Acta Pharmaceutica Sinica B最新文献
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PGC-1 -mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity
PGC-1 在新霉素诱发的耳毒性和肾毒性中介导线粒体-脂滴平衡失调
Pub Date : 2024-06-01
DOI: 10.1016/j.apsb.2024.05.024
Bin Chen, Cheng Cheng, Yunhao Wu, Siyu Li, Mo Han, Le Zhen, Ying Peng, Suhan Guo, Kaidi Shen, Xia Gao, Renjie Chai, Guangji Wang, Fang Zhou
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{"title":"PGC-1 -mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity","authors":"Bin Chen, Cheng Cheng, Yunhao Wu, Siyu Li, Mo Han, Le Zhen, Ying Peng, Suhan Guo, Kaidi Shen, Xia Gao, Renjie Chai, Guangji Wang, Fang Zhou","doi":"10.1016/j.apsb.2024.05.024","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.024","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Counteracting Alzheimer’s disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator
通过自调节多功能纳米调节器使神经血管正常化来对抗阿尔茨海默病
Pub Date : 2024-05-01
DOI: 10.1016/j.apsb.2024.05.017
Xue Xia, Ya Wei, Qianqian Huang, Yang Zhou, Xiaorong Wang, Yulong Shi, Xiaotong Yang, Wenqin Yang, Yiwei Zhang, Ting Lei, Yuan Huang, Hanmei Li, Meng Qin, Huile Gao
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{"title":"Counteracting Alzheimer’s disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator","authors":"Xue Xia, Ya Wei, Qianqian Huang, Yang Zhou, Xiaorong Wang, Yulong Shi, Xiaotong Yang, Wenqin Yang, Yiwei Zhang, Ting Lei, Yuan Huang, Hanmei Li, Meng Qin, Huile Gao","doi":"10.1016/j.apsb.2024.05.017","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.017","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Engineering the microenvironment of P450s to enhance the production of diterpenoids in Saccharomyces cerevisiae
改造 P450s 的微环境以提高酿酒酵母中二萜类化合物的产量
Pub Date : 2024-05-01
DOI: 10.1016/j.apsb.2024.05.019
Yatian Cheng, Linglong Luo, Hao Tang, Jian Wang, Li Ren, Guanghong Cui, Yujun Zhao, Jinfu Tang, Ping Su, Yanan Wang, Yating Hu, Ying Ma, Juan Guo, Luqi Huang
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{"title":"Engineering the microenvironment of P450s to enhance the production of diterpenoids in Saccharomyces cerevisiae","authors":"Yatian Cheng, Linglong Luo, Hao Tang, Jian Wang, Li Ren, Guanghong Cui, Yujun Zhao, Jinfu Tang, Ping Su, Yanan Wang, Yating Hu, Ying Ma, Juan Guo, Luqi Huang","doi":"10.1016/j.apsb.2024.05.019","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.019","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141141231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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A systematic, updated review of Xuezhikang, a domestically developed lipid-lowering drug, in the application of cardiovascular diseases
关于国产降脂药雪芝康在心血管疾病中应用的最新系统综述
Pub Date : 2024-05-01
DOI: 10.1016/j.apsb.2024.05.011
Cheng Yang, Yong-Jian Wu, Jie Qian, Jian-Jun Li
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{"title":"A systematic, updated review of Xuezhikang, a domestically developed lipid-lowering drug, in the application of cardiovascular diseases","authors":"Cheng Yang, Yong-Jian Wu, Jie Qian, Jian-Jun Li","doi":"10.1016/j.apsb.2024.05.011","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.011","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141033795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF-HSF1-HSP70-1 pathway: An effective treatment for hepatocellular carcinoma
通过靶向 MANF-HSF1-HSP70-1 通路重编程肿瘤相关巨噬细胞并抑制肿瘤新生血管：肝细胞癌的有效治疗方法
Pub Date : 2024-05-01
DOI: 10.1016/j.apsb.2024.05.001
Dan Han, Qiannan Ma, Petek Ballar, Chunyang Zhang, Min Dai, Xiaoyuan Luo, Jiong Gu, Chuan-sheng Wei, Panhui Guo, Lulu Zeng, Min Hu, Can Jiang, Yanyan Liang, Yanyan Wang, Chao Hou, Xian Wang, Lijie Feng, Yujun Shen, Yuxian Shen, Xiangpeng Hu, Jun Liu
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{"title":"Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF-HSF1-HSP70-1 pathway: An effective treatment for hepatocellular carcinoma","authors":"Dan Han, Qiannan Ma, Petek Ballar, Chunyang Zhang, Min Dai, Xiaoyuan Luo, Jiong Gu, Chuan-sheng Wei, Panhui Guo, Lulu Zeng, Min Hu, Can Jiang, Yanyan Liang, Yanyan Wang, Chao Hou, Xian Wang, Lijie Feng, Yujun Shen, Yuxian Shen, Xiangpeng Hu, Jun Liu","doi":"10.1016/j.apsb.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.001","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141036650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling
通过靶向ERα信号传导促进人骨髓间充质干细胞的成骨分化，从而逆转骨质疏松症
Pub Date : 2024-02-01
DOI: 10.1016/j.apsb.2024.02.005
Qing Zhao, Junjie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, J. Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao
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{"title":"Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling","authors":"Qing Zhao, Junjie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, J. Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao","doi":"10.1016/j.apsb.2024.02.005","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.005","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139823607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction
与ALS相关的C9orf72二肽重复序列通过调节BCL2-BECN1的相互作用抑制饥饿诱导的自噬作用
Pub Date : 2024-02-01
DOI: 10.1016/j.apsb.2024.02.004
Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Na-na Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying
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{"title":"ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction","authors":"Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Na-na Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying","doi":"10.1016/j.apsb.2024.02.004","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.004","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139893152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges
直接以 BAX 为靶点进行药物研发：治疗机遇与挑战
Pub Date : 2024-02-01
DOI: 10.1016/j.apsb.2024.02.010
Zhenwei Zhang, Linghui Hou, Dan Liu, Shenglin Luan, Min Huang, Linxiang Zhao
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{"title":"Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges","authors":"Zhenwei Zhang, Linghui Hou, Dan Liu, Shenglin Luan, Min Huang, Linxiang Zhao","doi":"10.1016/j.apsb.2024.02.010","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.010","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139814359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma
受circCPNE1/miR-330-3p途径启发的基于顺铂的miRNA递送策略治疗口腔鳞状细胞癌
Pub Date : 2024-02-01
DOI: 10.1016/j.apsb.2024.02.009
Hua-yang Fan, Ming-da Zhao, Hong-jie Jiang, Zhen-wei Yu, Yu-jiang Fan, Xin-hua Liang, Ya-Ling Tang, Yong Sun
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{"title":"Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma","authors":"Hua-yang Fan, Ming-da Zhao, Hong-jie Jiang, Zhen-wei Yu, Yu-jiang Fan, Xin-hua Liang, Ya-Ling Tang, Yong Sun","doi":"10.1016/j.apsb.2024.02.009","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.009","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits
气体推进纳米马达通过调节肠道免疫环境-血液循环-微生物群回路缓解结肠炎
Pub Date : 2024-02-01
DOI: 10.1016/j.apsb.2024.02.008
Bo Xiao, Yuqi Liang, Ga Liu, Lingshuang Wang, Zhan Zhang, Libin Qiu, Haiting Xu, Sean Carr, Xiaoxiao Shi, Rui L Reis, Subhas C. Kundu, Zhenghua Zhu
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{"title":"Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits","authors":"Bo Xiao, Yuqi Liang, Ga Liu, Lingshuang Wang, Zhan Zhang, Libin Qiu, Haiting Xu, Sean Carr, Xiaoxiao Shi, Rui L Reis, Subhas C. Kundu, Zhenghua Zhu","doi":"10.1016/j.apsb.2024.02.008","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.008","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139815948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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