Journal of neurology and experimental neural science最新文献

{"title":"Association between Covid-19 Vaccines and Anxiety","authors":"","doi":"10.29011/2577-1442.100051","DOIUrl":"https://doi.org/10.29011/2577-1442.100051","url":null,"abstract":"","PeriodicalId":73859,"journal":{"name":"Journal of neurology and experimental neural science","volume":"9 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139594320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Depressive Symptoms and Perceived Stress in Women Coping with Infertility, Following Mind-Body Interventions","authors":"","doi":"10.29011/2577-1442.100048","DOIUrl":"https://doi.org/10.29011/2577-1442.100048","url":null,"abstract":"","PeriodicalId":73859,"journal":{"name":"Journal of neurology and experimental neural science","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136166345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Cerebral Hemodynamics and Anemia on Processing Speed in Adults with Sickle Cell Disease.","authors":"Daniel Sop,&nbsp;Joel L Steinberg,&nbsp;Jennifer Jordan,&nbsp;Taylor Crouch,&nbsp;Yue May Zhang,&nbsp;Wally Smith","doi":"10.29011/2577-1442.100050","DOIUrl":"https://doi.org/10.29011/2577-1442.100050","url":null,"abstract":"<p><strong>Background and purpose: </strong>Compared to healthy controls, adult patients with Sickle Cell Disease (SCD) are anemic, and therefore have higher cardiac output and Cerebral Blood Flow (CBF) to maintain brain oxygenation. They also demonstrate comparatively more cognitive deficits due to either overt strokes or silent cerebral ischemia. However, there are few correlative studies between CBF and cognitive deficits, specifically processing speed in SCD. Such studies are important to develop biomarkers of central brain processing and ischemia for diagnosis, prognosis, and evaluating the effectiveness of potential interventions. This pilot cross-sectional study tested the hypotheses that adults with SCD and elevated CBF demonstrate lower central brain processing speed than controls on average and that CBF is inversely correlated with processing speed.</p><p><strong>Methods: </strong>We conducted a pilot cross-sectional study to assess the relation-ships between CBF, central brain processing speed, and hemoglobin levels in asymptomatic adults with SCD and controls from an urban academic medical center. MRI acquisitions at 3T consisted of 2D phase-contrast quantitative arteriograms (Qflow) of the bilateral internal carotid and vertebral arteries and 3D pseudo-continuous arterial spin labeling (pCASL) of the brain. Participants were patients with SCD (hemoglobin [Hb]SS, [Hb] SBetaThal°, or [Hb]SC) aged 22-52 years of African American descent (N=7) or community controls (Hb AA) (n=3). Processing speed was assessed as an in-direct functional marker of ischemia using a recommended test from the NIH Toolbox for Assessment of Neurological and Behavioral Function, the Pattern Comparison Processing Speed Test. t-tests were used to compare means of CBF, hemoglobin, and cognition between SCD patients and healthy controls. Among SCD patients only multivariate correla-tions were used to evaluate relationships between brain perfusion in specific brain regions vs. processing speed and CBF. The significance level was set at p≤0.05.</p><p><strong>Results: </strong>Adults with SCD reported higher CBF compared to healthy con-trols (72.15±28.90 vs. 47.23±12.30 ml/min/100g, p=0.04), and lower hemoglobin concentration (8.64±2.33 vs. 13.33±0.58, p=0.001). Heart rate in SCD patients was higher than in controls (86.29±1.37 vs. 74.00±2.10, p=0.04). Patients with SCD demonstrated lower processing speed (96.14±21.04 vs.123±13.74, p=0.02) than controls. Among adult patients with SCD, perfusion in specific regions of the brain showed an inverse relationship with processing speed, as did whole-brain CBF (p=0.0325).</p><p><strong>Conclusion: </strong>These findings, although from a small sample, lend a degree of validity to the claim that processing speed is slower in people with SCD than in controls and that CBF is significantly higher in SCD patients com-pared to controls. The results also lend credence to the finding that the degree of processing speed deficiencies am","PeriodicalId":73859,"journal":{"name":"Journal of neurology and experimental neural science","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464389/pdf/nihms-1922726.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10121048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Dietary Supplementation with High-Dose Choline Alfoscerate (Cerebrain® Forte) on Cognitive Functioning in Patients with Minor Neurocognitive Disorder (Mind): A Pilot Study","authors":"E. Garofalo, M. Sannino, A. Iavarone, Bruno, Ronga","doi":"10.29011/2577-1442.100046","DOIUrl":"https://doi.org/10.29011/2577-1442.100046","url":null,"abstract":"Effects of Dietary Supplementation with High-Dose Choline Alfoscerate (Cerebrain Forte) on Cognitive Functioning in Patients with Minor Neurocognitive Disorder (Mind): A Pilot Study. J Abstract Introduction and aim of the study: Normal and pathological aging have been related to deficits of several neurotransmitters able to account for cognitive, emotional and behavioral disorders associated with mild cognitive decline or overt dementia. Among the neurotransmitter deficits involved in cognitive disorders, with particular reference to those underlying memory and attentional functions, the cholinergic one is certainly the main one [1]. This justified the treatment of these disorders with drugs and supplements capable of enhancing cholinergic transmission by inhibiting the degradation of acetylcholine (acetylcholinesterase inhibitors) or by increasing the production of the neurotransmitter through the exogenous supply of precursors [2,3]. Choline Alfoscerate is at the forefront of these supplements. The effect of the supplements is dose-dependent, and it is therefore likely that a high-dose formulation is associated with effects on cognition of a higher entity than that with medium or medium-low dosages. Aim of this pilot study is to evaluate the effects of dietary supplementation","PeriodicalId":73859,"journal":{"name":"Journal of neurology and experimental neural science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41577557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Low-Frequency High-Intensity Pulsed Electromagnetic Fields (Diamagnetic Therapy) in the Treatment of Rare Diseases: A Case Series Preliminary Study","authors":"Felipe Torres Obando, P. Romeo, D. Vergara, Fede G Di, Pardo, Adriana Soto","doi":"10.29011/2577-1442.100045","DOIUrl":"https://doi.org/10.29011/2577-1442.100045","url":null,"abstract":"Rare and orphan diseases are a group of multiorgan disabilities that limit the life quality in young and adult patients, affecting the socio-economic burden for the families and the community. Despite the continuous attempts in research, no standardized and effective therapies are nowadays available. Orthosis supports and rehabilitation remain the unique possibilities to alleviate these challenging conditions. Among the emerging therapeutic odds, Pulsed Electromagnetic Fields (PEMFs) express anti-inflammatory and regenerative effects on musculoskeletal and parenchymal tissues. They have also shown intriguing properties to stimulate the central and peripheral nervous system either as Transcranial Magnetic Stimulation (TMS) and Low Frequency High-Intensity -Pulsed electromagnetic Field (LF-HI-PEMFs) or Diamagnetic Therapy (Diamagneto-therapy). This last modulates brain plasticity and is effective in pain, reducing muscles contractures and tissue oedema. Our experience refers to the use of Diamagnetic Therapy to rare and orphan diseases and reports promising functional and behavioural results, opening the possibility of therapeutic applications integrated with conventional rehabilitative methods. Journal of Neurology and Experimental Neural Science Obando FT, et al. J Neurol Exp Neural Sci 4: 145. www.doi.org/10.29011/2577-1442.100045 www.gavinpublishers.com Introduction Rare and orphan diseases are a group of pathologies that affect, by definition, small numbers of patients. The classification criteria are different in the various countries as there is no unified categorization globally accepted. According to the United States Rare Diseases Act (2002), a rare disease is a condition that affects about 1: 1500 person while the European Commission defines a rare disease as any disease that affects less than 1: 2000 people and some definitions rely on the existence of proper treatments [1]. Currently, despite their low prevalence, almost 8000 existing rare diseases are esteemed to affect about 350 million patients, with a worldwide impact on healthcare and the socio-economic systems in terms of direct and indirect costs. Recent progress in molecular biology, next-generation sequencing-based technologies, and genetics have enhanced the therapeutic choices: small-molecule drugs, protein-based therapeutics, antisense oligonucleotides, small interfering RNAs, gene and cell therapies [2] aim to trigger reparative molecular Citation: Obando FT, Romeo P, Vergara D, di Pardo F, Soto A (2022) The Effects of Low-Frequency High-Intensity Pulsed Electromagnetic Fields (Diamagnetic Therapy) in the Treatment of Rare Diseases: A Case Series Preliminary Study. J Neurol Exp Neural Sci 4: 145. DOI: 10.29011/2577-1442.100045 2 Volume 4; Issue 01 mechanisms. Nevertheless, there is still a lack of appropriate diagnostic tools and treatments that need more specific knowledge [3]. Thus, despite the growing interest in this field, the high costs related to the rarity of the d","PeriodicalId":73859,"journal":{"name":"Journal of neurology and experimental neural science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48374692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy Alterations and Chakras Energy Deficiencies in the Pathophysiology of Bell’s Palsy","authors":"H. Ling","doi":"10.29011/2577-1442.000140","DOIUrl":"https://doi.org/10.29011/2577-1442.000140","url":null,"abstract":"Introduction: Bell’s palsy (BP) is a loss of facial movement due to nerve damage. In traditional Chinese medicine (TCM), the physiopathology of BP is external Wind-Cold attacking the channels of the face. Purpose: To demonstrate which are the energy alterations on the chakras energy centers on patients with Bell’s palsy and the results of the treatment using TCM tools. Methods: Three case reports of patients with Bell’s palsy. All with history of developing Bell’s palsy after exposure to Cold and Wind. They received measurement of the chakras, and in all the cases, they had no energy in all seven chakras. The treatment was recommendation to avoid exposure to Cold and Wind, Chinese dietary counselling, acupuncture, and treatment for the chakras with homeopathy medication according to the theory of the author entitled Constitutional Homeopathy of the Five Elements based on Traditional Chinese Medicine and crystal-based medications. Results: All patients presented improvement of the Bell’s palsy, restoring nerve function, besides improving the ability of the patients to close their eyes and improvement of the well-being, self-esteem and emotional state. Conclusion: In this study, it was concluded that patients with Bell’s palsy have an energy deficiency on the chakras centers that make them more prone to invasion of Wind and Cold, due to weakened energy, leading, in this case, to the formation of Bell’s palsy. In this study, TCM tools were used for restoring the function of the facial nerves and muscles and rebalancing all the energy of the patients (Yin, Yang, Qi and Blood and chakras energy). The use of high-concentrated medication, such as corticosteroids, normally used in Western medicine treatment, may harm the vital energy of the patients even more, worsening or maintaining the condition of energy imbalance, and therefore, Bell’s palsy. Biography: Huang Wei Ling, born in Taiwan, raised in Brazil since the age of one, graduated in medicine in Brazil, specializing in infectious and parasitic diseases, General Practitioner, Parenteral and Enteral Medical Nutrition Therapist, Acupuncture and Pain Management Practitioner. Since 2007, she has been disseminating the knowledge of Oriental medicine, especially traditional Chinese medicine, in various places around the world, in the treatment of the various pathologies of the human body. Owner of Medical Acupuncture and Pain Management Clinic. Speaker Publications: 1. “The Importance of Correcting Chakras Energy Centers Alterations to Prevent Pacemaker Indication”. 2. “Energy Alterations Leading to Dyspnea in Patients with Mitral Valve Stenosis”. 3. “The Importance of Correcting Energy Imbalances in the Prevention and Treatment of Myocardial Infarction”. International Conference on Neurologists; WebinarNovember 27, 2020.","PeriodicalId":73859,"journal":{"name":"Journal of neurology and experimental neural science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69472216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy Disturbances in Panic Syndrome and How Can We Treat it in Adolescence?","authors":"","doi":"10.29011/2577-1442.000139","DOIUrl":"https://doi.org/10.29011/2577-1442.000139","url":null,"abstract":"","PeriodicalId":73859,"journal":{"name":"Journal of neurology and experimental neural science","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69471449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}