Materials technology (New York, N.Y.)最新文献

英文中文

3D printed antimicrobial PLA constructs functionalised with zinc- coated halloysite nanotubes-Ag-chitosan oligosaccharide lactate. 用锌涂层海泡石纳米管-壳聚糖寡糖乳酸盐功能化的三维打印抗菌聚乳酸结构。

Materials technology (New York, N.Y.)

Pub Date : 2022-01-01 Epub Date: 2020-08-11 DOI: 10.1080/10667857.2020.1806188

Ahmed Humayun, Yangyang Luo, Anusha Elumalai, David K Mills

The control and inhibition of microbial infection are of critical importance for patients undergoing dental or orthopedic surgery. A critical requirement is the prevention of bacterial growth, subsequent bacterial colonization of implant surfaces, and biofilm formation. Among biofilm-forming bacteria, S. aureus and S. epidermidis are the most common bacteria responsible for causing implant-related infections. The ability to produce customized and patient-specific antimicrobial treatments will significantly reduce infections leading to enhanced patient recovery. We propose that 3D-printed antimicrobial biomedical devices for on-demand infection prophylaxis and disease prevention are a rational solution for the prevention of infection. In this study, we modified 3D printed polylactic acid (PLA) constructs using an alkali treatment to increase hydrophilicity and functionalized the surface of the constructs using a suspension of Zinc/HNTs-Ag-Chitosan Oligosaccharide Lactate (ZnHNTs-Ag-COS). The morphologies of printed constructs were analyzed using Scanning Electron Microscopy-Energy Dispersive X-Ray Spectroscopy (SEM-EDS), and chemical analysis by Fourier-transform infrared spectroscopy (FTIR). Assessment of the antimicrobial potential of our constructs was assessed using agar diffusion and biofilm assays. The surface of 3D printed PLA constructs were chemically modified to increase hydrophilicity and suspensions of COS-ZnHNTs-Ag were adsorbed on the construct surface. Surface adsorption of ZnHNTs-Ag-COS on PLA printed constructs was determined to be a function of relative pore size. Morphological surface characterization using SEM-EDS confirmed the presence of the suspension coatings on the constructs, and FTIR analysis confirmed the presence of COS-ZnHNTs-Ag in the coatings. The inhibition of bacterial growth was evaluated using the agar diffusion method. Results obtained confirmed the antimicrobial potential of the PLA constructs (which was a function of the Ag content in the material).

对于接受牙科或整形外科手术的患者来说，控制和抑制微生物感染至关重要。其中一项关键要求是防止细菌生长、细菌随后在种植体表面定植以及生物膜的形成。在形成生物膜的细菌中，金黄色葡萄球菌和表皮葡萄球菌是导致植入物相关感染的最常见细菌。生产定制的、针对患者的抗菌治疗方法将大大减少感染，促进患者康复。我们建议，用于按需预防感染和疾病的 3D 打印抗菌生物医学设备是预防感染的合理解决方案。在本研究中，我们使用碱处理对 3D 打印聚乳酸（PLA）构建体进行改性，以增加亲水性，并使用乳酸锌/HNTs-Ag-壳聚糖低聚糖（ZnHNTs-Ag-COS）悬浮液对构建体表面进行功能化。使用扫描电子显微镜-能量色散 X 射线光谱法（SEM-EDS）分析了印刷构建体的形态，并使用傅立叶变换红外光谱法（FTIR）进行了化学分析。使用琼脂扩散和生物膜试验评估了我们构建物的抗菌潜力。对三维打印聚乳酸构建体的表面进行化学修饰以增加亲水性，并在构建体表面吸附 COS-ZnHNTs-Ag 悬浮液。聚乳酸打印结构体上 ZnHNTs-Ag-COS 的表面吸附被确定为相对孔径的函数。使用 SEM-EDS 进行的形态表面表征证实了构建体上存在悬浮涂层，傅立叶变换红外分析证实了涂层中存在 COS-ZnHNTs-Ag。使用琼脂扩散法评估了对细菌生长的抑制作用。结果证实了聚乳酸构筑物的抗菌潜力（与材料中的银含量有关）。

{"title":"3D printed antimicrobial PLA constructs functionalised with zinc- coated halloysite nanotubes-Ag-chitosan oligosaccharide lactate.","authors":"Ahmed Humayun, Yangyang Luo, Anusha Elumalai, David K Mills","doi":"10.1080/10667857.2020.1806188","DOIUrl":"10.1080/10667857.2020.1806188","url":null,"abstract":"The control and inhibition of microbial infection are of critical importance for patients undergoing dental or orthopedic surgery. A critical requirement is the prevention of bacterial growth, subsequent bacterial colonization of implant surfaces, and biofilm formation. Among biofilm-forming bacteria, S. aureus and S. epidermidis are the most common bacteria responsible for causing implant-related infections. The ability to produce customized and patient-specific antimicrobial treatments will significantly reduce infections leading to enhanced patient recovery. We propose that 3D-printed antimicrobial biomedical devices for on-demand infection prophylaxis and disease prevention are a rational solution for the prevention of infection. In this study, we modified 3D printed polylactic acid (PLA) constructs using an alkali treatment to increase hydrophilicity and functionalized the surface of the constructs using a suspension of Zinc/HNTs-Ag-Chitosan Oligosaccharide Lactate (ZnHNTs-Ag-COS). The morphologies of printed constructs were analyzed using Scanning Electron Microscopy-Energy Dispersive X-Ray Spectroscopy (SEM-EDS), and chemical analysis by Fourier-transform infrared spectroscopy (FTIR). Assessment of the antimicrobial potential of our constructs was assessed using agar diffusion and biofilm assays. The surface of 3D printed PLA constructs were chemically modified to increase hydrophilicity and suspensions of COS-ZnHNTs-Ag were adsorbed on the construct surface. Surface adsorption of ZnHNTs-Ag-COS on PLA printed constructs was determined to be a function of relative pore size. Morphological surface characterization using SEM-EDS confirmed the presence of the suspension coatings on the constructs, and FTIR analysis confirmed the presence of COS-ZnHNTs-Ag in the coatings. The inhibition of bacterial growth was evaluated using the agar diffusion method. Results obtained confirmed the antimicrobial potential of the PLA constructs (which was a function of the Ag content in the material).","PeriodicalId":74118,"journal":{"name":"Materials technology (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373048/pdf/nihms-1621769.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary Validation of a Dynamic Electrochemical Biodegradation Test Bench in Pseudo-Physiological Conditions. 模拟生理条件下动态电化学生物降解试验台的初步验证。

Materials technology (New York, N.Y.)

Pub Date : 2018-01-01 Epub Date: 2017-12-21 DOI: 10.1080/10667857.2017.1416972

Jessica Gayle, Anil Mahapatro, Hailey Lundin

There is a growing interest in the development of next generation stent materials. In vitro tests that accurately predict in vivo conditions, are needed for a full evaluation of a material's corrosion in vivo. In this manuscript a novel approach for the design of a dynamic electrochemical test bench is evaluated in hopes to later characterize and model biodegradable metallic stent materials. This dynamic test bench design allows for real-time corrosion testing with easy variation of temperature, shear stress, and simulated body fluids (SBF), with minimal complications of test sample fabrication. Preliminary tests have shown Tafel generation stable. Further testing of the stability of the test bench were conducted with the incorporation SBF, shear stress, and temperature. Shear stress was applied through variation in fluid velocities at 0 m/s, 0.127 m/s, 0.245 m/s, 0.372 m/s, 0.489 m/s at 37°C. Incorporation of the different SBFs showed no significant difference in corrosion readings; however, variances were observed higher in DMEM and PBS, than in Hanks, respectively. This dynamic test bench showed to be relatively stable under temperature and SBF modification; however, further optimization is needed to decrease variances seen throughout fluid velocity analysis.

人们对新一代支架材料的开发越来越感兴趣。为了全面评估材料在体内的腐蚀情况，需要能够准确预测体内条件的体外试验。在这篇论文中，动态电化学试验台设计的新方法被评估，希望以后表征和模拟可生物降解的金属支架材料。这种动态试验台设计允许实时腐蚀测试，温度、剪切应力和模拟体液(SBF)的变化很容易，测试样品制造的复杂性最小。初步测试表明塔非尔的生成稳定。对试验台的稳定性进行了进一步的试验，试验中加入了SBF、剪切应力和温度。在37°C下，通过0 m/s、0.127 m/s、0.245 m/s、0.372 m/s、0.489 m/s的流体速度变化施加剪切应力。加入不同的SBFs后，腐蚀读数没有显著差异;然而，DMEM和PBS的差异分别高于Hanks。该动态试验台在温度和SBF改性条件下相对稳定;然而，需要进一步优化，以减少在流体速度分析中看到的差异。

{"title":"Preliminary Validation of a Dynamic Electrochemical Biodegradation Test Bench in Pseudo-Physiological Conditions.","authors":"Jessica Gayle, Anil Mahapatro, Hailey Lundin","doi":"10.1080/10667857.2017.1416972","DOIUrl":"https://doi.org/10.1080/10667857.2017.1416972","url":null,"abstract":"There is a growing interest in the development of next generation stent materials. In vitro tests that accurately predict in vivo conditions, are needed for a full evaluation of a material's corrosion in vivo. In this manuscript a novel approach for the design of a dynamic electrochemical test bench is evaluated in hopes to later characterize and model biodegradable metallic stent materials. This dynamic test bench design allows for real-time corrosion testing with easy variation of temperature, shear stress, and simulated body fluids (SBF), with minimal complications of test sample fabrication. Preliminary tests have shown Tafel generation stable. Further testing of the stability of the test bench were conducted with the incorporation SBF, shear stress, and temperature. Shear stress was applied through variation in fluid velocities at 0 m/s, 0.127 m/s, 0.245 m/s, 0.372 m/s, 0.489 m/s at 37°C. Incorporation of the different SBFs showed no significant difference in corrosion readings; however, variances were observed higher in DMEM and PBS, than in Hanks, respectively. This dynamic test bench showed to be relatively stable under temperature and SBF modification; however, further optimization is needed to decrease variances seen throughout fluid velocity analysis.","PeriodicalId":74118,"journal":{"name":"Materials technology (New York, N.Y.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10667857.2017.1416972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37085982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Materials technology (New York, N.Y.)

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀