Recognizing multiple neuropathological entities in people with dementia improves understanding of diagnosis, prognosis, and expected outcomes from therapies. Care for the individual with dementia includes the evaluation and management of diseases associated with the aged brain, most commonly neurodegeneration and vascular brain injury (VBI). Terminology has evolved to keep pace with diagnostic, prognostic, and therapeutic advances, and autopsy studies have shown that multiple comorbid neuropathological entities are the rule, not the exception, especially in older individuals. With the advent of disease-modifying therapies, delivering dementia care requires an encompassing framework that allows clinicians to consider all of an individual's underlying diseases and their contributions to symptom burden. A diagnostic approach, common co-occurring pathologies, and implications for current and future clinical care are reviewed.
{"title":"A Precision Medicine Approach to Dementia Care: Syndrome, Etiology, and Copathology.","authors":"D Luke Fischer, William W Seeley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recognizing multiple neuropathological entities in people with dementia improves understanding of diagnosis, prognosis, and expected outcomes from therapies. Care for the individual with dementia includes the evaluation and management of diseases associated with the aged brain, most commonly neurodegeneration and vascular brain injury (VBI). Terminology has evolved to keep pace with diagnostic, prognostic, and therapeutic advances, and autopsy studies have shown that multiple comorbid neuropathological entities are the rule, not the exception, especially in older individuals. With the advent of disease-modifying therapies, delivering dementia care requires an encompassing framework that allows clinicians to consider all of an individual's underlying diseases and their contributions to symptom burden. A diagnostic approach, common co-occurring pathologies, and implications for current and future clinical care are reviewed.</p>","PeriodicalId":74484,"journal":{"name":"Practical neurology (Fort Washington, Pa.)","volume":"2023 ","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399644/pdf/nihms-1915720.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor German Patron, Yazmin Rustomji, Chadwick Yip, Lisanne Michelle Jenkins
Attachment deficits in the context of psychosocial factors may explain the presence of functional neurologic disorder.
心理社会因素背景下的依恋缺陷可以解释功能性神经障碍的存在。
{"title":"Psychiatric Comorbidities in Functional Neurologic Symptom Disorder.","authors":"Victor German Patron, Yazmin Rustomji, Chadwick Yip, Lisanne Michelle Jenkins","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Attachment deficits in the context of psychosocial factors may explain the presence of functional neurologic disorder.</p>","PeriodicalId":74484,"journal":{"name":"Practical neurology (Fort Washington, Pa.)","volume":"21 3","pages":"71-75"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836030/pdf/nihms-1818340.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9377548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular Imaging Biomarkers in Dementia: Amyloid and tau PET imaging aids evaluation of patients suspected of having Alzheimer disease or other dementias.","authors":"Brad Dickerson, Alireza Atri","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74484,"journal":{"name":"Practical neurology (Fort Washington, Pa.)","volume":"19 9","pages":"34-45"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387980/pdf/nihms-1677163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39363589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam M Staffaroni, Elena Tsoy, Jack Taylor, Adam L Boxer, Katherine L Possin
{"title":"Digital Cognitive Assessments for Dementia: Digital assessments may enhance the efficiency of evaluations in neurology and other clinics.","authors":"Adam M Staffaroni, Elena Tsoy, Jack Taylor, Adam L Boxer, Katherine L Possin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74484,"journal":{"name":"Practical neurology (Fort Washington, Pa.)","volume":"2020 ","pages":"24-45"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078574/pdf/nihms-1656445.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38931742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amyotrophic Lateral Sclerosis: Integrated care provides the best quality of life.","authors":"Jonathan R Brent, Senda Ajroud-Driss","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74484,"journal":{"name":"Practical neurology (Fort Washington, Pa.)","volume":"18 ","pages":"46-49"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978460/pdf/nihms-1676127.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25501926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosing and Treating Co-morbid Sleep Apnea in Neurological Disorders, Part II.","authors":"Erik K St Louis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74484,"journal":{"name":"Practical neurology (Fort Washington, Pa.)","volume":"9 5","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716573/pdf/nihms457492.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31240571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosing And Treating Co-Morbid Sleep Apnea In Neurological Disorders.","authors":"Erik K St Louis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":74484,"journal":{"name":"Practical neurology (Fort Washington, Pa.)","volume":"9 4","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268511/pdf/nihms228640.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30430523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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