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赶黄草多酚改善胰岛素抵抗的机制研究 赶黄草多酚改善胰岛素抵抗的机制研究
Pub Date : 2023-11-23 DOI: 10.19907/j.0490-6756.2023.066004
郑浩睿 | 王韬宇 | 薛海瑞 | 唐琳
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引用次数: 0
二茂铁基吡喃酮并喹啉化合物的高效合成及其抗氧化性能 二茂铁基吡喃酮并喹啉化合物的高效合成及其抗氧化性能
Pub Date : 2022-05-19 DOI: 10.19907/j.0490-6756.2022.035001
张晓平 | 金桂勇 | 马胜涛 | 王二彬 | 赵学斌 | 陈芝飞 | 李倬 | 楚文娟 | 赵旭 | 席高磊
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引用次数: 0
[Retraction Note: Association of Gene Polymorphisms in Wnt Signal Pathway with Tuberculosis in Chinese Tibetan Population.2016,47(6):920-925.] [回注:中国藏族人群Wnt信号通路基因多态性与结核病的关系。2016,47(6):920-925.]
Pub Date : 2019-03-01 DOI: 10.13464/j.scuxbyxb.2016.06.021
Wenjing Zhou, Xuejiao Hu, Jingya Zhang, Yi Zhou, Li-juan Wu, Minjin Wang, Nian Wang, Xiao-jun Lu, B. Ying
This corrects the article DOI: 10.13464/j.scuxbyxb.2016.06.021.
这更正了文章DOI: 10.13464/j.s ucxbyxb .2016.06.021。
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引用次数: 0
[Endovascular Treatment of Blood Blister-like Aneurysms in Internal Carotid Artery]. 颈内动脉血泡样动脉瘤的血管内治疗
Pub Date : 2018-08-28 DOI: 10.3760/CMA.J.ISSN.1673-4165.2018.08.008
Shouwei Xiang, Ding Xu, Chaohua Wang, Lijuan Hu, C. Zhang, Xiaodong Xie
OBJECTIVESTo study the feasibility and effectiveness of endovascular treatment to blood blister-like aneurysms (BBA) in internal carotid artery.METHODSRetrospective analyzed the clinical features, outcomes, and complications of 20 cases of BBA treated with endovascular intervention techniques from 2013-2015 in our center.RESULTSThe patients were treated with covered stent, internal carotid artery balloon occlusion, and stents assisted coiling, respectively. One death occurred after the patient accepted covered stent treatment, another 2 death was due to vasospasm after internal carotid artery balloon occlusion, and double stents assisted coiling, respectively. The modified Rankin Scale (mRS) score when patients being discharged were 0-2 in 15 cases, and 3-4 in 2 cases. There were 17 cases with clinical follow-up from 1 to 26 months (9.3 months on average), the mRS scores were all less than 2 points. 16 cases accepted angiographic review. 14 cases had BBA totally occluded, 1 case had stable neck residue, and 1 case had incompleted occlusion and the aneurysm dwindled at follow-up.CONCLUSIONSStent-assisted coiling is feasible and effective in the treatment of BBA in internal carotid artery.
目的探讨血管内治疗颈内动脉血泡样动脉瘤(BBA)的可行性和有效性。方法回顾性分析我院2013-2015年血管内介入治疗20例BBA的临床特点、预后及并发症。结果患者分别采用覆膜支架、颈动脉球囊闭塞和支架辅助盘绕治疗。1例患者在接受覆膜支架治疗后死亡,2例患者在颈动脉球囊闭塞后血管痉挛死亡,2例患者在双支架辅助盘绕下死亡。出院时改良Rankin量表(mRS)评分0-2分15例,3-4分2例。17例患者临床随访1 ~ 26个月(平均9.3个月),mRS评分均小于2分。16例接受血管造影复查。BBA完全闭塞14例,颈部残留稳定1例,闭塞不完全1例,随访时动脉瘤缩小。结论支架辅助盘绕治疗颈内动脉BBA是可行且有效的。
{"title":"[Endovascular Treatment of Blood Blister-like Aneurysms in Internal Carotid Artery].","authors":"Shouwei Xiang, Ding Xu, Chaohua Wang, Lijuan Hu, C. Zhang, Xiaodong Xie","doi":"10.3760/CMA.J.ISSN.1673-4165.2018.08.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4165.2018.08.008","url":null,"abstract":"OBJECTIVES\u0000To study the feasibility and effectiveness of endovascular treatment to blood blister-like aneurysms (BBA) in internal carotid artery.\u0000\u0000\u0000METHODS\u0000Retrospective analyzed the clinical features, outcomes, and complications of 20 cases of BBA treated with endovascular intervention techniques from 2013-2015 in our center.\u0000\u0000\u0000RESULTS\u0000The patients were treated with covered stent, internal carotid artery balloon occlusion, and stents assisted coiling, respectively. One death occurred after the patient accepted covered stent treatment, another 2 death was due to vasospasm after internal carotid artery balloon occlusion, and double stents assisted coiling, respectively. The modified Rankin Scale (mRS) score when patients being discharged were 0-2 in 15 cases, and 3-4 in 2 cases. There were 17 cases with clinical follow-up from 1 to 26 months (9.3 months on average), the mRS scores were all less than 2 points. 16 cases accepted angiographic review. 14 cases had BBA totally occluded, 1 case had stable neck residue, and 1 case had incompleted occlusion and the aneurysm dwindled at follow-up.\u0000\u0000\u0000CONCLUSIONS\u0000Stent-assisted coiling is feasible and effective in the treatment of BBA in internal carotid artery.","PeriodicalId":59725,"journal":{"name":"四川大学学报(自然科学版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83444513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prognostic determinants of adrenocortical carcinoma in adults]. 成人肾上腺皮质癌的预后决定因素。
Pub Date : 2014-05-20 DOI: 10.1200/JCO.2014.32.15_SUPPL.E15615
Ming-feng Zhang, Chun Wang, Hui Huang, Z. Ding, Yang Liu, Hao Deng, Shuang-qing Li
OBJECTIVETo investigate the clinical features and prognostic determinants of adrenocortical carcinoma (ACC) in adult patients.METHODSAll adult patients (aged > or =18 years old) who were admitted to West China Hospital, Sichuan University from 1st Jan., 2000 to 31st Jan., 2013 with a pathologically diagnosed ACC were included in this study. Data about the demographics, clinical characteristics, laboratory examinations and outcomes of those patients were extracted and analyzed.RESULTSA total of 52 cases were identified, with a median follow-up of 26 months (3-159 months). The patients had a median survival time of 29 months (1-156 months), with a 1-year, 3-year; and 5-year survival rate of 71.0%, 47.0%, and 42.7%, respectively. In the univariate analysis, aged >45 years old at diagnosis (P = 0.017), advanced stage (III-IV stage, P<0.001), incomplete resection (P = 0.011), symptomatic (P = 0.017), hypoalbuminemia (P = 0.003), and elevated lactate dehydrogenase (LDH) (P = 0.017) were associated with poor prognosis of ACC. The multivariate analysis confirmed that hypoalbuminemia Chazard ratio (HR) = 5.306; 95% confidence interval (95% CI: 1.975, 14.258; P = 0.001), female (HR = 4.020; 95% CI: 1.610, 10.038; P = 0.003), advanced stage (HR = 7.405; 95% CI: 2.561, 21.410; P < 0.001), and older age (HR = 4.628; 95% CI: 1.791, 11.959; P = 0.002) were predictors of poor prognosis of ACC.CONCLUSIONHypoalbuminemia, female, older age, and advanced stage are independent risk factors associated with poor prognosis of ACC.in adult patients.
目的探讨成人肾上腺皮质癌(ACC)的临床特点及影响预后的因素。方法选择2000年1月1日至2013年1月31日四川大学华西医院收治的病理诊断为ACC的成人患者(年龄> 18岁)。提取并分析这些患者的人口统计学、临床特征、实验室检查和结局等数据。结果共确诊52例,中位随访26个月(3 ~ 159个月)。患者的中位生存时间为29个月(1-156个月),其中1年,3年;5年生存率分别为71.0%、47.0%和42.7%。在单因素分析中,诊断时年龄>45岁(P = 0.017)、晚期(III-IV期,P<0.001)、切除不全(P = 0.011)、有症状(P = 0.017)、低白蛋白血症(P = 0.003)、乳酸脱氢酶(LDH)升高(P = 0.017)与ACC预后不良相关。多因素分析证实低白蛋白血症的危险比(HR) = 5.306;95%置信区间(95% CI: 1.975, 14.258;P = 0.001),女性(HR = 4.020;95% ci: 1.610, 10.038;P = 0.003),晚期(HR = 7.405;95% ci: 2.561, 21.410;P < 0.001),年龄越大(HR = 4.628;95% ci: 1.791, 11.959;P = 0.002)为ACC预后不良的预测因子。结论低白蛋白血症、女性、高龄、晚期是ACC预后不良的独立危险因素。在成人患者中。
{"title":"[Prognostic determinants of adrenocortical carcinoma in adults].","authors":"Ming-feng Zhang, Chun Wang, Hui Huang, Z. Ding, Yang Liu, Hao Deng, Shuang-qing Li","doi":"10.1200/JCO.2014.32.15_SUPPL.E15615","DOIUrl":"https://doi.org/10.1200/JCO.2014.32.15_SUPPL.E15615","url":null,"abstract":"OBJECTIVE\u0000To investigate the clinical features and prognostic determinants of adrenocortical carcinoma (ACC) in adult patients.\u0000\u0000\u0000METHODS\u0000All adult patients (aged > or =18 years old) who were admitted to West China Hospital, Sichuan University from 1st Jan., 2000 to 31st Jan., 2013 with a pathologically diagnosed ACC were included in this study. Data about the demographics, clinical characteristics, laboratory examinations and outcomes of those patients were extracted and analyzed.\u0000\u0000\u0000RESULTS\u0000A total of 52 cases were identified, with a median follow-up of 26 months (3-159 months). The patients had a median survival time of 29 months (1-156 months), with a 1-year, 3-year; and 5-year survival rate of 71.0%, 47.0%, and 42.7%, respectively. In the univariate analysis, aged >45 years old at diagnosis (P = 0.017), advanced stage (III-IV stage, P<0.001), incomplete resection (P = 0.011), symptomatic (P = 0.017), hypoalbuminemia (P = 0.003), and elevated lactate dehydrogenase (LDH) (P = 0.017) were associated with poor prognosis of ACC. The multivariate analysis confirmed that hypoalbuminemia Chazard ratio (HR) = 5.306; 95% confidence interval (95% CI: 1.975, 14.258; P = 0.001), female (HR = 4.020; 95% CI: 1.610, 10.038; P = 0.003), advanced stage (HR = 7.405; 95% CI: 2.561, 21.410; P < 0.001), and older age (HR = 4.628; 95% CI: 1.791, 11.959; P = 0.002) were predictors of poor prognosis of ACC.\u0000\u0000\u0000CONCLUSION\u0000Hypoalbuminemia, female, older age, and advanced stage are independent risk factors associated with poor prognosis of ACC.in adult patients.","PeriodicalId":59725,"journal":{"name":"四川大学学报(自然科学版)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76198151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Glucose metabolism in elderly patients with essential hypertension and risk of cardiovascular diseases]. [老年原发性高血压患者的糖代谢与心血管疾病的风险]。
Pub Date : 2010-03-01 DOI: 10.1097/00004872-201106001-00854
Yan Zhang, Xin-jun Zhang, Jun-qi Zhang, L. Zhong, Zhi Zeng
OBJECTIVETo investigate the characteristics of glucose metabolism in elderly patients with essential hypertension and its association with cardiovascular diseases.METHODSOne hundred and nineteen elderly patients with essential hypertension and no diagnosed diabetes mellitus were recruited. Thirty-one elderly patients with neither diagnosed diabetes mellitus nor essential hypertension served as controls. Data about the history of smoking, BMI, IRI and ISI were collected from the participants. According to oral glucose tolerance test (OGTT), the patients with essential hypertension were divided into normal glucose tolerance group (NGT), impaired glucose regulation group (IGR) and diabetes mellitus group (DM). The BMI, FPG, PPG, TG, TC, LDL, HDL, SBP, DBP, IMT, LVMI and LVEF were compared between the groups.RESULTSThe patients with essential hypertension had significantly higher smoking rate and higher BMI, IRI, ISI, PPG, FIN, PIN, Cr, UA, TG and HDL than the controls (P < 0.05). IRI was correlated with BMI, SBP, DBP, TG and HDL. DM, IGR and abnormal glucose metabolism were identified in 24.4%, 38.6%, and 63% of the elderly patients with essential hypertension patients, respectively. The patients in the IGR group and DM group had significantly higher FPG, PPG, PIN, IRI, ISI, BMI, Cr, TG, HDL, LDL and SBP than those in the NGT group (P < 0.05). The incidence of plaque and LVEF in the patients with IGR and DM were higher than in the patients with normal glucose tolerance (P < 0.05).CONCLUSIONElderly patients with essential hypertension have abnormalities in glucose metabolism. OGTT should be offered to the elderly patients with essential hypertension as a measure to detect DM and prevent cardiovascular diseases.
目的探讨老年原发性高血压患者糖代谢特点及其与心血管疾病的关系。方法选取无糖尿病的老年高血压患者119例。31例未确诊为糖尿病和原发性高血压的老年患者作为对照。收集了参与者的吸烟史、BMI、IRI和ISI数据。根据口服糖耐量试验(OGTT)将原发性高血压患者分为正常糖耐量组(NGT)、糖调节障碍组(IGR)和糖尿病组(DM)。比较两组患者BMI、FPG、PPG、TG、TC、LDL、HDL、SBP、DBP、IMT、LVMI、LVEF。结果原发性高血压患者吸烟率显著高于对照组,BMI、IRI、ISI、PPG、FIN、PIN、Cr、UA、TG、HDL均高于对照组(P < 0.05)。IRI与BMI、收缩压、舒张压、TG、HDL相关。老年原发性高血压患者中DM、IGR和糖代谢异常分别占24.4%、38.6%和63%。IGR组和DM组患者FPG、PPG、PIN、IRI、ISI、BMI、Cr、TG、HDL、LDL、SBP均显著高于NGT组(P < 0.05)。IGR和DM组斑块和LVEF的发生率均高于糖耐量正常组(P < 0.05)。结论老年原发性高血压患者存在糖代谢异常。老年原发性高血压患者应接受OGTT检查,作为发现糖尿病和预防心血管疾病的一项措施。
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引用次数: 0
[Immunogenicity of interleukin 12 and DNA vaccine prime-BCG boost against Mycobacterium tuberculosis]. [白细胞介素12和DNA疫苗对结核分枝杆菌的免疫原性]。
Pub Date : 2008-07-01 DOI: 10.1016/J.IJID.2010.02.609
Lei Gao, L. Bao, Mu Hao, Le Zhang, Z. Qin
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引用次数: 3
[Behavioral features of men who have sex with men]. [与男性发生性关系的男性的行为特征]。
Pub Date : 2004-05-01 DOI: 10.2202/1948-4682.1026
Y. Lan, Y. Gu, Bin Wang, D. Zhou, Jian-xin Zhang
OBJECTIVEThis behavioral surveillance survey in Sichuan province was aimed to gain an insight into the behavioral features related to HIV prevalence among men who have sex with men (MSM).METHODSThe pilot survey was initiated in the year from September to December, 2003. Two cities, Chengdu and Nanchong, were selected as the surveillance sites. All behavioral data were collected by a special questionnaire. Convenience sampling and snowball sampling techniques were applied to recruit participants in 5 types of places where MSM appeared more often.RESULTSMost of the participants sexed only with male partners, and the most common ways of intercourse for MSM were anal sex, mouth sex and masturbation. The cases of multiple sex partners existed generally in MSM. The median partner numbers for anal sex and mouth sex were 4.4 and 4.2 respectively. There were 491 MSM (84.7%) who had sexed with male partners 6 months before, in which 68.6% of them sexed with non-commercial regular male partners, 66.2% with non-commercial non-regular male partners, and 20.4% with commercial male partners. Condom use with different male partners varied significantly. The proportions of consistent condom use with non-commercial regular, non-commercial non-regular, and commercial male partners were 15.8%, 16.3% and 32.3% respectively. 1.9% of participants reported they had had the experience of injecting drug and 18.3% of participants reported they had been tested for HIV antibody 12 months before.CONCLUSIONHigh risk behaviors such as multiple sex partners, unprotected anal sex, commercial sex, and injecting drug use among the MSM population in the two cities were unveiled broadly.
目的通过对四川省男男性行为者(MSM)进行行为监测,了解与HIV感染相关的行为特征。方法于2003年9 - 12月开展试点调查。成都和南充两个城市被选为监测点。所有行为数据均通过专门的问卷收集。采用便利抽样和滚雪球抽样的方法,在男男性行为多发的5类场所进行调查。结果大多数参与者只与男性伴侣发生性行为,MSM最常见的性交方式是肛交、口交和手淫。MSM中普遍存在多个性伴侣。肛交和口交的伴侣数量中位数分别为4.4和4.2。共有491名男男性接触者(84.7%)在6个月前曾与男性伴侣发生过性行为,其中68.6%与非商业性正规男性伴侣发生过性行为,66.2%与非商业性非正规男性伴侣发生过性行为,20.4%与商业性男性伴侣发生过性行为。不同男性伴侣使用避孕套的情况差异很大。与非商业性正规男伴、非商业性非经常性男伴和商业性男伴持续使用避孕套的比例分别为15.8%、16.3%和32.3%。1.9%的参与者报告他们有注射毒品的经历,18.3%的参与者报告他们在12个月前进行了HIV抗体检测。结论两市MSM人群中存在多个性伴侣、无保护肛交、性交易、注射吸毒等高危行为。
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引用次数: 13
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四川大学学报(自然科学版)
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