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The metabolism of tromantadine. tromantadine的代谢。
Biomedical mass spectrometry
Pub Date : 1985-09-01
C Köppel, J Tenczer, E Rütten, F Klaschka

The metabolism of the antiviral drug tromantadine (1-adamantyl-2-(2-dimethylaminoethoxy)acetamide) was studied after an oral dose of 120 mg tromantadine hydrochloride using capillary gas chromatography/mass spectrometry. Most of the dose was excreted unchanged with the urine. Six metabolites could be identified. The main metabolic products were 1-aminoadamantane (amantadine) and 1-adamantyl-(2-hydroxy)acetamide. Further metabolic pathways were demethylation of the dimethylamino function and oxidative desamination to an unstable aldehyde which is oxidized to a carbonic acid or reduced to an alcohol.

采用毛细管气相色谱/质谱联用技术研究了口服盐酸曲金刚乙胺120 mg后抗病毒药物曲金刚乙胺(1-金刚乙胺-2-(2-二甲氨基乙氧基)乙酰胺的代谢。大部分剂量随尿液排出。鉴定出6种代谢物。主要代谢产物为1-氨基金刚烷(金刚烷胺)和1-金刚烷基-(2-羟基)乙酰胺。进一步的代谢途径是二甲胺功能的去甲基化和氧化脱胺生成不稳定的醛，醛被氧化为碳酸或还原为醇。
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引用次数: 0
The metabolism of tromantadine. tromantadine的代谢。
Biomedical mass spectrometry
Pub Date : 1985-09-01 DOI: 10.1002/BMS.1200120909
C. Köppel, J. Tenczer, E. Rütten, F. Klaschka
The metabolism of the antiviral drug tromantadine (1-adamantyl-2-(2-dimethylaminoethoxy)acetamide) was studied after an oral dose of 120 mg tromantadine hydrochloride using capillary gas chromatography/mass spectrometry. Most of the dose was excreted unchanged with the urine. Six metabolites could be identified. The main metabolic products were 1-aminoadamantane (amantadine) and 1-adamantyl-(2-hydroxy)acetamide. Further metabolic pathways were demethylation of the dimethylamino function and oxidative desamination to an unstable aldehyde which is oxidized to a carbonic acid or reduced to an alcohol.
采用毛细管气相色谱/质谱联用技术研究了口服盐酸曲金刚乙胺120 mg后抗病毒药物曲金刚乙胺(1-金刚乙胺-2-(2-二甲氨基乙氧基)乙酰胺的代谢。大部分剂量随尿液排出。鉴定出6种代谢物。主要代谢产物为1-氨基金刚烷(金刚烷胺)和1-金刚烷基-(2-羟基)乙酰胺。进一步的代谢途径是二甲胺功能的去甲基化和氧化脱胺生成不稳定的醛，醛被氧化为碳酸或还原为醇。
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引用次数: 3
Proceedings of the Fifth International Symposium on Mass Spectrometry in Life Sciences. Ghent, Belgium, 15-18 May 1984. 第五届生命科学质谱国际研讨会论文集。1984年5月15日至18日，比利时根特。
Biomedical mass spectrometry
Pub Date : 1985-09-01
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引用次数: 0
Symposium on mass spectrometry: the search for zero. 质谱研讨会:寻找零。
Biomedical mass spectrometry
Pub Date : 1981-09-01
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引用次数: 0
Letter: Ion monitoring nomenclature. 信:离子监测术语。
Biomedical mass spectrometry
Pub Date : 1975-02-01
B S Middleditch
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引用次数: 0
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