Delirium (Bielefeld, Germany)最新文献

Background: This study explored potential associations between microtubule-associated protein 2 (MAP2), as a marker of neuronal stress, and postoperative delirium.

Methods: Custom single-molecule immunoassays were used to measure MAP2 in serum collected from two small cohorts of older adults undergoing major cardiac surgery. An in vitro study of differentiated SH-SY5Y cells derived from a neuroblastoma cell line was performed to assess MAP2 secretion following exposure to acute glutamate stimulation.

Results: Patients who experienced postoperative delirium within 3 days of surgery had increased MAP2 serum levels on postoperative day 1. Perioperative blood sampling revealed an increase in circulating MAP2 at the end of cardiopulmonary bypass that was sustained up to postoperative day 3 in patients who developed delirium. Differentiated SH-SY5Y cells exposed to high-dose glutamate showed increased MAP2 in conditioned media independent of changes in total cytosolic protein levels suggesting that extracellular stimuli may promote acute secretion of MAP2 without inducing cell rupture.

Conclusion: Further studies exploring the MAP family as biomarkers of cognitive changes following surgery are warranted.

Background: Increasingly shorter intensive care unit stays have limited the screening for delirium and therefore our understanding of delirium risk and characteristics in the modern liver transplant population.

Objective: We sought to evaluate delirium prevalence in the intensive care unit, on the surgical floor, and overall during the liver transplant hospitalization.

Methods: We enrolled 50 liver transplant recipients to receive daily delirium assessments using both the 4AT and either the Confusion Assessment Method (CAM) for the ICU or the CAM short form immediately pre-transplant and until the first of discharge or post-transplant day 14. We evaluated delirium prevalence in the ICU, on the surgical floor, and overall and visualized the daily mental status of recipients and cumulative incidence of delirium in this cohort.

Results: Delirium was present in 58% of recipients, including 47% in the ICU and 43% on the surgical floor. Nine participants (31%) were captured as having delirium only on the surgical floor. Demographic and transplant characteristics were statistically similar between recipients with and without post-transplant delirium. Compared to recipients without post-transplant delirium, recipients with delirium had similar ICU length of stay [3 (2-5) vs. 2 (1-3) days, p=0.24] but significantly longer transplant hospitalization length of stay [16 (13-20) vs. 8 (8-13), p=0.004].

Conclusions: Delirium is highly prevalent among liver transplant recipients not only during their stay in the intensive care unit, but also on the surgical floor. These findings underscore the importance of continuing routine assessment for delirium on liver transplant recipients after transfer to the surgical floor to optimize post-transplant care.

Delirium is common in hospitalised patients, and there is currently no specific treatment. Identifying and treating underlying somatic causes of delirium is the first priority once delirium is diagnosed. Several international guidelines provide clinicians with an evidence-based approach to screening, diagnosis and symptomatic treatment. However, current guidelines do not offer a structured approach to identification of underlying causes. A panel of 37 internationally recognised delirium experts from diverse medical backgrounds worked together in a modified Delphi approach via an online platform. Consensus was reached after five voting rounds. The final product of this project is a set of three delirium management algorithms (the Delirium Delphi Algorithms), one for ward patients, one for patients after cardiac surgery and one for patients in the intensive care unit.

Background: Cognitive impairments, including delirium, are common after coronary artery bypass grafting (CABG). Improving cognition pre- and post-operatively using computerised cognitive training (CCT) may be an effective approach to improve cognitive outcomes in CABG patients.

Objectives: Investigate the effect of remotely supervised CCT on cognitive outcomes, including delirium, in older adults undergoing CABG surgery.

Methods: Thirty-six participants, were analysed in a single-blinded randomised controlled trial (CCT Intervention: n = 18, Control: n = 18). CCT was completed by the intervention group pre-operatively (every other day, 45-60-minute sessions until surgery) and post-operatively, beginning 1-month post-CABG (3 x 45-60-minute sessions/week for 12-weeks), while the control group maintained usual care plus weekly phone calls. Cognitive assessments were conducted pre- and post-operatively at multiple follow-ups (discharge, 4-months and 6-months). Post-operative delirium incidence was assessed daily until discharge. Cognitive change data were calculated at each follow-up for each cognitive test (Addenbrooke's Cognitive Examination III and CANTAB; z-scored).

Results: Adherence to the CCT intervention (completion of three pre-operative or 66% of post-operative sessions) was achieved in 68% of pre-CABG and 59% of post-CABG participants. There were no statistically significant effects of CCT on any cognitive outcome, including delirium incidence.

Conclusion: Adherence to the CCT program was comparatively higher than previous feasibility studies, possibly due to the level of supervision and support provided (blend of face-to-face and home-based training, with support phone calls). Implementing CCT interventions both pre- and post-operatively is feasible in those undergoing CABG. No statistically significant benefits from the CCT interventions were identified for delirium or cognitive function post-CABG, likely due to the sample size available (study recruitment greatly impacted by COVID-19). It also may be the case that multimodal intervention would be more effective.

Introduction: Delirium is associated with future dementia progression. Yet whether this occurs subclinically over months and years, or persistent delirium merges into worsened dementia is not understood. Our objective was to estimate the prevalence of persistent delirium and understand variation in its duration.

Methods: We adopted an identical search strategy to a previous systematic review, only including studies using a recognised diagnostic framework for ascertaining delirium at follow-up (persistent delirium). Studies included hospitalised older patients outside critical and palliative care settings. We searched MEDLINE, EMBASE, PsycINFO and the Cochrane Database of Systematic Reviews on 11th January 2022. We applied risk of bias assessments based on Standards of Reporting of Neurological Disorders criteria and assessed strength of recommendations using the grading of recommendation, assessment, development and evaluation (GRADE) approach. Estimates were pooled across studies using random-effects meta-analysis, and we estimated associations with follow-up duration using robust error meta-regression.

Results: We identified 13 new cohorts, which we added to 10 from the previous systematic review (23 relevant studies, with 39 reports of persistent delirium at 7 time-points in 3186 individuals admitted to hospital care (mean age 82 years and 41% dementia prevalence). Studies were mainly at moderate risk of bias. Pooled delirium prevalence estimates at discharge were 36% (95% CI 22% to 51%, 13 studies). Robust error meta-regression did not show variation in prevalence of persistent delirium over time (-1.6% per month, 95% CI -4.8 to 1.6, p=0.08). Margins estimates for this model indicate a prevalence of persistent delirium of 16% (95% CI 6% to 25%) at 12 months.

Conclusions: This systematic review emphasises the importance of delirium as a persistent and extensive problem (GRADE certainty = moderate), raising questions on chronic delirium as a clinical entity and how it might evolve into dementia. Addressing persistent delirium will require a whole-system, integrated approach to detect, follow-up and implement opportunities for recovery across all healthcare settings.