Pub Date : 2020-04-07DOI: 10.5772/intechopen.92097
Ã. Serrano-Aroca, S. Deb
Acrylate based hydrogels are one of the most promising soft biocompatible material platforms that significantly contribute to the delivery of therapeutics, contact lenses, corneal prosthesis, bone cements and wound dressing, and are being explored widely for potential applications in the field of regenerative medicine. A significant number of these materials, which possess excellent water sorption properties, have been supported by the Food and Drug Administration (FDA) of the United States for different applications. Nonetheless, many of their physical and biological properties required for certain biomedical and bioengineering applications are often poor when they are in the hydrated state at the body temperature: tensile/compression performance, water diffusion, antimicrobial activity, antifouling capacity, biological response, porosity for the fabrication of supports or scaffolds for tissue engineering, electrical and/or thermal properties, among other properties. Consequently, new acrylic-based hydrogels have been designed as multicomponent systems such as interpenetrated polymer networks, composites and nanocomposite materials, which have exhibited superior properties able to substantially enhance potential uses of these materials in the biomedical and bioengineering industry.
{"title":"Acrylic-Based Hydrogels as Advanced Biomaterials","authors":"Ã. Serrano-Aroca, S. Deb","doi":"10.5772/intechopen.92097","DOIUrl":"https://doi.org/10.5772/intechopen.92097","url":null,"abstract":"Acrylate based hydrogels are one of the most promising soft biocompatible material platforms that significantly contribute to the delivery of therapeutics, contact lenses, corneal prosthesis, bone cements and wound dressing, and are being explored widely for potential applications in the field of regenerative medicine. A significant number of these materials, which possess excellent water sorption properties, have been supported by the Food and Drug Administration (FDA) of the United States for different applications. Nonetheless, many of their physical and biological properties required for certain biomedical and bioengineering applications are often poor when they are in the hydrated state at the body temperature: tensile/compression performance, water diffusion, antimicrobial activity, antifouling capacity, biological response, porosity for the fabrication of supports or scaffolds for tissue engineering, electrical and/or thermal properties, among other properties. Consequently, new acrylic-based hydrogels have been designed as multicomponent systems such as interpenetrated polymer networks, composites and nanocomposite materials, which have exhibited superior properties able to substantially enhance potential uses of these materials in the biomedical and bioengineering industry.","PeriodicalId":6928,"journal":{"name":"Acrylate Polymers for Advanced Applications","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76684310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-18DOI: 10.5772/intechopen.91799
Ã. Serrano-Aroca, S. Deb
Acrylic-based polymers have been used for many years in biomedical applications because of their versatile properties. Many different polymers belong to this class of polymers, of which a significant number have been approved by the US Food and Drug Administration (FDA) and are frequently used in ophthalmologic devices, orthopaedics, tissue engineering applications and dental applications. The applications of this class of polymers have the potential to be expanded exponentially in the biomedical industry if their properties such as mechanical performance, electrical and/or thermal properties, fluid diffusion, biological behaviour, antimicrobial capacity and porosity can be tailored to specific requirements. Thus, acrylic-based materials have been produced as multicomponent polymeric platforms as interpenetrating polymer networks or in combination with other sophisticated materials such as fibres, nanofibres, carbon nanomaterials such as graphene and its derivatives and/or many other types of nanoparticles in the form of composite or nanocomposite biomaterials. Moreover, in regenerative medicine, acrylic porous supports (scaffolds) need to be structured with the necessary degree, type and morphology of pores by advanced technological fabrication techniques.
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Pub Date : 2019-03-14DOI: 10.5772/INTECHOPEN.82569
Thomas Swift
There are many polymers formed of acrylate monomers in existence. Here we interrogate four commonly-used examples and study how their solution properties are pH dependent, or how their state of ionisation can affect their solution properties. Poly(acrylic acid) and poly(methacrylic acid) are both polyelectrolytes, with ionisable functional groups that make them stimuli responsive, changing their hydrodynamic volume. Poly(acrylamide) is a mass-produced material used in a variety of industrial applications, often with an anionic and cationic co-monomer, which dictates both its efficacy and impact on the environment. Poly( N -isopropyl acrylamide) is a thermally responsive material with applications in smart bioengineering. In solution, these materials can interact with each other due to competing hydrogen bonding interactions. However, this interpolymer complexation is dependent on both the ionisation, and the conformational state, of the polymers involved. This review focuses on the results from fluorescence tagging and turbidimetric techniques.
{"title":"pH Dependence of Acrylate-Derivative Polyelectrolyte Properties","authors":"Thomas Swift","doi":"10.5772/INTECHOPEN.82569","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82569","url":null,"abstract":"There are many polymers formed of acrylate monomers in existence. Here we interrogate four commonly-used examples and study how their solution properties are pH dependent, or how their state of ionisation can affect their solution properties. Poly(acrylic acid) and poly(methacrylic acid) are both polyelectrolytes, with ionisable functional groups that make them stimuli responsive, changing their hydrodynamic volume. Poly(acrylamide) is a mass-produced material used in a variety of industrial applications, often with an anionic and cationic co-monomer, which dictates both its efficacy and impact on the environment. Poly( N -isopropyl acrylamide) is a thermally responsive material with applications in smart bioengineering. In solution, these materials can interact with each other due to competing hydrogen bonding interactions. However, this interpolymer complexation is dependent on both the ionisation, and the conformational state, of the polymers involved. This review focuses on the results from fluorescence tagging and turbidimetric techniques.","PeriodicalId":6928,"journal":{"name":"Acrylate Polymers for Advanced Applications","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82459806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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