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Opportunities for Fluorochlorozirconate and Other Glass-Ceramic Detectors in Medical Imaging Devices. 氟氯锆酸盐和其他玻璃陶瓷探测器在医疗成像设备中的机会。
Pub Date : 2015-01-01 Epub Date: 2015-06-25 DOI: 10.19104/jbtr.2015.102
Jacqueline A Johnson, Russell L Leonard, A R Lubinsky, Stefan Schweizer

This article gives an overview of fluorochlorozirconate glass-ceramic scintillators and storage phosphor materials: how they are synthesized, what their properties are, and how they can be used in medical imaging. Such materials can enhance imaging in x-ray radiography, especially mammography and dental imaging, computed tomography, and positron emission tomography. Although focusing on fluorochlorozirconate materials, the reader will find the discussion is relevant to other luminescent glass and glass-ceramic systems.

本文概述了氟氯锆酸盐玻璃陶瓷闪烁体和存储荧光粉材料:它们是如何合成的,它们的性质是什么,以及它们如何用于医学成像。这种材料可以增强x射线成像,特别是乳房x线摄影和牙科成像,计算机断层扫描和正电子发射断层扫描。虽然重点是氟氯锆酸盐材料,读者会发现讨论是相关的其他发光玻璃和玻璃陶瓷系统。
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引用次数: 3
Archimedean Spiral Pairs with no Electrical Connections as a Passive Wireless Implantable Sensor 无电连接的阿基米德螺旋对作为无源无线植入式传感器
Pub Date : 2014-08-18 DOI: 10.19104/JBTR.2014.110
John F. Drazan, A. Gunko, Matthew K. Dion, Omar T. Abdoun, N. Cady, K. Connor, E. Ledet
We have developed, modeled, fabricated, and tested a passive wireless sensor system that exhibits a linear frequency-displacement relationship. The displacement sensor is comprised of two anti-aligned Archimedean coils separated by an insulating dielectric layer. There are no electrical connections between the two coils and there are no onboard electronics. The two coils are inductively and capacitively coupled due to their close proximity. The sensor system is interrogated wirelessly by monitoring the return loss parameter from a vector network analyzer. The resonant frequency of the sensor is dependent on the displacement between the two coils. Due to changes in the inductive and capacitive coupling between the coils at different distances, the resonant frequency is modulated by coil separation. In a specified range, the frequency shift can be linearized with respect to coil separation. Batch fabrication techniques were used to fabricate copper coils for experimental testing with air as the dielectric. Through testing, we validated the performance of sensors as predicted within acceptable errors. Because of its simplicity, this displacement sensor has potential applications for in vivo sensing.
我们已经开发、建模、制造和测试了一种显示线性频率-位移关系的无源无线传感器系统。位移传感器由两个不对齐的阿基米德线圈组成,由绝缘介电层隔开。两个线圈之间没有电气连接,也没有机载电子设备。这两个线圈是电感和电容耦合,因为他们的近距离。传感器系统通过监测来自矢量网络分析仪的回波损耗参数进行无线询问。传感器的谐振频率取决于两个线圈之间的位移。由于线圈之间在不同距离处的电感和电容耦合的变化,谐振频率被线圈分离调制。在一定范围内,频移可以根据线圈间距线性化。以空气为介质,采用批量制备技术制备了用于实验测试的铜线圈。通过测试,我们在可接受的误差范围内验证了传感器的性能。由于其简单性,这种位移传感器在体内传感方面具有潜在的应用前景。
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引用次数: 11
Archimedean Spiral Pairs with no Electrical Connections as a Passive Wireless Implantable Sensor. 无电连接的阿基米德螺旋对作为无源无线植入式传感器。
Pub Date : 2014-01-01 Epub Date: 2014-08-18
John F Drazan, Aleksandra Gunko, Matthew Dion, Omar Abdoun, Nathaniel C Cady, Kenneth A Connor, Eric H Ledet

We have developed, modeled, fabricated, and tested a passive wireless sensor system that exhibits a linear frequency-displacement relationship. The displacement sensor is comprised of two anti-aligned Archimedean coils separated by an insulating dielectric layer. There are no electrical connections between the two coils and there are no onboard electronics. The two coils are inductively and capacitively coupled due to their close proximity. The sensor system is interrogated wirelessly by monitoring the return loss parameter from a vector network analyzer. The resonant frequency of the sensor is dependent on the displacement between the two coils. Due to changes in the inductive and capacitive coupling between the coils at different distances, the resonant frequency is modulated by coil separation. In a specified range, the frequency shift can be linearized with respect to coil separation. Batch fabrication techniques were used to fabricate copper coils for experimental testing with air as the dielectric. Through testing, we validated the performance of sensors as predicted within acceptable errors. Because of its simplicity, this displacement sensor has potential applications for in vivo sensing.

我们已经开发、建模、制造和测试了一种显示线性频率-位移关系的无源无线传感器系统。位移传感器由两个不对齐的阿基米德线圈组成,由绝缘介电层隔开。两个线圈之间没有电气连接,也没有机载电子设备。这两个线圈是电感和电容耦合,因为他们的近距离。传感器系统通过监测来自矢量网络分析仪的回波损耗参数进行无线询问。传感器的谐振频率取决于两个线圈之间的位移。由于线圈之间在不同距离处的电感和电容耦合的变化,谐振频率被线圈分离调制。在一定范围内,频移可以根据线圈间距线性化。以空气为介质,采用批量制备技术制备了用于实验测试的铜线圈。通过测试,我们在可接受的误差范围内验证了传感器的性能。由于其简单性,这种位移传感器在体内传感方面具有潜在的应用前景。
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引用次数: 0
The Effects of Metal Ions on Heparin/Heparin Sulfate-Protein Interactions. 金属离子对肝素/硫酸肝素-蛋白相互作用的影响。
Pub Date : 2014-01-01 Epub Date: 2014-05-19 DOI: 10.19104/jbtr.2014.101
Fuming Zhang, Xinle Liang, Julie M Beaudet, Yujin Lee, Robert J Linhardt

Heparin/heparin sulfate (HS) interacts with a number of proteins thereby playing an essential role in the regulation of many physiological processes. The understanding of heparin/HS-protein interactions at the molecular level is of fundamental importance to biology and will aid in the development of highly specific glycan-based therapeutic agents. The heparin-binding proteins (HBPs) interact with sulfated domains of heparin/HS chains primarily through ionic attraction between negatively charged groups in HS/heparin chains and basic amino acid residues within the protein. Reports in literature have been shown that heparin molecules have a high affinity for a wide range of metal ions. In the present study, we used surface plasmon resonance (SPR) to study the effects of metal ions (under physiological and non-physiological concentrations) on heparin/HS-protein interactions. The results showed that under non-physiological of metal ion concentration, different metal ions showed different effects on heparin binding to fibroblast growth factor-1 (FGF1) and interleakin-7 (IL7). While the effects of individual metal ion at physiological concentrations had little impact on protein binding, the mixed metal ions reduced the FGF1/heparin or IL7/heparin binding affinity, changing its binding profile.

肝素/硫酸肝素(HS)与许多蛋白质相互作用,从而在许多生理过程的调节中发挥重要作用。在分子水平上理解肝素/ hs -蛋白相互作用对生物学具有重要意义,并将有助于开发高度特异性的糖基治疗药物。肝素结合蛋白(HBPs)主要通过HS/肝素链中的负电荷基团与蛋白质内碱性氨基酸残基之间的离子吸引力与肝素/HS链的硫酸化结构域相互作用。文献报道表明,肝素分子对多种金属离子具有高亲和力。在本研究中,我们利用表面等离子体共振(SPR)研究了金属离子(生理和非生理浓度下)对肝素/ hs -蛋白相互作用的影响。结果表明,在非生生性金属离子浓度下,不同金属离子对肝素与成纤维细胞生长因子-1 (FGF1)和间漏素-7 (IL7)结合的影响不同。虽然生理浓度下单个金属离子对蛋白结合的影响不大,但混合金属离子降低了FGF1/肝素或IL7/肝素的结合亲和力,改变了其结合谱。
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引用次数: 13
Mesenchymal Stem Cell Paracrine Factors in Vascular Repair and Regeneration. 血管修复与再生中的间充质干细胞旁分泌因子。
Pub Date : 2014-01-01 Epub Date: 2014-08-28 DOI: 10.19104/jbtr.2014.107
Divya Pankajakshan, Devendra K Agrawal

Mesenchymal stem cell therapy show great optimism in the treatment of several diseases. MSCs are attractive candidates for cell therapy because of easy isolation, high expansion potential giving unlimited pool of transplantable cells, low immunogenicity, amenability to ex vivo genetic modification, and multipotency. The stem cells orchestrate the repair process by various mechanisms such as transdifferentiation, cell fusion, microvesicles or exosomes and most importantly by secreting paracrine factors. The MSCs release several angiogenic, mitogenic, anti-apoptotic, anti-inflammatory and anti-oxidative factors that play fundamental role in regulating tissue repair in various vascular and cardiac diseases. The therapeutic release of these factors by the cells can be enhanced by several strategies like genetic modification, physiological and pharmacological preconditioning, improved cell culture and selection methods, and biomaterial based approaches. The current review describes the impact of paracrine factors released by MSCs on vascular repair and regeneration in myocardial infarction, restenosis and peripheral artery disease, and the various strategies adopted to enhance the release of these paracrine factors to enhance organ function.

间充质干细胞治疗在几种疾病的治疗中显示出很大的前景。间充质干细胞因其易于分离、具有无限的可移植细胞池、低免疫原性、易于体外基因修饰和多能性而成为细胞治疗的有吸引力的候选者。干细胞通过各种机制,如转分化、细胞融合、微泡或外泌体,以及最重要的分泌旁分泌因子来协调修复过程。MSCs释放多种血管生成、有丝分裂、抗凋亡、抗炎和抗氧化因子,在调节各种血管和心脏疾病的组织修复中发挥重要作用。细胞对这些因子的治疗性释放可以通过几种策略来增强,如基因修饰、生理和药理学预处理、改进的细胞培养和选择方法以及基于生物材料的方法。本文综述了MSCs释放的旁分泌因子在心肌梗死、再狭窄和外周动脉疾病中对血管修复和再生的影响,以及促进这些旁分泌因子释放以增强器官功能的各种策略。
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引用次数: 66
期刊
Journal of biomedical technology and research
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