Pub Date : 2024-09-01DOI: 10.3928/23258160-20240819-01
Baruch D Kuppermann,Ashish Sharma,Lihteh Wu,Steven Bloom,Paulo Stanga,Hussain Ahmad Khaqan,Ursula Schmidt-Erfurth,Mertcan Sevgi,Pearse A Keane,Anjana Mirajkar,Manish Nagpal,Kourous A Rezaei
{"title":"RWC Update: Two Dropped IOLs, One Rigid IOL in Sulcus and Choroidal Detachment; Is AI Ready for the Clinical Retina Practice?; Pseudopapilledema From Leukemic Optic Nerve Infiltration.","authors":"Baruch D Kuppermann,Ashish Sharma,Lihteh Wu,Steven Bloom,Paulo Stanga,Hussain Ahmad Khaqan,Ursula Schmidt-Erfurth,Mertcan Sevgi,Pearse A Keane,Anjana Mirajkar,Manish Nagpal,Kourous A Rezaei","doi":"10.3928/23258160-20240819-01","DOIUrl":"https://doi.org/10.3928/23258160-20240819-01","url":null,"abstract":"","PeriodicalId":520102,"journal":{"name":"Ophthalmic Surgery, Lasers and Imaging Retina","volume":"15 1","pages":"490-493"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perfection in Imperfection: A Case of Autosomal Recessive Bestrophinopathy.","authors":"Prithvi Naveen,Sameera Nayak,P Srinivas Rao,Brijesh Takkar","doi":"10.3928/23258160-20240812-01","DOIUrl":"https://doi.org/10.3928/23258160-20240812-01","url":null,"abstract":"","PeriodicalId":520102,"journal":{"name":"Ophthalmic Surgery, Lasers and Imaging Retina","volume":"9 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.3928/23258160-20240813-02
Matteo Mario Carlà,Carlos Mateo
A 64-year-old highly myopic woman with macular hole retinal detachment (MHRD) in her left eye underwent vitrectomy, internal limiting membrane (ILM) peeling, and epiretinal implantation of a 4-mm diameter human amniotic membrane (hAM) patch. One month later, she developed a bullous superior RD in her right eye, associated with a huge MH and multiple posterior breaks. Vitrectomy and ILM peeling were combined with a 15-mm epiretinal hAM patch implantation. One year later, both eyes showed successful MH closure, but the right eye developed an eccentric hAM patch contraction starting 6 months postoperatively, causing a localized stable superonasal RD. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].
{"title":"Contraction of a Giant Epiretinal Human Amniotic Membrane Patch Used to Manage a Highly Myopic Retinal Detachment Associated With Multiple Breaks.","authors":"Matteo Mario Carlà,Carlos Mateo","doi":"10.3928/23258160-20240813-02","DOIUrl":"https://doi.org/10.3928/23258160-20240813-02","url":null,"abstract":"A 64-year-old highly myopic woman with macular hole retinal detachment (MHRD) in her left eye underwent vitrectomy, internal limiting membrane (ILM) peeling, and epiretinal implantation of a 4-mm diameter human amniotic membrane (hAM) patch. One month later, she developed a bullous superior RD in her right eye, associated with a huge MH and multiple posterior breaks. Vitrectomy and ILM peeling were combined with a 15-mm epiretinal hAM patch implantation. One year later, both eyes showed successful MH closure, but the right eye developed an eccentric hAM patch contraction starting 6 months postoperatively, causing a localized stable superonasal RD. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].","PeriodicalId":520102,"journal":{"name":"Ophthalmic Surgery, Lasers and Imaging Retina","volume":"7 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.3928/23258160-20240805-01
Megan S Steinkerchner,Neha Sharma,Matthew W Russell,Christopher Maatouk,Katherine E Talcott,Rishi P Singh
BACKGROUND AND OBJECTIVEThis study assesses long-term outcomes following surgical repair of idiopathic full-thickness macular holes (FTMHs) in patients with at least 5 years of postoperative follow-up.PATIENTS AND METHODSA retrospective study evaluated patients diagnosed with idiopathic FTMH who received surgical repair at a single tertiary center with at least 5 years of postoperative follow-up. Data collection included demographic and preoperative characteristics along with macular hole structural integrity as determined by spectral-domain optical coherence tomography (OCT). Functional and structural improvement were assessed by collection of visual acuity and findings on OCT at determined time points until 9 years of follow-up.RESULTSThe study comprised 90 eyes of 80 patients with a mean age of 67.2 ± 6.8 years, with an average postoperative follow-up of 80.8 ± 17.4 months (range 54 to 130 months). The mean macular hole diameter was 239.7 µm ± 92.2. Macular hole reoperation occurred in four eyes (4%) at a mean duration of 5.5 ± 6 months (range 0.3 to 13 months). Over the study duration, ellipsoid zone (EZ) integrity was maintained in 67.8% of eyes, with an absence of intraretinal fluid (IRF) in 96% on final OCT. The preoperative mean Early Treatment Diabetic Retinopathy Study (ETDRS) best visual acuity (BVA) of 51 improved to a mean BVA of 76 at 5 years postoperatively, with an average gain of 24 letters at one year that remained stable over 5 years (P < 0.05). Eight years after surgical repair, more than 80% of patients achieved a BVA > 65.CONCLUSIONSVitreoretinal surgery for idiopathic FTMH resulted in successful hole closure and sustained visual acuity improvement over long-term follow-up. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].
{"title":"Long-term Visual Outcomes in Patients With Idiopathic Macular Hole Surgery.","authors":"Megan S Steinkerchner,Neha Sharma,Matthew W Russell,Christopher Maatouk,Katherine E Talcott,Rishi P Singh","doi":"10.3928/23258160-20240805-01","DOIUrl":"https://doi.org/10.3928/23258160-20240805-01","url":null,"abstract":"BACKGROUND AND OBJECTIVEThis study assesses long-term outcomes following surgical repair of idiopathic full-thickness macular holes (FTMHs) in patients with at least 5 years of postoperative follow-up.PATIENTS AND METHODSA retrospective study evaluated patients diagnosed with idiopathic FTMH who received surgical repair at a single tertiary center with at least 5 years of postoperative follow-up. Data collection included demographic and preoperative characteristics along with macular hole structural integrity as determined by spectral-domain optical coherence tomography (OCT). Functional and structural improvement were assessed by collection of visual acuity and findings on OCT at determined time points until 9 years of follow-up.RESULTSThe study comprised 90 eyes of 80 patients with a mean age of 67.2 ± 6.8 years, with an average postoperative follow-up of 80.8 ± 17.4 months (range 54 to 130 months). The mean macular hole diameter was 239.7 µm ± 92.2. Macular hole reoperation occurred in four eyes (4%) at a mean duration of 5.5 ± 6 months (range 0.3 to 13 months). Over the study duration, ellipsoid zone (EZ) integrity was maintained in 67.8% of eyes, with an absence of intraretinal fluid (IRF) in 96% on final OCT. The preoperative mean Early Treatment Diabetic Retinopathy Study (ETDRS) best visual acuity (BVA) of 51 improved to a mean BVA of 76 at 5 years postoperatively, with an average gain of 24 letters at one year that remained stable over 5 years (P < 0.05). Eight years after surgical repair, more than 80% of patients achieved a BVA > 65.CONCLUSIONSVitreoretinal surgery for idiopathic FTMH resulted in successful hole closure and sustained visual acuity improvement over long-term follow-up. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].","PeriodicalId":520102,"journal":{"name":"Ophthalmic Surgery, Lasers and Imaging Retina","volume":"16 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.3928/23258160-20240625-01
Rishi P Singh,Thomas A Albini,Caroline R Baumal,Peter Y Chang,David Eichenbaum,Nancy Holekamp,Sumit Sharma,Michael Singer
BACKGROUND AND OBJECTIVEA consensus exercise was carried out to address unmet needs in the classification, diagnosis, and management of patients with chronic noninfectious uveitis affecting the posterior segment (NIU-PS), with a focus on chronic postoperative inflammation/cystoid macular edema.METHODSEight experts participated in roundtable discussions and consensus-building exercises to develop clear guidelines for the diagnosis and management of chronic NIU-PS. The group addressed questions surrounding clinical features, diagnostic tests, and treatment considerations.RESULTSClinicians agreed that chronic uveitis/intraocular inflammation should be defined as having persistence or recurrence for 3 or more months. Diagnosis is informed by evaluation of signs and symptoms, use of imaging, and exclusion of infectious etiologies. Management should be initiated with the least invasive therapies, proceeding to intraocular injections, and/or long-term intravitreal or systemic therapies, as necessary.CONCLUSIONThis manuscript offers an up-to-date consensus guideline based on clinical experience. Future clinical trials may help to test and reevaluate these recommendations. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].
{"title":"Development of a Consensus Guideline for the Diagnosis and Management of Chronic Noninfectious Uveitis Affecting the Posterior Segment.","authors":"Rishi P Singh,Thomas A Albini,Caroline R Baumal,Peter Y Chang,David Eichenbaum,Nancy Holekamp,Sumit Sharma,Michael Singer","doi":"10.3928/23258160-20240625-01","DOIUrl":"https://doi.org/10.3928/23258160-20240625-01","url":null,"abstract":"BACKGROUND AND OBJECTIVEA consensus exercise was carried out to address unmet needs in the classification, diagnosis, and management of patients with chronic noninfectious uveitis affecting the posterior segment (NIU-PS), with a focus on chronic postoperative inflammation/cystoid macular edema.METHODSEight experts participated in roundtable discussions and consensus-building exercises to develop clear guidelines for the diagnosis and management of chronic NIU-PS. The group addressed questions surrounding clinical features, diagnostic tests, and treatment considerations.RESULTSClinicians agreed that chronic uveitis/intraocular inflammation should be defined as having persistence or recurrence for 3 or more months. Diagnosis is informed by evaluation of signs and symptoms, use of imaging, and exclusion of infectious etiologies. Management should be initiated with the least invasive therapies, proceeding to intraocular injections, and/or long-term intravitreal or systemic therapies, as necessary.CONCLUSIONThis manuscript offers an up-to-date consensus guideline based on clinical experience. Future clinical trials may help to test and reevaluate these recommendations. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].","PeriodicalId":520102,"journal":{"name":"Ophthalmic Surgery, Lasers and Imaging Retina","volume":"5 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.3928/23258160-20240805-03
Andres Lisker-Cervantes,Zafar Gill,Jennifer L Patnaik,Ramya Gnanaraj,Anne M Lynch,Alan G Palestine,Marc Mathias,Niranjan Manoharan,Naresh Mandava,Talisa E de Carlo Forest
BACKGROUND AND OBJECTIVEInvestigate associations between systemic vascular endothelial growth factor (VEGF) and optical coherence tomography (OCT) biomarkers in eyes with complete retinal pigment epithelium and outer retina atrophy (cRORA) secondary to non-neovascular age-related macular degeneration.PATIENTS AND METHODSCross-sectional study of patients with cRORA. OCT images and blood samples were collected at study enrollment. OCT images were evaluated for biomarkers. Systemic VEGF levels were measured using a standard multiplex assay.RESULTSStudy included 187 eyes from 96 patients. Lower levels of systemic VEGF were significantly associated with retinal pseudocysts (RPs) and subretinal hyper-reflective material (SHRM), a median of 7.7 pg/mL and 6.1 pg/mL for patients with the imaging biomarkers compared to those without (10.3 pg/mL [P = 0.004] and 9.3 pg/mL [P = 0.02], respectively).CONCLUSIONThis novel study shows that lower systemic VEGF levels were associated with SHRM and RP, which was shown to correspond to an intermediate stage of the atrophic process in age-related macular degeneration. Systemic VEGF could be a useful biomarker and therapeutic target for eyes with cRORA. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].
背景和目的：研究继发于非血管性年龄相关性黄斑变性的完全性视网膜色素上皮和视网膜外层萎缩（cRORA）患者体内血管内皮生长因子（VEGF）与光学相干断层扫描（OCT）生物标志物之间的关联。在研究注册时收集 OCT 图像和血液样本。对 OCT 图像进行生物标记物评估。使用标准多重检测法测量全身血管内皮生长因子水平。全身血管内皮生长因子水平较低与视网膜假性囊肿（RPs）和视网膜下高反射物质（SHRM）明显相关，与没有成像生物标志物的患者相比，有成像生物标志物的患者的中位数分别为 7.7 pg/mL 和 6.1 pg/mL（10.3 pg/mL [P = 0.结论这项新研究表明，较低的全身血管内皮生长因子水平与 SHRM 和 RP 相关，这与年龄相关性黄斑变性萎缩过程的中间阶段相对应。全身血管内皮生长因子可能是一种有用的生物标志物，也是 cRORA 患者的治疗目标。[眼科手术激光成像视网膜2024;55:XX-XX]。
{"title":"Association Between Systemic Levels of Vascular Endothelial Growth Factor and Optical Coherence Tomography Biomarkers in a Non-Neovascular Age-Related Macular Degeneration Cohort.","authors":"Andres Lisker-Cervantes,Zafar Gill,Jennifer L Patnaik,Ramya Gnanaraj,Anne M Lynch,Alan G Palestine,Marc Mathias,Niranjan Manoharan,Naresh Mandava,Talisa E de Carlo Forest","doi":"10.3928/23258160-20240805-03","DOIUrl":"https://doi.org/10.3928/23258160-20240805-03","url":null,"abstract":"BACKGROUND AND OBJECTIVEInvestigate associations between systemic vascular endothelial growth factor (VEGF) and optical coherence tomography (OCT) biomarkers in eyes with complete retinal pigment epithelium and outer retina atrophy (cRORA) secondary to non-neovascular age-related macular degeneration.PATIENTS AND METHODSCross-sectional study of patients with cRORA. OCT images and blood samples were collected at study enrollment. OCT images were evaluated for biomarkers. Systemic VEGF levels were measured using a standard multiplex assay.RESULTSStudy included 187 eyes from 96 patients. Lower levels of systemic VEGF were significantly associated with retinal pseudocysts (RPs) and subretinal hyper-reflective material (SHRM), a median of 7.7 pg/mL and 6.1 pg/mL for patients with the imaging biomarkers compared to those without (10.3 pg/mL [P = 0.004] and 9.3 pg/mL [P = 0.02], respectively).CONCLUSIONThis novel study shows that lower systemic VEGF levels were associated with SHRM and RP, which was shown to correspond to an intermediate stage of the atrophic process in age-related macular degeneration. Systemic VEGF could be a useful biomarker and therapeutic target for eyes with cRORA. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].","PeriodicalId":520102,"journal":{"name":"Ophthalmic Surgery, Lasers and Imaging Retina","volume":"17 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.3928/23258160-20240802-01
Isabel Villalaín-Rodes,Aldara García-Sánchez,Mónica Asencio Durán,Francisco García-Río,Jesús García Martínez,Rafael Montejano-Milner
BACKGROUND AND OBJECTIVEThis study aimed to assess the effect of continuous positive airway pressure (CPAP) on the arteriolar-to-venular ratio (AVR) in patients with diabetic retinopathy (DR) and obstructive sleep apnea (OSA).PATIENTS AND METHODSA prospective, randomized, unblinded, and controlled clinical trial with parallel groups was performed. From a base of 138 patients, 83 were randomized to either CPAP or control. Nonstereoscopic 35º photographs were processed with Sirius software.RESULTSThe intention-to-treat analysis showed no differences in AVR, although the arteriolar diameter increased from baseline in the CPAP group. Per-protocol analysis showed a 12-month increase in AVR (P = 0.035) and arteriolar diameter (P = 0.033) in CPAP versus control group. The venular diameter showed a nonstatistically significant reduction.CONCLUSIONSCPAP is a potentially novel treatment for individuals with DR and concomitant OSA, improving the retinopathy status, reversing the arteriolar narrowing, and therefore increasing the AVR, tending to reduce the venular diameter. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].
{"title":"Effect of Continuous Positive Airway Pressure Treatment on the Arteriole-to-Venule Ratio in Patients With Nonproliferative Diabetic Retinopathy and Obstructive Sleep Apnea: A Randomized Trial.","authors":"Isabel Villalaín-Rodes,Aldara García-Sánchez,Mónica Asencio Durán,Francisco García-Río,Jesús García Martínez,Rafael Montejano-Milner","doi":"10.3928/23258160-20240802-01","DOIUrl":"https://doi.org/10.3928/23258160-20240802-01","url":null,"abstract":"BACKGROUND AND OBJECTIVEThis study aimed to assess the effect of continuous positive airway pressure (CPAP) on the arteriolar-to-venular ratio (AVR) in patients with diabetic retinopathy (DR) and obstructive sleep apnea (OSA).PATIENTS AND METHODSA prospective, randomized, unblinded, and controlled clinical trial with parallel groups was performed. From a base of 138 patients, 83 were randomized to either CPAP or control. Nonstereoscopic 35º photographs were processed with Sirius software.RESULTSThe intention-to-treat analysis showed no differences in AVR, although the arteriolar diameter increased from baseline in the CPAP group. Per-protocol analysis showed a 12-month increase in AVR (P = 0.035) and arteriolar diameter (P = 0.033) in CPAP versus control group. The venular diameter showed a nonstatistically significant reduction.CONCLUSIONSCPAP is a potentially novel treatment for individuals with DR and concomitant OSA, improving the retinopathy status, reversing the arteriolar narrowing, and therefore increasing the AVR, tending to reduce the venular diameter. [Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX.].","PeriodicalId":520102,"journal":{"name":"Ophthalmic Surgery, Lasers and Imaging Retina","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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