Pub Date : 2018-08-01DOI: 10.29199/2638-9940/CAOP-101013
Varun Kumar
In many neurological diseases, retina is affected leading to partial or complete vision loss, which further depends upon the severity of the disease. For example, majority of the stroke victims suffer vision loss due to stroke-induced retinal damage [1,2]. Similarly, there is an aggregation of toxic huntingtin protein [3], intra retinal amyloid deposition [4], and loss of retinal dopaminergic neurons [5] in mouse model of Huntington, Alzheimer and Parkinson’s disease respectively. These studies strongly suggest the association between brain and the eye. However, questions remain how important is the pathophysiological responses of the retina of the eye in understanding these neurological diseases? This has not been well investigated. Moreover, why eye is the mirror/ window to the brain pathology? Part of the reason is the retina being a structure of the brain, which projects out of the diencephalon, similar embryonic origin as brain, shares similar brain vasculature, blood barriers as well as pathophysiology. Moreover, earlier changes necessary to understand the pathophysiology of specific neurological diseases is easily demonstrated in the retina of the eye as described above.
{"title":"Eye is the Window to the Brain Pathology.","authors":"Varun Kumar","doi":"10.29199/2638-9940/CAOP-101013","DOIUrl":"https://doi.org/10.29199/2638-9940/CAOP-101013","url":null,"abstract":"In many neurological diseases, retina is affected leading to partial or complete vision loss, which further depends upon the severity of the disease. For example, majority of the stroke victims suffer vision loss due to stroke-induced retinal damage [1,2]. Similarly, there is an aggregation of toxic huntingtin protein [3], intra retinal amyloid deposition [4], and loss of retinal dopaminergic neurons [5] in mouse model of Huntington, Alzheimer and Parkinson’s disease respectively. These studies strongly suggest the association between brain and the eye. However, questions remain how important is the pathophysiological responses of the retina of the eye in understanding these neurological diseases? This has not been well investigated. Moreover, why eye is the mirror/ window to the brain pathology? Part of the reason is the retina being a structure of the brain, which projects out of the diencephalon, similar embryonic origin as brain, shares similar brain vasculature, blood barriers as well as pathophysiology. Moreover, earlier changes necessary to understand the pathophysiology of specific neurological diseases is easily demonstrated in the retina of the eye as described above.","PeriodicalId":72726,"journal":{"name":"Current advances in ophthalmology","volume":"1 1","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528662/pdf/nihms-1026185.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9938728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-27DOI: 10.29199/2638-9940/caop-101016
Jiannan Liu, S. Peng
Transscleral suture fixation plays a vital role during eye surgery, however postoperative complications still exist such as endophthalmitis, decentration or tilt of IOL (Intraocular Lens). Nowadays various sutureless intrascleral fixations of a Posterior Chamber IOL (PC-IOL) become popular in patients suffering insufficient capsular support. We enumerated and described 4 typical sutureless techniques of IOL fixation for aphakia. Further we also analyzed the advantages and disadvantages of the 4 techniques.
{"title":"Sutureless Scleral Fixated Posterior Chamber Intraocular Implantation","authors":"Jiannan Liu, S. Peng","doi":"10.29199/2638-9940/caop-101016","DOIUrl":"https://doi.org/10.29199/2638-9940/caop-101016","url":null,"abstract":"Transscleral suture fixation plays a vital role during eye surgery, however postoperative complications still exist such as endophthalmitis, decentration or tilt of IOL (Intraocular Lens). Nowadays various sutureless intrascleral fixations of a Posterior Chamber IOL (PC-IOL) become popular in patients suffering insufficient capsular support. We enumerated and described 4 typical sutureless techniques of IOL fixation for aphakia. Further we also analyzed the advantages and disadvantages of the 4 techniques.","PeriodicalId":72726,"journal":{"name":"Current advances in ophthalmology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46804272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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