Journal of nephrology research最新文献

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Is Response to Enuresis Treatment with Desmopressin Influenced by Family History, Associated Comorbidities or Obesity? 去氨加压素治疗遗尿反应受家族史、相关合并症或肥胖影响吗?

Journal of nephrology research

Pub Date : 2019-03-20 DOI: 10.17554/j.issn.2410-0579.2019.05.38

M. Kopač

Aim : To evaluate the role of family history of enuresis, associated comorbidities and body mass index in predicting response to enuresis treatment with desmopressin in children. Materials amd methods : 100 patients with monosymptomatic enuresis were evaluated in this retrospective study. The associations between family history of enuresis, associated comorbidities, body mass index and response to enuresis treatment with desmopressin were analysed with χ 2 statistical test. Results : Family history of enuresis was positive in 58.8 % of patients who responded to desmopressin treatment and in 54.5 % of non-responders. Among patients who responded to desmopressin treatment, obesity was present in 14.3 % and overweight in 19 % of patients. Among non-responders, obesity was present in 13.2 % and overweight in 7.9 % of patients. Among patients who responded to desmopressin treatment, comorbidity was present in 40.5 % of patients. Among 38 non-responders, comorbidity was present in 21.1 % of patients. The difference was not statistically significant in either of compared groups. Conclusion : The study did not prove statistically significant association between family history of enuresis, associated comorbidities or body mass index, and response to treatment with desmopressin.

目的：评估遗尿家族史、相关合并症和体重指数在预测儿童对去氨加压素遗尿治疗反应中的作用。材料与方法：对100例单症状遗尿患者进行回顾性研究。采用χ2统计检验分析遗尿家族史、相关合并症、体重指数和去氨加压素治疗遗尿反应之间的相关性。结果：58.8%的患者对去氨加压素治疗有反应，54.5%的无反应患者有遗尿家族史。在对去氨加压素治疗有反应的患者中，14.3%的患者肥胖，19%的患者超重。在无应答者中，13.2%的患者肥胖，7.9%的患者超重。在对去氨加压素治疗有反应的患者中，40.5%的患者存在合并症。在38名无应答者中，21.1%的患者存在合并症。两组的差异均无统计学意义。结论：该研究没有证明遗尿家族史、相关合并症或体重指数与去氨加压素治疗反应之间存在统计学意义的相关性。

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引用次数: 1

βENaC acts as a mechanosensor in renal vascular smooth muscle cells that contributes to renal myogenic blood flow regulation, protection from renal injury and hypertension. βENaC作为肾血管平滑肌细胞的机械传感器，参与肾肌源性血流调节，防止肾损伤和高血压。

Journal of nephrology research

Pub Date : 2015-06-26 DOI: 10.17554/J.ISSN.2410-0579.2015.01.12

H. Drummond, D. Stec

Pressure-induced constriction (also known as the "myogenic response") is an important mechanodependent response in small renal arteries and arterioles. The response is initiated by vascular smooth muscle cell (VSMC) stretch due to an increase in intraluminal pressure and leads to vasoconstriction. The myogenic response has two important roles as a mechanism of local blood flow autoregulation and protection against systemic blood pressure-induced microvascular damage. However, the molecular mechanisms underlying initiation of myogenic response are unresolved. Although several molecules have been considered initiators of the response, our laboratory has focused on the role of degenerin proteins because of their strong evolutionary link to mechanosensing in the nematode. Our laboratory has addressed the hypothesis that certain degenerin proteins act as mechanosensors in VSMCs. This article discusses the importance of a specific degenerin protein, β Epithelial Na+ Channel (βENaC), in pressure-induced vasoconstriction, renal blood flow and susceptibility to renal injury. We propose that loss of the renal myogenic constrictor response delays the correction of renal blood flow that occurs with fluctuations in systemic pressure, which allows pressure swings to be transmitted to the microvasculature, thus increasing the susceptibility to renal injury and hypertension. The role of βENaC in myogenic regulation is independent of tubular βENaC and thus represents a non-tubular role for βENaC in renal-cardiovascular homeostasis.

压力诱导的收缩(也称为“肌源性反应”)是肾小动脉和小动脉中重要的机械依赖性反应。这种反应是由血管平滑肌细胞(VSMC)因腔内压力增加而拉伸引起的，并导致血管收缩。肌源性反应有两个重要的作用，即局部血流自动调节机制和防止全身血压引起的微血管损伤。然而，引发肌源性反应的分子机制尚不清楚。虽然有几种分子被认为是这种反应的启动者，但我们的实验室主要关注退化素蛋白的作用，因为它们与线虫的机械感知有很强的进化联系。我们的实验室已经提出了一种假设，即某些变性蛋白在vsmc中起机械传感器的作用。本文讨论了一种特殊的变性蛋白β上皮Na+通道(β enac)在压力诱导的血管收缩、肾血流量和肾损伤易感性中的重要性。我们认为，肾肌原性收缩反应的丧失延迟了随着体压波动而发生的肾血流的纠正，从而使压力波动传递到微血管，从而增加了对肾损伤和高血压的易感性。βENaC在肌生成调节中的作用独立于管状βENaC，因此代表了βENaC在肾-心血管稳态中的非管状作用。

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引用次数: 11

Bladder cancer and urinary Schistosomiasis in Angola. 安哥拉的膀胱癌和尿路血吸虫病。

Journal of nephrology research

Pub Date : 2015-06-01 DOI: 10.17554/j.issn.2410-0579.2015.01.4

Monica C Botelho, Jacinta Figueiredo, Helena Alves

Schistosomiasis haematobia is among the most prevalent parasitosis in Angola. The pathology is characterized by serious and irreversible lesions in the urogenital tract induced by chronic infection with the parasite that can eventually lead to squamous cell carcinoma of the bladder. Considering the frequency and severe morbidity observed, even in younger ages, the purpose of this study was to assess the prevalence and morbidity of S. haematobium infection in Angola. A baseline survey was conducted between November 2007 and February 2008. A randomly sample of 300 inhabitants aged 15 to 75 years old participated in this study. Prevalence of S. haematobium infection was 71.7 % (215/300). Infection was higher in females (56.3 %) but no significant difference was found in prevalence and intensity between gender and age groups. The predominant selfreported symptoms were dysuria (91.2 %), hypogastralgia (88.7 %) and haematuria (87.1%) and these symptoms were strongly associated with S. haematobium infection (p<0.05). Ultrasound and cystoscopy examinations performed in a sub-sample of 29 individuals revealed pathological conditions at the urinary tract in all examined. Considering the high prevalence of S. haematobium infections in Angola and schistosomiasis-associated bladder cancer, our results indicate that this population should be targeted for follow up and implementation of measures for treatment and control of schistosomiasis.

血友病是安哥拉最普遍的寄生虫病之一。该疾病的病理特征是慢性寄生虫感染引起的泌尿生殖道严重且不可逆的病变，最终可导致膀胱鳞状细胞癌。考虑到其发病率的频率和严重程度，甚至在年轻人中也观察到，本研究的目的是评估安哥拉haematobium感染的患病率和发病率。基线调查于2007年11月至2008年2月期间进行。随机抽取300名年龄在15至75岁之间的居民参加了这项研究。血氧索菌感染率为71.7%(215/300)。女性感染率较高(56.3%)，但性别和年龄组之间的患病率和强度无显著差异。自我报告的主要症状是排尿困难(91.2%)、胃下痛(88.7%)和血尿(87.1%)，这些症状与血葡萄球菌感染密切相关(p

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引用次数: 18

Diagnosis and Management of Obstructive Uropathy in the Setting of Advanced Pelvic Malignancies. 晚期盆腔恶性肿瘤患者梗阻性尿病的诊断和治疗。

Journal of nephrology research

Pub Date : 2015-01-01 Epub Date: 2015-12-29

Grace G Zhu, Soroush Rais-Bahrami

Obstructive uropathy is a common urological problem, with a variety of etiologies, ranging from benign to malignant processes, extrinsic to intrinsic conditions. Its presentation depends largely on the location of the obstructive lesion and the acuity of the obstruction. Lower versus upper urinary tract obstruction present differently. A wide variety of imaging tools can aid in diagnosing the obstructive process and help delineate the etiology and the location of the obstruction. Treatment is geared towards alleviating the obstruction, either by restoring the normal urinary flow within the urinary tract by utilizing a ureteral stent for upper urinary tract obstruction or urethral catheters for lower urinary tract obstruction, or by diverting the urine by placing a percutaneous nephrostomy tube or suprapubic catheters. Pelvic malignancies are a subset of the many causes of obstructive uropathy and have unique considerations in treatment. Future directions in the realm of management of obstructive uropathy should focus on maximizing urinary drainage while minimizing the morbidities associated with the current available treatment options.

梗阻性尿路病是一种常见的泌尿系统疾病，病因多种多样，从良性到恶性，从外因到内因，不一而足。其表现主要取决于梗阻病变的位置和梗阻的严重程度。下尿路和上尿路梗阻的表现也不尽相同。各种影像学工具可帮助诊断梗阻过程，并有助于确定病因和梗阻位置。治疗的目的是缓解梗阻，上尿路梗阻时使用输尿管支架，下尿路梗阻时使用尿道导尿管，或者通过经皮肾造瘘管或耻骨上导尿管引流尿液，从而恢复尿路内的正常尿流。盆腔恶性肿瘤是导致梗阻性尿路病的众多原因中的一个子集，在治疗上有其独特的考虑因素。阻塞性尿路病变治疗的未来方向应侧重于最大限度地提高排尿率，同时尽量减少与现有治疗方案相关的发病率。

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引用次数: 0

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