We present a novel imaging system that combines an on-chip imaging sensor with a computational phase-retrieval framework that does not utilize any support constraint. This system represents a cost-effective and straightforward strategy for phase-imaging over large fields-of-view and with off-the-shelf components.
We demonstrate simultaneous dual-region in-vivo imaging of brain activity in mouse cortex through a miniaturized spatial-multiplexed two-photon microscope platform, which doubles the imaging speed. Neuronal signals from the two regions are computationally demixed and extracted.
We propose a time-multiplexed miniaturized two-photon microscope (TM-MINI2P), enabling a two-fold increase in imaging speed while maintaining a high spatial resolution. Using TM-MINI2P, we conducted high-speed in-vivo calcium imaging in mouse cortex.
GigaFIBI, an advancement of Fluorescence Imitating Brightfield Imaging (FIBI), displays significant promise in reducing positive margins and associated costs by capturing histology-grade images of 100×100 within minutes, offering intraoperative guidance.
We constructed a bioluminescence tomography(BLT) to localize soft tissue targets for preclinical radiotherapy study. With the threshold and margin designed for target volume, BLT can provide opportunity to perform conformal irradiation to malignancy.
We presented a single-pixel bioluminescence tomography (SPBLT) to monitor single or few cells in live animal. Simulations are proposed to validate the capability of SPBLT in detecting weak bioluminescence signal emitted from cells in vivo.
We proposed to build a mobile fluorescence tomography (mFT) system as an image-guided platform for pre-clinical radiotherapy research. The mFT system is expected to localize functional target/tumor, guide irradiation, and provide longitudinal treatment assessment.
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