Autoimmune and Infectious Diseases: Open Access最新文献

Comparison of the Efficacy of 3 Anti-Viral Regimens Containing Kaletra, Ribavirin and Sofosbuvir in COVID 19 Disease 卡雷特拉、利巴韦林和索非布韦3种抗病毒方案治疗COVID - 19的疗效比较

Autoimmune and Infectious Diseases: Open Access

Pub Date : 2020-01-01 DOI: 10.16966/2470-1025.129

Davoudi A, Najafi N, Sphandyari E, Kasgari Ha, Tayebi A, Akbari A, Tabarestani M, Beyzaee Am

Background: New therapeutic options are urgently needed to handle the ongoing pandemic of coronavirus disease 2019 (COVID-19). As some antiviral therapeutic regimens are assumed to be helpful, we decided to compare the efficacy of kaletra, kaletra plus ribavirin, and kaletra plus ribavirin plus sofosbuvir, as three different therapeutic regimens in covid 19 patients.

背景:为应对持续不断的2019冠状病毒病(COVID-19)大流行，迫切需要新的治疗方案。由于一些抗病毒治疗方案被认为是有帮助的，我们决定比较卡列妥拉、卡列妥拉加利巴韦林、卡列妥拉加利巴韦林加索非布韦作为三种不同治疗方案在covid - 19患者中的疗效。

引用次数: 0

High Prevalence of Altered Immunological Biomarkers in a Transgender Population 变性人群免疫生物标志物改变的高发率

Autoimmune and Infectious Diseases: Open Access

Pub Date : 2020-01-01 DOI: 10.16966/2470-1025.125

Ramos Sg, Ingenito F, Mormandi Ea, Nagelberg Aj, Otero Pm, Lessa Cf, Carballo Og

Prevalence of in a Transgender

在跨性别人群中的患病率

引用次数: 2

Mycobacterium tuberculosis/Cryptococcus neoformans Co-Infection in an Immunocompetent Non-HIV Patient 免疫功能正常的非hiv患者结核分枝杆菌/新型隐球菌合并感染

Autoimmune and Infectious Diseases: Open Access

Pub Date : 2020-01-01 DOI: 10.16966/2470-1025.127

Albahrani S, Al Hassan D, Vapra Y, Alsubaiae S, Shilash A

Background: Tuberculosis and cryptococcosis co-infection usually occurs in immunocompromised patients with impaired cell-mediated immunity. Here, we report a case of disseminated tuberculosis with co-existing pulmonary cryptococcosis in a non-HIV patient. However, there is a history of preceding exposure to anti-tumor necrosis agents.

背景:结核和隐球菌病合并感染通常发生在细胞介导免疫功能受损的免疫功能低下患者中。在这里，我们报告一个病例播散性肺结核与共存的肺隐球菌病在一个非艾滋病患者。然而，之前有接触抗肿瘤坏死剂的历史。

引用次数: 0

Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania. TLR4和MICA基因多态性与坦桑尼亚沙眼病的严重程度相关

Autoimmune and Infectious Diseases: Open Access

Pub Date : 2016-06-01 Epub Date: 2016-06-03 DOI: 10.16966/2470-1025.116

Muneer Abbas, Noureddine Berka, Mozna Khraiwesh, Ali Ramadan, Victor Apprey, Paulette Furbert-Harris, Thomas Quinn, Hassan Brim, Georgia Dunston

Aim: To examine the association of TLR4 Asp299Gly and MICA exon 5 microsatellites polymorphisms with severity of trachoma in a sub-Saharan East Africa population of Tanzanian villagers.

Methods: The samples were genotyped for MICA exon 5 microsatellites and the TLR4 299 A/G polymorphism by Restriction Fragment Length Polymorphism (RFLP), and GeneScan^®, respectively. The association of TLR4 Asp299Gly and MICA exon 5 microsatellites with inflammatory trachoma (TI) and trichiasis (TI) were examined.

Results: The results showed an association between TLR4 and MICA polymorphisms and trachoma disease severity, as well as with protection. TLR4 an allele was significantly associated with inflammatory trachoma (p=0.0410), while the G allele (p=0.0410) was associated with protection.

Conclusion: TLR4 and MICA may modulate the risk of severity to trachoma disease by modulating the immune response to Ct. In addition; the increased frequency of MICA-A9 heterozygote in controls may suggest a positive selection of these alleles in adaptation to environments where Ct is endemic.

目的:研究TLR4 Asp299Gly和MICA外显子5微卫星多态性与撒哈拉以南东非坦桑尼亚村民沙眼严重程度的关系。方法:采用限制性片段长度多态性(RFLP)和GeneScan®分别对MICA外显子5微卫星和TLR4 299 A/G多态性进行基因分型。研究了TLR4 Asp299Gly和MICA外显子5微卫星与炎症性沙眼(TI)和倒睫(TI)的相关性。结果:结果显示TLR4和MICA多态性与沙眼疾病严重程度以及保护作用之间存在关联。tlr4a等位基因与炎性沙眼显著相关(p=0.0410)，而G等位基因与保护相关(p=0.0410)。结论:TLR4和MICA可能通过调节对Ct的免疫反应来调节沙眼疾病严重程度的风险。除了;对照组中MICA-A9杂合子频率的增加可能表明，在适应Ct流行的环境时，这些等位基因出现了正选择。

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引用次数: 3

Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis 干细胞衍生调节性T细胞用于关节炎的治疗

Autoimmune and Infectious Diseases: Open Access

Pub Date : 2016-06-01 DOI: 10.16966/2470-1025.119

Jianxun Song

Pluripotent stem cells (PSCs) can be utilized to obtain a renewable source of healthy regulatory T cells (Tregs) to treat autoimmune arthritis as they have the ability to produce almost all cell types in the body, including Tregs. However, the right conditions for the development of antigen (Ag)-specific Tregs from PSCs (i.e., PSC-Tregs) remain unknown. An ongoing project will determine the mechanisms underlying the Ag-specific PSC-Treg treatments that aim to modulate tolerance in autoimmune arthritis. The knowledge gained from these studies will provide new insights into cell-based therapies in autoimmune arthritis, and advance the understanding of fundamental mechanisms underlying Treg differentiation.

多能干细胞(PSCs)可用于获得健康调节性T细胞(Tregs)的可再生来源，以治疗自身免疫性关节炎，因为它们具有产生体内几乎所有细胞类型的能力，包括Tregs。然而，从psc中发展抗原(Ag)特异性treg(即psc - treg)的正确条件仍然未知。一个正在进行的项目将确定ag特异性PSC-Treg治疗的机制，旨在调节自身免疫性关节炎的耐受性。从这些研究中获得的知识将为自身免疫性关节炎的细胞治疗提供新的见解，并促进对Treg分化的基本机制的理解。

引用次数: 1