Clinical research in pulmonology最新文献

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Early age at menarche and wheezing in adolescence. The 1993 Pelotas (Brazil) birth cohort study. 初潮年龄过早与青春期喘息。1993 年佩洛塔斯（巴西）出生队列研究。

Clinical research in pulmonology

Pub Date : 2015-01-01

Objective: To evaluate the effect of menarche before 11 years of age on the incidence of wheezing/asthma in girls 11 to 18 years of age.

Methods: The study sample comprised 1,350 girls from a birth cohort that started in 1993 in the urban area of the city of Pelotas, southern Brazil; this cohort was followed until 18 years of age. We assessed wheezing by the question, "Have you ever had wheezing in the chest at any time in the past?," from the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Early menarche was defined as occurring before 11 years of age. We estimated the cumulative incidence of wheezing excluding from the analysis all those participants who reported wheezing before age of 11 years. We performed the chi-square test to assess the association between ever wheezing and independent variables. Poisson regression models with robust variance were used to estimate cumulative incidence ratios.

Results: The average age at menarche in the cohort girls was 12 years (95% CI: 11.1-12.1). The prevalence of early menarche before 11 years of age was 11% (95% CI: 9.7-12.3). The cumulative incidence of wheezing from 11 to 18 years of age was 33.5% (95% CI: 30.9- 36.0). The crude association between ever wheezing in adolescence and early menarche before age 11 was 1.19 (95% CI: 0.96-1.48). After adjusting for early childhood and contemporaneous variables, no significant association for early menarche before 11 years of age and wheezing during adolescence was found (CIR: 1.18; CI95%: 0.93-1.49).

Conclusion: Early menarche before 11 years of age is not associated with an increased risk of wheezing during adolescence.

目的：评估 11 岁前初潮对 11 至 18 岁女孩喘息/哮喘发病率的影响：评估 11 岁前月经初潮对 11 至 18 岁女孩喘息/哮喘发病率的影响：研究样本包括巴西南部佩洛塔斯市城区 1993 年出生队列中的 1,350 名女孩；该队列一直跟踪研究到女孩 18 岁。我们通过 "国际儿童哮喘和过敏研究"（ISAAC）问卷中的问题 "您在过去的任何时候胸部是否出现过喘息 "来评估喘息情况。月经初潮早于 11 岁是指月经初潮早于 11 岁。我们在估算喘息的累积发生率时，排除了所有在 11 岁前报告喘息的参与者。我们采用卡方检验来评估曾经喘息与自变量之间的关系。我们使用具有稳健方差的泊松回归模型来估计累积发病率：结果：队列中女孩的平均初潮年龄为 12 岁（95% CI：11.1-12.1）。11 岁前初潮提前的发生率为 11%（95% CI：9.7-12.3）。11 至 18 岁期间喘息的累积发病率为 33.5%（95% CI：30.9-36.0）。青少年时期曾经喘息与 11 岁前月经初潮之间的粗略关联为 1.19（95% CI：0.96-1.48）。在对儿童早期和同期变量进行调整后，未发现 11 岁前月经初潮与青春期喘息有显著关联（CIR：1.18；CI95%：0.93-1.49）：结论：11 岁前初潮与青春期喘息的风险增加无关。

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