Advanced health care technologies最新文献

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Biofunctionalization of biomaterials for nitric oxide delivery: potential applications in regenerative medicine 一氧化氮递送生物材料的生物功能化:在再生医学中的潜在应用

Advanced health care technologies

Pub Date : 2018-08-01 DOI: 10.2147/AHCT.S144816

Kai Jen Tsai, Anna Rammou, Chuanyu Gao, A. Mel

*These authors contributed equally to this work Introduction: Mimicking physiological functions of nitric oxide (NO) has applications in regenerative medicine. However, few NO delivery systems have progressed to clinical trials owing to limitations in delivery. Materials and methods: A novel NO delivery system was explored by integrating S-nitroN-acetylpenicillamine-functionalized long-chain aliphatic hydrocarbons (LCAHs) into a polyurethane-based polymer. Results and discussion: Contact angle analysis determined the novel delivery system to be significantly more hydrophobic than control. Chemilluminscence showed a four-phase NO release profile of the delivery system with more stable and prolong NO release than control. Conclusion: LCAHs can optimize the duration and rate of NO delivery and present a viable option for use in surgical implants and biomedical applications.

简介:模拟一氧化氮(NO)的生理功能在再生医学中有应用。然而，由于递送的限制，很少有NO递送系统已经进展到临床试验。材料与方法:通过将s -硝基乙酰青霉胺功能化的长链脂肪烃(LCAHs)整合到聚氨酯基聚合物中，探索了一种新的NO递送系统。结果和讨论:接触角分析确定了新型给药系统明显比对照更疏水。化学发光结果表明，该给药体系的NO释放呈四相分布，且释放时间较对照组稳定和延长。结论:LCAHs可优化NO的输送时间和速度，为外科植入物和生物医学应用提供了可行的选择。

引用次数: 0

Smartphone electrocardiogram monitoring: current perspectives 智能手机心电图监测:当前观点

Advanced health care technologies

Pub Date : 2018-06-01 DOI: 10.2147/AHCT.S138445

Andrew L. Walker, J. Muhlestein

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引用次数: 19

Smartphone applications to support weight loss: current perspectives. 支持减肥的智能手机应用程序：当前视角。

Advanced health care technologies

Pub Date : 2015-07-01 DOI: 10.2147/AHCT.S57844

Christine A Pellegrini, Angela F Pfammatter, David E Conroy, Bonnie Spring

Lower cost alternatives are needed for the traditional in-person behavioral weight loss programs to overcome challenges of lowering the worldwide prevalence of overweight and obesity. Smartphones have become ubiquitous and provide a unique platform to aid in the delivery of a behavioral weight loss program. The technological capabilities of a smartphone may address certain limitations of a traditional weight loss program, while also reducing the cost and burden on participants, interventionists, and health care providers. Awareness of the advantages smartphones offer for weight loss has led to the rapid development and proliferation of weight loss applications (apps). The built-in features and the mechanisms by which they work vary across apps. Although there are an extraordinary number of a weight loss apps available, most lack the same magnitude of evidence-based behavior change strategies typically used in traditional programs. As features develop and new capabilities are identified, we propose a conceptual model as a framework to guide the inclusion of features that can facilitate behavior change and lead to reductions in weight. Whereas the conventional wisdom about behavior change asserts that more is better (with respect to the number of behavior change techniques involved), this model suggests that less may be more because extra techniques may add burden and adversely impact engagement. Current evidence is promising and continues to emerge on the potential of smartphone use within weight loss programs; yet research is unable to keep up with the rapidly improving smartphone technology. Future studies are needed to refine the conceptual model's utility in the use of technology for weight loss, determine the effectiveness of intervention components utilizing smartphone technology, and identify novel and faster ways to evaluate the ever-changing technology.

传统的面对面行为减肥计划需要成本更低的替代方案，以克服降低全球超重和肥胖患病率的挑战。智能手机已变得无处不在，它为帮助实施行为减肥计划提供了一个独特的平台。智能手机的技术能力可以解决传统减肥计划的某些局限性，同时还能降低参与者、干预者和医疗服务提供者的成本和负担。由于人们意识到智能手机在减肥方面的优势，减肥应用程序（Apps）迅速发展和普及。不同应用程序的内置功能和工作机制各不相同。虽然减肥应用程序的数量非常多，但大多数都缺乏传统程序中通常使用的循证行为改变策略。随着功能的发展和新功能的确定，我们提出了一个概念模型作为框架，以指导纳入可促进行为改变并导致体重减轻的功能。关于行为改变的传统观点认为越多越好（涉及行为改变技术的数量），而本模型则认为越少越好，因为额外的技术可能会增加负担并对参与度产生不利影响。目前的证据表明，智能手机在减肥计划中的应用潜力巨大，而且还在不断涌现；然而，研究工作却无法跟上智能手机技术的飞速发展。未来的研究需要完善概念模型在利用技术减肥方面的实用性，确定利用智能手机技术进行干预的有效性，并找出新颖、快速的方法来评估日新月异的技术。

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引用次数: 0

Smartphone applications to reduce alcohol consumption and help patients with alcohol use disorder: a state-of-the-art review. 智能手机应用程序减少酒精消耗，帮助酒精使用障碍患者:最新的审查。

Advanced health care technologies

Pub Date : 2015-01-01 Epub Date: 2015-12-11 DOI: 10.2147/AHCT.S65791

Steven E Meredith, Sheila M Alessi, Nancy M Petry

Hazardous drinking and alcohol use disorder (AUD) are substantial contributors to USA and global morbidity and mortality. Patient self-management and continuing care are needed to combat these public health threats. However, services are rarely provided to patients outside of clinic settings or following brief intervention. Smartphone applications (“apps”) may help narrow the divide between traditional health care and patient needs. The purpose of this review is to identify and summarize smartphone apps to reduce alcohol consumption or treat AUD that have been evaluated for feasibility, acceptability, and/or efficacy. We searched two research databases for peer-reviewed journal articles published in English that evaluated smartphone apps to decrease alcohol consumption or treat AUD. We identified six apps. Two of these apps (A-CHESS and LBMI-A) promoted self-reported reductions in alcohol use, two (Promillekoll and PartyPlanner) failed to promote self-reported reductions in alcohol use, and two (HealthCall-S and Chimpshop) require further evaluation and testing before any conclusions regarding efficacy can be made. In summary, few evaluations of smartphone apps to reduce alcohol consumption or treat AUD have been reported in the scientific literature. Although advances in smartphone technology hold promise for disseminating interventions among hazardous drinkers and individuals with AUD, more systematic evaluations are necessary to ensure that smartphone apps are clinically useful.

危险饮酒和酒精使用障碍(AUD)是美国和全球发病率和死亡率的重要因素。需要患者自我管理和持续护理来应对这些公共卫生威胁。然而，很少在诊所之外或在短暂干预后向患者提供服务。智能手机应用程序(“应用程序”)可能有助于缩小传统医疗保健和患者需求之间的差距。本综述的目的是识别和总结智能手机应用程序减少酒精消费或治疗AUD的可行性、可接受性和/或有效性评估。我们在两个研究数据库中搜索了同行评议的英文期刊文章，这些文章评估了智能手机应用程序减少酒精消费或治疗AUD的效果。我们确定了六个应用程序。其中两个应用程序(A-CHESS和LBMI-A)促进了自我报告的酒精使用减少，两个应用程序(promilllekoll和PartyPlanner)未能促进自我报告的酒精使用减少，两个应用程序(healthcal - s和Chimpshop)需要进一步评估和测试才能得出任何关于功效的结论。总之，科学文献中很少有关于智能手机应用程序减少酒精消费或治疗AUD的评估报告。尽管智能手机技术的进步有望在危险饮酒者和AUD患者中传播干预措施，但需要进行更系统的评估，以确保智能手机应用程序在临床上有用。

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引用次数: 46

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