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Network pharmacology and in vitro experiments reveal the potential therapeutic effects of Scrophularia ningpoensis Hemsl in the treatment of ameloblastoma. 网络药理学和体外实验揭示了宁波黄芩(Scrophularia ningpoensis Hemsl)治疗母细胞瘤的潜在疗效。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-15 DOI: 10.1016/j.jormas.2024.102146
Jing-Rui Yi, Bang Zeng, Bing Liu, Rui-Fang Li, Yin-Fu Che, Qi-Wen Man

Purpose: This study aimed to explore active ingredients in Scrophularia ningpoensis Hemsl (SNH) with potential effects on ameloblastoma (AM) using network pharmacological approach, bioinformatic gene analysis and in vitro cell experiments.

Methods: The active ingredients and their corresponding targets of SNH were identified from the Traditional Chinese Medicine Systems Pharmacology (TCMSP), as well as SwissTargetPrediction. Disease targets of AM were selected from GeneCards and DisGeNET databases. Differentially expressed genes (DEGs) of AM were identified, and Gene Ontology enrichment analysis were performed using the Gene Expression Omnibus (GEO) dataset GSE38494 through bioinformatic analysis. The STRING database platform was utilized to generate a protein-protein interaction network diagram, followed by hub gene analysis using Cytoscape software. AutoDock Vina software was used to perform molecular docking verification of the effects of the active ingredients on potential core targets. Additionally, in vitro experiments including quantitative reverse transcription polymerase chain reaction (RT-qPCR), EdU assay and CCK-8 cell proliferation assay were conducted using AM cell line AM-1 after SNH extract treatment.

Result: The study revealed that SNH contains eight active ingredients and a total of 388 drug targets, including 10 potential core targets in AM. Hub genes identified in the analysis were CCNA2, HRAS, PTGS2, PIK3CB, FGFR1, CASP3, MMP1, SLC2A1, MMP14, and MME. Molecular docking analysis demonstrated strong binding activity between key active ingredients (β-sitosterol, scropolioside A_qt, scropolioside D, scropolioside D_qt, and sugiol) and target genes (CASP3, FGFR1, HRAS, PTGS2, and SLC2A1). Gene Ontology enrichment analysis indicated that SNH exerts its effects on AM through pathways related to cellular response to abiotic stimulus, cellular response to hypoxia, and exopeptidase activity. Immunohistochemical analysis using tissue microarray showed higher expression of MMP14 and PTGS2 in AM compared to dentigerous cyst. Using AM-1 cell line, RT-qPCR results confirmed that SNH suppressed the expression of MMP14 and PTGS2 at mRNA level. Additionally, the EdUassay and CCK-8 assay indicated the inhibitory effect of SNH on the proliferation of AM-1 cells.

Conclusion: These findings showed that SNH could suppress expression of MMP14 and PTGS2 and restrain the proliferation of AM. Our study highlights the potential of SNH as a promising therapeutic candidate for AM, which may provide more options for clinical treatment.

目的:本研究旨在通过网络药理学方法、生物信息学基因分析和体外细胞实验,探讨宁波黄芩(Scrophularia ningpoensis Hemsl,SNH)中对骨髓母细胞瘤(ameloblastoma,AM)具有潜在作用的有效成分:方法:从《中药系统药理学》(TCMSP)和 SwissTargetPrediction 中确定 SNH 的有效成分及其相应靶点。从GeneCards和DisGeNET数据库中筛选出AM的疾病靶点。通过生物信息学分析,利用基因表达总库(GEO)数据集 GSE38494 确定了 AM 的差异表达基因(DEGs),并进行了基因本体富集分析。利用 STRING 数据库平台生成蛋白质-蛋白质相互作用网络图,然后使用 Cytoscape 软件进行枢纽基因分析。使用 AutoDock Vina 软件对活性成分对潜在核心靶点的影响进行分子对接验证。此外,还利用 AM 细胞株 AM-1 进行了 SNH 提取物处理后的体外实验,包括定量反转录聚合酶链反应(RT-qPCR)、EdU 检测和 CCK-8 细胞增殖检测:研究结果表明,SNH 含有八种有效成分,共有 388 个药物靶点,其中包括 AM 的 10 个潜在核心靶点。分析发现的枢纽基因包括 CCNA2、HRAS、PTGS2、PIK3CB、FGFR1、CASP3、MMP1、SLC2A1、MMP14 和 MME。分子对接分析表明,主要活性成分(β-谷甾醇、山榄香甙 A_qt、山榄香甙 D、山榄香甙 D_qt 和杉醇)与靶蛋白(CASP3、FGFR1、HRAS、PTGS2 和 SLC2A1)之间具有很强的结合活性。基因本体富集分析表明,SNH 通过与细胞对非生物刺激的反应、细胞对缺氧的反应和外肽酶活性相关的途径对 AM 发挥作用。利用组织芯片进行的免疫组化分析表明,与齿状囊肿相比,AM 中 MMP14 和 PTGS2 的表达量更高。利用 AM-1 细胞系,RT-qPCR 结果证实 SNH 在 mRNA 水平上抑制了 MMP14 和 PTGS2 的表达。此外,EdUassay 和 CCK-8 检测表明 SNH 对这些细胞的增殖有抑制作用:这些研究结果表明,SNH 可抑制 MMP14 和 PTGS2 的表达,抑制 AM 的增殖。我们的研究强调了SNH作为AM治疗候选药物的潜力,这可能为临床治疗提供更多选择。
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引用次数: 0
Optimising titanium implant stability and infection resistance through iron nanoparticle coatings: A preclinical investigation. 通过铁纳米粒子涂层优化钛植入物的稳定性和抗感染能力:临床前研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-15 DOI: 10.1016/j.jormas.2024.102155
Santosh Nelogi, Anand Kumarpatil, Ramesh Chowdhary, Richa Roy

Background: Attaining adequate osseointegration and mitigating infections are paramount issues in implantology, especially within dental and orthopaedic domains. Titanium implants have been utilised for their biocompatibility and mechanical strength; yet, problems such as peri‑implant infections and inadequate bone integration may undermine their efficacy. Coating titanium implants with iron nanoparticles (FeNp) has surfaced as a promising approach to improve osseointegration and antibacterial characteristics. FeNp's distinctive capacity to react to magnetic fields and produce reactive oxygen species (ROS) has the potential to enhance implant results.

Objective: To assess the influence of FeNp-coated titanium implants on osseointegration, mechanical stability, osteogenesis, and antibacterial effectiveness against prevalent implant-associated infections, Staphylococcus aureus and Escherichia coli.

Materials and methods: In vivo investigations were performed on animal models to evaluate implant stability by resonance frequency analysis (RFA) and removal torque measurements at 6 and 12 weeks post-implantation. Histopathological assessment was conducted to analyze the osseous formation and vascularization surrounding the implants. Furthermore, in vitro experiments were employed to assess the antibacterial efficacy of magnetized FeNp against S. aureus and E. coli.

Results: At 6 weeks, no substantial change was detected in (RFA) or removal torque between the control group (GROUP A) and the test group (GROUP B). However, by 12 weeks, GROUP B demonstrated significantly higher RFA scores (75.02 ± 5.11) compared to GROUP A (67.41 ± 9.85), indicating improved implant stability (p < 0.05). Removal torque values were also significantly higher in GROUP B at 12 weeks (76.30 ± 14.20) compared to GROUP A (46.10 ± 9.25), suggesting enhanced mechanical integration (p < 0.01). Histopathological analysis revealed greater new bone formation, increased osteoblast activity, and improved vascularization around FeNp-coated implants in GROUP B. Additionally, in vitro antibacterial testing demonstrated that FeNp coatings effectively inhibited the growth of Staphylococcus aureus and E. coli, providing further evidence of its antimicrobial effect CONCLUSION: FeNp-coated implants have dual advantages: improved osseointegration and antibacterial defence. The findings indicate that FeNp coatings might substantially enhance implant longevity and diminish the likelihood of infection, offering a potential approach for clinical applications, especially for patients at elevated risk of implant failure. Subsequent research should concentrate on enhancing the application of FeNp coatings in clinical environments and further examining their long-term biocompatibility and effectiveness.

背景:获得充分的骨结合和减少感染是种植学的首要问题,尤其是在牙科和整形外科领域。钛种植体具有生物相容性和机械强度,但种植体周围感染和骨整合不足等问题可能会削弱其功效。在钛植入物上涂覆纳米铁粒子(FeNp)已成为改善骨结合和抗菌特性的一种可行方法。铁纳米粒子具有独特的磁场反应能力,能产生活性氧(ROS),因此有可能提高植入效果:评估 FeNp 涂层钛种植体对骨结合、机械稳定性、成骨和抗菌效果的影响,以预防与种植体相关的常见感染--金黄色葡萄球菌和大肠杆菌:对动物模型进行体内研究,通过共振频率分析(RFA)和植入后 6 周和 12 周的移除扭矩测量来评估植入体的稳定性。组织病理学评估分析了植入物周围的骨形成和血管化情况。此外,还采用了体外实验来评估磁化 FeNp 对金黄色葡萄球菌和大肠杆菌的抗菌效果:6 周时,对照组(A 组)和试验组(B 组)之间在(RFA)或移除扭矩方面未发现实质性变化。但在 12 周时,B 组的 RFA 评分(75.02 ± 5.11)明显高于 A 组(67.41 ± 9.85),表明种植体的稳定性有所提高(p < 0.05)。与 A 组(46.10 ± 9.25)相比,B 组在 12 周时的移除扭矩值(76.30 ± 14.20)也明显更高,这表明机械整合性得到了增强(p < 0.01)。此外,体外抗菌测试表明,FeNp 涂层能有效抑制金黄色葡萄球菌和大肠杆菌的生长,进一步证明了其抗菌效果:FeNp涂层植入物具有双重优势:改善骨结合和抗菌防御。研究结果表明,FeNp 涂层可大大延长种植体的使用寿命,降低感染的可能性,为临床应用提供了一种潜在的方法,特别是对种植体失败风险较高的患者。后续研究应集中于加强氮化铁涂层在临床环境中的应用,并进一步研究其长期生物相容性和有效性。
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引用次数: 0
Dysbiosis and interactions of the salivary bacteriome in obese individuals: A human cross-sectional study. 肥胖者唾液细菌群的菌群失调和相互作用:一项人体横断面研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-14 DOI: 10.1016/j.jormas.2024.102131
Liang Beibei, Jing Yuzi, Yang Hengye, Fan Yifan, Lin Yanli, Yang Dongru, Zhao Chen, Liu Qing

Introduction: The prevalence of obesity is continually rising worldwide, posing a risk for the development of various serious diseases. The pathogenesis of obesity is complex and recent research suggests a link between obesity and the oral microbiome, though the specific mechanisms remain unclear.

Material and methods: We collected saliva samples from 9 non-obese and 13 obese participants and conducted 16S rRNA sequencing to analyze the differences in oral microbiota between obese and non-obese individuals in terms of microbial abundance, functionality, and interaction networks.

Results: Obese participants exhibited a distinct composition of salivary microbiota compared to non-obese participants, with a greater number of ASVs detected and higher α diversity indices. Specifically, Haemophilus, Aggregatibacter, and Actinobacillus were significantly enriched, while Actinomyces showed significant depletion. Functional prediction analysis indicated that biofilm formation pathways were significantly more abundant in the obese group. Random forest regression model analysis identified Bergeyella as the most contributive genus, and interaction network analysis suggested that Bergeyella may function as a bridge node, linking the obese group-enriched genera to the broader microbial community and facilitating the exchange of information and resources.

Discussion: Our study suggests that obesity may be closely associated with salivary microbiota dysbiosis and functional changes. Further research is needed to elucidate the causal relationship and underlying molecular mechanisms between obesity and oral microbiota dysbiosis, or to determine if they mutually influence each other.

引言肥胖症的发病率在全球范围内持续上升,有可能引发各种严重疾病。肥胖症的发病机制十分复杂,最近的研究表明肥胖症与口腔微生物组之间存在联系,但具体机制仍不清楚:我们收集了 9 名非肥胖者和 13 名肥胖者的唾液样本,并进行了 16S rRNA 测序,以分析肥胖者和非肥胖者口腔微生物群在微生物丰度、功能和相互作用网络方面的差异:结果:与非肥胖者相比,肥胖者口腔唾液微生物群的组成截然不同,检测到的 ASV 数量更多,α 多样性指数更高。具体来说,嗜血杆菌、聚集杆菌和放线菌明显增多,而放线菌则明显减少。功能预测分析表明,肥胖组的生物膜形成途径明显更多。随机森林回归模型分析表明,Bergeyella 是最有贡献的菌属,而相互作用网络分析表明,Bergeyella 可能起到桥梁节点的作用,将肥胖组富集的菌属与更广泛的微生物群落联系起来,促进信息和资源的交流:讨论:我们的研究表明,肥胖可能与唾液微生物群的菌群失调和功能变化密切相关。要阐明肥胖与口腔微生物群失调之间的因果关系和潜在的分子机制,或确定它们是否相互影响,还需要进一步的研究。
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引用次数: 0
Prognostic implications across histological subtypes of head and neck squamous cell carcinoma: An update. 头颈部鳞状细胞癌各组织学亚型的预后影响:更新。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-14 DOI: 10.1016/j.jormas.2024.102149
Moisés Willian Aparecido Gonçalves, Reydson Alcides de Lima-Souza, Maria Clara Falcão Ribeiro-de-Assis, Marcelo Elias Schempf Cattan, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, arising from the mucosal epithelium of the oral cavity, oropharynx, hypopharynx, nasopharynx, larynx, and sinuses. In addition to the conventional morphologic pattern characterized by the degree of cellular atypia and squamous differentiation, HNSCC is classified into eight histopathologic subtypes: basaloid, spindle cell, adenosquamous, cuniculatum, verrucous, lymphoepithelial, papillary, and acantholytic.

Methods: This review provides a comprehensive review of the literature on the prognostic implications of the histological subtypes of HNSCC.

Results: Although there is extensive literature on HNSCC, few studies specifically focus on the treatment and prognosis of its histopathologic subtypes. Among these subtypes, verrucous squamous cell carcinoma and carcinoma cuniculatum generally have a favorable prognosis, while others, such as basaloid and spindle cell squamous cell carcinoma, tend to follow a more aggressive clinical course.

Conclusion: In this review, we delve into the histopathological subtypes of HNSCC and explore their clinicopathological, molecular, and prognostic findings. Further molecular investigations aimed at identifying targeted therapies for these subtypes are necessary. Moreover, it is crucial to recognize the emerging histopathological variants documented in the literature, considering the ongoing limitations in prognostic assessment.

背景:头颈部鳞状细胞癌(HNSCC)是全球最常见的恶性肿瘤之一,多发于口腔、口咽、下咽、鼻咽、喉和鼻窦的粘膜上皮。除了以细胞不典型性和鳞状分化程度为特征的传统形态学模式外,HNSCC 还可分为八种组织病理学亚型:基底细胞型、纺锤形细胞型、腺鳞状细胞型、阴沟癌型、疣状细胞型、淋巴上皮型、乳头状细胞型和棘细胞型:本综述全面回顾了有关 HNSCC 组织学亚型预后影响的文献:尽管有关 HNSCC 的文献很多,但很少有研究特别关注其组织病理学亚型的治疗和预后。在这些亚型中,疣状鳞状细胞癌和阴沟癌的预后一般较好,而其他亚型,如基底细胞鳞状细胞癌和纺锤形细胞鳞状细胞癌的临床病程往往更具侵袭性:在这篇综述中,我们深入研究了 HNSCC 的组织病理学亚型,并探讨了它们的临床病理学、分子和预后结果。有必要进一步开展分子研究,以确定针对这些亚型的靶向疗法。此外,考虑到目前预后评估的局限性,认识到文献中记录的新出现的组织病理学变异至关重要。
{"title":"Prognostic implications across histological subtypes of head and neck squamous cell carcinoma: An update.","authors":"Moisés Willian Aparecido Gonçalves, Reydson Alcides de Lima-Souza, Maria Clara Falcão Ribeiro-de-Assis, Marcelo Elias Schempf Cattan, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano","doi":"10.1016/j.jormas.2024.102149","DOIUrl":"10.1016/j.jormas.2024.102149","url":null,"abstract":"<p><strong>Background: </strong>Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, arising from the mucosal epithelium of the oral cavity, oropharynx, hypopharynx, nasopharynx, larynx, and sinuses. In addition to the conventional morphologic pattern characterized by the degree of cellular atypia and squamous differentiation, HNSCC is classified into eight histopathologic subtypes: basaloid, spindle cell, adenosquamous, cuniculatum, verrucous, lymphoepithelial, papillary, and acantholytic.</p><p><strong>Methods: </strong>This review provides a comprehensive review of the literature on the prognostic implications of the histological subtypes of HNSCC.</p><p><strong>Results: </strong>Although there is extensive literature on HNSCC, few studies specifically focus on the treatment and prognosis of its histopathologic subtypes. Among these subtypes, verrucous squamous cell carcinoma and carcinoma cuniculatum generally have a favorable prognosis, while others, such as basaloid and spindle cell squamous cell carcinoma, tend to follow a more aggressive clinical course.</p><p><strong>Conclusion: </strong>In this review, we delve into the histopathological subtypes of HNSCC and explore their clinicopathological, molecular, and prognostic findings. Further molecular investigations aimed at identifying targeted therapies for these subtypes are necessary. Moreover, it is crucial to recognize the emerging histopathological variants documented in the literature, considering the ongoing limitations in prognostic assessment.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102149"},"PeriodicalIF":2.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the positioning guide mandatory for the virtual planning of orthognathic surgery? A randomized double-blind trial. 正颌外科手术的虚拟规划是否必须使用定位指南?随机双盲试验。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-14 DOI: 10.1016/j.jormas.2024.102150
Adalmir Gonzaga Dos Santos Queiroz, Claudio Roberto Pacheco Jodas, Shajadi Carlos Pardo Kaba, Rubens Gonçalves Teixeira

Objectives: The aim of this study is to verify the positioning of the condyles in computed tomography (CT) scans of skeletal Class II and Class III patients in virtual surgical planning before orthognathic surgery. The secondary aim is to determine whether occlusal devices are mandatory for performing a CT examination.

Materials and methods: In this retrospective randomized double-blind study, 42 CT scans were evaluated from patients who had undergone to orthognathic surgery at the University Hospital of the University of São Paulo. Male and female patients between the ages of 25 and 40 were included. The sample consisted of skeletal Class II and III patients. The CTs were randomly selected into centric relation (CR) and maximal intercuspal position (MI). Statistical analysis was performed with R Statistical Package and was considered significant in the case of p <0.0001.

Results: A total of 504 measurements were carried out in 42 patients. Three joint spaces on each side were used. No statistically significant difference between the inter- and intraobservers was found for CR and MI. Some scores were performed to avoid the risk of gender bias.

Conclusions: No statistically significant value was found between patients in CR and MI after mandibular manipulation. The use of a positioning guide to perform a CT scan prior to virtual planning is not absolutely necessary.

研究目的本研究的目的是在正颌手术前的虚拟手术规划中,验证骨骼Ⅱ类和Ⅲ类患者计算机断层扫描(CT)中髁突的定位。次要目的是确定在进行 CT 检查时是否必须使用咬合装置:在这项回顾性随机双盲研究中,对圣保罗大学附属医院接受正颌外科手术的 42 名患者的 CT 扫描结果进行了评估。研究对象包括 25 至 40 岁的男女患者。样本包括骨骼二级和三级患者。CT被随机选取为中心关系(CR)和最大间隙位置(MI)。使用 R 统计软件包进行统计分析,以 p 为显著结果:共对 42 名患者进行了 504 次测量。每侧使用了三个关节间隙。在 CR 和 MI 方面,观察者之间和观察者内部的差异无统计学意义。为避免性别偏差风险,进行了一些评分:下颌关节操作后,CR 和 MI 患者之间没有发现明显的统计学价值。在虚拟规划前使用定位指南进行 CT 扫描并非绝对必要。
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引用次数: 0
The discovery of migratory lesion in mandibular sclerosing osteomyelitis during biological inhibitors therapy: Two cases report and literature review. 在生物抑制剂治疗期间发现下颌骨硬化性骨髓炎的移行性病变:两例报告和文献综述。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-14 DOI: 10.1016/j.jormas.2024.102127
Weihua Han, Mu Wang, Ge Kong, Chen Li, Wen Zhang, Lian Zhou

Background: Diffuse sclerosing osteomyelitis (DSO) in mandible is a disease with unusual and undefined clinicoradiographic manifestations. Several medicines have been administrated for therapy, but the efficacy in bone remolding remains to be systematically evaluated.

Observation: A 37-year-old male and a 28-year-old female were diagnosed DSO after revealing diffuse sclerosis and osteolytic changes in the mandible, and treated by Janus-activated kinase signal and IL-6 inhibitor, respectively. Their symptoms were well controlled and the inflammatory indicators were decreased. During the mandible remolding, the osteolytic destruction in one patient migrated from the left mandible to the right, while DSO lesion migrated from the left mandibular body to the ramus and condyle in the other.

Conclusion: DSO presented as migratory lesions in mandible after biological inhibitors therapy, while the periosteal reaction wasn't conformed to the osteolytic focus. These findings suggest that periostitis may be the direct cause of DSO rather than the infectious triggers.

背景:下颌骨弥漫性硬化性骨髓炎(DSO)是一种临床放射学表现不常见、不明确的疾病。目前已有多种药物用于治疗,但对骨重塑的疗效仍有待系统评估:一名 37 岁的男性和一名 28 岁的女性在发现下颌骨弥漫性硬化和溶骨性改变后被诊断为 DSO,并分别接受了 Janusactivated 激酶信号和 IL-6 抑制剂的治疗。他们的症状得到了很好的控制,炎症指标也有所下降。在下颌骨重塑过程中,一名患者的溶骨性破坏从左侧下颌骨移向右侧,而另一名患者的DSO病变则从左侧下颌骨体移向颧骨和髁状突:结论:DSO在生物抑制剂治疗后表现为下颌骨的移行性病变,而骨膜反应与溶骨病灶并不一致。这些研究结果表明,骨膜炎可能是导致 DSO 的直接原因,而非感染诱因。
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引用次数: 0
Comparative study of 3D contact area percentage between zygomatic implant and bone in different surgical approaches: clinical and biomechanical perspectives. 不同手术方式下颧骨种植体与骨的三维接触面积百分比比较研究:临床和生物力学视角。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-14 DOI: 10.1016/j.jormas.2024.102148
Ting Xin Hong, Aaron Yu Jen Wu, Yuan Chien Chen, Jui Ting Hsu, Lih Jyh Fuh, Heng Li Huang

Background: Zygomatic implants, either alone or in combination with dental implant placement, have emerged as a viable surgical option for elderly patients with severe bone atrophy for occlusal restoration. This study aims to examine the biomechanical impact of the three-dimensional contact area between zygomatic implants and bone on biomechanics under different surgical methods.

Material and methods: Using Cone Beam Computed Tomography (CBCT) images from 10 patients with severe bone atrophy, we reconstructed 3D maxillary bone models and created corresponding 3D zygomatic implant models. Two distinct surgical methods (extramaxillary or intrasinus approaches) were employed based on the position and angle of the zygomatic implant for each patient. The 3D bone-to-implant contact percentage (BIC%) was calculated, and finite element analysis with nonlinear contact was conducted to assess the relationship between 3D BIC% and surrounding bone stress for both surgical methods.

Results: The 3D BIC% of extramaxillary approach (57.63 %) and intrasinus approach (56.49 %) for total bone (including cortical and cancellous bone) was similar (P = 0.425) in zygomatic implant surgery. In contrast, the intrasinus method exhibited higher 3D BIC% in cortical bone contact (28.08 %) compared to the extramaxillary approach (21.92 %) (P = 0.011). The correlation between 3D BIC% and high bone stress was stronger in the intrasinus approach, likely due to increased contact area in cortical bone.

Conclusion: The intrasinus approach led to lower bone stress and a more robust correlation between bone stress and 3D BIC%, particularly in cortical bone contact. Importantly, the coverage area of cortical bone surrounding the zygomatic implant significantly influenced biomechanical performance of the zygomatic implants.

背景:对于骨质严重萎缩的老年患者来说,颧骨种植体,无论是单独使用还是与牙种植体结合使用,都是一种可行的咬合修复手术选择。本研究旨在探讨在不同手术方法下,颧骨种植体与牙槽骨之间的三维接触面积对生物力学的影响:利用10名严重骨萎缩患者的锥形束计算机断层扫描(CBCT)图像,我们重建了三维上颌骨模型,并创建了相应的三维颧骨种植体模型。根据每位患者颧骨种植体的位置和角度,我们采用了两种不同的手术方法(颌外或窦内方法)。计算了三维骨与种植体接触百分比(BIC%),并进行了非线性接触有限元分析,以评估两种手术方法的三维BIC%与周围骨应力之间的关系:在颧骨种植手术中,颌外入路法(57.63%)和窦内入路法(56.49%)的全骨(包括皮质骨和松质骨)三维BIC%相似(P=0.425)。相反,与颌外入路相比,窦内入路在皮质骨接触方面(28.08%)显示出更高的 3D BIC%(21.92%)(P=0.011)。窦内入路法的三维BIC%与高骨应力之间的相关性更强,这可能是由于皮质骨接触面积增大所致:结论:窦内入路可降低骨应力,骨应力与 3D BIC% 之间的相关性更强,尤其是在皮质骨接触部位。重要的是,颧骨种植体周围皮质骨的覆盖面积极大地影响了颧骨种植体的生物力学性能。
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引用次数: 0
The detection of distomolar teeth on panoramic radiographs using different artificial intelligence models. 使用不同的人工智能模型检测全景 X 光片上的远臼齿。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-14 DOI: 10.1016/j.jormas.2024.102151
Onur Erdem Korkmaz, Hatice Guller, Ozkan Miloglu, İbrahim Yucel Ozbek, Emin Argun Oral, Mustafa Taha Guller

Purposes: One notable anomaly, presence of distomolars, arises beyond the typical sequence of the human dental system. In this study, convolutional neural networks (CNNs) based machine learning methods were employed to classify distomolar tooth existence using panoramic radiography (PR).

Methods: PRs dataset, composed of 117 subjects with distomolar teeth and 146 subjects without distomolar teeth, was constructed. These images were assessed using AlexNet, DarkNet, DenseNet, EfficientNet, GoogLeNet, ResNet, MobileNet, NasNet-Mobile, VGG, and XceptionNet frameworks for distomolar teeth existence. Considering the moderate number dataset samples, transfer learning was also utilized to improve the performance of these CNN based networks along with 5-fold cross-validation. The final classification was obtained through the fusion of the classifiers results.

Results: Performance of the experimental studies was assessed utilizing accuracy (Acc), sensitivity (sen), specificity (spe) and precision (pre) metrics. Best accuracy value of 96.2 % was obtained for the fusion of DarkNet, DenseNet, and ResNet, three best individual performing architectures, in distomolar teeth classification problem.

Conclusion and practical implications: In summary, this study has demonstrated the significant potential of CNNs in accurately detecting distomolar teeth in dental radiographs, a critical task for clinical diagnosis and treatment planning. The fusion of CNN architectures, particularly ResNet, Darknet, and DenseNet, has shown exceptional performance, pointing towards the future of artificial intelligence (AI) driven dental diagnostics. Our findings showed that these systems can help clinicians during radiologic examinations.

目的:远臼齿是一种明显的异常现象,它的存在超出了人类牙齿系统的典型序列。本研究采用基于卷积神经网络(CNNs)的机器学习方法,利用全景放射摄影(PR)对远磨牙的存在进行分类:方法:构建了由 117 名有远磨齿和 146 名无远磨齿受试者组成的 PRs 数据集。使用 AlexNet、DarkNet、DenseNet、EfficientNet、GoogLeNet、ResNet、MobileNet、NasNet-Mobile、VGG 和 XceptionNet 框架对这些图像进行了评估。考虑到数据集样本数量适中,还利用迁移学习和 5 倍交叉验证来提高这些基于 CNN 的网络的性能。最终的分类结果是通过融合分类器的结果得出的:利用准确度(Acc)、灵敏度(sen)、特异度(spe)和精确度(pre)指标评估了实验研究的性能。在远磨牙分类问题中,DarkNet、DenseNet 和 ResNet 这三个性能最好的单独架构的融合获得了 96.2% 的最佳准确率:总之,本研究证明了 CNN 在准确检测牙科 X 射线照片中的远磨齿方面的巨大潜力,而远磨齿是临床诊断和治疗计划中的一项关键任务。CNN 体系结构的融合,尤其是 ResNet、Darknet 和 DenseNet 的融合,显示出卓越的性能,为人工智能(AI)驱动的牙科诊断的未来指明了方向。我们的研究结果表明,这些系统可以在放射检查中帮助临床医生。
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引用次数: 0
Facing a new reality: Significant increase in necrotizing fasciitis in the post-COVID era? 面对新现实:后科维德时代坏死性筋膜炎病例大幅增加?
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-13 DOI: 10.1016/j.jormas.2024.102145
O da Costa Senior, E Van de Casteele, G Van Hemelen, N Nadjmi, H Vercruysse

Background: Necrotizing fasciitis (NF) is a rare, rapidly progressing soft tissue infection characterized by the widespread necrosis of fascial planes and surrounding tissues.

Material and methods: We discuss four consecutive necrotizing fasciitis cases of the head and neck region, that accrued in a time window of 6 months. Patient demographics, clinical features, laboratory analyses, imaging findings, surgical interventions, and outcome were collected, assessed and discussed. These findings were checked against recent epidemiological data of invasive Group A Streptococcus (iGAS) in Europe.

Results: Four patients (two males and two females) aged between 31 and 65 years were included. The most common presenting symptom was severe pain and facial swelling (100 %), followed by fever (50 %) and erythema (50 %). All patients underwent emergency surgical debridement, and broad-spectrum antimicrobial therapy was initiated promptly. Streptococcus pyogenes was isolated in every patient. Three patients required multiple debridement procedures, and one case necessitated extensive neck resection due to the involvement of deeper structures. Overall, two patients recovered with no to minor residual deficits, one patient experienced persistent trismus and one patient passed away due to septic shock and multiorgan failure.

Conclusion: Prevalence of iGAS infections have increased in European countries, therefore increased vigilance is recommended so that a quick diagnosis can be established and appropriate treatment can be administered to avoid serious morbidity and mortality.

背景:坏死性筋膜炎(NF坏死性筋膜炎(NF)是一种罕见的、进展迅速的软组织感染,其特点是筋膜平面和周围组织广泛坏死:我们讨论了在 6 个月内连续发生的 4 例头颈部坏死性筋膜炎病例。我们收集、评估并讨论了患者的人口统计学特征、临床特征、实验室分析、影像学检查结果、手术干预和治疗效果。这些结果与欧洲侵袭性 A 群链球菌(iGAS)的最新流行病学数据进行了核对:共纳入四名患者(两男两女),年龄在 31 岁至 65 岁之间。最常见的首发症状是剧烈疼痛和面部肿胀(100%),其次是发热(50%)和红斑(50%)。所有患者均接受了急诊手术清创,并迅速开始了广谱抗菌治疗。每位患者都分离出了化脓性链球菌。三名患者需要进行多次清创手术,其中一例患者因累及深层结构而需要进行大面积颈部切除术。总的来说,两名患者痊愈后没有或仅有轻微的后遗症,一名患者出现持续性三足畸形,一名患者因脓毒性休克和多器官功能衰竭而去世:结论:iGAS 感染在欧洲国家的发病率有所上升,因此建议提高警惕,以便快速确诊并进行适当治疗,避免严重的发病率和死亡率。
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引用次数: 0
Ocular complications associated with inferior dental nerve block: A systematic review. 与牙下神经阻滞相关的眼部并发症:系统综述。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-12 DOI: 10.1016/j.jormas.2024.102141
Pablo Andrés Crespo-Reinoso, Erika Paola Padilla-Viñanzaca, Jessica Daniela Peralta-Quezada

Ocular complications associated with anesthesia of the lower dental nerve may arise during or after administration of the local anesthetic, whether temporary or permanent. This situation generates concern for both the clinician and the patient. The purpose of this article is to identify ocular complications related to lower dental nerve block, analyzing signs, symptoms, gender, age, type of procedure, and duration of complications.

Methods: In September 2023, we conducted a systematic review using various databases, such as PubMed, ScienceDirect, and Google Scholar, using relevant search terms. There were no restrictions on the date or language of the articles.

Results: We identified 39 articles that met the selection criteria, covering an analysis of 45 cases. Complications showed a higher incidence in women, with 65.11 %, compared to 34.8 % in men. The most frequent ocular complications reported were diplopia (44 %), amaurosis (28 %) and eyelid ptosis (17.77 %).

Conclusions: Ocular complications related to lower tooth nerve block are rare, but they can occur. A higher incidence is observed in women than in men, and there is no specific age that predominates in its appearance. Diplopia is the most common ocular complication, followed by amaurosis, eyelid ptosis, and blurred vision. These complications may manifest during the infiltration of the anesthetic, immediately after the procedure, or a few hours later.

与下牙神经麻醉相关的眼部并发症可能会在使用局麻药期间或之后出现,无论是暂时性的还是永久性的。这种情况会引起临床医生和患者的担忧。本文旨在确定与下牙神经阻滞相关的眼部并发症,分析并发症的体征、症状、性别、年龄、手术类型和持续时间:2023 年 9 月,我们利用 PubMed、ScienceDirect 和 Google Scholar 等多个数据库,使用相关检索词进行了系统性综述。对文章的日期和语言没有限制:我们找到了 39 篇符合筛选标准的文章,对 45 个病例进行了分析。女性的并发症发生率较高,为 65.11%,而男性为 34.8%。最常见的眼部并发症是复视(44%)、眼睑下垂(17.77%):结论:与下齿神经阻滞相关的眼部并发症虽然罕见,但也有可能发生。结论:与下齿神经阻滞相关的眼部并发症很少见,但也有可能发生。女性的发病率高于男性,而且没有特定的主要发病年龄。复视是最常见的眼部并发症,其次是眼球突出、眼睑下垂和视力模糊。这些并发症可能在注射麻醉剂时、手术后立即或几小时后出现。
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引用次数: 0
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Journal of Stomatology Oral and Maxillofacial Surgery
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