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Integrating machine learning with web-based tools for personalized prognosis in oral adenoid cystic carcinoma. 将机器学习与基于网络的工具相结合,对口腔腺样囊性癌进行个性化预后分析。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-08 DOI: 10.1016/j.jormas.2024.102143
Sakhr Alshwayyat, Mesk Alkhatib, Hebah Almahariq, Mustafa Alshwayyat, Tala Abdulsalam Alshwayyat, Hamza Al Salieti, Lina Khasawneh

Background: Adenoid cystic carcinoma (ACC) of the oral cavity is a rare head and neck cancer. This rarity contributes to the paucity of comprehensive research on this cancer thereby complicating the development of evidence-based treatment strategies. This study aims to use machine learning (ML) techniques to analyze survival outcomes and optimize treatment approaches of ACC.

Methods: The SEER database (2000-2020) was used in this study. Cox regression analysis was used to identify the prognostic variables; prognostic models using five ML algorithms were constructed to predict the 5-year survival rates. A validation method incorporating the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to validate the accuracy and reliability of ML models. Also, Kaplan-Meier survival analysis was performed.

Results: This study's sample included 645 patients. The most common primary site for ACC was the hard palate, followed by the cheek mucosa. Survival rates varied across treatment groups, with the highest rates observed in patients who underwent surgery only. ML models revealed that the most significant prognostic factors were age, metastasis, and surgery.

Conclusions: This study contributes evidence and knowledge to the limited literature on ACC and emphasizes the importance of adjuvant radiotherapy. This study highlights that metastasis and age are key prognostic factors. Furthermore, the developed ML-based web tool offers a novel approach for the personalized prognosis of these rare cancer types.

背景:口腔腺样囊性癌(ACC)是一种罕见的头颈部癌症:口腔腺样囊性癌(ACC)是一种罕见的头颈部癌症。这种罕见性导致对这种癌症的综合研究很少,从而使循证治疗策略的制定变得复杂。本研究旨在利用机器学习(ML)技术分析 ACC 的生存结果并优化治疗方法:本研究使用了 SEER 数据库(2000-2020 年)。方法:本研究使用 SEER 数据库(2000-2020 年),采用 Cox 回归分析确定预后变量;使用五种 ML 算法构建预后模型,预测 5 年生存率。研究采用接收者操作特征曲线(ROC)曲线下面积(AUC)的验证方法来验证 ML 模型的准确性和可靠性。此外,还进行了 Kaplan-Meier 生存分析:本研究的样本包括 645 名患者。ACC最常见的原发部位是硬腭,其次是颊粘膜。不同治疗组的存活率各不相同,仅接受手术治疗的患者存活率最高。ML模型显示,最重要的预后因素是年龄、转移和手术:本研究为有限的 ACC 文献提供了证据和知识,并强调了辅助放疗的重要性。本研究强调,转移和年龄是关键的预后因素。此外,所开发的基于 ML 的网络工具为这些罕见癌症类型的个性化预后提供了一种新方法。
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引用次数: 0
Impact of contralateral occult neck metastasis in HPV-associated tonsil cancer: Is elective contralateral neck dissection required? HPV 相关扁桃体癌对侧隐性颈部转移的影响:是否需要进行选择性对侧颈部切除?
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-07 DOI: 10.1016/j.jormas.2024.102140
Geun-Jeon Kim, Jooin Bang, Oh-Hyeong Lee, Sang-Yeon Kim, Dong-Il Sun

Background: Contralateral elective neck dissection in human papillomavirus (HPV)- associated tonsil cancer is a matter of debate.

Objectives: The aim of this study was to analyze rates of contralateral lymph node (LN) metastasis and their prognostic effects on HPV-associated tonsil cancer. We also assessed the necessity of elective contralateral neck dissection.

Methods: To investigate the pathologic incidence of and risk factors for contralateral nodal disease in HPV-associated tonsil cancer treated with upfront primary surgery and bilateral neck dissection, the records of 68 patients were reviewed.

Results: Six (8.8%) patients displayed pathologic contralateral nodal disease; four of the patients had LN metastasis confirmed in contralateral level II, one patient had LN metastasis in level III, and one patient had multi-level metastasis in contralateral levels II and III. Contralateral LN metastasis showed a significant association with greater depth of invasion (DOI) in primary tumor (p = 0.032), count of positive LN (p = 0.008), and positive LN ratio of the ipsilateral neck (p = 0.01). Patients with contralateral LN metastasis showed a significantly worse five-year overall survival but no significant difference in disease-free survival.

Conclusion: HPV-associated tonsil cancer has exceedingly low rates of occult contralateral LN metastasis. However, in cases of ipsilateral multiple node metastases and higher DOI, it may be worth considering elective contralateral neck dissection based on the risk of occult metastasis.

背景:人类乳头瘤病毒(HPV)相关扁桃体癌的对侧选择性颈部切除术是一个争论的问题:人乳头瘤病毒(HPV)相关扁桃体癌的对侧选择性颈部切除术是一个有争议的问题:本研究旨在分析对侧淋巴结(LN)转移率及其对HPV相关扁桃体癌预后的影响。我们还评估了选择性对侧颈部切除的必要性:方法:为了研究采用前期原发手术和双侧颈部切除术治疗的 HPV 相关性扁桃体癌中对侧结节病的病理发生率和风险因素,我们回顾了 68 例患者的病历:结果:6 名患者(8.8%)出现了病理上的对侧结节病;其中 4 名患者的 LN 转移证实发生在对侧 II 层,1 名患者的 LN 转移发生在 III 层,1 名患者的对侧 II 层和 III 层出现了多层次转移。对侧淋巴结转移与原发肿瘤侵犯深度(DOI)(P=0.032)、阳性淋巴结数量(P=0.008)和同侧颈部阳性淋巴结比例(P=0.01)显著相关。有对侧LN转移的患者五年总生存率明显较低,但无病生存率无明显差异:结论:HPV相关性扁桃体癌的隐匿性对侧LN转移率极低。结论:HPV相关性扁桃体癌的隐匿性对侧LN转移率极低,但在同侧多发结节转移和DOI较高的病例中,值得根据隐匿性转移的风险考虑选择性对侧颈部切除。
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引用次数: 0
The role of patients' understanding of the pathophysiology in improving their symptoms in Burning Mouth Syndrome: A cohort study. 患者对病理生理学的理解对改善烧灼感综合征症状的作用:一项队列研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-06 DOI: 10.1016/j.jormas.2024.102135
Donadon Elisa, Lassaux Victoire, Boutin François, Aterkoui Ouassila, Torres Jacques-Henri

Introduction: Burning Mouth Syndrome (BMS) can present with a variety of oral mucosal symptoms such as burning, discomfort, xerostomia, dysgeusia, involving part or all of the mouth and lips but without visible lesions. This study assesses the patients' understanding of the pathophysiology of their condition and that influence on their outcome.

Material and methods: A single-center, observational, retrospective study was conducted. 136 patients diagnosed with BMS between February 2019 and September 2023 were recruited with follow-up in October 2023.

Results: Patients' understanding of their diagnosis and symptom improvement were statistically associated in both univariate (OR 7.25; CI 2.26-32.5) and multivariate analyses (OR 4.94; CI 1.31-24.6). A significant association was also found between a shorter history of symptoms and improvement.

Conclusion: A patient's understanding of their condition appears to benefit their outcome.

简介烧灼感口腔综合征(BMS)可表现为各种口腔黏膜症状,如烧灼感、不适、口腔干燥症、口腔溃疡,可涉及部分或全部口腔和嘴唇,但无明显病变。本研究评估了患者对其病理生理学的理解及其对治疗结果的影响:本研究是一项单中心、观察性、回顾性研究。招募了 136 名在 2019 年 2 月至 2023 年 9 月期间被诊断为 BMS 的患者,并于 2023 年 10 月进行了随访:在单变量分析(OR 7.25;CI 2.26-32.5)和多变量分析(OR 4.94;CI 1.31-24.6)中,患者对诊断的理解与症状改善之间存在统计学关联。此外,病史较短与病情改善之间也存在明显关联:结论:患者对自身病情的了解似乎有利于其治疗效果。
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引用次数: 0
Incidence of caries and pathological findings in different positions of impacted third molars: A retrospective analysis. 影响第三磨牙不同位置的龋病发生率和病理结果:回顾性分析
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-06 DOI: 10.1016/j.jormas.2024.102137
Yunus Balel, Havva Nur Bülbül, Süleyman Said Aşar, Aslı Başal

Objectives: Impacted third molars(3 M), commonly known as wisdom teeth, are prone to caries and pathological formations depending on their position in the jaw. This study aimed to determine and compare the incidence of caries, pathological formations, and the superposition of the roots of the mandibular impacted third molar over the mandibular canal in different positions of impacted 3Ms.

Meterials and methods: This retrospective study was conducted on orthopantomographs of patients who presented with 3 M complaints at the Tokat Gaziosmanpaşa University Oral and Maxillofacial Surgery Department between 2019 and 2023. The 3 M were classified according to their position by two researchers independently and were evaluated for caries, pathology, and nerve superposition. The position of the 3Ms classified using Pell and Gregory and Winter's classifications. The primary outcome variable was the presence of caries in the 3 M The secondary outcome variable was the presence of pathological formations around the 3 M The tertiary outcome variable was the superposition of the roots of the mandibular 3 M over the mandibular canal.

Results: A total of 7,038 patients were included in the study, with 53.74 % being female. The mean age was 32.15±7.2 years. The highest incidence of caries was associated with the vertical position in both maxillary and mandibular 3Ms (right maxillary: 9.98 %, P < 0.001; left maxillary: 12.74 %, P < 0.001; left mandibular: 11.66 %, p = 0.003; right mandibular: 11.69 %, p = 0.031). Pathological formations were most commonly observed in the vertical position, but the highest incidence was found in the horizontal or mesioangular positions (right maxillary: 36.84 %, p < 0.001; left maxillary: 40 %, p < 0.001; left mandibular: 62.04 %, p < 0.001; right mandibular: 62.25 %, p < 0.001). Nerve superposition was most common in the vertical position but was highest in the distoangular position (left mandibular: 74.69 %, p < 0.001; right mandibular: 76.66 %, p < 0.001).

Conclusions: The position of 3Ms plays a critical role in the development of complications such as caries and pathological formations. Prophylactic extraction may be considered more seriously in cases where the position of the tooth poses a higher risk of complications.

目的:撞击性第三磨牙(3M)俗称智齿,根据其在颌骨中的位置不同,容易发生龋齿和病变。本研究旨在确定和比较不同位置的阻生第三磨牙的龋齿发生率、病理形态以及下颌阻生第三磨牙的牙根与下颌管的重叠情况:这项回顾性研究对 2019 年至 2023 年期间在托卡特加齐奥斯曼帕萨大学口腔颌面外科就诊的 3M 主诉患者的正侧位片进行了研究。两名研究人员根据 3M 的位置对其进行了独立分类,并对龋齿、病理和神经重叠进行了评估。3Ms 的位置采用佩尔和格雷戈里以及温特的分类法进行分类。主要结果变量是 3M 是否存在龋齿。二级结果变量是 3M 周围是否存在病理形态。三级结果变量是下颌 3M 的牙根与下颌管的重叠情况:研究共纳入了 7038 名患者,其中 53.74% 为女性。平均年龄为(32.15±7.2)岁。上颌和下颌 3Ms 垂直位置的龋病发生率最高(右上颌:9.98%,PC 结论:上颌和下颌 3Ms 垂直位置的龋病发生率最高,PC 结论:上颌和下颌 3Ms 垂直位置的龋病发生率最高:3Ms的位置对龋病和病理形成等并发症的发生起着关键作用。如果牙齿的位置引起并发症的风险较高,则应更认真地考虑预防性拔牙。
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引用次数: 0
Does radiofrequency ablation reduce pain and improve maximal incisal opening more effectively than electrocautery in temporomandibular joint arthroscopy? A pilot study. 在颞下颌关节镜手术中,射频消融是否比电灼更有效地减轻疼痛和改善最大切迹开度?一项试点研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-05 DOI: 10.1016/j.jormas.2024.102138
Brunno di Azevedo Abdalla Barbosa, Patricia Radaic, Luís Eduardo Charles Pagotto, Lilian Dos Santos Freitas, Gabriel Pires Pastore

Objective: The study compared the effectiveness of radiofrequency and electrocautery techniques in TMJ arthroscopic surgeries by evaluating changes in pain levels and maximal incisal opening before surgery and throughout a 30-day postoperative period.

Materials and methods: This prospective, randomized controlled trial included 62 patients with bilateral TMJ disorders classified as Wilkes stages III and IV. Patients were randomly assigned to two groups: Group 1 (n = 31) underwent arthroscopy with electrocautery, and Group 2 (n = 31) received radiofrequency ablation. Inclusion criteria were patients with Wilkes stages III or IV TMJ disorders. Exclusion criteria included previous TMJ surgery, significant systemic disease, or contraindications to surgery. Pain levels were assessed using the McGill Pain Questionnaire, and maximal incisal opening was measured preoperatively and up to 30 days postoperatively.

Results: The sample included 62 subjects with a mean age of 33.5 years, 80.6% female. The electrocautery group showed significantly greater maximal incisal opening at 12 h, 7 days, and 14 days post-surgery compared to the radiofrequency ablation group. Pain levels did not differ significantly between groups, though the electrocautery group reported higher pain scores on postoperative day 14. Both groups showed similar pain improvement and maximal incisal opening changes over 30 days, with a trend towards more improvement in maximal incisal opening in the radiofrequency ablation group. No significant differences in complications or overall pain improvement were observed.

Conclusion: Electrocautery and radiofrequency did not differ in postoperative pain outcomes; however, electrocautery was more effective in improving maximal incisal opening up to postoperative day 14.

目的:该研究通过评估术前和术后 30 天内疼痛程度和最大切口开度的变化,比较射频和电灼技术在颞下颌关节镜手术中的有效性:这项前瞻性随机对照试验包括 62 名双侧颞下颌关节紊乱的患者,这些患者被划分为威尔克斯 III 期和 IV 期。患者被随机分配到两组:第一组(31 人)接受关节镜电灼术,第二组(31 人)接受射频消融术。纳入标准为威尔克斯 III 期或 IV 期颞下颌关节紊乱症患者。排除标准包括曾接受过颞下颌关节手术、严重的全身性疾病或手术禁忌症。使用麦吉尔疼痛问卷评估疼痛程度,并在术前和术后30天内测量最大切口开度:样本包括 62 名受试者,平均年龄为 33.5 岁,80.6% 为女性。与射频消融组相比,电灼组在术后 12 小时、7 天和 14 天的最大切口开度明显更大。虽然电灼组在术后第 14 天的疼痛评分较高,但两组的疼痛程度并无明显差异。两组的疼痛改善程度和最大切口开度在 30 天内的变化相似,但射频消融组的最大切口开度有更大改善的趋势。并发症和总体疼痛改善情况无明显差异:结论:电灼术和射频消融术在术后疼痛结果上没有差异;但电灼术在改善术后第 14 天的最大切迹开度方面更有效。
{"title":"Does radiofrequency ablation reduce pain and improve maximal incisal opening more effectively than electrocautery in temporomandibular joint arthroscopy? A pilot study.","authors":"Brunno di Azevedo Abdalla Barbosa, Patricia Radaic, Luís Eduardo Charles Pagotto, Lilian Dos Santos Freitas, Gabriel Pires Pastore","doi":"10.1016/j.jormas.2024.102138","DOIUrl":"10.1016/j.jormas.2024.102138","url":null,"abstract":"<p><strong>Objective: </strong>The study compared the effectiveness of radiofrequency and electrocautery techniques in TMJ arthroscopic surgeries by evaluating changes in pain levels and maximal incisal opening before surgery and throughout a 30-day postoperative period.</p><p><strong>Materials and methods: </strong>This prospective, randomized controlled trial included 62 patients with bilateral TMJ disorders classified as Wilkes stages III and IV. Patients were randomly assigned to two groups: Group 1 (n = 31) underwent arthroscopy with electrocautery, and Group 2 (n = 31) received radiofrequency ablation. Inclusion criteria were patients with Wilkes stages III or IV TMJ disorders. Exclusion criteria included previous TMJ surgery, significant systemic disease, or contraindications to surgery. Pain levels were assessed using the McGill Pain Questionnaire, and maximal incisal opening was measured preoperatively and up to 30 days postoperatively.</p><p><strong>Results: </strong>The sample included 62 subjects with a mean age of 33.5 years, 80.6% female. The electrocautery group showed significantly greater maximal incisal opening at 12 h, 7 days, and 14 days post-surgery compared to the radiofrequency ablation group. Pain levels did not differ significantly between groups, though the electrocautery group reported higher pain scores on postoperative day 14. Both groups showed similar pain improvement and maximal incisal opening changes over 30 days, with a trend towards more improvement in maximal incisal opening in the radiofrequency ablation group. No significant differences in complications or overall pain improvement were observed.</p><p><strong>Conclusion: </strong>Electrocautery and radiofrequency did not differ in postoperative pain outcomes; however, electrocautery was more effective in improving maximal incisal opening up to postoperative day 14.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102138"},"PeriodicalIF":2.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mandibular growth following distraction osteogenesis in children with craniofacial microsomia from a skeletal units perspective. 从骨骼单位的角度看颅面微畸形儿童牵引成骨术后的下颌骨生长。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-05 DOI: 10.1016/j.jormas.2024.102136
Xiyuan Li, Zhiyong Zhang, Liu Wei

Background: Mandibular growth following distraction osteogenesis (DO) in patients with craniofacial microsomia (CFM) remains unclear. We aimed to investigate both the short- and long-term effects of DO on mandibular growth in children with Pruzansky-Kaban type IIA CFM based on skeletal units.

Materials and methods: We collected computed tomography data from 15 children with CFM preoperatively(T0), immediately after distractor removal(T1), and 4-6 years after distractor removal(T2). Measurements were taken to assess the size and orientation of the skeletal units. Linear and angular measurements were analyzed to evaluate the short- and long-term effects of DO. Bilateral differences in growth rates (GRs) for each unit between T1 and T2 were assessed.

Results: Preoperatively, the affected side exhibited smaller condylar and body units than the unaffected side. From T0 to T1, there was a significant increase in the body unit and normalization of the skeletal unit orientation on the affected side. However, from T1 to T2, the GRs of the units on the affected side were significantly slower than those on the unaffected side. Although the condylar and body unit length on the affected side did not show statistically significant increases, the angular unit length decreased. Relapses were also observed in the alignment of the units on the affected side.

Conclusions: Our findings suggest a potential long-term inhibitory effect of early DO on mandibular growth in children with CFM. This issue requires further attention as strategies to promote the growth of skeletal units following DO are critical for optimal long-term treatment outcomes.

背景:颅面显微畸形(CFM)患者牵张成骨(DO)后的下颌骨生长情况仍不清楚。我们的目的是根据骨骼单位研究牵张成骨术对普鲁赞斯基-卡班 IIA 型 CFM 患儿下颌骨生长的短期和长期影响:我们收集了15名CFM患儿术前(T0)、移除牵引器后(T1)和移除牵引器后4-6年(T2)的计算机断层扫描数据。测量结果用于评估骨骼单位的大小和方向。对线性和角度测量进行分析,以评估DO的短期和长期影响。评估了T1和T2期间每个单元的双侧生长率(GRs)差异:结果:术前,患侧的髁突和体单位比未受影响的一侧小。从 T0 到 T1,患侧的体单位显著增加,骨骼单位方向趋于正常。然而,从 T1 到 T2,患侧单位的 GRs 明显慢于未受影响的一侧。虽然患侧的髁状突和体部单位长度没有出现统计学意义上的显著增加,但角度单位长度却有所减少。受影响一侧的单位排列也出现了复发:我们的研究结果表明,早期 DO 对 CFM 患儿的下颌骨生长有潜在的长期抑制作用。这个问题需要进一步关注,因为在 DO 之后促进骨骼单位生长的策略对于获得最佳的长期治疗效果至关重要。
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引用次数: 0
A molecular viewpoint of the intricate relationships among HNSCC, HPV infections, and the oral microbiota dysbiosis. 从分子角度看 HNSCC、HPV 感染和口腔微生物群失调之间错综复杂的关系。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-11-03 DOI: 10.1016/j.jormas.2024.102134
Kaviyarasi Renu

HPV infection and the type of host microbiota play a role in the formation of HNCs. In contrast to other forms of OSCC, where the relationship between HPV and the cancer is less obvious, HPV-HNSCC is a particular type of oropharyngeal cancer. HPV has infected a stratified squamous epithelium, which includes the throat, mouth, anogenital tract, respiratory tract, and skin on the hands and feet. HPV DNA was found in high amounts in the saliva and gargle samples of patients with HPV-related HNSCC. It has been discovered that the specificity of oral mRNA (HPV) and HPV DNA identification varies from 23 % to 82 % in the identification of OPSCCs. The higher rate of HPV transmission through vaginal-oral compared to penile-oral sexual activity may be the reason for the difference in HPV-positive HNSCC patients between males and females. The researchers postulate that HPV-inactive tumours signify an advanced stage of HPV-positive HNSCC, which explains why there are racial disparities in gene expression that correspond to different disease progressions in Black and White patients. The increase of CD8+ T cells in the cancer microenvironment, linked to P16 activation, extends life expectancy in OSCC. tumour markers methylation caused by HPV and suggested using them as possible HNC biomarkers. Fusobacterium levels are much higher in patients with OSCC, while Actinobacteria phylum and Firmicutes are significantly lower. It also serves as a biomarker for notable variations found in Firmicutes, Actinobacteria, Fusobacteriales, Fusobacteriia, Fusobacterium, and Fusobacteriaceae. Therefore, based on this we evidence, we could investigate the role of oral microbiota as a maker for the HPV associated HNSCC.

人乳头瘤病毒感染和宿主微生物群的类型在 HNC 的形成过程中起着一定的作用。与其他形式的口咽癌(OSCC)相比,HPV 与癌症之间的关系并不明显,HPV-HNSCC 是口咽癌的一种特殊类型。HPV 感染了分层鳞状上皮,包括咽喉、口腔、生殖道、呼吸道和手足皮肤。在 HPV 相关 HNSCC 患者的唾液和漱口水样本中发现了大量的 HPV DNA。研究发现,口腔 mRNA(HPV)和 HPV DNA 鉴定在 OPSCC 鉴定中的特异性从 23% 到 82% 不等。与阴茎-口腔性行为相比,HPV 通过阴道-口腔的传播率更高,这可能是男性和女性 HPV 阳性 HNSCC 患者之间存在差异的原因。研究人员推测,HPV活性肿瘤标志着HPV阳性HNSCC的晚期阶段,这也解释了为什么黑人和白人患者的基因表达存在种族差异,对应着不同的疾病进展。癌症微环境中 CD8+ T 细胞的增加与 P16 激活有关,可延长 OSCC 的预期寿命。在 OSCC 患者中,Fusobacterium 的水平要高得多,而放线菌门和真菌门则明显较低。它也是一种生物标记物,可用于检测在固缩菌门、放线菌门、镰刀菌门、镰刀菌科、镰刀菌属和镰刀菌科中发现的显著变异。因此,基于这些证据,我们可以研究口腔微生物群在人乳头瘤病毒相关 HNSCC 中的作用。
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引用次数: 0
Automatic detection of temporomandibular joint osteoarthritis radiographic features using deep learning artificial intelligence. A Diagnostic accuracy study. 利用深度学习人工智能自动检测颞下颌关节骨关节炎的影像学特征。诊断准确性研究。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-10-31 DOI: 10.1016/j.jormas.2024.102124
Louloua Mourad, Nayer Aboelsaad, Wael M Talaat, Nada M H Fahmy, Hams H Abdelrahman, Yehia El-Mahallawy

Objective: The purpose of this study was to investigate the diagnostic performance of a neural network Artificial Intelligence model for the radiographic confirmation of Temporomandibular Joint Osteoarthritis in reference to an experienced radiologist.

Materials and methods: The diagnostic performance of an AI model in identifying radiographic features in patients with TMJ-OA was evaluated in a diagnostic accuracy cohort study. Adult patients elected for radiographic examination by the Diagnostic Criteria for Temporomandibular Disorders decision tree were included. Cone-beam computed Tomography images were evaluated by object detection YOLO deep learning model. The diagnostic performance was verified against examiner radiographic evaluation.

Results: The differences between the AI model and examiner were non-significant statistically, except in the subcortical cyst (P=0.049*). AI model showed substantial to near-perfect levels of agreement when compared to those of the examiner data. Regarding each radiographic phenotype, the AI model reported favorable sensitivity, specificity, accuracy, and highly statistically significant Receiver Operating Characteristic (ROC) analysis (p<0.001). Area Under Curve ranged from 0.872, for surface erosion, to 0.911 for subcortical cyst.

Conclusion: AI object detection model could open the horizon for a valid, automated, and convenient modality for TMJ-OA radiographic confirmation and radiomic features identification with a significant diagnostic power.

研究目的本研究的目的是参照经验丰富的放射科医生,研究神经网络人工智能模型在颞下颌关节骨关节炎放射学确诊方面的诊断性能:在一项诊断准确性队列研究中,评估了人工智能模型在识别颞下颌关节骨关节炎患者放射学特征方面的诊断性能。研究对象包括根据颞下颌关节紊乱诊断标准决策树选择进行放射学检查的成人患者。锥形束计算机断层扫描图像由物体检测 YOLO 深度学习模型进行评估。诊断结果与检查员的放射学评估结果进行了验证:除皮质下囊肿外(P=0.049*),人工智能模型与检查者之间的差异在统计学上不显著。与检查者的数据相比,人工智能模型显示出相当接近完美的一致性。就每种放射学表型而言,人工智能模型都具有良好的灵敏度、特异性和准确性,其接收者操作特征(ROC)分析具有高度统计学意义(P < 0.001)。曲线下面积从表面侵蚀的 0.872 到皮质下囊肿的 0.911 不等:结论:人工智能物体检测模型可为颞下颌关节-颌面关节放射影像学确认和放射学特征识别提供有效、自动化和便捷的模式,并具有显著的诊断能力。
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引用次数: 0
Open reduction and internal fixation of mandibular condyle fractures using AUTOFIX 2.0® cannulated compression screw system: A technical innovation with intraoperative CT-scan. 使用 AUTOFIX 2.0® 套管加压螺钉系统进行下颌骨髁突骨折的切开复位和内固定术:术中CT扫描技术创新。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-10-31 DOI: 10.1016/j.jormas.2024.102133
Alexandra Delay, Matthieu Olivetto, Georges Bettega, Déborah Dehaene, Rodolphe Lartizien

Condylar process fractures remain a matter of ongoing controversy in maxillofacial surgery because of variety of opinions and proposed treatment modalities offered in the literature. The trend is toward open reduction and internal fixation (ORIF) whenever there is displacement or dislocation combined with unstable occlusal conditions. The fundamental treatment goals are anatomical fixation and early return to function. However, ORIF of a fractured condyle carries significant risks, including facial nerve damage, and presents challenges in reducing and stabilizing the fractured segment in an area of limited access. We present here an innovative technique for ORIF of condylar head fractures. It consists in fracture reduction and stabilization with two Kirschner wires followed by osteosynthesis with two cannulated headless compression screws using the AUTOFIX 2.0® system (Stryker, Kalamazoo, USA). This new technique, combined with intraoperative CT scan, ensures satisfactory reduction and stabilization of the dislocated joint segment, thereby restoring the condyle to its physiologically normal position.

在颌面外科领域,髁突骨折一直是一个存在争议的问题,因为各种观点和文献中提出的治疗方法各不相同。目前的趋势是,只要出现移位或脱位,同时咬合条件不稳定,就应采取切开复位内固定术(ORIF)。基本的治疗目标是解剖固定和尽早恢复功能。然而,髁突骨折的口内固定术具有很大的风险,包括面神经损伤,而且在有限的区域内缩小和稳定骨折段也是一项挑战。我们在此介绍一种创新的髁状突头部骨折切开复位术。该技术包括使用两根 Kirschner 钢丝进行骨折复位和稳定,然后使用 AUTOFIX 2.0® 系统(美国卡拉马祖,史赛克公司)的两根插管无头加压螺钉进行骨合成。这项新技术与术中 CT 扫描相结合,确保了对脱位关节段进行令人满意的缩小和稳定,从而使髁状突恢复到生理正常位置。
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引用次数: 0
Clinicopathological analysis of hybrid carcinomas of the salivary glands: A systematic review. 唾液腺混合癌的临床病理分析:系统综述。
IF 2.2 3区 医学 Q2 Dentistry Pub Date : 2024-10-31 DOI: 10.1016/j.jormas.2024.102132
Talita de Carvalho Kimura, Reydson Alcides de Lima-Souza, Luccas Lavareze, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

Hybrid carcinomas (HC) are the association of two or more malignant neoplasms arising within the same topographical area. The present study is a systematic review of HC of the salivary glands. This study aimed to assess HC clinicopathological features and molecular profile. Observational studies, case series, and case reports were included. PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched until June 2024. A total of 18 articles including 34 patients were included. HC of the salivary glands is presented as a painless mass affecting mainly the parotid gland of adults with a preference for male patients. Histologically, adenoid cystic carcinoma and epithelial-myoepithelial carcinoma were the most prevalent association, being surgical excision with radiotherapy the most common treatment. The most aggressive component, even when representing only a small proportion of the tumor, should guide the patient's treatment. Further molecular studies are necessary to determine if HC are distinct entities or biologically identical to the individual neoplasms. In conclusion, this systematic review may contribute to a better understanding of this rare lesion, their biological behavior, treatments employed, and the outcome of these patients.

混合癌(HC)是指在同一地形区域内出现的两种或两种以上恶性肿瘤。本研究对唾液腺混合癌进行了系统回顾。本研究旨在评估唾液腺肿瘤的临床病理特征和分子特征。研究纳入了观察性研究、系列病例和病例报告。研究人员检索了 PubMed、Scopus、EMBASE、Lilacs、Web of Science 和灰色文献,检索期至 2024 年 6 月。共纳入 18 篇文章,包括 34 名患者。唾液腺 HC 主要表现为影响成人腮腺的无痛性肿块,好发于男性患者。从组织学角度看,腺样囊性癌和上皮-肌上皮癌是最常见的癌种,手术切除和放射治疗是最常见的治疗方法。由此可见,最具侵袭性的成分可能会指导患者的治疗和预后。有必要进行进一步的分子研究,以确定 HC 是不同的实体,还是在生物学上与单个肿瘤相同。总之,本系统综述有助于更好地了解这种罕见病变、其生物学行为、采用的治疗方法以及这些患者的预后。
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Journal of Stomatology Oral and Maxillofacial Surgery
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