Bobby D Nossaman, Haseeb A Akuly, George F Lasker, Vaughn E Nossaman, Philip A Rothberg, Philip J Kadowitz
Nitrite was a therapeutic agent used in the treatment of angina pectoris and hypertension, but was replaced by nitroglycerin. However, nitrite has recently been rediscovered following observations that this anion possesses novel pharmacologic actions such as producing vasodilation, modulating hypoxic vasodilation, and providing cytoprotection in ischemia-reperfusion injury. Moreover, recent observations in animal and human studies have demonstrated that the reduction of nitrite to vasoactive nitric oxide occurs through both enzymatic and non-enzymatic processes. These findings suggest that nitrite may act as a storage form for nitric oxide and provide support for investigating the use of nitrite in the treatment of ischemic disease states including pulmonary hypertension.
{"title":"The Reemergence of Nitrite as a Beneficial Agent in the Treatment of Ischemic Cardiovascular Diseases.","authors":"Bobby D Nossaman, Haseeb A Akuly, George F Lasker, Vaughn E Nossaman, Philip A Rothberg, Philip J Kadowitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nitrite was a therapeutic agent used in the treatment of angina pectoris and hypertension, but was replaced by nitroglycerin. However, nitrite has recently been rediscovered following observations that this anion possesses novel pharmacologic actions such as producing vasodilation, modulating hypoxic vasodilation, and providing cytoprotection in ischemia-reperfusion injury. Moreover, recent observations in animal and human studies have demonstrated that the reduction of nitrite to vasoactive nitric oxide occurs through both enzymatic and non-enzymatic processes. These findings suggest that nitrite may act as a storage form for nitric oxide and provide support for investigating the use of nitrite in the treatment of ischemic disease states including pulmonary hypertension.</p>","PeriodicalId":88829,"journal":{"name":"Asian Journal of Experimental Biological Sciences","volume":"1 2","pages":"451-459"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955410/pdf/nihms223288.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29356159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-03-01DOI: 10.3923/JAS.2009.1936.1942
H. Khazali
{"title":"Effect of orexin infusion into third ventricle on the GnRH and LH secretions in the prepubertal rat fed restricted.","authors":"H. Khazali","doi":"10.3923/JAS.2009.1936.1942","DOIUrl":"https://doi.org/10.3923/JAS.2009.1936.1942","url":null,"abstract":"","PeriodicalId":88829,"journal":{"name":"Asian Journal of Experimental Biological Sciences","volume":"50 1","pages":"597-604"},"PeriodicalIF":0.0,"publicationDate":"2009-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85576601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号