{"title":"Problems of Contraception in Commune IV of the District of Bamako about 109 Cases","authors":"Sirama Diarra, Birama Traoré, Yacouba Dembélé, Brahima Dembélé, Salif Diarra, Déssé Diarra, A. Saye","doi":"10.4236/abcr.2023.123007","DOIUrl":"https://doi.org/10.4236/abcr.2023.123007","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.124013
Zhengkai Zhuang
Breast cancer is one of the most common cancers among women in the world, with more than two million new cases of breast cancer every year. This disease is associated with numerous clinical and genetic characteristics. In recent years, machine learning technology has been increasingly applied to the medical field, including predicting the risk of malignant tumors such as breast cancer. Based on clinical and targeted sequencing data of 1980 primary breast cancer samples, this article aimed to analyze these data and predict living conditions after breast cancer. After data engineering, feature selection, and comparison of machine learning methods, the light gradient boosting machine model was found the best with hyperparameter tuning (precision = 0.818, recall = 0.816, f1 score = 0.817, roc-auc = 0.867). And the top 5 determinants were clinical features age at diagnosis, Nottingham Prognostic Index, cohort and genetic features rheb, nr3c1. The study shed light on rational allocation of medical resources and provided insights to early prevention, diagnosis and treatment of breast cancer with the identified risk clinical and genetic factors.
{"title":"Decipher Clinical and Genetic Underpins of Breast Cancer Survival with Machine Learning Methods","authors":"Zhengkai Zhuang","doi":"10.4236/abcr.2023.124013","DOIUrl":"https://doi.org/10.4236/abcr.2023.124013","url":null,"abstract":"Breast cancer is one of the most common cancers among women in the world, with more than two million new cases of breast cancer every year. This disease is associated with numerous clinical and genetic characteristics. In recent years, machine learning technology has been increasingly applied to the medical field, including predicting the risk of malignant tumors such as breast cancer. Based on clinical and targeted sequencing data of 1980 primary breast cancer samples, this article aimed to analyze these data and predict living conditions after breast cancer. After data engineering, feature selection, and comparison of machine learning methods, the light gradient boosting machine model was found the best with hyperparameter tuning (precision = 0.818, recall = 0.816, f1 score = 0.817, roc-auc = 0.867). And the top 5 determinants were clinical features age at diagnosis, Nottingham Prognostic Index, cohort and genetic features rheb, nr3c1. The study shed light on rational allocation of medical resources and provided insights to early prevention, diagnosis and treatment of breast cancer with the identified risk clinical and genetic factors.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135157938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.124009
Ayriana Safari Baesmat
{"title":"Relation between Neurotransmitters and NK Cells in Adrenal and Breast Cancer","authors":"Ayriana Safari Baesmat","doi":"10.4236/abcr.2023.124009","DOIUrl":"https://doi.org/10.4236/abcr.2023.124009","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.122005
Ashwini Sharma
{"title":"Pre-Operative MRI in HER-2 Receptor Positive and Her-2 Receptor Negative Breast Cancer: A Comparison","authors":"Ashwini Sharma","doi":"10.4236/abcr.2023.122005","DOIUrl":"https://doi.org/10.4236/abcr.2023.122005","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.121002
Mouelle Michel Auguste, Sarah Gaëlle Adiang, E. Meka
{"title":"Darier Ferrand Mammary Dermatofibrosarcoma Simulating a Breast-Type Myofibroblastoma: A Case Report","authors":"Mouelle Michel Auguste, Sarah Gaëlle Adiang, E. Meka","doi":"10.4236/abcr.2023.121002","DOIUrl":"https://doi.org/10.4236/abcr.2023.121002","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.122004
Emilija Sagaityte, Richard S. Dowd, Kendall Lane, S. Graff, S. Toms
{"title":"The Role of RNA Epitranscriptomics and the RNA Fat Mass and Obesity-Associated Demethylase in Triple Negative Breast Cancer","authors":"Emilija Sagaityte, Richard S. Dowd, Kendall Lane, S. Graff, S. Toms","doi":"10.4236/abcr.2023.122004","DOIUrl":"https://doi.org/10.4236/abcr.2023.122004","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.123006
N. Dharsee, K. Mwakatobe, M. Haule, Queen Tarimo, Mohammed Mbwana
{"title":"Needs and Opportunities for Information in Patients with Metastatic Breast Cancer Attending a Tertiary Hospital in Tanzania—A Qualitative Study","authors":"N. Dharsee, K. Mwakatobe, M. Haule, Queen Tarimo, Mohammed Mbwana","doi":"10.4236/abcr.2023.123006","DOIUrl":"https://doi.org/10.4236/abcr.2023.123006","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.124011
Augustin Tozoula Bambara, Dagnagnewende Dieudonne Kabore, Michel Ilboudo, Titavouro Nafissatou Prisca Hien, Faiza Abba-Ousmane, Alice Cynthia Sama
Breast cancers classified T4 according to the TNM code are frequent in Burkina Faso. A better knowledge of these cancers would help to better organize the fight against breast cancer in general. We conducted this study to present the clinical and prognostic aspects of T4 breast cancer in Ouagadougou. It was a descriptive retrospective study based on the medical record of patients received from January 1, 2017 to December 31, 2021 in the cancer department of Yalgado Ouedraogo University Hospital. Patients followed for histologically confirmed breast cancer who were classified in the cT4 category of the TNM code 8e edition were included. We collected a total of 286 patients. Non-salaried patients accounted for 90.56%. In this study, 53.3% of patients lived in urban area and 36.7% in rural area. Menopausal patients accounted for 56.8% of cases. One hundred and thirty-three (46.5%) patients were overweight or obese and 121 (42.3%) patients had a normal weight. The average consultation time, which is the time between the first signs and consultation in a specialized center, was 12 months, with a median of 11 months. According to category T of the TNM code, 19 patients (6.6%) were classified T4d, 176 (61.5%) were classified T4c, 69 (24.1%) were classified T4b and 22 (7.7%) T4a. One hundred and twenty patients (42%) were metastatic. The median overall survival of all patients in our sample was 20 months. In univariate analysis, metastatic status was risk factor for death, while obesity and surgery were protective factors. In multivariate analysis, obesity, surgery and metastatic status were independently associated with survival; obesity and surgery were protective factors. Survival is poor due to advanced stages and difficulties in the management of these cancers. Measures to facilitate access to care would improve the prognosis of these cancers.
{"title":"Clinical, Prognostic and Socio-Economic Aspects of T4 Breast Cancers in Ouagadougou, Burkina Faso: A Retrospective Study","authors":"Augustin Tozoula Bambara, Dagnagnewende Dieudonne Kabore, Michel Ilboudo, Titavouro Nafissatou Prisca Hien, Faiza Abba-Ousmane, Alice Cynthia Sama","doi":"10.4236/abcr.2023.124011","DOIUrl":"https://doi.org/10.4236/abcr.2023.124011","url":null,"abstract":"Breast cancers classified T4 according to the TNM code are frequent in Burkina Faso. A better knowledge of these cancers would help to better organize the fight against breast cancer in general. We conducted this study to present the clinical and prognostic aspects of T4 breast cancer in Ouagadougou. It was a descriptive retrospective study based on the medical record of patients received from January 1, 2017 to December 31, 2021 in the cancer department of Yalgado Ouedraogo University Hospital. Patients followed for histologically confirmed breast cancer who were classified in the cT4 category of the TNM code 8e edition were included. We collected a total of 286 patients. Non-salaried patients accounted for 90.56%. In this study, 53.3% of patients lived in urban area and 36.7% in rural area. Menopausal patients accounted for 56.8% of cases. One hundred and thirty-three (46.5%) patients were overweight or obese and 121 (42.3%) patients had a normal weight. The average consultation time, which is the time between the first signs and consultation in a specialized center, was 12 months, with a median of 11 months. According to category T of the TNM code, 19 patients (6.6%) were classified T4d, 176 (61.5%) were classified T4c, 69 (24.1%) were classified T4b and 22 (7.7%) T4a. One hundred and twenty patients (42%) were metastatic. The median overall survival of all patients in our sample was 20 months. In univariate analysis, metastatic status was risk factor for death, while obesity and surgery were protective factors. In multivariate analysis, obesity, surgery and metastatic status were independently associated with survival; obesity and surgery were protective factors. Survival is poor due to advanced stages and difficulties in the management of these cancers. Measures to facilitate access to care would improve the prognosis of these cancers.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136004124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breast Self-Examination (BSE): Association between “Belief in BSE” and “Awareness of BSE” among University Female Students in Uganda","authors":"Nwanna Uchechukwu Kevin, R. Suubi, Akimana Ornella Danny, Niranjan Shridhar Divekar","doi":"10.4236/abcr.2023.121003","DOIUrl":"https://doi.org/10.4236/abcr.2023.121003","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4236/abcr.2023.124012
Mawahib Ahmed Elawad Abu Elgasim, Yousra Abdelmoniem Suleiman, Lobaina Abozaid, Dlal Alser Hassan Mohmmed, Soha Saad Aldin Mohamad Suliman, Duaa Hamd Abdulatif Farh
Background: In Sudan, the common endocrine therapy tamoxifen is prescribed to HR-positive patients, which is associated with a variety of complications such as hot flashes, vaginal discharge, and vaginal dryness. Objective: This study aimed to determine the gynecological side effects of tamoxifen among Sudanese women who have been diagnosed with breast cancer in Khartoum, Sudan. Methods: A retrospective cross-sectional study was conducted at Alzara Hospital in Al Amal Toure Revere, Sudan. A convenience sample of individuals previously diagnosed with breast cancer attended refer clinic. From October 2020 to September 2021, all patients attending were checked for eligibility. Results: A total of 100 patients were enrolled in the study; 60% of patients reported increased vaginal secretions after taking the drug, 28% reported normal vaginal secretions with no change, and 11% reported decreased secretions after taking the medication, while 22% developed vaginal bleeding, and 22% of the ultrasound results revealed endometrial masses among the study patients. Also, 54 percent of female patients experienced hot flashes after taking the medication, and 12% of women missed some doses of treatment. Conclusion: Tamoxifen results in several gynecological side effects in women with breast cancer. A high percentage of women in the study developed hot flashes, vaginal bleeding, and discharge, in addition to having ultrasound results showing endometrial masses among them.
背景:在苏丹，常见的内分泌治疗他莫昔芬是给hr阳性患者开的，这与各种并发症如潮热、阴道分泌物和阴道干燥有关。目的:本研究旨在确定他莫昔芬在苏丹喀土穆被诊断为乳腺癌的苏丹妇女中的妇科副作用。方法:在苏丹Al Amal Toure Revere的Alzara医院进行回顾性横断面研究。一个方便的样本是以前被诊断患有乳腺癌的人参加了转诊诊所。从2020年10月到2021年9月，对所有就诊的患者进行了资格检查。结果:共纳入100例患者;60%的患者服药后阴道分泌物增加，28%的患者阴道分泌物正常，无变化，11%的患者服药后分泌物减少，22%的患者出现阴道出血，22%的患者超声结果显示子宫内膜肿块。此外，54%的女性患者在服药后出现潮热，12%的女性错过了一些剂量的治疗。结论:他莫昔芬对乳腺癌患者有多种妇科副作用。研究中有很大比例的女性出现了潮热、阴道出血和分泌物，此外超声结果还显示子宫内膜肿块。
{"title":"Gynecological Side Effects of Tamoxifen among Sudanese Women, Khartoum, Sudan, 2020","authors":"Mawahib Ahmed Elawad Abu Elgasim, Yousra Abdelmoniem Suleiman, Lobaina Abozaid, Dlal Alser Hassan Mohmmed, Soha Saad Aldin Mohamad Suliman, Duaa Hamd Abdulatif Farh","doi":"10.4236/abcr.2023.124012","DOIUrl":"https://doi.org/10.4236/abcr.2023.124012","url":null,"abstract":"Background: In Sudan, the common endocrine therapy tamoxifen is prescribed to HR-positive patients, which is associated with a variety of complications such as hot flashes, vaginal discharge, and vaginal dryness. Objective: This study aimed to determine the gynecological side effects of tamoxifen among Sudanese women who have been diagnosed with breast cancer in Khartoum, Sudan. Methods: A retrospective cross-sectional study was conducted at Alzara Hospital in Al Amal Toure Revere, Sudan. A convenience sample of individuals previously diagnosed with breast cancer attended refer clinic. From October 2020 to September 2021, all patients attending were checked for eligibility. Results: A total of 100 patients were enrolled in the study; 60% of patients reported increased vaginal secretions after taking the drug, 28% reported normal vaginal secretions with no change, and 11% reported decreased secretions after taking the medication, while 22% developed vaginal bleeding, and 22% of the ultrasound results revealed endometrial masses among the study patients. Also, 54 percent of female patients experienced hot flashes after taking the medication, and 12% of women missed some doses of treatment. Conclusion: Tamoxifen results in several gynecological side effects in women with breast cancer. A high percentage of women in the study developed hot flashes, vaginal bleeding, and discharge, in addition to having ultrasound results showing endometrial masses among them.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135009033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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