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The Alcohol Flush Response. 酒精潮红反应
Pub Date : 2024-01-01 Epub Date: 2024-02-22 DOI: 10.7191/gmr.807
Isabel Moh, Daniel Simon, Eric R Gross

Nearly 540 million people world-wide have facial flushing and an increased heart rate after consuming alcohol. Known as the alcohol flushing response, this reaction to alcohol is a result of a genetic variant in an enzyme aldehyde dehydrogenase 2 (ALDH2), known as ALDH2*2. Mainly carried by those of East Asian descent, the genetic variant is likely the most common genetic variant carried in the world. Carrying this ALDH2*2 genetic variant has important health implications with respect cancer risk which is increased when carriers of the ALDH2*2 genetic variant frequently use of alcohol or tobacco products. This comic explains the alcohol flush response and the health risks associated with alcohol and tobacco use for those who carry an ALDH2*2 variant.

全世界有近 5.4 亿人在饮酒后会出现面部潮红和心率加快的现象。这种对酒精的反应被称为 "酒精脸红反应",是醛脱氢酶 2(ALDH2)(ALDH2*2)基因变异的结果。这种基因变异主要由东亚后裔携带,可能是世界上最常见的基因变异。携带这种 ALDH2*2 基因变异对健康有重要影响,因为当 ALDH2*2 基因变异携带者经常使用酒精或烟草产品时,患癌症的风险就会增加。本漫画解释了携带 ALDH2*2 基因变异体的人的酒精冲淡反应以及使用酒精和烟草对健康造成的风险。
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Graphic medicine review
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