PHYTOnutrients (Karachi, Pakistan)最新文献

Dietary chemoprevention has emerged as a cost-effective approach to control most prevalent chronic diseases including cancer. Changes in dietary patterns and lifestyle, such as increasing the consumption of fruits and vegetables and more balanced intakes of meat and plant foods, are a practical and effective strategy for reducing the incidence of chronic diseases. Phytonutrients (or phytochemicals) are found in eatable fruits and vegetables that, daily ingested, may exhibit a potential for modulating human metabolism in a manner favourable for the prevention of chronic and degenerative diseases. Carotenoids and flavonoids (anthocyanins, phenolic acids, polyphenols) are examples of phytonutrients. Consumption of total phytochemical intake has been consistently linked to protection from chronic diseases, including cardiovascular disease, cancer and neurodegenerative diseases. To highlight the beneficial health effects of phytonutrients in plants, we choose two interesting plants, the potato and the citrus fruits. They were chosen owing to their phytonutrient content, and low price, which makes them more easily acquired in low incoming populations, and consequently they are highly consumed not only in developing but also in developed countries. Due to its high nutrient and phytochemical content, the potato can lower oxidative stress, a key mechanism for cancer and cardiovascular disease prevention. Its phenolic compounds act as antioxidants and improve heart health. Furthermore, this review emphasizes the bioactive compounds in citrus which can reduce inflammatory mediators and reactive oxygen species generation, thus attenuating the risk of neurodegenerative diseases, cardiovascular disease, diabetes, and cancer. Besides important applications in the functional food sector, phytochemicals are also employed in the production of cosmetic and/or cosmeceutical products.

THIS study was designed to investigate the anxiolytic and antidepressant activity of Duchesnea Indica. The methanolic extract and n-hexane fraction of plant were tested in albino mice (20-30 g of 6-8 week). Safety profile of each extract was determined at different doses. Anxiolytic effect of plant was determined by Elevated Plus Maze and Light and Dark Model at different doses of methanolic and n-hexane extract. Antidepressant activities were assisted by Tail Suspension and Forced Swim Model at different doses. Result illustrated that D. Indica had a significant (P < 0.05) potential of reducing anxiety and depression. The methanolic extract at 100 mg and 200 mg significantly increased the time spend in light region of light and dark model and more time spent in open arm of Elevated Plus Maze model. n-hexane extract at dose of 5 mg and 10 mg/kg significantly increases the time spend in light region of Light and dark model and more time spend in open arm of Elevated Plus Maze model as compare to Control group. Methanolic extract of D. Indica significantly reduced the time of immobility in Tail Suspension and Force Swim Model at Dose of 100 mg and 200mg/kg. n-hexane extract also exhibit anti-depressant effect by reducing the time of immobility in Force swim and tail suspension Model at 100 mg and 200mg/kg dose as compare to control group. From the above observations, it could be assumed that the plant has marked anxiolytic and antidepressant potential. However further additional studies will be necessary to determine the underlying exact mechanism and clinical uses.