J Kunze, V Ngai, S Koelling, J J Jacobs, M A Wimmer
Ultra-high molecular weight polyethylene (UHMWPE) is the most common counterface material against metals or ceramics in artificial hip or knee joints. Wear and the resulting particulate debris, however, limit the life span of the implant. In this study, the general feasibility of using Europium (Eu) as tracer material to quantify UHMWPE wear in joint fluid is investigated. Using Inductively Coupled Mass Spectrometry (ICP-MS), recovery experiments of Eu in artificial joint fluid were performed. In order to dope polyethylene with 50 ppm Eu, nascent UHMWPE powder was mixed with a solution of Eu-stearate. The heterogeneity of the mixture was assessed by determining the coefficient of variation (CV) of the Eu content in various weighted samples. After molding of the UHMWPE powder mixture, cylindrical pins of 10 mm diameter were machined and worn against cobalt-chromium metal disks submersed in artificial joint fluid. The Eu-content of fluid samples taken at certain time intervals was measured and compared with UHMWPE weight loss of the pins. A satisfactory homogenization of Eu in the UHMWPE powder was achieved. Tracer-based and weight-loss determined wear rates were highly correlated (Pearson correlation coefficients > 0.991). Also the detection bias was within acceptable limits. Thus both methods demonstrated good agreement.
{"title":"The Use of Europiumstearate to Trace Polyethylene Wear Debris in Joint Fluid after Prosthetic Joint Replacement - A Feasibility Study.","authors":"J Kunze, V Ngai, S Koelling, J J Jacobs, M A Wimmer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ultra-high molecular weight polyethylene (UHMWPE) is the most common counterface material against metals or ceramics in artificial hip or knee joints. Wear and the resulting particulate debris, however, limit the life span of the implant. In this study, the general feasibility of using Europium (Eu) as tracer material to quantify UHMWPE wear in joint fluid is investigated. Using Inductively Coupled Mass Spectrometry (ICP-MS), recovery experiments of Eu in artificial joint fluid were performed. In order to dope polyethylene with 50 ppm Eu, nascent UHMWPE powder was mixed with a solution of Eu-stearate. The heterogeneity of the mixture was assessed by determining the coefficient of variation (CV) of the Eu content in various weighted samples. After molding of the UHMWPE powder mixture, cylindrical pins of 10 mm diameter were machined and worn against cobalt-chromium metal disks submersed in artificial joint fluid. The Eu-content of fluid samples taken at certain time intervals was measured and compared with UHMWPE weight loss of the pins. A satisfactory homogenization of Eu in the UHMWPE powder was achieved. Tracer-based and weight-loss determined wear rates were highly correlated (Pearson correlation coefficients > 0.991). Also the detection bias was within acceptable limits. Thus both methods demonstrated good agreement.</p>","PeriodicalId":90378,"journal":{"name":"Trends in applied spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049185/pdf/nihms573092.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32416264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fourier transform infrared spectroscopy (FTIR) has the potential to mark up the chemical changes of the materials, as almost all the materials contain their signatures in infrared region. Spectroscopy combined with spatial resolution enables the possibility of characterizing samples up to microscopic level. The emerging development of instrumentation to provide spatial information for infrared (IR) spectroscopy, termed as IR microscopy, provides an opening for newer applications in terms of image analysis, novel data processing tools, etc. Characterization of biomaterials using IR spectroscopy has a trace back to 1950s. The advent of FTIR with imaging capability made characterization possible in cartilage tissue and other biological systems. Extensive analysis of chemical constituents of cartilage and tendon, collagen orientation and polarization property of cartilage using FTIR imaging (FTIRI) has been actively explored during the last two decades. Also, studies using specialized instrumentations like synchrotron FTIR imaging have been attempted to understand the characteristics of biological samples like cartilage. This review covers most of those investigations on cartilage with FTIRI to characterize the same in terms of component characteristics and quantification, collagen orientation, zonal boundary determination, influence of mechanical compression on tissue nature and its correlation to other techniques in last 20 years.
{"title":"Fourier-transform infrared spectroscopic imaging of articular cartilage and biomaterials: A review.","authors":"Nagarajan Ramakrishnan, Yang Xia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fourier transform infrared spectroscopy (FTIR) has the potential to mark up the chemical changes of the materials, as almost all the materials contain their signatures in infrared region. Spectroscopy combined with spatial resolution enables the possibility of characterizing samples up to microscopic level. The emerging development of instrumentation to provide spatial information for infrared (IR) spectroscopy, termed as IR microscopy, provides an opening for newer applications in terms of image analysis, novel data processing tools, etc. Characterization of biomaterials using IR spectroscopy has a trace back to 1950s. The advent of FTIR with imaging capability made characterization possible in cartilage tissue and other biological systems. Extensive analysis of chemical constituents of cartilage and tendon, collagen orientation and polarization property of cartilage using FTIR imaging (FTIRI) has been actively explored during the last two decades. Also, studies using specialized instrumentations like synchrotron FTIR imaging have been attempted to understand the characteristics of biological samples like cartilage. This review covers most of those investigations on cartilage with FTIRI to characterize the same in terms of component characteristics and quantification, collagen orientation, zonal boundary determination, influence of mechanical compression on tissue nature and its correlation to other techniques in last 20 years.</p>","PeriodicalId":90378,"journal":{"name":"Trends in applied spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830739/pdf/nihms-1008360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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