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"They Just Love Me"-An Examination of Social Support Experiences and Values Among People With TBI. "他们就是爱我"--对创伤性脑损伤患者的社会支持经历和价值观的研究。
Pub Date : 2024-04-29 DOI: 10.1097/htr.0000000000000944
Jessica Kersey, Hannah Rice, Lisa Tabor Connor, Beth Fields, Joy Hammel
Social support is important for health and functional outcomes after traumatic brain injury (TBI), but many adults with TBI report inadequate social support. Little research has examined the social support priorities of adults with TBI or what an optimal social support network should include. The objective of this study was to describe the social support structures and experiences of adults with TBI.
社会支持对创伤性脑损伤(TBI)后的健康和功能结果非常重要,但许多患有 TBI 的成年人表示社会支持不足。很少有研究对患有创伤性脑损伤的成年人的社会支持重点或最佳社会支持网络应包括哪些内容进行研究。本研究旨在描述患有创伤性脑损伤的成年人的社会支持结构和经历。
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引用次数: 0
Genetic Variants and Persistent Impairment Following Mild Traumatic Brain Injury: A Systematic Review. 遗传变异与轻度脑外伤后的持续损伤:系统回顾。
Pub Date : 2024-04-26 DOI: 10.1097/HTR.0000000000000907
Chaim M Feigen, Molly F Charney, Simone Glajchen, Cameron Myers, Steven Cherny, Ronni Lipnitsky, Wendy W Yang, Nancy R. Glassman, Michael L Lipton
OBJECTIVEThe purpose of this review is to systematically assess primary research publications on known genetic variants, which modify the risk for symptoms or dysfunction persisting 30 days or more following mild traumatic brain injury (mTBI).SUMMARY OF REVIEWA search of PubMed and Embase from inception through June 2022 identified 42 studies that associated genetic variants with the presence of symptoms or cognitive dysfunction 30 days or more following mTBI. Risk of bias was assessed for each publication using the Newcastle Ottawa Scale (NOS). Fifteen of the 22 studies evaluating apolipoprotein E (APOE) ɛ4 concluded that it was associated with worse outcomes and 4 of the 8 studies investigating the brain-derived neurotrophic factor (BDNF) reported the Val66Met allele was associated with poorer outcomes. The review also identified 12 studies associating 28 additional variants with mTBI outcomes. Of these, 8 references associated specific variants with poorer outcomes. Aside from analyses comparing carriers and noncarriers of APOE ɛ4 and BDNF Val66Met, most of the reviewed studies were too dissimilar, particularly in terms of specific outcome measures but also in genes examined, to allow for direct comparisons of their findings. Moreover, these investigations were observational and subject to varying degrees of bias.CONCLUSIONSThe most consistent finding across articles was that APOE ɛ4 is associated with persistent post-mTBI impairment (symptoms or cognitive dysfunction) more than 30 days after mTBI. The sparsity of other well-established and consistent findings in the mTBI literature should motivate larger, prospective studies, which characterize the risk for persistent impairment with standardized outcomes in mTBI posed by other genetic variants influencing mTBI recovery.
本综述旨在系统评估有关已知遗传变异的主要研究出版物,这些遗传变异会改变轻度创伤性脑损伤(mTBI)后 30 天或更长时间内症状或功能障碍持续存在的风险。综述对 PubMed 和 Embase 从开始到 2022 年 6 月进行的检索发现了 42 项研究,这些研究将遗传变异与轻度创伤性脑损伤(mTBI)后 30 天或更长时间内症状或认知功能障碍的存在联系起来。采用纽卡斯尔-渥太华量表(Newcastle Ottawa Scale,NOS)对每篇文献的偏倚风险进行了评估。在对载脂蛋白 E (APOE) ɛ4进行评估的 22 项研究中,有 15 项得出结论认为其与较差的预后有关;在对脑源性神经营养因子 (BDNF) 进行调查的 8 项研究中,有 4 项报告 Val66Met 等位基因与较差的预后有关。综述还发现了 12 项研究,其中 28 个额外变异与 mTBI 结果有关。其中,8 篇参考文献将特定变异与较差的预后联系起来。除了对 APOE ɛ4 和 BDNF Val66Met 的携带者和非携带者进行比较分析外,大多数综述研究的差异都很大,特别是在具体的结果测量方面,而且在所研究的基因方面,因此无法对其研究结果进行直接比较。结论各文章最一致的发现是 APOE ɛ4 与 mTBI 后超过 30 天的持续性损伤(症状或认知功能障碍)有关。mTBI 文献中缺乏其他公认且一致的研究结果,因此应开展更大规模的前瞻性研究,以确定影响 mTBI 恢复的其他遗传变异在 mTBI 中造成持续性损伤和标准化结果的风险。
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引用次数: 0
Cost-Effectiveness of Sleep Apnea Diagnosis and Treatment in Hospitalized Persons With Moderate to Severe Traumatic Brain Injury. 中重度创伤性脑损伤住院患者睡眠呼吸暂停诊断和治疗的成本效益。
Pub Date : 2024-04-18 DOI: 10.1097/HTR.0000000000000951
Athanasios Tsalatsanis, C. Dismuke-Greer, Ambuj Kumar, Jeanne M. Hoffman, K. Monden, U. Magalang, Daniel J. Schwartz, Aaron M. Martin, R. Nakase-Richardson
OBJECTIVETo assess the cost-effectiveness of alternative approaches to diagnose and treat obstructive sleep apnea (OSA) in patients with traumatic brain injury (TBI) during inpatient rehabilitation.SETTINGData collected during the Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome (C-SAS) clinical trial (NCT03033901) on an inpatient rehabilitation TBI cohort were used in this study.STUDY DESIGNDecision tree analysis was used to determine the cost-effectiveness of approaches to diagnosing and treating sleep apnea. Costs were determined using 2021 Centers for Medicare and Medicaid Services reimbursement codes. Effectiveness was defined in terms of the appropriateness of treatment. Costs averted were extracted from the literature. A sensitivity analysis was performed to account for uncertainty. Analyses were performed for all severity levels of OSA and a subgroup of those with moderate to severe OSA. Six inpatient approaches using various phases of screening, testing, and treatment that conform to usual care or guideline-endorsed interventions were evaluated: (1) usual care; (2) portable diagnostic testing followed by laboratory-quality testing; (3) screening with the snoring, tiredness, observed apnea, high BP, BMI, age, neck circumference, and male gender (STOP-Bang) questionnaire; (4) Multivariable Apnea Prediction Index (MAPI) followed by portable diagnostic testing and laboratory-quality testing; (5) laboratory-quality testing for all; and (6) treatment for all patients.MAIN MEASURESCost, Effectiveness, and Incremental Cost-Effectiveness Ratio (ICER).RESULTSPhased approaches utilizing screening and diagnostic tools were more effective in diagnosing and allocating treatment for OSA than all alternatives in patients with mild to severe and moderate to severe OSA. Usual care was more costly and less effective than all other approaches for mild to severe and moderate to severe OSA.CONCLUSIONSDiagnosing and treating OSA in patients with TBI is a cost-effective strategy when compared with usual care.
目的评估在住院康复期间诊断和治疗创伤性脑损伤(TBI)患者阻塞性睡眠呼吸暂停(OSA)的替代方法的成本效益。研究设计采用决策树分析法确定诊断和治疗睡眠呼吸暂停方法的成本效益。成本使用 2021 年美国医疗保险和医疗补助服务中心的报销代码确定。疗效根据治疗的适当性来定义。从文献中提取了避免的成本。为考虑不确定性因素,进行了敏感性分析。对所有严重程度的 OSA 和中重度 OSA 患者分组进行了分析。对六种住院方法进行了评估,这些方法采用了符合常规护理或指南认可的干预措施的不同阶段的筛查、检测和治疗:(1) 常规护理;(2) 便携式诊断检测,然后进行实验室质量检测;(3) 使用打鼾、疲倦、观察到的呼吸暂停、高血压、体重指数、年龄、颈围和男性性别(STOP-Bang)问卷进行筛查;(4) 多变量呼吸暂停预测指数(MAPI),然后进行便携式诊断检测和实验室质量检测;(5) 对所有患者进行实验室质量检测;以及 (6) 对所有患者进行治疗。结果对于轻度至重度和中度至重度 OSA 患者,利用筛查和诊断工具的分阶段方法在诊断和分配 OSA 治疗方面比所有替代方法更有效。对于轻度至重度和中度至重度 OSA 患者,常规护理比所有其他方法成本更高、效果更差。
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引用次数: 0
Age Suppresses the Association Between Traumatic Brain Injury Severity and Functional Outcomes: A Study Using the NIDILRR TBIMS Dataset. 年龄抑制了脑外伤严重程度与功能结果之间的关联:使用 NIDILRR TBIMS 数据集的研究。
Pub Date : 2024-04-17 DOI: 10.1097/HTR.0000000000000955
Laraine Winter, Helene Moriarty, Keith M Robinson, Benjamin E. Leiby, Krista Schmidt, Christina R Whitehouse, R. Swanson
OBJECTIVESRecovery from traumatic brain injury (TBI) is extremely difficult to predict, with TBI severity usually demonstrating weak predictive validity for functional or other outcomes. A possible explanation may lie in the statistical phenomenon called suppression, according to which a third variable masks the true association between predictor and outcome, making it appear weaker than it actually is. Age at injury is a strong candidate as a suppressor because of its well-established main and moderating effects on TBI outcomes. We tested age at injury as a possible suppressor in the predictive chain of effects between TBI severity and functional disability, up to 10 years post-TBI.SETTINGFollow-up interviews were conducted during telephone interviews.PARTICIPANTSWe used data from the 2020 NDILRR Model Systems National Dataset for 4 successive follow-up interviews: year 1 (n = 10,734), year 2 (n = 9174), year 5 (n = 6,201), and year 10 (n = 3027).DESIGNSuccessive cross-sectional multiple regression analyses.MAIN MEASURESInjury severity was operationalized using a categorical variable representing duration of posttrauma amnesia. The Glasgow Outcomes Scale-Extended (GOS-E) operationally defined functioning. Sociodemographic characteristics having significant bivariate correlations with GOS-E were included.RESULTSEntry of age at injury into the regression models significantly increases the association between TBI severity and functioning up to 10 years post-TBI.CONCLUSIONSAge at injury is a suppressor variable, masking the true effect of injury severity on functional outcomes. Identifying the mediators of this suppression effect is an important direction for TBI rehabilitation research.
目的创伤性脑损伤(TBI)后的恢复极难预测,TBI 的严重程度通常对功能或其他结果的预测效力较弱。一种可能的解释是,统计学上有一种叫做 "抑制 "的现象,即第三个变量掩盖了预测因子与结果之间的真实联系,使其看起来比实际情况要弱。由于受伤年龄对创伤性脑损伤结果的主要影响和调节作用已得到证实,因此它是抑制因素的有力候选者。我们测试了受伤年龄作为创伤后 10 年内创伤性脑损伤严重程度与功能性残疾之间预测效应链中可能的抑制因子的作用。参与者我们使用了2020年NDILRR模型系统国家数据集中的数据,连续进行了4次随访:第1年(n = 10734)、第2年(n = 9174)、第5年(n = 6201)和第10年(n = 3027).设计连续横截面多元回归分析.主要测量伤害严重程度使用代表创伤后失忆持续时间的分类变量进行操作。格拉斯哥结果量表扩展版(GOS-E)对功能进行了操作性定义。结果在回归模型中加入受伤时的年龄会显著增加创伤后 10 年内创伤性脑损伤严重程度与功能之间的关联。确定这种抑制效应的中介因素是创伤后康复研究的一个重要方向。
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引用次数: 0
Neurobehavioral Symptom Profiles for the Behavioral Assessment Screening Tool in Chronic Traumatic Brain Injury. 用于慢性脑外伤行为评估筛查工具的神经行为症状档案。
Pub Date : 2024-04-09 DOI: 10.1097/HTR.0000000000000950
Shannon B Juengst, Brittany Wright, Annalyn DeMello, Leia Vos, Fedora Biney, Luis Leon Novelo, Michael Williams
OBJECTIVETo identify neurobehavioral symptom profiles among persons with chronic traumatic brain injury (TBI) using the Behavioral Assessment Screening Tool (BAST) and to consider participant characteristics that differ between profile groups.SETTINGCommunity.PARTICIPANTSParticipants (n = 615) were English-speaking adults (≥18) and had a self-reported history of at least one TBI of any severity.DESIGNSecondary analysis of cross-sectional data.MAIN MEASURESThe BAST measures neurobehavioral symptoms in the domains of Negative Affect, Fatigue, Executive Dysfunction, Impulsivity, and Substance Misuse.RESULTSUsing latent profile analysis (LPA), we identified 3 different neurobehavioral profiles. Overall symptom frequency and differences in the pattern of symptom frequency across domains differentiated the profile groups. Average domain scores differed significantly across the profiles (P < .001) for all domains except Fatigue (P = .076). Those in profile 3 (High-Risk group) reported the most frequent symptoms across all domains (similar Negative Affect frequency as profile 1). Substance Misuse was especially high in this group. Compared to profile 2 (High Negative Affect group), participants in profile 1 (Moderate-Risk group) endorsed significantly more frequent (and more variable) symptoms across all BAST domains, particularly Impulsivity and Substance Misuse. Participants in profile 2 endorsed the least frequent symptoms across all domains. Demographic comparison showed that groups differed based on gender, age, and injury severity (mild vs moderate-severe), with profile 3 composed of the most men and the most persons in early adulthood, and profile 2 composed of the most women and those with mild TBI.CONCLUSIONSWe differentiated 3 neurobehavioral symptom profiles among persons with chronic TBI and determined differences in sociodemographic factors between the groups. Future research should focus on validating these profiles in another sample of individuals with chronic TBI. Characterizing persons according to multidimensional symptom profiles could allow for more tailored approaches to predict and prevent long-term negative outcomes.
目的利用行为评估筛查工具(BAST)确定慢性脑外伤(TBI)患者的神经行为症状特征,并考虑不同特征组之间存在差异的参与者特征。设计对横断面数据进行二次分析。主要测量BAST测量消极情绪、疲劳、执行功能障碍、冲动和药物滥用等领域的神经行为症状。结果通过潜伏特征分析(LPA),我们发现了3种不同的神经行为特征。总体症状频率和各领域症状频率模式的差异区分了不同的特征组。除疲劳(P = .076)外,各特征组在所有领域的平均得分均有显著差异(P < .001)。特征 3(高危组)报告的症状在所有领域中最为频繁(消极情绪频率与特征 1 相似)。该组的药物滥用率尤其高。与特征 2(高负性情绪组)相比,特征 1(中度风险组)的参与者在 BAST 的所有领域,特别是冲动性和药物滥用方面,症状出现的频率明显更高(且更多变)。特征 2 的参与者在所有领域中出现症状的频率最低。人口统计学比较显示,各组在性别、年龄和受伤严重程度(轻度与中重度)方面存在差异,特征 3 中男性最多,成年早期的人最多,特征 2 中女性和轻度 TBI 患者最多。未来的研究应侧重于在另一个慢性 TBI 患者样本中验证这些特征。根据多维症状特征对患者进行特征描述,可使预测和预防长期不良后果的方法更具针对性。
{"title":"Neurobehavioral Symptom Profiles for the Behavioral Assessment Screening Tool in Chronic Traumatic Brain Injury.","authors":"Shannon B Juengst, Brittany Wright, Annalyn DeMello, Leia Vos, Fedora Biney, Luis Leon Novelo, Michael Williams","doi":"10.1097/HTR.0000000000000950","DOIUrl":"https://doi.org/10.1097/HTR.0000000000000950","url":null,"abstract":"OBJECTIVE\u0000To identify neurobehavioral symptom profiles among persons with chronic traumatic brain injury (TBI) using the Behavioral Assessment Screening Tool (BAST) and to consider participant characteristics that differ between profile groups.\u0000\u0000\u0000SETTING\u0000Community.\u0000\u0000\u0000PARTICIPANTS\u0000Participants (n = 615) were English-speaking adults (≥18) and had a self-reported history of at least one TBI of any severity.\u0000\u0000\u0000DESIGN\u0000Secondary analysis of cross-sectional data.\u0000\u0000\u0000MAIN MEASURES\u0000The BAST measures neurobehavioral symptoms in the domains of Negative Affect, Fatigue, Executive Dysfunction, Impulsivity, and Substance Misuse.\u0000\u0000\u0000RESULTS\u0000Using latent profile analysis (LPA), we identified 3 different neurobehavioral profiles. Overall symptom frequency and differences in the pattern of symptom frequency across domains differentiated the profile groups. Average domain scores differed significantly across the profiles (P < .001) for all domains except Fatigue (P = .076). Those in profile 3 (High-Risk group) reported the most frequent symptoms across all domains (similar Negative Affect frequency as profile 1). Substance Misuse was especially high in this group. Compared to profile 2 (High Negative Affect group), participants in profile 1 (Moderate-Risk group) endorsed significantly more frequent (and more variable) symptoms across all BAST domains, particularly Impulsivity and Substance Misuse. Participants in profile 2 endorsed the least frequent symptoms across all domains. Demographic comparison showed that groups differed based on gender, age, and injury severity (mild vs moderate-severe), with profile 3 composed of the most men and the most persons in early adulthood, and profile 2 composed of the most women and those with mild TBI.\u0000\u0000\u0000CONCLUSIONS\u0000We differentiated 3 neurobehavioral symptom profiles among persons with chronic TBI and determined differences in sociodemographic factors between the groups. Future research should focus on validating these profiles in another sample of individuals with chronic TBI. Characterizing persons according to multidimensional symptom profiles could allow for more tailored approaches to predict and prevent long-term negative outcomes.","PeriodicalId":519229,"journal":{"name":"The Journal of Head Trauma Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140722336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthy Days at Home Among Older Medicare Beneficiaries With Traumatic Brain Injury Requiring Inpatient Rehabilitation. 需要住院康复的创伤性脑损伤老年医疗保险受益人的健康居家天数。
Pub Date : 2024-04-01 DOI: 10.1097/htr.0000000000000954
Raj G Kumar, Emily Evans, Jennifer S Albrecht, Raquel C Gardner, Kristen Dams-O'Connor, Kali S Thomas
The objectives of this study were to characterize and identify correlates of healthy days at home (HDaH) before and after TBI requiring inpatient rehabilitation. Setting: Inpatient hospital, nursing home, and home health services.
本研究的目的是描述并确定需要住院康复的创伤性脑损伤前后在家健康天数(HDaH)的相关因素。研究地点住院医院、疗养院和家庭保健服务。
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引用次数: 0
Two Decades of Department of Veterans Affairs Traumatic Brain Injury Care and Benefits for Veterans of Post-9/11 Conflicts. 退伍军人事务部对 9/11 冲突后退伍军人的创伤性脑损伤护理和福利二十年。
Pub Date : 2024-04-01 DOI: 10.1097/HTR.0000000000000952
G. Whiteneck, William Williams, Emily Almeida, Douglas E. Bidelspach, William Culpepper, Linda M Picon, CB Eagye, David Dr Mellick
OBJECTIVETo describe the background, methodology, and results of the congressionally mandated Department of Veterans Affairs (VA) Traumatic Brain Injury (TBI) Veterans Health Registry.SETTINGVeterans Health Administration (VHA) and Veterans Benefit Administration (VBA).PARTICIPANTSA total of 441 639 Veterans of post-9/11 conflicts who exhibited symptoms associated with TBI and sought care or benefits from the VA between September 2001 and September 2021. Design: Retrospective analysis of VHA and VBA administrative records.MAIN MEASURES(1) VA/Department of Defense Identity Repository to identify Veterans with a deployment to the Southwest Asia theater of operations; (2) the VA TBI Screening and Evaluation Program data; (3) Inpatient and Outpatient Encounter data; and (4) an extract of the VBA Corporate Database to identify Veterans filing benefit claims based on TBI.RESULTSAn unduplicated total of 441 639 post-9/11 Veterans were identified in the Registry via three different pathways to entry: 369 909 Veterans through a positive TBI Screen, 253 177 Veterans receiving healthcare including a TBI diagnosis, and 108 541 Veterans filing TBI disability claims. Among Veterans reporting current TBI symptoms who completed a clinical evaluation, a diagnosis of TBI was confirmed by a TBI specialist in 68.7% of the cases. The TBI severity of confirmed cases was classified as mild in 86.6% of the cases, moderate in 8.3%, and severe in 4.1%. The TBI Registry Veterans were hospitalized 66 503 times and seen 1 521 898 times as outpatients in VHA facilities with diagnoses including TBI. Among Veterans filing TBI disability claims, 67.3% were adjudicated as service-connected.CONCLUSIONThe VA TBI Health Registry has identified over 440 000 Veterans of post-9/11 conflicts who presented to the VA for care or benefits with TBI symptomatology. This large number and the volume of TBI health care and benefits provided over the two decades since 9/11 demonstrate the need for the VA's strong ongoing focus on screening, evaluation, and rehabilitation of TBI. Key words:Department of Veterans Affairs, post-9/11, Registry, TBI, traumatic brain injury, VA, VBA, Veterans, Veterans Benefit Administration, Veterans Health Administration, VHA.
目的描述美国国会授权退伍军人事务部(VA)建立的创伤性脑损伤(TBI)退伍军人健康登记处的背景、方法和结果。参与者2001年9月至2021年9月期间,共有441 639名911冲突后退伍军人表现出与创伤性脑损伤相关的症状,并向退伍军人事务部寻求治疗或福利。设计:主要措施(1)退伍军人事务部/国防部身份信息库,以识别曾被部署到西南亚战区的退伍军人;(2)退伍军人事务部创伤性脑损伤筛查和评估计划数据;(3)住院病人和门诊病人就诊数据;以及(4)退伍军人事务部企业数据库提取物,以识别因创伤性脑损伤而提出福利申请的退伍军人。结果通过三种不同的进入途径,登记处共识别出 441 639 名 9/11 事件后的退伍军人(未重复数据):369 909 名退伍军人通过了 TBI 筛选,253 177 名退伍军人接受了包括 TBI 诊断在内的医疗服务,108 541 名退伍军人提出了 TBI 伤残索赔。在报告目前有 TBI 症状并完成临床评估的退伍军人中,68.7% 的病例经 TBI 专家确诊为 TBI。确诊病例中,有 86.6% 的 TBI 严重程度被归类为轻度,8.3% 为中度,4.1% 为重度。创伤性脑损伤登记处的退伍军人共住院 66 503 人次,在退伍军人医疗服务机构门诊就诊 1 521 898 人次,诊断结果包括创伤性脑损伤。在提出 TBI 伤残索赔的退伍军人中,67.3% 被裁定为与服役有关。结论退伍军人 TBI 健康登记处已确认有超过 44 万名 9/11 冲突后退伍军人因 TBI 症状到退伍军人事务部寻求治疗或福利。这个庞大的数字以及自9/11事件后二十年间提供的TBI医疗保健和福利的数量表明,退伍军人事务部有必要持续关注TBI的筛查、评估和康复。关键词:退伍军人事务部、9/11 事件后、登记处、TBI、创伤性脑损伤、VA、VBA、退伍军人、退伍军人福利管理局、退伍军人健康管理局、VHA。
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引用次数: 0
Distinguishing Characteristics of Admissions to Various Types of Posthospital Brain Injury Rehabilitation Programs. 各类院后脑损伤康复计划入院人员的区别特征。
Pub Date : 2024-04-01 DOI: 10.1097/htr.0000000000000953
David B Salisbury, Devan Parrott, Irwin M Altman, Vicki Eicher, Daniel M Logan, Claire McGrath, G Joseph Walters, James F Malec
Describe and compare the demographic characteristics and disability profiles of individuals admitted to 6 types of posthospital brain injury rehabilitation (PHBIR) programs.
描述并比较 6 种住院后脑损伤康复(PHBIR)项目收治人员的人口特征和残疾情况。
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引用次数: 0
期刊
The Journal of Head Trauma Rehabilitation
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