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Stroke, Smoking and Vaping: The No-Good, the Bad and the Ugly. 中风、吸烟和电子烟:不好的、坏的和丑陋的。
Pub Date : 2021-01-01
Adam P Klein, Karen Yarbrough, John W Cole

Both stroke and smoking continue to be major public health crises in the United States, with stroke being the third and fourth leading cause of death among women and men, respectively. The goal of this review will be to provide clinicians a succinct overview regarding the epidemiology, economics, and biology of stroke in the setting of smoking and electronic cigarette use. Special attention will be given to the escalating public health crisis of electronic cigarette use, emphasizing mechanistic relationships of stroke and lung injury. Readers will be made aware of the need for continued scientific advancement and study regarding these relationships, as well as the need for improved governmental and public health efforts to curb these ongoing public health crises.

中风和吸烟仍然是美国主要的公共卫生危机,中风分别是妇女和男子死亡的第三和第四大原因。本综述的目的是为临床医生提供关于吸烟和电子烟使用背景下中风的流行病学、经济学和生物学的简要概述。将特别关注电子烟使用引发的公共卫生危机,强调中风和肺损伤的机制关系。读者将意识到需要继续对这些关系进行科学进步和研究,以及需要改善政府和公共卫生工作,以遏制这些持续的公共卫生危机。
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引用次数: 0
The Long Covid abyss in Brazil; Is this another concern for an overwhelmed healthcare system? 巴西漫长的疫情深渊;这是不堪重负的医疗系统的另一个问题吗?
Pub Date : 2021-01-01 DOI: 10.47739/publichealth.1111
Phiri P, Cavalini Hfs, Delanerolle G, Shi Jq, Shetty A, Magalhães Pf, Fernanda E, Padovez Rdfc, Neves Vr
Long Covid is an ongoing health hazard to many patients who had an original Covid-19 diagnosis. Whilst there has been much debate about the phenotypic nature of the disease, the implications of these among differing populations is yet to be comprehensively reviewed. This is particularly important for low-to-middle-income countries such as Brazil, that have limited resources and infrastructure within their healthcare systems to manage patients long-term that have had Covid-19 and Long covid. Brazil have had to stare at the Covid abyss with over-crowding of their intensive care units that left their healthcare system in chaos. The ongoing long-Covid case numbers therefore are exacerbating an ongoing issue for patients, policy makers and healthcare professionals. In line with this, and the population density of Brazil, we have explored the prevalence of long-Covid in one of the largest municipalities in northeast Brazil to report active patient and clinical reported outcomes that would enable a better understanding of the next steps require to curb these issues to a manageable situation. Methods: We designed a two-step approach to demonstrate the wider implications of long-covid using a commentary and a retrospective, cross-sectional study using realworld data. Findings: In this commentary we highlight the current issues and potential barriers Brazil faces. We will follow this up with a retrospective, cross-sectional study using real world data to report on the prevalence of long covid within 1,600 patients.
对于许多最初诊断为Covid-19的患者来说,长期Covid是一种持续的健康危害。虽然关于该病的表型性质有很多争论,但这些在不同人群中的影响尚未得到全面审查。这对巴西等低收入和中等收入国家尤其重要,因为这些国家的医疗保健系统资源和基础设施有限,无法长期管理已感染covid -19和长期感染covid -19的患者。巴西不得不盯着新冠肺炎的深渊,重症监护室过度拥挤,导致医疗系统陷入混乱。因此,持续的长期病例数加剧了患者、政策制定者和医疗保健专业人员面临的一个持续问题。根据这一点和巴西的人口密度,我们在巴西东北部最大的城市之一探索了长期covid的流行情况,以报告活跃的患者和临床报告结果,这将有助于更好地了解将这些问题控制在可管理的情况下所需的下一步措施。方法:我们设计了一种两步方法,通过评论和使用现实世界数据的回顾性横断面研究来证明长期covid的更广泛影响。在这篇评论中,我们强调了巴西当前面临的问题和潜在障碍。我们将进行一项回顾性的横断面研究,使用真实世界的数据来报告1,600名患者中长冠状病毒的流行情况。
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引用次数: 0
Contributions of Immune Response to Individual Differences in Zika Virus Infection. 免疫反应对寨卡病毒感染个体差异的贡献。
Pub Date : 2017-01-01 Epub Date: 2017-04-05
Erica L Mc Grath, Ping Wu

Zika virus has emerged as a public health crisis and is associated with a number of neurological deficits; however, only subsets of individuals who contract a Zika virus infection develop severe symptoms. The mechanism underlying Zika virus-induced neuropathogenesis is still poorly understood. Recent studies have implicated the host immune response as a key regulator in Zika virus neuropathology. Specifically, immune responses generated from previous flavi virus infection may contribute to antibody-dependent enhancement of Zika virus infection. Innate immunity may also play an important role for the broad array of individual symptomatic differences. Therefore, host immunity may serve as a therapeutic target to reduce Zika-associated neuropathogenesis.

寨卡病毒已成为一种公共卫生危机,并与多种神经系统缺陷有关;然而,只有部分感染寨卡病毒的人才会出现严重症状。人们对寨卡病毒诱发神经发病的机制仍知之甚少。最近的研究表明,宿主免疫反应是寨卡病毒神经病理学的关键调节因素。具体来说,先前黄病毒感染所产生的免疫反应可能有助于抗体依赖性寨卡病毒感染的增强。先天免疫也可能在广泛的个体症状差异中发挥重要作用。因此,宿主免疫可作为减少寨卡相关神经病变的治疗靶点。
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引用次数: 0
Psychological Wellbeing in the Face of Adversity among American Indians: Preliminary Evidence of a New Population Health Paradox? 美国印第安人面对逆境时的心理健康:新人口健康悖论的初步证据?
Pub Date : 2016-01-01 Epub Date: 2016-01-14
Melissa Walls, Cynthia Pearson, Margarette Kading, Ciwang Teyra

Our objective was to determine self-reported psychological wellbeing of American Indians (AIs). Data are from two surveys, a) 218 adults from the 2011 - 2012 Mino Giizhigad study including Ojibwe adults in Minnesota and Wisconsin, and b) 146 AI women aged 15 - 35 years from the 2011 Sacred Journey study residing in the Pacific Northwest. Reports of AI mental wellness/positive mental health were on par with or higher than found in previous studies with non-AI samples despite simultaneously disparate rates of AI anxiety, depressive symptoms, and differential exposure to sociohistorical stressors. Results are a paradoxical mismatch between mental wellness and mental stressors consistent across two separate, diverse samples of AI adults.

我们的目标是确定美国印第安人(AIs)的自我心理健康报告。数据来自两项调查:a) 2011 - 2012 年米诺-吉日加德(Mino Giizhigad)研究中的 218 名成年人,包括明尼苏达州和威斯康星州的奥吉布韦成年人;b) 2011 年神圣之旅(Sacred Journey)研究中居住在西北太平洋地区的 146 名 15 - 35 岁的印第安妇女。尽管同时存在不同比例的亚裔焦虑、抑郁症状和不同的社会历史压力暴露,但亚裔精神健康/积极心理健康的报告与之前非亚裔样本的研究结果相当或更高。研究结果表明,在两个不同的人工智能成年人样本中,心理健康与心理压力之间存在着矛盾的不匹配。
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引用次数: 0
Evaluation of Environmental Sampling Methods for Detection of Staphylococcus aureus on Fomites. 金黄色葡萄球菌环境采样检测方法的评价。
Pub Date : 2015-01-29
Patrick G Hogan, Carey-Ann D Burnham, Lauren N Singh, Carol E Patrick, J Christian Lukas, Jeffrey W Wang, Victoria J Fraser, Stephanie A Fritz

We evaluated a variety of methods to recover S. aureus from inanimate surfaces. Two contact agar plates and three swab sampling methods were tested on porous and non-porous surfaces and bar soap. The cost and ease of use of each method was also evaluated. S. aureus was recovered using all methods on both porous and non-porous surfaces. S. aureus could not be detected on three of four brands of soap.

我们评估了从无生命表面回收金黄色葡萄球菌的各种方法。采用两种接触琼脂板和三种棉签取样方法对多孔和非多孔表面和肥皂进行了测试。并对每种方法的成本和易用性进行了评价。采用各种方法在多孔表面和非多孔表面均可回收金黄色葡萄球菌。在四种牌子的肥皂中,有三种没有检测到金黄色葡萄球菌。
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引用次数: 0
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