International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems最新文献
Pub Date : 2019-06-01Epub Date: 2019-08-22DOI: 10.1109/transducers.2019.8808688
Habib M N Ahmad, Bo Si, Gaurab Dutta, John R Csoros, William Rudolf Seitz, Edward Song
We present a novel electrochemical biosensing platform for the detection of neurotransmitter glutamate using templated polymer-based target receptors. Our sensing approach demonstrates, for the first time, a non-enzymatic approach without the need of glutamate oxidase, leading to a more specific and rapid response. The proposed detection principle is based on the following two claims: (1) our templated polymer-based receptor results in specific molecular recognition of the target glutamate and, (2) upon target binding, the polymer undergoes a conformation change which can then be measured via electrochemical techniques. This sensing platform has the potential to provide direct monitoring of a variety of non-electroactive species and to eliminate the incorporation of enzymes thereby providing a simpler and more robust alternative to enzyme-based sensors.
{"title":"NON-ENZYMATIC ELECTROCHEMICAL DETECTION OF GLUTAMATE USING TEMPLATED POLYMER-BASED TARGET RECEPTORS.","authors":"Habib M N Ahmad, Bo Si, Gaurab Dutta, John R Csoros, William Rudolf Seitz, Edward Song","doi":"10.1109/transducers.2019.8808688","DOIUrl":"10.1109/transducers.2019.8808688","url":null,"abstract":"<p><p>We present a novel electrochemical biosensing platform for the detection of neurotransmitter glutamate using templated polymer-based target receptors. Our sensing approach demonstrates, for the first time, a non-enzymatic approach without the need of glutamate oxidase, leading to a more specific and rapid response. The proposed detection principle is based on the following two claims: (1) our templated polymer-based receptor results in specific molecular recognition of the target glutamate and, (2) upon target binding, the polymer undergoes a conformation change which can then be measured via electrochemical techniques. This sensing platform has the potential to provide direct monitoring of a variety of non-electroactive species and to eliminate the incorporation of enzymes thereby providing a simpler and more robust alternative to enzyme-based sensors.</p>","PeriodicalId":91719,"journal":{"name":"International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems","volume":"2019 ","pages":"613-616"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/transducers.2019.8808688","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38207642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-01DOI: 10.1109/TRANSDUCERS.2017.7994006
Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Marie Obien, Jan Müller, Yihui Chen, Andreas Hierlemann
We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm2 array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm2). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement and 28 neurotransmitter-detection channels and 16 voltage/current stimulation channels. The system enables real-time and label-free monitoring of position, size, morphology and electrical activity of brain slices.
{"title":"High-Density Mapping of Brain Slices using a Large Multi-Functional High-Density CMOS Microelectrode Array System.","authors":"Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Marie Obien, Jan Müller, Yihui Chen, Andreas Hierlemann","doi":"10.1109/TRANSDUCERS.2017.7994006","DOIUrl":"10.1109/TRANSDUCERS.2017.7994006","url":null,"abstract":"<p><p>We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices <i>in-vitro</i> with multiple readout modalities. The 4.48×2.43 mm<sup>2</sup> array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm<sup>2</sup>). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement and 28 neurotransmitter-detection channels and 16 voltage/current stimulation channels. The system enables real-time and label-free monitoring of position, size, morphology and electrical activity of brain slices.</p>","PeriodicalId":91719,"journal":{"name":"International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems","volume":"2017 ","pages":"135-138"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TRANSDUCERS.2017.7994006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35322839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-21Epub Date: 2015-08-06DOI: 10.1109/TRANSDUCERS.2015.7181103
W Gong, J Sencar, D Jäckel, J Müller, M Fiscella, M Radivojevic, D Bakkum, A Hierlemann
A novel system to cultivate and record brain slices directly on high-density microelectrode arrays (HD-MEA) was developed. This system allows to continuously record electrical activity of selected individual neurons at high spatial resolution, while monitoring neuronal network activity at the same time. For the first time, properties of single neurons and the corresponding neuronal network in an organotypic hippocampal slice culture were studied over four consecutive weeks at daily intervals.
{"title":"Long-Term, High-Spatiotemporal Resolution Recording From Cultured Organotypic Slices with High-Density Microelectrode Arrays.","authors":"W Gong, J Sencar, D Jäckel, J Müller, M Fiscella, M Radivojevic, D Bakkum, A Hierlemann","doi":"10.1109/TRANSDUCERS.2015.7181103","DOIUrl":"https://doi.org/10.1109/TRANSDUCERS.2015.7181103","url":null,"abstract":"<p><p>A novel system to cultivate and record brain slices directly on high-density microelectrode arrays (HD-MEA) was developed. This system allows to continuously record electrical activity of selected individual neurons at high spatial resolution, while monitoring neuronal network activity at the same time. For the first time, properties of single neurons and the corresponding neuronal network in an organotypic hippocampal slice culture were studied over four consecutive weeks at daily intervals.</p>","PeriodicalId":91719,"journal":{"name":"International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems","volume":"18 ","pages":"1037-1040"},"PeriodicalIF":0.0,"publicationDate":"2015-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TRANSDUCERS.2015.7181103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38885034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-01Epub Date: 2015-08-06DOI: 10.1109/transducers.2015.7180966
P Wang, S J A Majerus, R Karam, B Hanzlicek, D L Lin, H Zhu, J M Anderson, M S Damaser, C A Zorman, W H Ko
This paper reports long-term evaluation of a micropackage technology for an implantable MEMS pressure sensor. The all-polymer micropackage survived 160 days when subjected to accelerated lifetime testing at 85 °C in a 1% wt. saline solution. The package shows minimum effect on sensors' sensitivity and nonlinearity, which deviated by less than 5% and 0.3%, respectively. A 6-month in vivo evaluation of 16 MEMS-based pressure sensors demonstrated that the proposed micropackage has good biocompatibility and can protect the MEMS pressure sensor. To the best of our knowledge, these results establish new lifetime records for devices packaged using an all-polymer micropackaging approach.
{"title":"LONG-TERM EVALUATION OF A NON-HERMETIC MICROPACKAGE TECHNOLOGY FOR MEMS-BASED, IMPLANTABLE PRESSURE SENSORS.","authors":"P Wang, S J A Majerus, R Karam, B Hanzlicek, D L Lin, H Zhu, J M Anderson, M S Damaser, C A Zorman, W H Ko","doi":"10.1109/transducers.2015.7180966","DOIUrl":"https://doi.org/10.1109/transducers.2015.7180966","url":null,"abstract":"<p><p>This paper reports long-term evaluation of a micropackage technology for an implantable MEMS pressure sensor. The all-polymer micropackage survived 160 days when subjected to accelerated lifetime testing at 85 °C in a 1% wt. saline solution. The package shows minimum effect on sensors' sensitivity and nonlinearity, which deviated by less than 5% and 0.3%, respectively. A 6-month <i>in vivo</i> evaluation of 16 MEMS-based pressure sensors demonstrated that the proposed micropackage has good biocompatibility and can protect the MEMS pressure sensor. To the best of our knowledge, these results establish new lifetime records for devices packaged using an all-polymer micropackaging approach.</p>","PeriodicalId":91719,"journal":{"name":"International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems","volume":"2015 ","pages":"484-487"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/transducers.2015.7180966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38906594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensors and Microsystems","authors":"C. Di Natale, A. D'Amico, G. Sberveglieri","doi":"10.1142/3236","DOIUrl":"https://doi.org/10.1142/3236","url":null,"abstract":"","PeriodicalId":91719,"journal":{"name":"International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86103397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems
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