Daniel Manzur-Sandoval, G. Jiménez-Rodríguez, J. Elizalde-Silva, Meredith Fernanda Sánchez-Torres, Uriel Encarnación-Martínez, Cristhian Josué Gaytán-García, J. O. Salazar-Delgado, Guadalupe Lisseth Hernández-González, Gustavo Rojas-Velasco
{"title":"Left atrial venoarterial extracorporeal membrane oxygenation strategy in postcardiotomy cardiogenic shock: A case series","authors":"Daniel Manzur-Sandoval, G. Jiménez-Rodríguez, J. Elizalde-Silva, Meredith Fernanda Sánchez-Torres, Uriel Encarnación-Martínez, Cristhian Josué Gaytán-García, J. O. Salazar-Delgado, Guadalupe Lisseth Hernández-González, Gustavo Rojas-Velasco","doi":"10.58464/2378-2706.1065","DOIUrl":"https://doi.org/10.58464/2378-2706.1065","url":null,"abstract":"","PeriodicalId":518957,"journal":{"name":"The VAD Journal","volume":"15 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141928344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite the remarkable progress made over the past few decades in the management of patients with both solid and hematologic malignancies, radiation-and chemotherapy-related cardiotoxicity remains an ongoing problem. This is true even for newer highly targeted therapies, including tyrosine kinase inhibitors (TKIs). This report presents a case of late/severe right heart dysfunction secondary to pulmonary hypertension, developed after ten years of therapy with dasatinib. We also review the history of this known, but often unrecognized, and potentially reversible complication, and we suggest treatment options. Additionally, this case highlights the remarkable effectiveness of TKIs in patients with chronic myelogenous leukemia while also emphasizing the ever-present concern that even in the absence of clinical or laboratory evidence of residual leukemic disease, discontinuing chemotherapeutic agents may result in prompt recrudescence and death.
{"title":"Late Cardiotoxicity from the Tyrosine Kinase Inhibitor, Dasatinib: Pleural Effusions, Pulmonary Arterial Hypertension, and Right Heart Failure","authors":"Mark Jay Zucker, Andrew M. Zucker","doi":"10.58464/2378-2706.1062","DOIUrl":"https://doi.org/10.58464/2378-2706.1062","url":null,"abstract":"Despite the remarkable progress made over the past few decades in the management of patients with both solid and hematologic malignancies, radiation-and chemotherapy-related cardiotoxicity remains an ongoing problem. This is true even for newer highly targeted therapies, including tyrosine kinase inhibitors (TKIs). This report presents a case of late/severe right heart dysfunction secondary to pulmonary hypertension, developed after ten years of therapy with dasatinib. We also review the history of this known, but often unrecognized, and potentially reversible complication, and we suggest treatment options. Additionally, this case highlights the remarkable effectiveness of TKIs in patients with chronic myelogenous leukemia while also emphasizing the ever-present concern that even in the absence of clinical or laboratory evidence of residual leukemic disease, discontinuing chemotherapeutic agents may result in prompt recrudescence and death.","PeriodicalId":518957,"journal":{"name":"The VAD Journal","volume":"65 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：