We have examined the role of integrins in the development of dendrites in embryonic rat sympathetic neurons in vitro. Previous studies have established that exposure to a basement membrane extract (BME) causes these neurons to form dendrites (Lein and Higgins, 1989). The current experiments demonstrate that the dendrite-promoting activity of BME can be markedly inhibited by antibodies directed against the β1 integrin subunit. Although the specific ∝ integrin sub-unit(s) that mediate the effect of BME on dendritic growth were not identified, it was found that neither the ∝1, or ∝4 sub-units, nor RGD-binding integrins were involved to any significant extent. These data suggest that, in addition to their well established role in regulating axonal growth, β1 integrins also participate in dendritic growth.
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