H. Witmanowski, E. Lewandowicz, Daria Sobieszek, J. Rykala, Magdalena Łuczkowska
Introduction: Malignant tumors of the skin are the most common human cancers. Among them facial skin cancers form a sizable group. In recent years there has been a dynamic increase in morbidity. They are characterized by local invasiveness, they infiltrate the surrounding tissues, destroy adjacent structures and lead to significant loss of tis sue, which represent a serious therapeutic problem as they are reported in advanced stages of development, and after surgery there are extensive losses of disrupting the aesthetics and function of the face. The most common tumor is basal-cell carcinoma (BCC), another is squamous cell carcinoma (SCC). In available bibliography there is no clear information about the standards of treatment of this type of cancer is observed, which led us to try to pre sent basic information about facial skin cancers, their morphological and histological forms, and the routine treat ment depending on location. Aim: The paper presents the current knowledge on non-melanoma cancers of the face, the algorithm according to the primary lesion location and the related therapeutic options. It also presents the possibility of reconstruction of tissue defects, depending on the location of the change on the basis of selected patients treated at the Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz. Material and methods: In the Clinic of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz in the years 1998-2008, 398 patients were treated because of non-melanoma skin cancers. Results: The method of surgical treatment depended on the type of cancer, its stage and location. In the case of changes located on the face, in the advancement of T1 (T1N0M0), a surgical excision with local plastics was intro duced, in other cases – local flaps or skin grafts was applied. Conclusions: Despite enormous progress in medical science, surgery remains the method of choice in treating facial cancers. Only the primary cut and the suitable technique of plastic surgery, selected individually for each patient provides satisfactory results.
{"title":"Original papers Facial skin cancers: general information and an overview of treatment methods","authors":"H. Witmanowski, E. Lewandowicz, Daria Sobieszek, J. Rykala, Magdalena Łuczkowska","doi":"10.5114/PDIA.2012.30462","DOIUrl":"https://doi.org/10.5114/PDIA.2012.30462","url":null,"abstract":"Introduction: Malignant tumors of the skin are the most common human cancers. Among them facial skin cancers form a sizable group. In recent years there has been a dynamic increase in morbidity. They are characterized by local invasiveness, they infiltrate the surrounding tissues, destroy adjacent structures and lead to significant loss of tis sue, which represent a serious therapeutic problem as they are reported in advanced stages of development, and after surgery there are extensive losses of disrupting the aesthetics and function of the face. The most common tumor is basal-cell carcinoma (BCC), another is squamous cell carcinoma (SCC). In available bibliography there is no clear information about the standards of treatment of this type of cancer is observed, which led us to try to pre sent basic information about facial skin cancers, their morphological and histological forms, and the routine treat ment depending on location. Aim: The paper presents the current knowledge on non-melanoma cancers of the face, the algorithm according to the primary lesion location and the related therapeutic options. It also presents the possibility of reconstruction of tissue defects, depending on the location of the change on the basis of selected patients treated at the Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz. Material and methods: In the Clinic of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Lodz in the years 1998-2008, 398 patients were treated because of non-melanoma skin cancers. Results: The method of surgical treatment depended on the type of cancer, its stage and location. In the case of changes located on the face, in the advancement of T1 (T1N0M0), a surgical excision with local plastics was intro duced, in other cases – local flaps or skin grafts was applied. Conclusions: Despite enormous progress in medical science, surgery remains the method of choice in treating facial cancers. Only the primary cut and the suitable technique of plastic surgery, selected individually for each patient provides satisfactory results.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76263412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lichen sclerosus (LS) is a chronic inflammatory skin disease of unclear etiology in which lymphocytes play an impor tant role. There is some evidence that LS is an autoimmune disease. The lesions are observed on mucosa areas in many cases in women genital region and on the skin of any part of the body. We report a case of a 54-year-old man. The single, inflamed lesion was situated in the scapula area of the back. It was clinically diagnosed as Bowen’s dis ease. A significant improvement was observed after treatment with clobederm ointment.
{"title":"Case reports Lichen sclerosus mimicking Bowen’s disease","authors":"H. Rotsztejn, ewa trznadel-Grodzka, T. Krawczyk","doi":"10.5114/PDIA.2012.30474","DOIUrl":"https://doi.org/10.5114/PDIA.2012.30474","url":null,"abstract":"Lichen sclerosus (LS) is a chronic inflammatory skin disease of unclear etiology in which lymphocytes play an impor tant role. There is some evidence that LS is an autoimmune disease. The lesions are observed on mucosa areas in many cases in women genital region and on the skin of any part of the body. We report a case of a 54-year-old man. The single, inflamed lesion was situated in the scapula area of the back. It was clinically diagnosed as Bowen’s dis ease. A significant improvement was observed after treatment with clobederm ointment.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74047408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Common acne is a very frequent disorder of sebaceous glands which affects mainly young people. In the majority of patients (85%) acne is mild to moderate, and amenable to topical therapy. According to the European Evidencebased (S3) Guidelines for the Treatment of Acne, therapy of comedonal acne should begin with topical retinoids (preferably adapalene), while mild to moderate cases of papulopustular acne should be initially treated with com bination drugs (clindamycin + benzoyl peroxide or adapalene + benzoyl peroxide). It needs to be stressed that all of the above-mentioned combination drugs demonstrate similar efficacy in terms of reducing the number of skin lesions, both inflammatory and non-inflammatory. The onset of therapeutic effect, however, has been shown to be significantly more rapid with the clindamycin + benzoyl peroxide combination. Moreover, the combination is much better tolerated by patients than adapalene + benzoyl peroxide, and has a greater safety profile, as demonstrated in a clinical trial involving a total of 382 patients suffering from common acne. The present article discusses the prop erties of individual components of the combination drugs listed above, and compares both combinations in terms of their therapeutic efficacy, tolerability and safety.
{"title":"Review papers Role of topical combination drug containing clindamycin and benzoyl peroxide 279 in the treatment of common acne","authors":"M. Pastuszka, A. Kaszuba","doi":"10.5114/PDIA.2012.30468","DOIUrl":"https://doi.org/10.5114/PDIA.2012.30468","url":null,"abstract":"Common acne is a very frequent disorder of sebaceous glands which affects mainly young people. In the majority of patients (85%) acne is mild to moderate, and amenable to topical therapy. According to the European Evidencebased (S3) Guidelines for the Treatment of Acne, therapy of comedonal acne should begin with topical retinoids (preferably adapalene), while mild to moderate cases of papulopustular acne should be initially treated with com bination drugs (clindamycin + benzoyl peroxide or adapalene + benzoyl peroxide). It needs to be stressed that all of the above-mentioned combination drugs demonstrate similar efficacy in terms of reducing the number of skin lesions, both inflammatory and non-inflammatory. The onset of therapeutic effect, however, has been shown to be significantly more rapid with the clindamycin + benzoyl peroxide combination. Moreover, the combination is much better tolerated by patients than adapalene + benzoyl peroxide, and has a greater safety profile, as demonstrated in a clinical trial involving a total of 382 patients suffering from common acne. The present article discusses the prop erties of individual components of the combination drugs listed above, and compares both combinations in terms of their therapeutic efficacy, tolerability and safety.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83185079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Incontinentia pigmenti (IP, Bloch-Sulzberger syndrome) is a very rare genodermatosis characterized by typical skin lesions accompanied by dental, central nervous system, bone and ocular abnormalities. Incontinentia pigmenti is usually observed among women, as this X-linked dominantly inherited disorder is lethal in males. The hallmark fea ture of IP is cutaneous eruption along the lines of Blaschko, usually accompanied by neurological disorders. Apart from clinical features of the disease, skin biopsy is the best diagnostic tool to confirm the diagnosis. We present a case of a newborn with typical vesicular and then verrucous lesions affecting the lower legs.
{"title":"Case report Bloch-Sulzberger syndrome: a case report","authors":"Anna Rosińska-Więckowicz, M. Czarnecka-Operacz","doi":"10.5114/pdia.2012.31494","DOIUrl":"https://doi.org/10.5114/pdia.2012.31494","url":null,"abstract":"Incontinentia pigmenti (IP, Bloch-Sulzberger syndrome) is a very rare genodermatosis characterized by typical skin lesions accompanied by dental, central nervous system, bone and ocular abnormalities. Incontinentia pigmenti is usually observed among women, as this X-linked dominantly inherited disorder is lethal in males. The hallmark fea ture of IP is cutaneous eruption along the lines of Blaschko, usually accompanied by neurological disorders. Apart from clinical features of the disease, skin biopsy is the best diagnostic tool to confirm the diagnosis. We present a case of a newborn with typical vesicular and then verrucous lesions affecting the lower legs.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81814260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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