Idayat Titilayo Gbadamosi, Lekan Abdullahi Raji, A. Oyagbemi, T. O. Omobowale
Musa paradisiaca (Plantain) fruit has been shown to be useful for nutritional, medicinal and industrial purposes. It contains serotonin (5-HT) and its immediate precursor, 5-Hydroxytryptophan (5-HTP). Serotonin plays a fundamental role in integration of behaviour and many physiological functions including regulation of mood, anxiety, arousal, aggression, impulse control, and thinking abilities. In this study, the effect of plantain-containing mouse diet on brain serotonin mice was investigated in mice. Thirty adult Swiss mice were divided into three groups of ten each and fed normal rodent chow containing 0%, 50% and 100% unripe plantain. After thirty days, the brain levels of 5-HT and 5-HTP were measured using High Performance Liquid Chromatography (HPLC) technique. Results show that 5-HT level was significantly increased in the plantain-diet fed mice. Conversely, 5-HTP level was reduced in the 100% plantain fed mice when compared with the control. Keywords : Musa paradisiaca , Unripe plantain, serotonin, 5-Hydroxytryptophan
{"title":"Effects of Diets Containing Unripe Plantain Diet on Brain Serotonin in Mice","authors":"Idayat Titilayo Gbadamosi, Lekan Abdullahi Raji, A. Oyagbemi, T. O. Omobowale","doi":"10.4314/AJBR.V20I3","DOIUrl":"https://doi.org/10.4314/AJBR.V20I3","url":null,"abstract":"Musa paradisiaca (Plantain) fruit has been shown to be useful for nutritional, medicinal and industrial purposes. It contains serotonin (5-HT) and its immediate precursor, 5-Hydroxytryptophan (5-HTP). Serotonin plays a fundamental role in integration of behaviour and many physiological functions including regulation of mood, anxiety, arousal, aggression, impulse control, and thinking abilities. In this study, the effect of plantain-containing mouse diet on brain serotonin mice was investigated in mice. Thirty adult Swiss mice were divided into three groups of ten each and fed normal rodent chow containing 0%, 50% and 100% unripe plantain. After thirty days, the brain levels of 5-HT and 5-HTP were measured using High Performance Liquid Chromatography (HPLC) technique. Results show that 5-HT level was significantly increased in the plantain-diet fed mice. Conversely, 5-HTP level was reduced in the 100% plantain fed mice when compared with the control. Keywords : Musa paradisiaca , Unripe plantain, serotonin, 5-Hydroxytryptophan","PeriodicalId":53615,"journal":{"name":"African Journal Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4314/AJBR.V20I3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48089003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Olanrewaju, B. Anyaehie, C. O. Ezeh, K. Onyekwelu, R. Ezeh
Association of hypogonadism and visceral obesity (VO) was recently demonstrated in male auto-mechanics occupationally exposed to endocrine disruptors (ED)-lead, cadmium, mercury and arsenic, known to alter the hypothalamic-pituitary-testicular axis. The effects of exposure to these EDs on pituitary and gonadal hormones in normal weight auto-mechanics in Ibadan were investigated. Ninety-nine normal weight male adults without any metabolic syndrome component-elevated VO, blood pressure, tryglycerides, fasting plasma glucose (FPG) and reduced high density lipoprotein cholesterol (HDLC), enrolled into this prospective cross sectional study. They were 50 auto-mechanics, age and anthropometry matched with 49 eugonadic males (occupationally unexposed to EDs) in Ibadan (control). Demography, lifestyle, sexual and reproductive history, anthropometery and blood pressure were obtained by standard methods. Fasting blood (15 mL) obtained was used for biochemical analyses-hormones (follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, oestradiol and testosterone) by ELISA; EDs-Lead, cadmium, mercury and arsenic by AAS; FPG, HDLC, triglycerides and oxidative stress (OS) biomarker-total antioxidant capacity (TAC) by spectrophotometry. Data obtained were statistically significant at P <0.05. Only 45 (90%) auto-mechanics were eugonadic. EDs except arsenic were significantly higher while libido and TAC level were significantly lower in the auto-mechanics compared with control ( P <0.05). In automechanics only, lead had an inverse relationship with testosterone ( P = 0.001) but direct relationship with FSH ( P = 0.013). LH had a direct relationship with mercury ( P = 0.031) but indirect relationship with TAC ( P <0.001). Auto mechanics may be occupational exposed to lead, cadmium and mercury with the induction of oxidative stress and testicular dysfunction. Keywords: Heavy Metals, Hypogonadism, Metabolic Syndrome, Total Antioxidant Capacity, Testosterone
{"title":"Effects of endocrine disrupting heavy metals on pituitary and gonadal hormones in normal weight automechanics in Ibadan, Nigeria","authors":"E. Olanrewaju, B. Anyaehie, C. O. Ezeh, K. Onyekwelu, R. Ezeh","doi":"10.4314/AJBR.V20I1","DOIUrl":"https://doi.org/10.4314/AJBR.V20I1","url":null,"abstract":"Association of hypogonadism and visceral obesity (VO) was recently demonstrated in male auto-mechanics occupationally exposed to endocrine disruptors (ED)-lead, cadmium, mercury and arsenic, known to alter the hypothalamic-pituitary-testicular axis. The effects of exposure to these EDs on pituitary and gonadal hormones in normal weight auto-mechanics in Ibadan were investigated. Ninety-nine normal weight male adults without any metabolic syndrome component-elevated VO, blood pressure, tryglycerides, fasting plasma glucose (FPG) and reduced high density lipoprotein cholesterol (HDLC), enrolled into this prospective cross sectional study. They were 50 auto-mechanics, age and anthropometry matched with 49 eugonadic males (occupationally unexposed to EDs) in Ibadan (control). Demography, lifestyle, sexual and reproductive history, anthropometery and blood pressure were obtained by standard methods. Fasting blood (15 mL) obtained was used for biochemical analyses-hormones (follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, oestradiol and testosterone) by ELISA; EDs-Lead, cadmium, mercury and arsenic by AAS; FPG, HDLC, triglycerides and oxidative stress (OS) biomarker-total antioxidant capacity (TAC) by spectrophotometry. Data obtained were statistically significant at P <0.05. Only 45 (90%) auto-mechanics were eugonadic. EDs except arsenic were significantly higher while libido and TAC level were significantly lower in the auto-mechanics compared with control ( P <0.05). In automechanics only, lead had an inverse relationship with testosterone ( P = 0.001) but direct relationship with FSH ( P = 0.013). LH had a direct relationship with mercury ( P = 0.031) but indirect relationship with TAC ( P <0.001). Auto mechanics may be occupational exposed to lead, cadmium and mercury with the induction of oxidative stress and testicular dysfunction. Keywords: Heavy Metals, Hypogonadism, Metabolic Syndrome, Total Antioxidant Capacity, Testosterone","PeriodicalId":53615,"journal":{"name":"African Journal Biomedical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46273259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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