International journal of biochemistry & physiology最新文献

英文中文

Fibrinogen in Hamster Cauda Sperm. 仓鼠尾鳍精子中的纤维蛋白原

International journal of biochemistry & physiology

Pub Date : 2023-01-01 Epub Date: 2023-10-21 DOI: 10.23880/ijbp-16000237

T Salters, B Sharpe, S S Raychoudhury, S K Nagdas

Epididymis plays a vital role in promoting sperm maturation and maintaining sperm viability. It has been shown the presence of nonviable sperm in cauda epididymis. We previously identified a secretory protein (260/280KDa oligomers) of hamster cauda epididymal principal cells that binds to nonviable sperm. The 260/280KDa oligomers are composed of 64kDa FGL2 (fibrinogen-like protein-2) and 33kDa FGL1) (fibrinogen-like protein-1). In addition, we have demonstrated that FGL2 is a phospholipid-activated serine protease; the conversion of prothrombin to thrombin by FGL2 followed by the conversion of soluble fibrinogen to insoluble fibrin polymers by thrombin. In the present study, we have shown the presence of a 56kDa fibrinogen β in hamster cauda sperm. The potential role of fibrinogen in hamster physiology is being discussed.

附睾在促进精子成熟和保持精子活力方面起着至关重要的作用。有研究表明，尾状附睾中存在不能存活的精子。我们之前发现仓鼠尾状附睾主细胞的一种分泌蛋白（260/280KDa 低聚物）能与不能存活的精子结合。260/280KDa 寡聚体由 64kDa FGL2（纤维蛋白原样蛋白-2）和 33kDa FGL1（纤维蛋白原样蛋白-1）组成。）此外，我们还证明 FGL2 是一种磷脂激活的丝氨酸蛋白酶；FGL2 将凝血酶原转化为凝血酶后，凝血酶又将可溶性纤维蛋白原转化为不溶性纤维蛋白聚合物。在本研究中，我们发现仓鼠尾鳍精子中存在 56kDa 的纤维蛋白原 β。我们正在讨论纤维蛋白原在仓鼠生理学中的潜在作用。

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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