Journal of Stomatology Oral and Maxillofacial Surgery最新文献

Introduction: The relationship between vertical facial patterns and the morphology of the alveolar bone and teeth is crucial for successful orthodontic treatment planning. This study aimed to evaluate the relationship between vertical facial patterns, bone thickness, and root-crown dimensions in the maxillary anterior teeth.

Methods: This retrospective study screened 300 cone-beam computed tomography (CBCT) scans of orthodontic patients between December 2022 and November 2023, with 115 meeting the inclusion criteria. Buccal and lingual alveolar bone thickness, along with crown and root lengths of maxillary anterior teeth, were measured and compared across short, normal, and long facial types, classified according to the Frankfort-Mandibular Plane Angle. One-way ANOVA, independent-samples Kruskal-Wallis, and post-hoc tests were used for statistical analysis.

Results: Significant differences in alveolar bone thickness were observed across facial types, with short facial types showing consistently greater thickness in the apical and mid-palatal regions compared to normal and long facial types (p < 0.05). No significant differences in crown or root lengths were found among the facial types.

Conclusion: Facial type significantly influences alveolar bone thickness, particularly in short facial types, which demonstrate greater bone support. These findings underscore the importance of considering facial type in orthodontic treatment planning to minimize complications.

Objectives: Unilateral condylar hyperplasia (UCH), marked by progressive condylar growth, occurs between ages 11-30 with unclear etiology. This retrospective study aims to clarify the clinical, radiographic, and demographic features of UCH to improve its diagnosis and treatment.

Material and methods: Data for all patients included in this study were retrieved from the archive. Inclusion criteria were the diagnosis of UCH supported by a positive bone scan above 10% of condylar uptake in SPECT/CT, the patient's history of progressive facial asymmetry, symptoms confirmed by the orthodontist during follow-up, and clinical and radiological evaluation. Demographic characteristics, along with volumetric and linear measurements, were statistically evaluated.

Results: Forty-one patients were included in this study with 70.73% female predominance. Patients were classified as transverse and vertical type condylar hyperplasia (CH) according to their prominent asymmetry characteristics. Eighteen patients were classified as vertical type CH and 23 patients were classified as transverse type CH. Twenty had left-side condylar overgrowth, and 21 had right-side overgrowth. Condylar volume difference was significantly higher in vertical type CH patients compared to transverse type CH (p = 0.004). No correlation was found between growth rate (bone scan uptake ratio) and condylar volume difference in patients with vertical type and transverse type CH patients (p = 0.205).

Conclusion: Particularly in cases that exhibit a pronounced vertical growth tendency, volumetric and linear measurements can guide the timing and treatment planning process.

Objective: Indoleamine 2,3-dioxygenase-1 (IDO1) is a promising antitumor target and predictive biomarker in a variety of cancers. Hence, we performed this meta-analysis to evaluate the clinicopathological and prognostic significance of IDO1 in head and neck squamous cell carcinoma (HNSCC).

Methods: We searched PubMed, Embase, Web of Science and Scopus databases from inception to May 2024, to identify studies measuring the clinicopathological and prognostic significance of IDO1 in HNSCC. The role of IDO1 in HNSCC was evaluated by pooled hazard ratios (HR), odd ratios (OR) and 95% confidence intervals (CI). The meta-analysis was performed using the meta package in R. Omics analyses on IDO1 were also performed.

Results: Ten studies (1,119 participants) were included in the review. The analysis showed an insignificant relationship between IDO1 expression and poor overall survival, and progression free survival as indicated by the pooled HR (HR: 1.65, 95% CI: 0.68-4.02), (HR: 1.73, 95% CI: 0.63-4.77), respectively. Additionally, elevated expression of IDO1 was significantly associated with tumor T stage (OR: 1.44, 95% CI: 1.06-1.94). However, it was insignificantly correlated with positive lymph node metastasis (N status) (OR: 1.11; 95% CI: 0.82-1.50) and tumor-node-metastasis (TNM) stage (OR: 1.14; 95% CI: 0.79-1.64).

Conclusion: While higher IDO1 expression is associated with the risk of advanced tumor stage in HNSCC, its impact on overall and progression-free survival remains inconclusive. Further research is needed to elucidate its prognostic significance and therapeutic potential.

Introduction: The significance of facial aesthetics has been steadily rising, leading people to seek different ways to improve their looks and self-esteem. The study aimed to evaluate the differences in facial satisfaction between participants with straight and convex profiles and the relationship between facial satisfaction and the different styles of self-expression.

Materials and methods: The study was conducted from 110 extraoral profile photos of female participants. The questions in modules for FACE-QTM Aesthetic Appearance of the overall face, Craniofacial appearance of the Jaws, Teeth, Lips, and a survey regarding participants' demographic data and preferred self-expression methods were answered by the participants.

Results: Facial Convexity Angle (p = 0.001), Total Facial Convexity Angle (p = 0.001), Nasal Proportion (p = 0.007) were great; lower Third Angle (p = 0.001), Nasolabial Angle (p = 0.010), nasofacial angle (p = 0.001), and lip-chin proportion (p = 0.001) were small in participants with straight profiles. There was no significant correlation between soft tissue measurements and FACE-Q subscale scores.

Conclusion: The women with straight profiles preferred hair dyeing and nonsurgical aesthetics. Although the lip appearance was more satisfactory in the participants with a convex profile, they tended to have more piercings, tattoos, and aesthetic surgery.

Abnormal widening of the mandibular canal (MC) is rarely observed on radiography. Nonetheless, as most of the current research on abnormal mandibular widening is limited to case reports and MCs have relatively deep and hidden positions, there are challenges in diagnosing and formulating treatment plans for patients with abnormal MC widening. To provide ideas for the differential diagnosis and treatment choices of the characteristic clinical sign, this study included patients with abnormal widening of the MC between July 2014 and October 2023. The patient's medical records were reviewed, general information, disease details and radiographic features (panoramic reconstructive computed tomography) of MC widening were collected. Patients were followed up to assess treatment outcomes. In conclusion, the abnormal widening of the MC often implies a pathological state of the mandible. And different morphologies of the widened MC are helpful for differential diagnosis of protential mandibular disease.

Background: To investigate the effect of lower border osteotomy on the lingual split pattern and IAN in BSSO procedures.

Materials and methods: The study comprised 32 patients (64 operated sides) who underwent bilateral sagittal split osteotomy (BSSO) due to dentofacial abnormalities between the periods of April 2021 and April 2022. In the mandible, 32 sides (the conventional group) received standard BSSO surgery, while 32 sides (the modified group) additionally received lower border osteotomy. Data regarding the split difficulty of the mandibular in BSSO surgery and the recovery status of the inferior alveolar nerve (IAN) one year after surgery were obtained and evaluated from patient records. The fracture line was radiographically evaluated for the lingual split pattern following surgery.

Results: A statistically significant difference was observed in favor of the modified group when the mandibular split difficulty of the groups was compared (p = 0.032). The split time of the modified group was found to be statistically shorter than the conventional group (p ≤ 0.001). The mean numbness level of the modified group one year after surgery was statistically significantly lower than that of the conventional group (p = 0.019). Although there was no statistically significant difference between the two groups in terms of lingual fracture pattern, the rate of type 1 (87.5 %) fracture was higher in the modified group compared to the other group (68.8 %) (p = 0.089).

Conclusion: The lower border osteotomy performed in addition to the conventional BSSO surgery allows the split procedure easier and in a shorter time. The modification resulted in an increased incidence of type 1 lingual fracture pattern in the mandible. The neurosensory recovery capacity of the IAN in the postoperative period is higher in areas where lower-border osteotomies are performed.

Objective: To analyze the relationship between extent, severity, and rate of progression of periodontitis with the implant outcome.

Methods: Dental records of adult patients who had attended the dental clinics of the universities contributing data to the BigMouth network between 2011 and 2022 seeking implant therapy were evaluated. Patients' records were furthered examined for a periodontal diagnosis based on the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Patients were further categorized based on extent (generalized/localized), severity (stage I, II, III, IV), and rate of progression (grade A, B, C). Information including demographic characteristics, self-reported medical conditions, as well as the number of missing teeth were extracted from patients' electronic health records.

Results: Records of 50,312 dental implants placed in 20,842 patients over a 12-year period were screened. Three hundred twenty-two records of implants were placed in patients with a recorded periodontitis diagnosis based on the 2017 periodontal classification. The mean age of the cohort was 57.53±12.95 years which consisted of 52.2 % males, 74.2 % non-Hispanic, 55.9 % white individuals, 9 % diabetics, 3.4 % tobacco users. The univariate analysis demonstrated that periodontitis extent, severity, and rate of progression were not significantly associated with the treatment outcome. The implant failure rate was estimated to be 5.6 %.

Conclusions: Within the limitations of this retrospective study that utilized records of dental implants placed in institutions in the United States contributing data to the BigMouth network, the implant failure rate was estimated to be 5.6 %. Periodontitis extent, severity, and rate of progression were not significantly associated with the implant treatment outcome.

Uremic stomatitis is an underreported disease that occurs in the oral mucosa, associated with high levels of blood urea in patients with chronic kidney disease. This case report describes a 36-year-old male patient with severe and multiple oral manifestations of uremic disease. Intraoral examination revealed ulceration, atrophic and hemorrhagic areas were seen on the ventral surface of the tongue, floor of the mouth, and buccal mucosa. The treatment included hemodialysis, analgesics, and mouthwashes. After 10 days of treatment and seven hemodialysis sessions, the oral lesions were significantly better. Considering that the manifestations presented are commonly painful and debilitating for the patient early diagnosis and a treatment that comprises oral measures and kidney disease control are mandatory.

Background: The method most frequently employed to alleviate the deficiency of vertical bone volume in the maxillary posterior region is maxillary sinus augmentation. Given its importance in the field of dental implants and its possible impact on implant survival, it is crucial to assess the caliber and bibliometric characteristics of research related to maxillary sinus augmentation. This study aimed to understand the development and trends of studies and guide future studies by performing a bibliometric analysis of research related to maxillary sinus augmentation.

Methods: The Web of Science database was searched on 29.05.2024 with the developed search strategy. Articles were listed in descending order according to the number of citations and analyzed using the Bibliometrix program prepared in R base. The articles were analyzed in four sections: performance analysis, word analysis, collaboration analysis, and thematic analysis.

Results: Wang HL is the most frequently listed author on this topic with 24 h-indexes and 1686 total citations. The highest number of articles were published in 2017, with 102 articles with an average of 2.7 citations. The most popular keyword was "dental implants." with 426 usages. Italy and the USA are the countries that have published the most collaborative papers. Clinical Oral Implants Research comes at the top when evaluating the journals that publish on maxillary sinus augmentation based on the h-index. Basic research and technical-oriented studies between 1999 and 2005 have given way to more clinical and patient-oriented research.

Conclusion: This bibliometric study will serve as a guide for future research by illustrating the existing state of knowledge and limitations regarding the development of sinus lifting methods, given the constantly growing demand for implant therapy.

Background: Next generation sequencing (NGS) is a massive, high-throughput sequencing technology used to analyze various mutations and genetic changes in cancer. Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck region. OSCC usually arises from oral potentially malignant disorders, like oral leukoplakia, oral submucous fibrosis and erythroplakia, and shows mutation of tumor suppressor genes, and several other critical genes involved in apoptotic pathways, cell migration, and cell growth.

Aim: To analyze the molecular profiles of oral epithelial dysplasia and different grades of oral squamous cell carcinoma using NGS in the Indian subpopulation.

Methodology: 21 patients (5 patients each of well differentiated, moderately differentiated, poorly differentiated squamous cell carcinoma, severe epithelial dysplasia, and 1 normal appearing mucosal tissue from apparently healthy individuals) were included in the study. Next generation sequencing was carried out using 50 hotspot gene panel. Protein-protein analysis was carried out using STRING Consortium 2023 and the methylation profile of the expressed genes was evaluated using the UALCAN portal.

Results: Severe epithelial dysplasia showed TP53 (c.743G>A, p.R248Q) pathogenic mutations (SNV) in suboptimal QC parameters. Well differentiated squamous cell carcinoma showed TP53 (c.328delC, p.Arg110fs*13), APC (c.4135G>T, p.Glu1379*), and FBXW7 (c.832C>T, p.Arg278*) mutations. CTNNB1 (c.134C>T, p.Ser45PheS45F), TP53 (c.637C>T, Arg213TerR213*), NRAS (c.183A>C, p.Gln61HisQ61H) and PDGFRA (c.1672C>T, p.Arg558Cys) mutations were seen in moderately differentiated squamous cell carcinoma. No pathogenic mutations were evident in poorly differentiated squamous cell carcinoma. STRING analysis showed that all the expressed proteins in each group were interrelated to each other. No significant difference was evident in the methylation profile of all the expressed genes when compared to the normal controls.

Conclusion: The results obtained in this study explain the diverse genetic mutations in various grades of oral squamous cell carcinoma. Identification of these mutations would help in providing better treatment, designing a proper treatment plan for the patients with OSCC and support minimal intervention medicine.