Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.123009
Y. Hasegawa, Yukiko Kishimoto, Y. Kanemitsu, T. Tanabe, K. Nagahara, T. Nakamoto
Purpose: In implant treatment, the abutments and superstructures form a transmucosal area. In addition to providing appropriate cleaning instructions to patients, its material properties must be carefully considered. It is not clear how much plaque adhesion occurs at each site during treatment process, and the effect of materials on plaque adhesion. Methods: In this study, 33 patients, 13 maxillary cases and 20 mandibular cases, who had implants placed in the missing molars were evaluated for the plaque adhesion of provisional restorations made of acrylic resin and monolithic zirconia final restoration after a period of more than 4 weeks. In addition, oral hygiene instructions were thoroughly given for 12 cases at the time of staining after the provisional restorations, and re-evaluated in 4 weeks. Results: About 20% of the buc-cal-lingual area of the prosthetic device fabricated with acrylic resin showed plaque staining, whereas about 40% of the area of the mesial and distal. On the other hand, for the zirconia final restorations, the percentage of staining was about 5% for buccal and lingual surface and 10% for mesial and distal surface. The stained area ratio of the provisional restoration correlated with the zirconia superstructure area ratio. Even with careful oral hygiene, it be-came clear that the amount of plaque adhesion due to the difference in materials could not be overcome. Conclusion: The zirconia superstructure is ex-tremely good from the viewpoint of plaque adhesion, but cases with a large stained area at the time of provisional restoration should be carefully followed up.
{"title":"A Study of Plaque Adhesion during Implant Treatment of Missing Molars","authors":"Y. Hasegawa, Yukiko Kishimoto, Y. Kanemitsu, T. Tanabe, K. Nagahara, T. Nakamoto","doi":"10.4236/ojst.2022.123009","DOIUrl":"https://doi.org/10.4236/ojst.2022.123009","url":null,"abstract":"Purpose: In implant treatment, the abutments and superstructures form a transmucosal area. In addition to providing appropriate cleaning instructions to patients, its material properties must be carefully considered. It is not clear how much plaque adhesion occurs at each site during treatment process, and the effect of materials on plaque adhesion. Methods: In this study, 33 patients, 13 maxillary cases and 20 mandibular cases, who had implants placed in the missing molars were evaluated for the plaque adhesion of provisional restorations made of acrylic resin and monolithic zirconia final restoration after a period of more than 4 weeks. In addition, oral hygiene instructions were thoroughly given for 12 cases at the time of staining after the provisional restorations, and re-evaluated in 4 weeks. Results: About 20% of the buc-cal-lingual area of the prosthetic device fabricated with acrylic resin showed plaque staining, whereas about 40% of the area of the mesial and distal. On the other hand, for the zirconia final restorations, the percentage of staining was about 5% for buccal and lingual surface and 10% for mesial and distal surface. The stained area ratio of the provisional restoration correlated with the zirconia superstructure area ratio. Even with careful oral hygiene, it be-came clear that the amount of plaque adhesion due to the difference in materials could not be overcome. Conclusion: The zirconia superstructure is ex-tremely good from the viewpoint of plaque adhesion, but cases with a large stained area at the time of provisional restoration should be carefully followed up.","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70659932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.1212033
Hiroshi Yamamoto, Yukiko Iizuka, E. Iwai, S. Fushimi, Ryutaro Tsuchimoto, Minami Akagi, Shina Kato, Kunio Hayashi, Mitsuko Nakayama, M. Suemitsu, T. Utsunomiya, Y. Nakayama, K. Kuyama, M. Komiya
Salivary gland tumors represent 2% - 6.5% of all head and neck tumors. Since salivary gland tumors have various clinical features and histological types, it is often difficult to diagnose and treat them. The aim of this study was to con-duct a retrospective clinical-statistical analysis of 37 minor salivary gland tumors (MSGTs) treated in the Department of Oral Surgery at Nihon University School of Dentistry at Matsudo over a 16-year period. The frequencies and distributions of sex, age, occurrence site, preoperative examination (fine needle cytology and/or biopsy), treatment, and prognosis of the tumors were analyzed and compared with previous reports. The average age at diagnosis was 58.1 years (range 22 - 91 years). The peak occurrence of tumors was in the sixties (10 cases, 27.0%), followed by the forties (8 cases, 21.6%) and the seventies (7 cases,
{"title":"Minor Salivary Gland Tumors: A Retrospective Study of 37 Cases","authors":"Hiroshi Yamamoto, Yukiko Iizuka, E. Iwai, S. Fushimi, Ryutaro Tsuchimoto, Minami Akagi, Shina Kato, Kunio Hayashi, Mitsuko Nakayama, M. Suemitsu, T. Utsunomiya, Y. Nakayama, K. Kuyama, M. Komiya","doi":"10.4236/ojst.2022.1212033","DOIUrl":"https://doi.org/10.4236/ojst.2022.1212033","url":null,"abstract":"Salivary gland tumors represent 2% - 6.5% of all head and neck tumors. Since salivary gland tumors have various clinical features and histological types, it is often difficult to diagnose and treat them. The aim of this study was to con-duct a retrospective clinical-statistical analysis of 37 minor salivary gland tumors (MSGTs) treated in the Department of Oral Surgery at Nihon University School of Dentistry at Matsudo over a 16-year period. The frequencies and distributions of sex, age, occurrence site, preoperative examination (fine needle cytology and/or biopsy), treatment, and prognosis of the tumors were analyzed and compared with previous reports. The average age at diagnosis was 58.1 years (range 22 - 91 years). The peak occurrence of tumors was in the sixties (10 cases, 27.0%), followed by the forties (8 cases, 21.6%) and the seventies (7 cases,","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.124013
T. Osundwa, M. Mungania, Safari Paterne, Nelson W Oduor
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign, locally invasive neoplasm afflicting the infant more often in the craniofacial region. The current understanding is that this tumor’s origin is neural crest cells. The typical presentation is that a rapidly growing non-ulcerated anterior maxillary mass occurs in an infant usually less than six months old. This tumor may involve other areas including the ovaries, epididymis, femur, mandible, and brain. We present that an 8-month-old infant with a maxillary lesion of MNTI appeared encapsulated, which is a hitherto unreported feature. Inves-tigations leading to the diagnosis and the management of the case are also presented. The need to report cases of this rare entity cannot be overempha-sized as this will go a long way in adding new knowledge about its biological nature.
{"title":"Melanotic Neuroectodermal Tumor of Infancy —A Rare Case of an Encapsulated Tumor","authors":"T. Osundwa, M. Mungania, Safari Paterne, Nelson W Oduor","doi":"10.4236/ojst.2022.124013","DOIUrl":"https://doi.org/10.4236/ojst.2022.124013","url":null,"abstract":"Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign, locally invasive neoplasm afflicting the infant more often in the craniofacial region. The current understanding is that this tumor’s origin is neural crest cells. The typical presentation is that a rapidly growing non-ulcerated anterior maxillary mass occurs in an infant usually less than six months old. This tumor may involve other areas including the ovaries, epididymis, femur, mandible, and brain. We present that an 8-month-old infant with a maxillary lesion of MNTI appeared encapsulated, which is a hitherto unreported feature. Inves-tigations leading to the diagnosis and the management of the case are also presented. The need to report cases of this rare entity cannot be overempha-sized as this will go a long way in adding new knowledge about its biological nature.","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.125015
A. Alansy, T. Saeed, Yuqing Guo, Yanwei Yang, Bin Liu, Zengjie Fan
Lack of antibacterial properties in resin-based composites (RBCs) is one of the flaws that cause the failure of filling clinically. Several agents have been incorporated to endow RBCs with antibacterial properties. In this review, we summarize the recent antibacterial agents between 2015 and 2020 using keywords of antibacterial or antimicrobial dental resin composites by PubMed databases. The most effective strategies are concerned with polymerizable monomers (50%), followed by filler particles (39%) and leachable agents (11%). A recent modification of the antibacterial agent is either by combining two agents from the same category or mixing agents from different categories in one. More than two methods were used in one study to assess antibacterial efficacy. The most common method was biofilm colony-forming units (CFUs) counting method (40%), followed by live/dead bacteria staining assay of biofilms (25%), metabolic activity assay of biofilms using MTT assay (16%), lactic acid production assay of biofilms (8%), agar diffusion test (8%), and other methods (3%) such as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).
{"title":"Antibacterial Dental Resin Composites: A Narrative Review","authors":"A. Alansy, T. Saeed, Yuqing Guo, Yanwei Yang, Bin Liu, Zengjie Fan","doi":"10.4236/ojst.2022.125015","DOIUrl":"https://doi.org/10.4236/ojst.2022.125015","url":null,"abstract":"Lack of antibacterial properties in resin-based composites (RBCs) is one of the flaws that cause the failure of filling clinically. Several agents have been incorporated to endow RBCs with antibacterial properties. In this review, we summarize the recent antibacterial agents between 2015 and 2020 using keywords of antibacterial or antimicrobial dental resin composites by PubMed databases. The most effective strategies are concerned with polymerizable monomers (50%), followed by filler particles (39%) and leachable agents (11%). A recent modification of the antibacterial agent is either by combining two agents from the same category or mixing agents from different categories in one. More than two methods were used in one study to assess antibacterial efficacy. The most common method was biofilm colony-forming units (CFUs) counting method (40%), followed by live/dead bacteria staining assay of biofilms (25%), metabolic activity assay of biofilms using MTT assay (16%), lactic acid production assay of biofilms (8%), agar diffusion test (8%), and other methods (3%) such as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.128020
H. Helovuo, Elvi Tunnela, J. Ollikainen, K. Paunio
The aim of the study was to gather further information regarding the reasons for superinfections and soft tissue necrosis, and to compare them with common gingivitis and periodontitis. A further aim is to see if there are differences in the recovery from these diseases which all are associated with microorganisms. The information was gathered retrospectively from 250 patients and al-together 4022 visits to a specialist. The material was chosen randomly according to the first letter of the patient’s surname, among the 250 patients that were selected. The treatments of 155 patients took place between 1987-2016. The treatment of some patients had started earlier, but the controls had been continued for a long time after 1987. The examinations have been clinical, microbiological, and based on anamnesis, roentgenograms and histopatho-logical examinations. The follow-up time was between 1 to 40 years. The patients who had periodontitis or superinfection were treated in the same way. Antibiotic therapy was prescribed for recurring infections, or if the patient had a difficult disease. In periodontal-endodontic infections, root canals were treated. Periapical lesions were surgically treated. Both periodontitis and superinfections occurred predominantly in the age group between 41 and 60 years. Narcotic- or snuff-addicts were not included in the material, nor were alcoholics, although 6 patients did report moderate use of alcohol. Diseases and other infections had been treated both in patients with periodontitis and in the superinfection group. Oral symptoms were the same, except that the superinfections were violent. multiply resistant organisms were found. The prognosis of the treatment was good both for patients with periodontitis and superinfection. Flap necrosis is a local, rare surgical complication, in which one factor is superinfection. In-correct treatment of soft tissue did not lead to flap necrosis in this study. Superinfection is a different disease to periodontitis or gingivitis, because it is induced by antibiotics, and it is linked with multiply resistant microorganisms that are not sensitive to the antibiotics used. Normal periodontal, surgical and endodontic treatments are suitable for patients with periodon-tal-endodontic problems or superinfection. Superinfection can be very severe, locally or in the whole periodontium, if the infection is bacterial. When the infection was due to yeasts or moulds, local infection was not found. The recovery prognosis is good both in periodontitis and in superinfection. The connection to other diseases is not clear. Cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, accidents and other infections were in anamnesis both in patients with periodontitis and in patients with superinfection. Patients with urinary tract infections who were prescribed antibiotic treatments were more prone to superinfection. Anyone can contract a superinfection. In a healthy gingival, it appears as ulcers, covering
{"title":"Origins and Recovery from Superinfections and Soft Tissue Necrosis","authors":"H. Helovuo, Elvi Tunnela, J. Ollikainen, K. Paunio","doi":"10.4236/ojst.2022.128020","DOIUrl":"https://doi.org/10.4236/ojst.2022.128020","url":null,"abstract":"The aim of the study was to gather further information regarding the reasons for superinfections and soft tissue necrosis, and to compare them with common gingivitis and periodontitis. A further aim is to see if there are differences in the recovery from these diseases which all are associated with microorganisms. The information was gathered retrospectively from 250 patients and al-together 4022 visits to a specialist. The material was chosen randomly according to the first letter of the patient’s surname, among the 250 patients that were selected. The treatments of 155 patients took place between 1987-2016. The treatment of some patients had started earlier, but the controls had been continued for a long time after 1987. The examinations have been clinical, microbiological, and based on anamnesis, roentgenograms and histopatho-logical examinations. The follow-up time was between 1 to 40 years. The patients who had periodontitis or superinfection were treated in the same way. Antibiotic therapy was prescribed for recurring infections, or if the patient had a difficult disease. In periodontal-endodontic infections, root canals were treated. Periapical lesions were surgically treated. Both periodontitis and superinfections occurred predominantly in the age group between 41 and 60 years. Narcotic- or snuff-addicts were not included in the material, nor were alcoholics, although 6 patients did report moderate use of alcohol. Diseases and other infections had been treated both in patients with periodontitis and in the superinfection group. Oral symptoms were the same, except that the superinfections were violent. multiply resistant organisms were found. The prognosis of the treatment was good both for patients with periodontitis and superinfection. Flap necrosis is a local, rare surgical complication, in which one factor is superinfection. In-correct treatment of soft tissue did not lead to flap necrosis in this study. Superinfection is a different disease to periodontitis or gingivitis, because it is induced by antibiotics, and it is linked with multiply resistant microorganisms that are not sensitive to the antibiotics used. Normal periodontal, surgical and endodontic treatments are suitable for patients with periodon-tal-endodontic problems or superinfection. Superinfection can be very severe, locally or in the whole periodontium, if the infection is bacterial. When the infection was due to yeasts or moulds, local infection was not found. The recovery prognosis is good both in periodontitis and in superinfection. The connection to other diseases is not clear. Cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, accidents and other infections were in anamnesis both in patients with periodontitis and in patients with superinfection. Patients with urinary tract infections who were prescribed antibiotic treatments were more prone to superinfection. Anyone can contract a superinfection. In a healthy gingival, it appears as ulcers, covering","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.124012
A. Fukatsu, O. Tsuzukibashi, M. Fuchigami, Satoshi Uchibori, C. Komine, Koji Umezawa, Sachiyo Hayashi, Yuji Takahashi, Taira Kobayashi, M. Wakami, H. Murakami, M. Fukumoto
{"title":"Study on the Distribution at Species Level of Genus <i>Candida</i> in Human Oral Cavities, Using Culture and Multiplex PCR Methods","authors":"A. Fukatsu, O. Tsuzukibashi, M. Fuchigami, Satoshi Uchibori, C. Komine, Koji Umezawa, Sachiyo Hayashi, Yuji Takahashi, Taira Kobayashi, M. Wakami, H. Murakami, M. Fukumoto","doi":"10.4236/ojst.2022.124012","DOIUrl":"https://doi.org/10.4236/ojst.2022.124012","url":null,"abstract":"","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.129023
D. Parmenter, B. Millar
{"title":"Analysis of Referrals for Mandibular Advancement Appliances for Sleep Apnoea","authors":"D. Parmenter, B. Millar","doi":"10.4236/ojst.2022.129023","DOIUrl":"https://doi.org/10.4236/ojst.2022.129023","url":null,"abstract":"","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.1210027
Mahmoud F. Abu-Ta’a, Rawia Karameh
{"title":"Laser and Its Application in Periodontology: A Review of Literature","authors":"Mahmoud F. Abu-Ta’a, Rawia Karameh","doi":"10.4236/ojst.2022.1210027","DOIUrl":"https://doi.org/10.4236/ojst.2022.1210027","url":null,"abstract":"","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70659832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.124011
O. Tsuzukibashi, A. Fukatsu, M. Fuchigami, Satoshi Uchibori, C. Komine, Koji Umezawa, Sachiyo Hayashi, Takashi Asano, Taira Kobayashi, M. Fukumoto
{"title":"Isolation and Identification Methods for <i>Actinomyces israelii</i> Involved in Actinomycosis","authors":"O. Tsuzukibashi, A. Fukatsu, M. Fuchigami, Satoshi Uchibori, C. Komine, Koji Umezawa, Sachiyo Hayashi, Takashi Asano, Taira Kobayashi, M. Fukumoto","doi":"10.4236/ojst.2022.124011","DOIUrl":"https://doi.org/10.4236/ojst.2022.124011","url":null,"abstract":"","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/ojst.2022.122006
R. Alkattan, S. Banerji, S. Deb
{"title":"Damage and Fatigue Failure of Conventional and Bulk-Filled Resin Composites","authors":"R. Alkattan, S. Banerji, S. Deb","doi":"10.4236/ojst.2022.122006","DOIUrl":"https://doi.org/10.4236/ojst.2022.122006","url":null,"abstract":"","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70660040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}