Journal of nursing (Luton, England)最新文献

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Using the NIH symptom science model to understand fatigue and mitochondrial bioenergetics. 使用NIH症状科学模型来理解疲劳和线粒体生物能量学。

Journal of nursing (Luton, England)

Pub Date : 2020-01-01 DOI: 10.7243/2056-9157-7-2

Qiuhua Shen, Diane Mahoney, Jill Peltzer, Faith Rahman, Kathryn J Krueger, John B Hiebert, Janet D Pierce

The symptom of fatigue is prevalent among patients with chronic diseases and conditions such as congestive heart failure and cancer. It has a significant debilitating impact on patients' physical health, quality of life, and well-being. Early detection and appropriate assessment of fatigue is essential for diagnosing, treating, and monitoring disease progression. However, it is often challenging to manage the symptom of fatigue without first investigating the underlying biological mechanisms. In this narrative review, we conceptualize the symptom of fatigue and its relationship with mitochondrial bioenergetics using the National Institute of Health Symptom Science Model (NIH-SSM). In particular, we discuss mental and physical measures to assess fatigue, the importance of adenosine triphosphate (ATP) in cellular and organ functions, and how impaired ATP production contributes to fatigue. Specific methods to measure ATP are described. Recommendations are provided concerning how to integrate biological mechanisms with the symptom of fatigue for future research and clinical practice to help alleviate symptoms and improve patients' quality of life.

疲劳的症状在患有慢性疾病和诸如充血性心力衰竭和癌症的患者中很普遍。它对患者的身体健康、生活质量和福祉有重大的衰弱影响。早期发现和适当评估疲劳对于诊断、治疗和监测疾病进展至关重要。然而，在不首先调查潜在的生物学机制的情况下，管理疲劳症状往往是具有挑战性的。在这篇叙述性综述中，我们概念化疲劳症状及其与线粒体生物能量学的关系，使用美国国立卫生研究院症状科学模型(NIH-SSM)。特别是，我们讨论了评估疲劳的精神和身体措施，三磷酸腺苷(ATP)在细胞和器官功能中的重要性，以及ATP产生受损如何导致疲劳。介绍了测量ATP的具体方法。就如何将疲劳的生物学机制与疲劳症状结合起来，为今后的研究和临床实践提供建议，以帮助缓解疲劳症状，提高患者的生活质量。

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