Pub Date : 2018-07-20DOI: 10.15436/2381-1404.18.1900
Tao Wu, H. Cao, Jing Li, D. Mao, Cun-bang Wang, H. Bai, Ommega Internationals
Philadelphia (Ph) chromosome is the derivative chromosome 22 that results from reciprocal translocation t(9;22) (q34;q11). It has been found in about 95% of chronic myeloid leukemia (CML), less often presented in acute lymphocytic leukemia (ALL, about 25% in adult and 2 4% in pediatrics) and occasionally observed in acute myelogenous leukemia (AML) [1]. While double Ph chromosomes can be reported in some cases of CML during blastcrisis, it is rarely reported in ALL. We present a rare case of a lady with a diagnosis of double Ph-positive B-ALL who achieved a continuous complete response after treatment with a combination of conventional chemotherapy and tyrosine kinase inhibitor (TKI) as follows.
{"title":"Double Philadelphia Chromosome-Positive B Acute Lymphoblastic Leukemia","authors":"Tao Wu, H. Cao, Jing Li, D. Mao, Cun-bang Wang, H. Bai, Ommega Internationals","doi":"10.15436/2381-1404.18.1900","DOIUrl":"https://doi.org/10.15436/2381-1404.18.1900","url":null,"abstract":"Philadelphia (Ph) chromosome is the derivative chromosome 22 that results from reciprocal translocation t(9;22) (q34;q11). It has been found in about 95% of chronic myeloid leukemia (CML), less often presented in acute lymphocytic leukemia (ALL, about 25% in adult and 2 4% in pediatrics) and occasionally observed in acute myelogenous leukemia (AML) [1]. While double Ph chromosomes can be reported in some cases of CML during blastcrisis, it is rarely reported in ALL. We present a rare case of a lady with a diagnosis of double Ph-positive B-ALL who achieved a continuous complete response after treatment with a combination of conventional chemotherapy and tyrosine kinase inhibitor (TKI) as follows.","PeriodicalId":91287,"journal":{"name":"International journal of hematology & therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48318321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.15436/2381-1404.15.003
C. Bemrich-Stolz, J. Halanych, T. Howard, L. Hilliard, J. Lebensburger
BACKGROUND Young adults with sickle cell anemia are at high risk for increased hospitalization and death at the time of transition to adult care. This may be related to failure of the transition system to prepare young adults for the adult healthcare system. This qualitative study was designed to identify factors related to transition that may affect the health of adults with sickle cell anemia. PROCEDURE Ten patients currently treated in an adult hematology clinic participated in semi-structured qualitative interviews to describe their experience transitioning from pediatric to adult care and differences in adult and pediatric healthcare systems. RESULTS Participants were generally unprepared for the adult healthcare system. Negative issues experienced by participants included physician mistrust, difficulty with employers, keeping insurance, and stress in personal relationships. Positive issues experienced by participants included improved self efficacy with improved self care and autonomy. CONCLUSIONS In the absence of a formalized transition program, adults with sickle cell anemia experience significant barriers to adult care. In addition to medical history review and identification of an adult provider, transition programs should incorporate strategies to navigate the adult medical system, insurance and relationships as well as encouraging self efficacy.
{"title":"Exploring Adult Care Experiences and Barriers to Transition in Adult Patients with Sickle Cell Disease.","authors":"C. Bemrich-Stolz, J. Halanych, T. Howard, L. Hilliard, J. Lebensburger","doi":"10.15436/2381-1404.15.003","DOIUrl":"https://doi.org/10.15436/2381-1404.15.003","url":null,"abstract":"BACKGROUND Young adults with sickle cell anemia are at high risk for increased hospitalization and death at the time of transition to adult care. This may be related to failure of the transition system to prepare young adults for the adult healthcare system. This qualitative study was designed to identify factors related to transition that may affect the health of adults with sickle cell anemia. PROCEDURE Ten patients currently treated in an adult hematology clinic participated in semi-structured qualitative interviews to describe their experience transitioning from pediatric to adult care and differences in adult and pediatric healthcare systems. RESULTS Participants were generally unprepared for the adult healthcare system. Negative issues experienced by participants included physician mistrust, difficulty with employers, keeping insurance, and stress in personal relationships. Positive issues experienced by participants included improved self efficacy with improved self care and autonomy. CONCLUSIONS In the absence of a formalized transition program, adults with sickle cell anemia experience significant barriers to adult care. In addition to medical history review and identification of an adult provider, transition programs should incorporate strategies to navigate the adult medical system, insurance and relationships as well as encouraging self efficacy.","PeriodicalId":91287,"journal":{"name":"International journal of hematology & therapy","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77352844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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