Minas K Minas, Tsoleridis Theofilos, Tampaki Stavroula
Comparison of Apixaban versus Rivaroxaban in Patients with Deep Vein
阿哌沙班与利伐沙班在深静脉患者中的比较
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Pub Date : 2018-01-01Epub Date: 2018-01-06DOI: 10.4172/2572-9462.1000124
M D Zielinski, J R Stubbs, S F Polites, A Xue, Dal Haugen, R Emery, D H Jenkins, M S Park
Background: Warm fresh whole blood (WFWB) is an ideal resuscitation fluid for exsanguinating patients but there are myriad logistic and infectious issues associated with its use. Cold whole blood (CWB) may be an acceptable alternative to the reconstituted whole blood (RWB), the current standard of care. A leukoreduction filter has been developed which maintains platelet count while eliminating white blood cells but its effect on platelet function is unknown. We hypothesize that CWB will retain an acceptable functional coagulation profile after filtration and over time.
Study design and methods: WFWB and CWB samples were obtained from eight donors and four units of RWB were created. The quantitative and qualitative in vitro coagulation profiles of WFWB, RWB, and CWB over time were compared.
Results: Filtration was successful at removing white blood cells (5.5 ± 1.2 vs. 0.3 ± 0.3 × 106/L) while retaining an adequate platelet count (172.0 ± 47.0 to 166.0 ± 42.3 × 109/L) and hemoglobin concentration (13.7 ± 0.5 vs. 13.0 ± 0.7 g/dL). Rotational Thromboelastography (ROTEM) results revealed a similar clotting time (CT) before and after filtration (64.9 ± 5.1 vs. 64.1 ± 6.8 s) but a decreased maximum clot firmness (MCF) (58.6 ± 4.2 vs. 54.9 ± 4.6 mm). Platelet aggregation decreased substantially (28.8 ± 6.7 vs. 9.3 ± 2.1 ohm) immediately after filtration. CWB function continued to diminish over time.
Conclusion: CWB holds great promise as a surrogate for WFWB, but use of a platelet-sparing LR filter diminishes platelet function almost immediately after filtration.
{"title":"<i>In vitro</i> Analysis of the Hemostatic Properties of Whole Blood Products Prepared with a Platelet-Sparing Leukoreduction Filter.","authors":"M D Zielinski, J R Stubbs, S F Polites, A Xue, Dal Haugen, R Emery, D H Jenkins, M S Park","doi":"10.4172/2572-9462.1000124","DOIUrl":"10.4172/2572-9462.1000124","url":null,"abstract":"<p><strong>Background: </strong>Warm fresh whole blood (WFWB) is an ideal resuscitation fluid for exsanguinating patients but there are myriad logistic and infectious issues associated with its use. Cold whole blood (CWB) may be an acceptable alternative to the reconstituted whole blood (RWB), the current standard of care. A leukoreduction filter has been developed which maintains platelet count while eliminating white blood cells but its effect on platelet function is unknown. We hypothesize that CWB will retain an acceptable functional coagulation profile after filtration and over time.</p><p><strong>Study design and methods: </strong>WFWB and CWB samples were obtained from eight donors and four units of RWB were created. The quantitative and qualitative <i>in vitro</i> coagulation profiles of WFWB, RWB, and CWB over time were compared.</p><p><strong>Results: </strong>Filtration was successful at removing white blood cells (5.5 ± 1.2 <i>vs.</i> 0.3 ± 0.3 × 10<sup>6</sup>/L) while retaining an adequate platelet count (172.0 ± 47.0 to 166.0 ± 42.3 × 10<sup>9</sup>/L) and hemoglobin concentration (13.7 ± 0.5 <i>vs.</i> 13.0 ± 0.7 g/dL). Rotational Thromboelastography (ROTEM) results revealed a similar clotting time (CT) before and after filtration (64.9 ± 5.1 <i>vs.</i> 64.1 ± 6.8 s) but a decreased maximum clot firmness (MCF) (58.6 ± 4.2 <i>vs.</i> 54.9 ± 4.6 mm). Platelet aggregation decreased substantially (28.8 ± 6.7 <i>vs.</i> 9.3 ± 2.1 ohm) immediately after filtration. CWB function continued to diminish over time.</p><p><strong>Conclusion: </strong>CWB holds great promise as a surrogate for WFWB, but use of a platelet-sparing LR filter diminishes platelet function almost immediately after filtration.</p>","PeriodicalId":73994,"journal":{"name":"Journal of thrombosis and circulation: open access","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/14/a2/nihms-945725.PMC10022254.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9152470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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