Objective To discuss the clinical application of DSA and Xper-CT in guiding lung tumor radiofrequency ablation(RFA). Methods Navigated by DSA and Xper-CT images, RFA was performed in21 patients with lung tumor. The tumors included peripheral lung cancer(n = 3) and lung metastases from hepatocellular carcinoma(n = 12) or from colorectal cancer(n = 6). The lesions were located at left upper lobe(n = 5), at left lower lobe(n = 2), at right upper lobe(n = 5), at right middle lobe(n = 6) and at right lower lobe(n = 4). One lesion was situated at the right thoracic wall and one lesion was situated at the left thoracic wall. Results A total of 24 lesions were detected in the 21 patients. Of the 24 lesions,successful puncturing with single procedure was obtained in 22, with a success rate of 91.67%. Two lesions had the diameter less than one cm, and the treatment was accomplished after two times of puncturing.Conclusion For the treatment of lung tumors, DSA and Xper-CT-guided radiofrequency ablation is clinically-safe and technically-simple with higher localizing accuracy. Therefore, this technique should be recommended in clinical practice.
{"title":"The clinical application of DSA and Xper-CT in guiding lung tumor radiofrequency ablation procedure","authors":"Hui Shi, Jiechao Liang, Jia Hu, Jie-min Cheng, Zhi-ping Yan, Jian-hua Wang","doi":"10.3969/J.ISSN.1008-794X.2014.03.019","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-794X.2014.03.019","url":null,"abstract":"Objective To discuss the clinical application of DSA and Xper-CT in guiding lung tumor radiofrequency ablation(RFA). Methods Navigated by DSA and Xper-CT images, RFA was performed in21 patients with lung tumor. The tumors included peripheral lung cancer(n = 3) and lung metastases from hepatocellular carcinoma(n = 12) or from colorectal cancer(n = 6). The lesions were located at left upper lobe(n = 5), at left lower lobe(n = 2), at right upper lobe(n = 5), at right middle lobe(n = 6) and at right lower lobe(n = 4). One lesion was situated at the right thoracic wall and one lesion was situated at the left thoracic wall. Results A total of 24 lesions were detected in the 21 patients. Of the 24 lesions,successful puncturing with single procedure was obtained in 22, with a success rate of 91.67%. Two lesions had the diameter less than one cm, and the treatment was accomplished after two times of puncturing.Conclusion For the treatment of lung tumors, DSA and Xper-CT-guided radiofrequency ablation is clinically-safe and technically-simple with higher localizing accuracy. Therefore, this technique should be recommended in clinical practice.","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"23 1","pages":"257-260"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-10-01DOI: 10.3969/J.ISSN.1008-794X.2013.10.008
Wei Zhang, Zhi Guo, W. Xing, Fang Liu, Bao-guo Li, Hai-peng Yu, T. Si, Xiu-ying Guo, Chang-fu Liu
Objective To evaluate the short-term effect and safety of CT-guided radioactive 125I seeds implantation,used as salvage therapy,for adrenal metastases.Methods The clinical data of 11 patients with adrenal metastases,who received radioactive 125I seeds implantation as a salvage therapy,were retrospectively analyzed.The number of lesions was 11 in total,and the longest diameter of the lesions ranged from 2.1 cm to 6.5 cm with a mean of(3.4±1.5) cm.Treatment plan system(TPS) was used to design the optimal distribution and needed number of 125I seeds according to matched peripheral dose(MPD).Under CT guidance,125I seeds were implanted into the adrenal lesions.All patients were followed up for two months,and the overall response rate,quality of life and clinical complications were evaluated.Results The overall response rate,quality of life and clinical complications were assessed at two months after the operation.Of the 11 patients,complete response(CR) was obtained in 3,partial response(PR) in 6 and stable disease(SD)in 2.The remission rate(CR+PR) was 81.8%.The general living quality did not deteriorate when compared with the preoperative condition.The short-term adverse effects were very mild.No severe complications such as hypertensive crisis,massive bleeding,infection,etc.occurred.Conclusion As a salvage therapy for adrenal metastases,CT-guided radioactive 125I seeds implantation is safe,effective and minimally-invasive with fewer and mild complications.Therefore,this technique can be used as an effective local therapy to reduce tumor load.
{"title":"CT-guided radioactive 125I seeds implantation as a salvage therapy for adrenal metastases: Evaluation of short-term effect in 11 cases","authors":"Wei Zhang, Zhi Guo, W. Xing, Fang Liu, Bao-guo Li, Hai-peng Yu, T. Si, Xiu-ying Guo, Chang-fu Liu","doi":"10.3969/J.ISSN.1008-794X.2013.10.008","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-794X.2013.10.008","url":null,"abstract":"Objective To evaluate the short-term effect and safety of CT-guided radioactive 125I seeds implantation,used as salvage therapy,for adrenal metastases.Methods The clinical data of 11 patients with adrenal metastases,who received radioactive 125I seeds implantation as a salvage therapy,were retrospectively analyzed.The number of lesions was 11 in total,and the longest diameter of the lesions ranged from 2.1 cm to 6.5 cm with a mean of(3.4±1.5) cm.Treatment plan system(TPS) was used to design the optimal distribution and needed number of 125I seeds according to matched peripheral dose(MPD).Under CT guidance,125I seeds were implanted into the adrenal lesions.All patients were followed up for two months,and the overall response rate,quality of life and clinical complications were evaluated.Results The overall response rate,quality of life and clinical complications were assessed at two months after the operation.Of the 11 patients,complete response(CR) was obtained in 3,partial response(PR) in 6 and stable disease(SD)in 2.The remission rate(CR+PR) was 81.8%.The general living quality did not deteriorate when compared with the preoperative condition.The short-term adverse effects were very mild.No severe complications such as hypertensive crisis,massive bleeding,infection,etc.occurred.Conclusion As a salvage therapy for adrenal metastases,CT-guided radioactive 125I seeds implantation is safe,effective and minimally-invasive with fewer and mild complications.Therefore,this technique can be used as an effective local therapy to reduce tumor load.","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"22 1","pages":"815-818"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-06-01DOI: 10.3969/J.ISSN.1008-794X.2013.06.013
Chang-fu Liu, Zhi Guo, T. Si, W. Xing, Fang Liu, Hai-peng Yu
Objective To investigate the impact of high mobility group protein B1(HGMB1) on cryoimmunology response in hormone-refractory prostate cancer(HRPC).Methods Mouse models of HRPC were established by subcutaneous injection of RM-1 prostate cancer cells,and a total of 50 tumor-bearing mice were randomly divided into control group(n = 25) and cryoablation group(n = 25).Cryoablation was applied to the tumor lesion through cryosurgery needle with 1.7mm diameter by using Endocare Argon-Helium cryosurgery system(AHCS).The number and maturation changes of dendritic cell(DC) in tumor were assessed by flow cytometry and the levels of HMGB1 in tumor tissues were determined by Western blot technology one day before cryosurgery as well as one,7,14 and 21 days after cryosurgery separately.Results In cryoablation group,the levels of HMGB1 as well as the number and maturation of DC in tumor tissues reached their highest peaks in the 7th day after AHCS,and compared with the levels determined before treatment the differences were statistically significant(P 0.05).However,in control group no significant differences in the levels of HMGB1 as well as in the number and maturation of DC in tumor tissues existed between preoperative data and post operative ones(P 0.05).The levels of HMGB1 as well as the number and maturation changes of DC in tumor tissues determined at one,7 and 14 days after cryosurgery in cryoablation group were significantly higher than those in control group (P 0.05).Correlation analysis showed that the expression levels of HMGB1 had a parallel relationship with the number of DC(r = 0.883,P 0.05) as well as with the maturation changes of DC(r = 0.997,P 0.05) in the cryoablation group.Conclusion Cryoablation therapy can make the tumor cells release large amount of HMGB1 in association with tumor cell necrosis.And the released extracellular HMGB1 plays an important role in stimulating the body to produce the tumor-specific immune response after the cryoablation therapy.
{"title":"The effect of high mobility group protein B1 on cryoimmunologic reaction in hormone-refractory prostate cancer: An experimental study in rats","authors":"Chang-fu Liu, Zhi Guo, T. Si, W. Xing, Fang Liu, Hai-peng Yu","doi":"10.3969/J.ISSN.1008-794X.2013.06.013","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-794X.2013.06.013","url":null,"abstract":"Objective To investigate the impact of high mobility group protein B1(HGMB1) on cryoimmunology response in hormone-refractory prostate cancer(HRPC).Methods Mouse models of HRPC were established by subcutaneous injection of RM-1 prostate cancer cells,and a total of 50 tumor-bearing mice were randomly divided into control group(n = 25) and cryoablation group(n = 25).Cryoablation was applied to the tumor lesion through cryosurgery needle with 1.7mm diameter by using Endocare Argon-Helium cryosurgery system(AHCS).The number and maturation changes of dendritic cell(DC) in tumor were assessed by flow cytometry and the levels of HMGB1 in tumor tissues were determined by Western blot technology one day before cryosurgery as well as one,7,14 and 21 days after cryosurgery separately.Results In cryoablation group,the levels of HMGB1 as well as the number and maturation of DC in tumor tissues reached their highest peaks in the 7th day after AHCS,and compared with the levels determined before treatment the differences were statistically significant(P 0.05).However,in control group no significant differences in the levels of HMGB1 as well as in the number and maturation of DC in tumor tissues existed between preoperative data and post operative ones(P 0.05).The levels of HMGB1 as well as the number and maturation changes of DC in tumor tissues determined at one,7 and 14 days after cryosurgery in cryoablation group were significantly higher than those in control group (P 0.05).Correlation analysis showed that the expression levels of HMGB1 had a parallel relationship with the number of DC(r = 0.883,P 0.05) as well as with the maturation changes of DC(r = 0.997,P 0.05) in the cryoablation group.Conclusion Cryoablation therapy can make the tumor cells release large amount of HMGB1 in association with tumor cell necrosis.And the released extracellular HMGB1 plays an important role in stimulating the body to produce the tumor-specific immune response after the cryoablation therapy.","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"22 1","pages":"494-497"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-04-01DOI: 10.3969/J.ISSN.1008-794X.2013.04.011
Wei Zhang, Zhi Guo, Bao-guo Li, Hai-peng Yu, T. Si, H. Ni, Yanhong Yao
Objective To evaluate the short-term clinical effects and safety of CT-guided radioactive seeds 125I implantation used as salvage therapy for malignant pelvic tumors.Methods A total of 32 patients(4 males and 28 females,aged 22-74 years) with recurrent or metastatic malignant pelvic tumors were enrolled in this study.The detected lesions were 35 in total.The longest diameter of the lesions ranged from 3 to 12 cm with a mean of(6.8 ± 2.3) cm.All the patients had received combination therapy such as surgery,chemotherapy,radiotherapy,etc.before.Treatment plan system(TPS) was used to design the optimal distribution and needed number of 125I seeds according to matched peripheral dose(MPD).Under CT guidance,125I seeds were implanted into the pelvic lesions.All patients were followed up for two months,and the clinical effective rate,pain relief,quality of life and clinical complications were evaluated.Results The clinical effective rate,pain relief,quality of life and clinical complications were assessed at two months after the treatment.Of the 35 patients,complete response(CR) was obtained in 4,partial response(PR) in 20,stable disease(SD) in 6 and progressive disease(PD) in 5.The clinical effective rate(CR + PR + SD) was 85.7%(30/35).The pain relief rate was 89.3%(25/28).The general living quality was significantly improved when compared with the preoperative condition(P 0.01).The short-term adverse effects were very mild.No severe complications such as massive bleeding,pelvic abscess,intestinal fistula,intestinal perforation,etc.occurred.Conclusion As a salvage therapy for recurrent or metastatic malignant pelvic tumors,CT-guided radioactive seeds 125 I implantation is safe,simple and minimally-invasive with higher short-term clinical effective rate.Therefore,this technique can be used as an effective local therapy to improve patient’s living quality as well as to reduce the tumor load.
{"title":"CT-guided radioactive seeds 125I implantation used as salvage therapy for malignant pelvic tumors: evaluation of short-term effects","authors":"Wei Zhang, Zhi Guo, Bao-guo Li, Hai-peng Yu, T. Si, H. Ni, Yanhong Yao","doi":"10.3969/J.ISSN.1008-794X.2013.04.011","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-794X.2013.04.011","url":null,"abstract":"Objective To evaluate the short-term clinical effects and safety of CT-guided radioactive seeds 125I implantation used as salvage therapy for malignant pelvic tumors.Methods A total of 32 patients(4 males and 28 females,aged 22-74 years) with recurrent or metastatic malignant pelvic tumors were enrolled in this study.The detected lesions were 35 in total.The longest diameter of the lesions ranged from 3 to 12 cm with a mean of(6.8 ± 2.3) cm.All the patients had received combination therapy such as surgery,chemotherapy,radiotherapy,etc.before.Treatment plan system(TPS) was used to design the optimal distribution and needed number of 125I seeds according to matched peripheral dose(MPD).Under CT guidance,125I seeds were implanted into the pelvic lesions.All patients were followed up for two months,and the clinical effective rate,pain relief,quality of life and clinical complications were evaluated.Results The clinical effective rate,pain relief,quality of life and clinical complications were assessed at two months after the treatment.Of the 35 patients,complete response(CR) was obtained in 4,partial response(PR) in 20,stable disease(SD) in 6 and progressive disease(PD) in 5.The clinical effective rate(CR + PR + SD) was 85.7%(30/35).The pain relief rate was 89.3%(25/28).The general living quality was significantly improved when compared with the preoperative condition(P 0.01).The short-term adverse effects were very mild.No severe complications such as massive bleeding,pelvic abscess,intestinal fistula,intestinal perforation,etc.occurred.Conclusion As a salvage therapy for recurrent or metastatic malignant pelvic tumors,CT-guided radioactive seeds 125 I implantation is safe,simple and minimally-invasive with higher short-term clinical effective rate.Therefore,this technique can be used as an effective local therapy to improve patient’s living quality as well as to reduce the tumor load.","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"22 1","pages":"308-311"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-11-01DOI: 10.3969/J.ISSN.1008-794X.2012.12.008
Hu Li, Zhi Guo, Hai Tao Wang, T. Si, Chang-fu Liu, Hai-peng Yu
Objective To discuss the correlation between regulatory T cells(Treg) level in peripheral blood and the prognosis in patients with hepatocellular carcinoma(HCC) after transcatheter arterial chemoembolization(TACE).Methods A total of 122 patients with HCC who received TACE at authors' hospital were enrolled in this study.The CD3+ T,CD4+ T,CD8+ T,NK and Treg levels in peripheral blood were assessed by flow cytometry method.The relationship between the Treg level in peripheral blood and the survival time was evaluated by Cox regression and Kaplan-Meier analysis.Results In HCC patients after TACE,the ratio of Treg cells to CD4+ T was significantly increased(6.109 and 6.834,P = 0.000).In lower ratio group(ratio of Treg cells to CD4+ T 6.7),the median survival time of patients was 19.3 months,while in higher ratio group(ratio of Treg cells to CD4+ T ≥ 6.7),the median survival time of patients was 12.0 months.The difference between the two groups was statistically significant by using single factor analysis(χ2 = 8.771,P = 0.003) or multivariate analysis(P = 0.020).Conclusion The Treg level in peripheral blood is an independent predictive factor for judging the prognosis of HCC patients after TACE.
{"title":"The effect of regulatory T cells level in peripheral blood on the prognosis in HCC patients after TACE","authors":"Hu Li, Zhi Guo, Hai Tao Wang, T. Si, Chang-fu Liu, Hai-peng Yu","doi":"10.3969/J.ISSN.1008-794X.2012.12.008","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-794X.2012.12.008","url":null,"abstract":"Objective To discuss the correlation between regulatory T cells(Treg) level in peripheral blood and the prognosis in patients with hepatocellular carcinoma(HCC) after transcatheter arterial chemoembolization(TACE).Methods A total of 122 patients with HCC who received TACE at authors' hospital were enrolled in this study.The CD3+ T,CD4+ T,CD8+ T,NK and Treg levels in peripheral blood were assessed by flow cytometry method.The relationship between the Treg level in peripheral blood and the survival time was evaluated by Cox regression and Kaplan-Meier analysis.Results In HCC patients after TACE,the ratio of Treg cells to CD4+ T was significantly increased(6.109 and 6.834,P = 0.000).In lower ratio group(ratio of Treg cells to CD4+ T 6.7),the median survival time of patients was 19.3 months,while in higher ratio group(ratio of Treg cells to CD4+ T ≥ 6.7),the median survival time of patients was 12.0 months.The difference between the two groups was statistically significant by using single factor analysis(χ2 = 8.771,P = 0.003) or multivariate analysis(P = 0.020).Conclusion The Treg level in peripheral blood is an independent predictive factor for judging the prognosis of HCC patients after TACE.","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"21 1","pages":"998-1001"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-01DOI: 10.3969/J.ISSN.1008-794X.2012.09.019
Hu Li, Zhi Guo, T. Si, Hai Tao Wang
Objective To assess the clinical efficacy of urinary internal ureteral stenting(IUS) and percutaneous nephrostomy(PCN) in the management of malignant ureteral obstruction complicated by renal insufficiency,to analyze its impact on the patient's quality of life,and to discuss the indications of IUS and PCN.Methods A total of 75 patients with malignant ureteral obstruction accompanied with renal insufficiency were enrolled in this study.The clinical data were retrospectively analyzed.Retrograde IUS,or anterograde IUS or PCN was carried out in each patient.The pelvis separation,creatinine and urea nitrogen levels were determined before and after the treatment.Observation of the postoperative changes in patient's quality of life was conducted.Reasonable selection of the indications was analyzed.Results After the treatment the pelvis separation,creatinine and urea nitrogen decreases from preoperative(2.76±1.25)cm,(377±236)umol/L and(19.1±8.4)mmol/L respectively to postoperative(1.32±0.60)cm(P0.01),(149±106)umol/L(P0.01) and(12.9±6.6) mmol/L(P0.01) respectively.The score of life quality decreases form preoperative 86.2±9.8 to posto-perative 84.4±9.2(P0.01).Conclusion IUS and PCN can improve the severity of hydronephrosis and renal insufficiency as well as the worsen living quality caused by malignant ureteral obstruction.The pyelic drainage pattern should be selected according to the clinical condition and the patient's own will.
{"title":"Clinical application of different pyelic drainage methods in the management of malignant ureteral obstruction","authors":"Hu Li, Zhi Guo, T. Si, Hai Tao Wang","doi":"10.3969/J.ISSN.1008-794X.2012.09.019","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-794X.2012.09.019","url":null,"abstract":"Objective To assess the clinical efficacy of urinary internal ureteral stenting(IUS) and percutaneous nephrostomy(PCN) in the management of malignant ureteral obstruction complicated by renal insufficiency,to analyze its impact on the patient's quality of life,and to discuss the indications of IUS and PCN.Methods A total of 75 patients with malignant ureteral obstruction accompanied with renal insufficiency were enrolled in this study.The clinical data were retrospectively analyzed.Retrograde IUS,or anterograde IUS or PCN was carried out in each patient.The pelvis separation,creatinine and urea nitrogen levels were determined before and after the treatment.Observation of the postoperative changes in patient's quality of life was conducted.Reasonable selection of the indications was analyzed.Results After the treatment the pelvis separation,creatinine and urea nitrogen decreases from preoperative(2.76±1.25)cm,(377±236)umol/L and(19.1±8.4)mmol/L respectively to postoperative(1.32±0.60)cm(P0.01),(149±106)umol/L(P0.01) and(12.9±6.6) mmol/L(P0.01) respectively.The score of life quality decreases form preoperative 86.2±9.8 to posto-perative 84.4±9.2(P0.01).Conclusion IUS and PCN can improve the severity of hydronephrosis and renal insufficiency as well as the worsen living quality caused by malignant ureteral obstruction.The pyelic drainage pattern should be selected according to the clinical condition and the patient's own will.","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"21 1","pages":"776-779"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-01DOI: 10.3969/J.ISSN.1008-794X.2012.08.007
Chuntao Ma, Zhi Guo
Objective To explore the clinical efficacy and the adverse effects of erlotinib,used as a 2nd-line treatment,in treating lung adenocarcinoma complicated by brain metastases after the failure of arterial infusion chemotherapy.Methods During the period from November 2008 to January 2011,a total of 20 cases with lung adenocarcinoma complicated by brain metastases received arterial infusion chemotherapy. This procedure was performed once every 4 weeks until the intracranial lesions became worse or intolerable toxicity emerged.Then erlotinib was employed as a 2nd-line treatment in all the patients.The dose of erlotinib was 150 mg/day,and the treatment was kept on till the diseases deteriorated or intolerable adverse effects occurred.The remission rate,progression free survival time,overall survival time and the adverse effects of erlotinib were evaluated.Results All the 20 patients received arterial infusion chemotherapy for at least 2 times,the median treatment times was 3 times.For the 20 cases receiving erlotinib treatment,the overall response rate(CR + PR) was 75%(15/20) and the disease control rate(CR + PR + SD) was 90%(18/20). The median progression free survival time was 9 months with the 95%CI being(7.65 - 10.35) months.The Overall median survival time was 15 months and the 95%CI was(11.48 - 18.53) months.The 6-month survival rate and one-year survival rate were 90%and 75%respectively.The most common adverse effects of erlotinib were skin rash(90%,18/20) and diarrhea(75%,15/20).Most adverse effects were of gradeⅠ-Ⅱ,and only 10%(2/20) of patients got adverse effects of≥3grade.Conclusion As a 2nd-line treatment for lung adenocarcinoma with brain metastases,erlotinib is very effective and tolerable.Therefore,erlotinib can be employed as a therapeutic option for the patients who has failed to respond to the arterial infusion chemotherapy.)
{"title":"Erlotinib used for the treatment of advanced brain metastases from lung adenocarcinomas after arterial infusion chemotherapy: A clinical analysis","authors":"Chuntao Ma, Zhi Guo","doi":"10.3969/J.ISSN.1008-794X.2012.08.007","DOIUrl":"https://doi.org/10.3969/J.ISSN.1008-794X.2012.08.007","url":null,"abstract":"Objective To explore the clinical efficacy and the adverse effects of erlotinib,used as a 2nd-line treatment,in treating lung adenocarcinoma complicated by brain metastases after the failure of arterial infusion chemotherapy.Methods During the period from November 2008 to January 2011,a total of 20 cases with lung adenocarcinoma complicated by brain metastases received arterial infusion chemotherapy. This procedure was performed once every 4 weeks until the intracranial lesions became worse or intolerable toxicity emerged.Then erlotinib was employed as a 2nd-line treatment in all the patients.The dose of erlotinib was 150 mg/day,and the treatment was kept on till the diseases deteriorated or intolerable adverse effects occurred.The remission rate,progression free survival time,overall survival time and the adverse effects of erlotinib were evaluated.Results All the 20 patients received arterial infusion chemotherapy for at least 2 times,the median treatment times was 3 times.For the 20 cases receiving erlotinib treatment,the overall response rate(CR + PR) was 75%(15/20) and the disease control rate(CR + PR + SD) was 90%(18/20). The median progression free survival time was 9 months with the 95%CI being(7.65 - 10.35) months.The Overall median survival time was 15 months and the 95%CI was(11.48 - 18.53) months.The 6-month survival rate and one-year survival rate were 90%and 75%respectively.The most common adverse effects of erlotinib were skin rash(90%,18/20) and diarrhea(75%,15/20).Most adverse effects were of gradeⅠ-Ⅱ,and only 10%(2/20) of patients got adverse effects of≥3grade.Conclusion As a 2nd-line treatment for lung adenocarcinoma with brain metastases,erlotinib is very effective and tolerable.Therefore,erlotinib can be employed as a therapeutic option for the patients who has failed to respond to the arterial infusion chemotherapy.)","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"21 1","pages":"641-644"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70180102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-01-01DOI: 10.3109/9781841848075-30
Chen Zuo-quan
Objective To evaluate the treatment of spinal cord vascular malformations by endo vascular therapy. Methods All 41 patients including 3 cases were embolized by 3 0 silk line segments, 14 cases by selective embolization of dry dura particles, 16 by PVA and 8 cases by NBCA. Results Lesions were completely embolized in 27 cases, and partialy embolized in 14 cases. Paralysis of limbs were significantly improved in 36 cases, the other 5 cases showed no improvement on account of previous resection of the lesions. During 32 months follow up period, 18 cases recovered completely but with recurrence in 5. Conclusion Endovascular therapy is effective for spinal cord vascular malformations.
{"title":"Endovascular treatment of spinal vascualar malformation","authors":"Chen Zuo-quan","doi":"10.3109/9781841848075-30","DOIUrl":"https://doi.org/10.3109/9781841848075-30","url":null,"abstract":"Objective To evaluate the treatment of spinal cord vascular malformations by endo vascular therapy. Methods All 41 patients including 3 cases were embolized by 3 0 silk line segments, 14 cases by selective embolization of dry dura particles, 16 by PVA and 8 cases by NBCA. Results Lesions were completely embolized in 27 cases, and partialy embolized in 14 cases. Paralysis of limbs were significantly improved in 36 cases, the other 5 cases showed no improvement on account of previous resection of the lesions. During 32 months follow up period, 18 cases recovered completely but with recurrence in 5. Conclusion Endovascular therapy is effective for spinal cord vascular malformations.","PeriodicalId":52558,"journal":{"name":"Journal of Interventional Radiology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69466633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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