28%) was evaluated, 14 members are positive for pregnancy. \u0000Conclusion: In our study we concluded that G-CSF and letrozole will improve increases endometrium thickness and conceiving rates in COS-IUI cycles.","PeriodicalId":517865,"journal":{"name":"Journal of Medicine and Health Research","volume":"50 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-23DOI: 10.56557/jomahr/2024/v9i18493
Bede C. Azudialu, Ahaiwe Vivien, N. Uchenna, Ogunnaya Francis Ugonna, Nkem Benjamin, N. R. I. Austin
Erectile dysfunction (ED) is a complex disorder with a biopsychosocial etiology that causes chronic stress on the individual thereby worsening the outcome of the disorder. The aim of this study is to establish an association between stress level and erectile dysfunction among adult patients presenting in the general outpatient of our tertiary hospital. A cross sectional study involving 421 adult males selected by simple random sampling was conducted using the International Index of Erectile Dysfunction (IIEF-5) and the Modified Percieved Stress Scale (PSS-10) Among the respondents, 219(52%) had ED while a greater proportion of those who had ED had mild ED 109 (49.8%). The other factors associated with ED on bivariate analysis include tobacco use (p < 0.05), alcohol intake (p < 0.05), diabetes mellitus, hypertension, use of anti hypertensive drugs, use of oral hyperglycaemic drugs, and perceived stress levels. Logistic regression showed that age, tobacco use, alcohol intake, and perceived stress levels were independent predictors of ED among the respondents. Perceived stress level has been found to be associated with ED. Routine evaluation of sexual health and the perceived stress levels of men isrecommended, while stress management as part of management of ER is highly advocated.
勃起功能障碍（ED）是一种复杂的疾病，其生物-心理-社会病因会给患者造成长期压力，从而导致疾病恶化。本研究的目的是在我们三级医院普通门诊的成年患者中建立压力水平与勃起功能障碍之间的联系。研究采用国际勃起功能障碍指数（IIEF-5）和改良压力认知量表（PSS-10）对简单随机抽样选出的 421 名成年男性进行了横断面研究，受访者中有 219 人（52%）患有勃起功能障碍，其中 109 人（49.8%）患有轻度勃起功能障碍。根据双变量分析，与 ED 相关的其他因素包括吸烟（P < 0.05）、酒精摄入量（P < 0.05）、糖尿病、高血压、使用抗高血压药物、使用口服降糖药和感知压力水平。逻辑回归显示，年龄、吸烟、酒精摄入量和感知压力水平是受访者发生 ED 的独立预测因素。已发现感知压力水平与 ED 有关。建议对男性的性健康和感知压力水平进行常规评估，同时大力提倡将压力管理作为急诊室管理的一部分。
{"title":"Association between Stress and Erectile Dysfunction among Adult Patients in a Tertiary Center in Nigeria","authors":"Bede C. Azudialu, Ahaiwe Vivien, N. Uchenna, Ogunnaya Francis Ugonna, Nkem Benjamin, N. R. I. Austin","doi":"10.56557/jomahr/2024/v9i18493","DOIUrl":"https://doi.org/10.56557/jomahr/2024/v9i18493","url":null,"abstract":"Erectile dysfunction (ED) is a complex disorder with a biopsychosocial etiology that causes chronic stress on the individual thereby worsening the outcome of the disorder. The aim of this study is to establish an association between stress level and erectile dysfunction among adult patients presenting in the general outpatient of our tertiary hospital. A cross sectional study involving 421 adult males selected by simple random sampling was conducted using the International Index of Erectile Dysfunction (IIEF-5) and the Modified Percieved Stress Scale (PSS-10) Among the respondents, 219(52%) had ED while a greater proportion of those who had ED had mild ED 109 (49.8%). The other factors associated with ED on bivariate analysis include tobacco use (p < 0.05), alcohol intake (p < 0.05), diabetes mellitus, hypertension, use of anti hypertensive drugs, use of oral hyperglycaemic drugs, and perceived stress levels. Logistic regression showed that age, tobacco use, alcohol intake, and perceived stress levels were independent predictors of ED among the respondents. Perceived stress level has been found to be associated with ED. Routine evaluation of sexual health and the perceived stress levels of men isrecommended, while stress management as part of management of ER is highly advocated.","PeriodicalId":517865,"journal":{"name":"Journal of Medicine and Health Research","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140498316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-03DOI: 10.56557/jomahr/2024/v9i18478
Rahul Kushwah, Rajiv Muradia, A. Bist
Hypertension, a prevalent global health concern, necessitates accurate and non-invasive blood pressure estimation techniques for effective monitoring and management. This paper proposes a novel machine learning approach utilizing Photo plethysmography (PPG) signals for precise blood pressure estimation. PPG signals, obtained conveniently through wearable devices, offer valuable physiological information related to cardiovascular activity. Leveraging advanced machine learning algorithms, including deep learning architectures and feature extraction methods, our proposed technique aims to establish a robust model for blood pressure estimation using facial image analysis. The methodology involves preprocessing PPG signals, extracting relevant features, and employing sophisticated machine learning models for regression analysis. The evaluation of this novel approach involves comprehensive experimentation with diverse datasets, ensuring its efficacy across various demographic groups and conditions. Results demonstrate promising accuracy and reliability in estimating blood pressure values, suggesting the potential for practical implementation in healthcare settings. The proposed technique showcases a promising avenue for non-invasive and accessible blood pressure monitoring, contributing significantly to personalized healthcare and continuous health monitoring systems.
{"title":"Utilization of Facial PPG Signals as a Novel Source for Blood Pressure Estimation","authors":"Rahul Kushwah, Rajiv Muradia, A. Bist","doi":"10.56557/jomahr/2024/v9i18478","DOIUrl":"https://doi.org/10.56557/jomahr/2024/v9i18478","url":null,"abstract":"Hypertension, a prevalent global health concern, necessitates accurate and non-invasive blood pressure estimation techniques for effective monitoring and management. This paper proposes a novel machine learning approach utilizing Photo plethysmography (PPG) signals for precise blood pressure estimation. PPG signals, obtained conveniently through wearable devices, offer valuable physiological information related to cardiovascular activity. Leveraging advanced machine learning algorithms, including deep learning architectures and feature extraction methods, our proposed technique aims to establish a robust model for blood pressure estimation using facial image analysis. The methodology involves preprocessing PPG signals, extracting relevant features, and employing sophisticated machine learning models for regression analysis. The evaluation of this novel approach involves comprehensive experimentation with diverse datasets, ensuring its efficacy across various demographic groups and conditions. Results demonstrate promising accuracy and reliability in estimating blood pressure values, suggesting the potential for practical implementation in healthcare settings. The proposed technique showcases a promising avenue for non-invasive and accessible blood pressure monitoring, contributing significantly to personalized healthcare and continuous health monitoring systems.","PeriodicalId":517865,"journal":{"name":"Journal of Medicine and Health Research","volume":"117 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140514535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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