Pub Date : 2008-10-01DOI: 10.1016/j.toxlet.2008.06.674
M. Karimfar, K. Tabrizian, K. Azami, A. Hosseini-Sharifabad, A. Hoseini, M. Pourghorban, Mehdi Aghsami, S. Gholizadeh, M. Abdollahi, A. Roghani, M. Sharifzadeh
{"title":"Time course effects of lithium administration on spatial memory acquisition and cholinergic marker expression in rats","authors":"M. Karimfar, K. Tabrizian, K. Azami, A. Hosseini-Sharifabad, A. Hoseini, M. Pourghorban, Mehdi Aghsami, S. Gholizadeh, M. Abdollahi, A. Roghani, M. Sharifzadeh","doi":"10.1016/j.toxlet.2008.06.674","DOIUrl":"https://doi.org/10.1016/j.toxlet.2008.06.674","url":null,"abstract":"","PeriodicalId":55185,"journal":{"name":"Daru-Journal of Faculty of Pharmacy","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.toxlet.2008.06.674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55388356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-04-01DOI: 10.1016/J.YJMCC.2008.02.190
M. Najafi, H. Nazemieh, H. Ghavimi, A. Gharahkhani, A. Garjani
{"title":"Effects of hydroalcoholic extract of Cynodon dactylon (L.) pers. on ischemia/reperfusion-induced arrhythmias","authors":"M. Najafi, H. Nazemieh, H. Ghavimi, A. Gharahkhani, A. Garjani","doi":"10.1016/J.YJMCC.2008.02.190","DOIUrl":"https://doi.org/10.1016/J.YJMCC.2008.02.190","url":null,"abstract":"","PeriodicalId":55185,"journal":{"name":"Daru-Journal of Faculty of Pharmacy","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.YJMCC.2008.02.190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55326581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of immunosuppressive medication such as Azathioprine, methoterxate and mercaptopurine in treatment of rheumatic disease in women at childbearing age has some risks of teratogeniesis. Cyclosporine is one of the newer medicines, which has been introduced for this disease but little is known about its teratogenicity. This study was designed to investigate the possible teratogenicity of this drug by using cultured rat limb bud cells, which were obtained from rat embryos 13 days after conception. Cells were incubated in trypsin-EDTA solution for 30 min at 37°C and then filtered through 50 µm nylon filters. The resultant cell suspension was cultivated in 1 ml Dulbecco modified Eagle medium (DMEM) containing 10% fetal bovine serum and 445 µg/L L-glutamine at 37°C with 5% CO2. After 8 days of culture the differentiated foci extract were measured by staining with 1% alcian blue. To assess the teratogenic effects of cyclosporine, it was placed in the culture well together with the cells. Results showed that the decrease in the expression of the extracellular matrix at dose of 0.01 molar of cyclosporine is due to limb bud cell toxicity rather than inhibition of cell differentiation.
{"title":"The study of teratogenic effect of Cyclosporine in vitro","authors":"S. Ostad, M. Abdollahi, O. Sabzevari, F. Daghiani","doi":"10.1042/BST028A292C","DOIUrl":"https://doi.org/10.1042/BST028A292C","url":null,"abstract":"The use of immunosuppressive medication such as Azathioprine, methoterxate and mercaptopurine in treatment of rheumatic disease in women at childbearing age has some risks of teratogeniesis. Cyclosporine is one of the newer medicines, which has been introduced for this disease but little is known about its teratogenicity. This study was designed to investigate the possible teratogenicity of this drug by using cultured rat limb bud cells, which were obtained from rat embryos 13 days after conception. Cells were incubated in trypsin-EDTA solution for 30 min at 37°C and then filtered through 50 µm nylon filters. The resultant cell suspension was cultivated in 1 ml Dulbecco modified Eagle medium (DMEM) containing 10% fetal bovine serum and 445 µg/L L-glutamine at 37°C with 5% CO2. After 8 days of culture the differentiated foci extract were measured by staining with 1% alcian blue. To assess the teratogenic effects of cyclosporine, it was placed in the culture well together with the cells. Results showed that the decrease in the expression of the extracellular matrix at dose of 0.01 molar of cyclosporine is due to limb bud cell toxicity rather than inhibition of cell differentiation.","PeriodicalId":55185,"journal":{"name":"Daru-Journal of Faculty of Pharmacy","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/BST028A292C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"58313401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1981-01-01DOI: 10.3109/13880208509070686
M. H. Surmaghi, Y. Amin, Z. Mahmoodi
A total of 149 plant extracts representing 49 different families has been screened for saponins, flavonoids, tannins and alkalodids. positive tests obtained were 145 (97) for saponins 74 (50%) for alkaloids 16 (51%) for fiavonoisds and 60 (40%) for tannins.
{"title":"Survey of Iranian Plants For Saponins Alkaloids Flavonoids And Tannins. IV","authors":"M. H. Surmaghi, Y. Amin, Z. Mahmoodi","doi":"10.3109/13880208509070686","DOIUrl":"https://doi.org/10.3109/13880208509070686","url":null,"abstract":"A total of 149 plant extracts representing 49 different families has been screened for saponins, flavonoids, tannins and alkalodids. positive tests obtained were 145 (97) for saponins 74 (50%) for alkaloids 16 (51%) for fiavonoisds and 60 (40%) for tannins.","PeriodicalId":55185,"journal":{"name":"Daru-Journal of Faculty of Pharmacy","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/13880208509070686","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69349077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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