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Plants, Pills, and the Brain: Exploring Phytochemicals and Neurological Medicines. 植物、药片和大脑:探索植物化学物质和神经学药物。
Pub Date : 2025-01-01 Epub Date: 2025-08-04 DOI: 10.26502/ijpaes.4490180
Arnav Aggarwal, Resmi Rajalekshmi, Anshu Aggarwal, Devendra K Agrawal

Neurological disorders, such as Alzheimer's disease, Parkinson's disease, epilepsy, spinal cord injuries, and traumatic brain injuries, represent substantial global health challenges due to their chronic and often progressive nature. While allopathic medicine offers a range of pharmacological interventions aimed at managing symptoms and mitigating disease progression, it is accompanied by limitations, including adverse side effects, the development of drug resistance, and incomplete efficacy. In parallel, phytochemicals-bioactive compounds derived from plants-are receiving increased attention for their potential neuroprotective, antioxidant, and anti-inflammatory properties. This review will explore the therapeutic landscape of neurological diseases by providing a comprehensive overview of prevalent conditions and the current allopathic treatments available. Furthermore, this review will investigate specific phytochemicals, including flavonoids, alkaloids, and terpenoids, that exhibit promise in modulating various disease pathways. Emphasis will be placed on the interactions between plant-derived compounds and prescription medications, highlighting both potential synergistic effects and possible adverse interactions. A thorough understanding of these interactions is essential for the development of integrative treatment approaches that enhance therapeutic efficacy while minimizing harm. By bridging traditional herbal medicine with contemporary pharmacotherapy, this review aims to promote a more holistic perspective on the management of neurological diseases, while also encouraging further research into safe and effective combinatory therapies.

神经系统疾病,如阿尔茨海默病、帕金森病、癫痫、脊髓损伤和创伤性脑损伤,由于其慢性和往往进行性,构成了重大的全球健康挑战。虽然对抗疗法提供了一系列旨在控制症状和减缓疾病进展的药理学干预措施,但它也伴随着局限性,包括不良副作用、耐药性的发展和疗效不完全。与此同时,植物化学物质——从植物中提取的生物活性化合物——因其潜在的神经保护、抗氧化和抗炎特性而受到越来越多的关注。这篇综述将探讨神经系统疾病的治疗前景,提供一个全面的概述,普遍的条件和目前的对抗疗法可用。此外,本综述将研究特定的植物化学物质,包括黄酮类化合物、生物碱和萜类化合物,它们在调节各种疾病途径中表现出前景。重点将放在植物衍生化合物和处方药之间的相互作用,强调潜在的协同作用和可能的不良相互作用。全面了解这些相互作用对于开发综合治疗方法至关重要,从而提高治疗效果,同时将危害降到最低。通过将传统草药与现代药物治疗相结合,本综述旨在促进对神经系统疾病管理的更全面的看法,同时也鼓励进一步研究安全有效的联合疗法。
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引用次数: 0
Therapeutic Efficacy of Medicinal Plants with Allopathic Medicine in Musculoskeletal Diseases. 药用植物与对抗疗法药物治疗肌肉骨骼疾病的疗效。
Pub Date : 2024-01-01 Epub Date: 2024-12-23 DOI: 10.26502/ijpaes.4490170
Resmi Rajalekshmi, Devendra K Agrawal

Musculoskeletal diseases encompass a diverse array of disorders affecting the muscles, bones, joints, and connective tissues, leading to significant impairments in mobility, function, and quality of life. Affecting over 1.3 billion individuals globally, musculoskeletal diseases represent a major source of disability and economic burden. Conventional treatment modalities, including pharmacological interventions and surgical procedures, are frequently limited by adverse side effects, prolonged recovery periods, and patient dissatisfaction, particularly when focused solely on symptom management. In response, complementary and alternative medicine, particularly the use of medicinal plants, has garnered increasing interest to enhance the management of musculoskeletal diseases. Medicinal plants possess a wide spectrum of pharmacologically active compounds with anti-inflammatory, analgesic, and antioxidant properties, making them promising adjuncts to conventional therapies. This review critically evaluates the potential synergy between medicinal plants and allopathic medicine for the management of musculoskeletal diseases, with an emphasis on integrated therapy that combines both modalities. Specifically, a critical discussion is presented on how medicinal plants with scientifically supported pharmacological properties can augment the therapeutic efficacy of conventional medications, reduce their doses, and mitigate adverse effects. Furthermore, the challenges associated with incorporating herbal medicine into established healthcare systems are discussed, including the need for rigorous clinical validation, standardization, and regulatory frameworks. Overall, the article underscores the potential of integrated therapeutic approaches to improve clinical outcomes, enhance patient well-being, and establish a more sustainable model for the treatment of musculoskeletal diseases.

肌肉骨骼疾病包括影响肌肉、骨骼、关节和结缔组织的各种疾病,导致活动能力、功能和生活质量的严重损害。肌肉骨骼疾病影响全球超过13亿人,是残疾和经济负担的主要来源。传统的治疗方式,包括药物干预和外科手术,经常受到不良副作用、恢复期延长和患者不满的限制,特别是当只关注症状管理时。因此,补充和替代医学,特别是使用药用植物,已引起人们越来越多的兴趣,以加强对肌肉骨骼疾病的管理。药用植物具有广泛的药理活性化合物,具有抗炎、镇痛和抗氧化的特性,使它们成为传统治疗的有希望的辅助药物。这篇综述批判性地评估了药用植物和对抗疗法治疗肌肉骨骼疾病的潜在协同作用,重点是结合两种方式的综合治疗。具体地说,一个关键的讨论提出了药用植物如何具有科学支持的药理学特性可以增强传统药物的治疗效果,减少他们的剂量,并减轻不良反应。此外,本文还讨论了将草药纳入现有医疗保健系统所面临的挑战,包括对严格临床验证、标准化和监管框架的需求。总之,这篇文章强调了综合治疗方法的潜力,以改善临床结果,增强患者的福祉,并建立一个更可持续的模式来治疗肌肉骨骼疾病。
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引用次数: 0
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International journal of plant, animal and environmental sciences
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